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1. 发明授权

US5837752A Semi-interpenetrating polymer networks 失效
标题翻译：半互穿聚合物网络
公开(公告)号：US5837752A
公开(公告)日：1998-11-17
申请号：US895762
申请日：1997-07-17
申请人： Venkatram R. Shastri , Robert S. Langer , Peter J. Tarcha
发明人： Venkatram R. Shastri , Robert S. Langer , Peter J. Tarcha
IPC分类号： A61L27/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/26 , A61L27/58 , A61L31/00 , A61L31/04 , A61L31/14 , A61P19/00 , C08F283/00 , C08F283/02
CPC分类号： A61L31/041 , A61L27/26 , A61L27/58 , A61L31/148 , C08F283/00 , A61F2/28 , A61F2002/30062 , A61F2002/30583 , A61F2002/30677 , A61F2210/0004 , A61F2210/0085 , Y10S525/903 , Y10S623/923
摘要： Compositions for bone repair have been developed based on linear hydrophobic degradable polymers and monomers or macromers, at least one of which includes an anhydride linkage. The monomers and/or macromers crosslink each other but not to the linear polymer to form semi-interpenetrating networks. The compositions can include various excipients, therapeutic and/or diagnostic agents. The compositions can be polymerized in the presence of dissolvable particles such as inorganic salts and proteinaceous materials to provide a porous polymer network. The compositions can be injected into a patient and polymerized in situ or can be polymerized ex vivo and implanted. When polymerized ex vivo, the composition can be shaped into various articles, such as pins, screws, and hollow tubes, which can be used to repair broken bones.
摘要翻译：已经基于线性疏水性可降解聚合物和单体或大分子单体开发用于骨修复的组合物，其中至少一种包括酸酐键。单体和/或大分子单体彼此交联而不与线性聚合物交联以形成半互穿网络。组合物可以包括各种赋形剂，治疗剂和/或诊断剂。组合物可以在可溶性颗粒如无机盐和蛋白质物质的存在下聚合以提供多孔聚合物网络。组合物可以注射到患者中并原位聚合或离体聚合并植入。当离体聚合时，组合物可以成形为各种制品，例如针，螺钉和中空管，其可用于修复断骨。

2. 发明授权

US6095148A Neuronal stimulation using electrically conducting polymers 失效
标题翻译：使用导电聚合物进行神经元刺激
公开(公告)号：US6095148A
公开(公告)日：2000-08-01
申请号：US552761
申请日：1995-11-03
申请人： Venkatram R. Shastri , Christine E. Schmidt , Robert S. Langer , Joseph P. Vacanti
发明人： Venkatram R. Shastri , Christine E. Schmidt , Robert S. Langer , Joseph P. Vacanti
IPC分类号： A61L17/00 , A61L27/00 , A61L31/04 , A61L31/06 , A61L31/14 , C12N5/00 , C12N5/06 , C12N13/00 , A61B19/00
CPC分类号： C12N13/00 , A61L31/048 , A61L31/06 , A61L31/14 , C12M25/08 , C12M35/02 , C12M35/08 , C12N5/0068 , C12N2533/30 , C12N2533/40
摘要： Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric support for in vitro nerve cell regeneration, or in vivo to aid in healing nervous tissue defects. The conductive polymers may implanted adjacent to or seeded with nerve cells. Voltage or current is applied to the polymer in a range which induces the desired effect on the cells while not damaging the cells. The methods and systems can be used in a variety of applications to enhance in vivo or in vitro growth or regeneration of nervous tissue.
摘要翻译：提供了用于修饰细胞的再生，分化或功能的方法和支持系统。在一个实施方案中，导电生物相容性聚合物可以单独使用或与用于体外神经细胞再生的聚合物载体组合使用，或在体内用于帮助治愈神经组织缺陷。导电聚合物可以与神经细胞相邻或接种植入。电压或电流在一定范围内施加到聚合物上，该范围对细胞产生期望的影响，同时不破坏细胞。所述方法和系统可用于各种应用以增强神经组织的体内或体外生长或再生。

3. 发明授权

US06582717B1 Drug delivery composition and device 失效
标题翻译：药物输送成分及装置
公开(公告)号：US06582717B1
公开(公告)日：2003-06-24
申请号：US09543964
申请日：2000-04-07
申请人： Venkatram R. Shastri , Isaac Yue , Robert S. Langer
发明人： Venkatram R. Shastri , Isaac Yue , Robert S. Langer
IPC分类号： A61F200
CPC分类号： A61K9/0063 , B33Y80/00
摘要： Drug delivery composition. The composition includes a polymeric material, a complexing agent, and a bioactive agent complexed with the complexing agent. The polymeric material, the complexing agent and the bioactive agent are formed into a delivery matrix. The delivery matrix is particularly adapted for placement below the gum line in a periodontal cavity.
摘要翻译：药物输送成分。该组合物包括聚合物材料，络合剂和与络合剂络合的生物活性剂。将聚合物材料，络合剂和生物活性剂形成为递送基质。递送基质特别适于放置在牙周腔中的牙龈线下方。

4. 发明授权

US06471993B1 Three-dimensional polymer matrices 失效
标题翻译：三维聚合物基质
公开(公告)号：US06471993B1
公开(公告)日：2002-10-29
申请号：US09463709
申请日：2000-01-28
申请人： Venkatram R. Shastri , Ivan Martin , Robert S. Langer , Joachim Seidel
发明人： Venkatram R. Shastri , Ivan Martin , Robert S. Langer , Joachim Seidel
IPC分类号： A61K914
CPC分类号： A61L27/3882 , A61K9/1641 , A61K9/1647 , A61K35/32 , A61K38/465 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/3843 , A61L27/3847 , A61L27/56 , B33Y80/00 , C08J9/26 , C12N5/0068 , C12N5/0655 , C12N2500/38 , C12N2501/115 , C12N2501/39 , C12N2533/40 , C12Y301/03001 , G01N33/545 , C08L67/04
摘要： Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed. Methods for preparing these matrices are also disclosed.
摘要翻译：公开了包括具有半固体网络和空隙的宏观结构的矩阵，以及具有空隙的微结构，其中微结构位于半固体网络内。还公开了制备这些基质的方法。

5. 发明授权

US10696944B2 Intracellular delivery 有权
公开(公告)号：US10696944B2
公开(公告)日：2020-06-30
申请号：US14352354
申请日：2012-10-17
申请人： Massachusetts Institute of Technology , Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
发明人： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
IPC分类号： C12N5/071 , C12M1/42 , C12M3/06 , C12N15/87 , B82Y5/00
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.

6. 发明授权

US09333179B2 Amphiphilic compound assisted nanoparticles for targeted delivery 有权
标题翻译：两亲化合物辅助纳米颗粒用于靶向递送
公开(公告)号：US09333179B2
公开(公告)日：2016-05-10
申请号：US12573591
申请日：2009-10-05
申请人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
发明人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/51 , A61K47/48 , B82Y5/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译：本发明通常涉及具有两亲性组分的纳米颗粒。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。本发明的其它方面涉及使用纳米颗粒文库的方法。

7. 发明授权

US09216188B2 Hydrogels for vocal cord and soft tissue augmentation and repair 有权
标题翻译：用于声带和软组织增强和修复的水凝胶
公开(公告)号：US09216188B2
公开(公告)日：2015-12-22
申请号：US12553800
申请日：2009-09-03
申请人： Steven M. Zeitels , Robert Edward Hillman , Sandeep Sidram Karajanagi , Robert S. Langer
发明人： Steven M. Zeitels , Robert Edward Hillman , Sandeep Sidram Karajanagi , Robert S. Langer
IPC分类号： A61K9/00 , A61K31/00 , A61K31/7052 , A61L27/26 , A61L27/38 , A61L27/52 , C08J3/075 , C08J3/24
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译：本发明提供水凝胶及其组合物，用于声带修复或增强，以及其它软组织修复或增强（例如，膀胱颈增大，皮肤填充剂，乳房植入物，椎间盘，肌肉质量）。将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜，从而恢复患者的声音。特别地，已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。本发明还提供了制备和使用本发明水凝胶的方法。

8. 发明授权

US08808681B2 Crosslinked, degradable polymers and uses thereof 有权
标题翻译：交联的可降解聚合物及其用途
公开(公告)号：US08808681B2
公开(公告)日：2014-08-19
申请号：US11758078
申请日：2007-06-05
申请人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
发明人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
IPC分类号： A61K47/32 , A61K35/00 , C08F2/48 , C08G73/00 , C08F299/04 , C08F290/06 , C08F283/00 , C08G73/02 , C08F299/02 , C08L79/02 , C08G63/685
CPC分类号： C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译：丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。因此，可以调整材料的性质以达到期望的用途。制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

9. 发明授权

US08637028B2 Adjuvant incorporation in immunonanotherapeutics 有权
标题翻译：佐剂掺入免疫疗法
公开(公告)号：US08637028B2
公开(公告)日：2014-01-28
申请号：US13123888
申请日：2009-10-09
申请人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
IPC分类号： A61K39/40 , A61K39/395 , A61K49/04
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译：本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。本发明提供包含免疫表面和免疫刺激部分的纳米载体。在一些实施方案中，免疫刺激部分是佐剂。本发明提供包含本发明纳米载体的药物组合物。本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。

10. 发明申请

US20130302401A1 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 有权
标题翻译：聚（氨基 - 氨基醇），其制备及其用途
公开(公告)号：US20130302401A1
公开(公告)日：2013-11-14
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

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