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1. 发明授权

US06473491B2 Method and x-ray device using adaptable power source 失效
标题翻译：使用适应电源的方法和x射线装置
公开(公告)号：US06473491B2
公开(公告)日：2002-10-29
申请号：US09748296
申请日：2000-12-21
申请人： Victor I. Chornenky , Graham S. Kerslick , Michael R. Satteson , Steven T. Meyer
发明人： Victor I. Chornenky , Graham S. Kerslick , Michael R. Satteson , Steven T. Meyer
IPC分类号： H05G134
CPC分类号： A61N5/1001 , H05G1/32
摘要： A method described includes positioning an x-ray emitter at a treatment area, where the x-ray emitter is connected to a cable, setting a voltage source at a source voltage, and measuring a current through the x-ray emitter. The method may include comparing a current flowing through the emitter with a limit and a low limit. The method further includes increasing the source voltage if the current is higher than the high limit. The method includes determining the high limit and the low limit based on the source voltage and the desired radiation. An apparatus of the invention includes an x-ray emitter with a voltage source and a current sensor. The apparatus may include a current comparison device for comparing the measured current with a high limit and a low limit, and further include a voltage source control. A current integrator for integrating a current from the x-ray emitter may also be included.
摘要翻译：所描述的方法包括将x射线发射器定位在处理区域，其中x射线发射器连接到电缆，将电压源设置为源极电压，并测量通过x射线发射器的电流。该方法可以包括比较流经发射器的电流与极限和下限。该方法还包括如果电流高于上限，则增加源极电压。该方法包括基于源电压和期望的辐射来确定上限和下限。本发明的装置包括具有电压源和电流传感器的x射线发射器。该装置可以包括用于将测量的电流与上限和下限进行比较的电流比较装置，并且还包括电压源控制。还可以包括用于积分来自x射线发射器的电流的电流积分器。

2. 发明授权

US06771737B2 X-ray catheter with miniature emitter and focusing cup 失效
标题翻译：带微型发射器和聚焦杯的X射线导管
公开(公告)号：US06771737B2
公开(公告)日：2004-08-03
申请号：US09902659
申请日：2001-07-12
申请人： Graham S. Kerslick , Victor I. Chornenky , Ali Jaafar
发明人： Graham S. Kerslick , Victor I. Chornenky , Ali Jaafar
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , A61N5/1002 , H01J35/32 , H01J2235/062 , H01J2235/164
摘要： A cathode for a miniature X-ray device includes an insulating shell, a cathode and an anode. The cathode includes a focusing cup formed into an end. The focusing cup can include a thin metal layer that conforms to an inner surface of the cathode. An emitting material having a low work function, such as diamond, is deposited directly onto the internal surface of the focusing cup. The anode has a flat receiving surface for collecting electrons emitted from the anode. An interior coating is applied as a circumferential belt on the interior surface of the insulating shell. The interior coating, formed of a negative secondary emission yield material, extends lengthwise in the region of the cathode to an anode gap, covering the region of the insulating shell most likely to be subject to stray electrons emitted from the cathode.
摘要翻译：用于微型X射线装置的阴极包括绝缘壳，阴极和阳极。阴极包括形成在一端的聚焦杯。聚焦杯可以包括符合阴极内表面的薄金属层。具有低功函数的发射材料（例如金刚石）直接沉积在聚焦杯的内表面上。阳极具有用于收集从阳极发射的电子的平坦的接收表面。内部涂层作为周向带施加在绝缘壳体的内表面上。由负二次发射产生材料形成的内部涂层在阴极的区域中纵向延伸到阳极间隙，覆盖最可能经受从阴极发射的杂散电子的绝缘壳体的区域。

3. 发明授权

US06546077B2 Miniature X-ray device and method of its manufacture 失效
公开(公告)号：US06546077B2
公开(公告)日：2003-04-08
申请号：US09760815
申请日：2001-01-17
申请人： Victor I. Chornenky , Eunsung Park , Graham S. Kerslick , Ali Jaafar , Mark Gailloux
发明人： Victor I. Chornenky , Eunsung Park , Graham S. Kerslick , Ali Jaafar , Mark Gailloux
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , H01J35/32 , H01J2235/164
摘要： An emitter for a miniature X-ray apparatus comprises an insulating shell, an anode, and a cathode. The insulating shell includes a conical brazing surface, brazed to a conical brazing surface on the anode. The braze consists of a pure titanium layer and a pure tin layer. During brazing, the pure metals react and bond to the insulating shell and create a titanium-tin alloy between the pure layers. Pure tin is sputtered from tin sputter target onto the exposed brazing surfaces of the cathode cap and the anode. The insulating shell is placed in a vacuum chamber of deposition applicator, which deposits an active metal onto the shell brazing surface. In a brazing oven, the anode is placed within insulating shell such that the anode conical brazing surface and the shell conical brazing surface are contacting and aligned with each other. During brazing, the cathode is brought into contact with the insulating shell. The sealed emitters are placed in a sputtering machine's vacuum chamber. A metal is sputtered from a sputtering target to form a metal layer on the exterior of insulating shell.

4. 发明授权

US06415016B1 Crystal quartz insulating shell for X-ray catheter 失效
标题翻译：用于X射线导管的水晶石英绝缘壳
公开(公告)号：US06415016B1
公开(公告)日：2002-07-02
申请号：US09756287
申请日：2001-01-09
申请人： Victor I. Chornenky , Ali Jaafar , Graham S. Kerslick
发明人： Victor I. Chornenky , Ali Jaafar , Graham S. Kerslick
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , H01J35/32 , H01J2235/164
摘要： An insulating housing shell for a miniature x-ray emitter is provided. The housing shell is cut from a quartz monocrystal which is a suitable material for the insulating housing shell due to its resistivity and dielectric strength properties. The x-ray emitter can be inserted into a subject's body to deliver x-ray radiation. The emitter includes a cable, having a proximal and a distal portion. The insulating housing shell is coupled to the distal portion of the cable, and an anode and a cathode are disposed within the insulating housing shell. The cathode has a granular surface and is operative with the anode and the connector to produce the x-ray radiation. The cathode is composed of a material that also allows it to act as a getter.
摘要翻译：提供了一种用于微型x射线发射器的绝缘外壳。壳体由石英单晶切割，由于其电阻率和介电强度特性，绝缘外壳是合适的材料。 X射线发射器可插入受试者的身体以传送X射线辐射。发射器包括具有近端部分和远端部分的电缆。绝缘壳体壳体耦合到电缆的远端部分，阳极和阴极设置在绝缘外壳壳体内。阴极具有颗粒表面并且与阳极和连接器一起工作以产生x射线辐射。阴极由也可以用作吸气剂的材料组成。

5. 发明申请

US20100262067A1 Method for Treatment of Neoplastic Cells in the Prostate of a Patient 有权
标题翻译：用于治疗患者前列腺中的肿瘤细胞的方法
公开(公告)号：US20100262067A1
公开(公告)日：2010-10-14
申请号：US12820955
申请日：2010-06-22
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61N1/30 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B2018/00029 , A61B2018/00285 , A61B2018/00434 , A61B2018/00517 , A61B2018/00547 , A61B2018/00613 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/325
摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.
摘要翻译：公开了一种用于治疗良性前列腺增生的装置和方法。该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

6. 发明授权

US07130697B2 Apparatus and method for the treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的装置和方法
公开(公告)号：US07130697B2
公开(公告)日：2006-10-31
申请号：US10668775
申请日：2003-09-23
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61F2/00 , A61B18/18
CPC分类号： A61N1/325 , A61B18/1477 , A61B18/1485 , A61B2017/00274 , A61B2018/00547 , A61B2018/1425
摘要： An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.
摘要翻译：公开了用于治疗良性前列腺增生的装置和方法，其中所述装置包括具有探针的施用器，所述探针具有近端和远端探针部分，其中所述近端和远端探针部分各自限定轴线，并且其中所述轴线不共线。

7. 发明授权

US06280413B1 Thrombolytic filtration and drug delivery catheter with a self-expanding portion 失效
标题翻译：具有自膨胀部分的溶栓过滤和药物输送导管
公开(公告)号：US06280413B1
公开(公告)日：2001-08-28
申请号：US08889432
申请日：1997-07-08
申请人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
发明人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
IPC分类号： A61M2900
CPC分类号： A61M25/0082 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0071 , A61M25/0074 , A61M2025/0057
摘要： A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.
摘要翻译：公开了溶栓过滤和药物递送导管，其包括纵轴的轴。肋骨被压缩，同时前进到感兴趣的部位，并在现场释放，扩张到比轴的直径大。例如，可以通过套筒或螺纹将肋压缩。药物或其他药剂可以通过轴和肋中的腔进出，通过肋中的端口排出。优选地，端口被定位成在肋之间并且在由肋限定的区域内递送药物或其它药剂。

8. 发明授权

US5925016A Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure 失效
标题翻译：用于药物递送的系统和方法，包括通过压力通过血栓驱动药物或溶解剂来治疗血栓形成
公开(公告)号：US5925016A
公开(公告)日：1999-07-20
申请号：US534856
申请日：1995-09-27
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/09 , A61M25/10 , A61M2025/0047 , A61M2025/09008 , A61M2025/09083 , A61M2025/1052 , A61M2205/36 , A61M25/007 , A61M25/1011
摘要： Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.
摘要翻译：公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管，具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管血栓在压力下。优选地，引导导管的内腔用于抽吸靠近血栓的材料，从而降低血栓近端的压力。管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。然后将过滤的药物或溶解剂再次送入远端区域。以这种方式回收药物或溶解剂降低了程序的成本。本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

9. 发明授权

US07938824B2 Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation 有权
公开(公告)号：US07938824B2
公开(公告)日：2011-05-10
申请号：US11106835
申请日：2005-04-15
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/00 , A61N5/00 , C12N13/00
CPC分类号： A61N1/325 , A61N1/0424 , A61N1/327 , A61N1/328 , A61N1/36014
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

10. 发明申请

US20100002840A1 FIELD EMISSION X-RAY APPARATUS, METHODS, AND SYSTEMS 有权
标题翻译：场发射X射线装置，方法和系统
公开(公告)号：US20100002840A1
公开(公告)日：2010-01-07
申请号：US12337290
申请日：2008-12-17
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： H01J35/00 , G21F3/00
CPC分类号： H01J35/065 , H01J35/32
摘要： Disclosed herein is an x-ray field emission apparatus, system and method, the apparatus having a hollow probe held at vacuum; a cathode enclosed within the probe, the cathode producing an electron stream when connected to a high negative potential; an anode enclosed within the probe and separated from the cathode by a gap, said the providing a target for the electron stream; and a shield assembly comprising a hollow shield electrode positioned within the probe and about the cathode.
摘要翻译：本文公开了一种x射线场发射装置，系统和方法，该装置具有保持在真空下的中空探针; 封装在探针内的阴极，阴极在连接到高负电位时产生电子流; 阳极包围在探针内并与阴极隔开间隙，所述提供电子流的靶; 以及屏蔽组件，其包括位于探针内并围绕阴极的中空屏蔽电极。

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