专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050137136A1 Biospecific probes against Salmonella 审中-公开
标题翻译：针对沙门氏菌的生物特异性探针
公开(公告)号：US20050137136A1
公开(公告)日：2005-06-23
申请号：US10835405
申请日：2004-04-29
申请人： Valery Petrenko , Iryna Sorokulova , Bryan Chin , James Barbaree , Vitaly Vodyanoy , I-Hsuan Chen , Alexandre Samoylov
发明人： Valery Petrenko , Iryna Sorokulova , Bryan Chin , James Barbaree , Vitaly Vodyanoy , I-Hsuan Chen , Alexandre Samoylov
IPC分类号： A61K38/00 , C07H21/04 , C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07H21/04 , Y02A50/481
摘要： Compositions and methods for binding to Salmonella bacteria are provided. The compositions comprise peptide sequences which bind to Salmonella bacteria with high specificity. The compositions are useful in identification, detection, and isolation of Salmonella bacteria. The compositions are also useful for the delivery of a wide variety of compounds to Salmonella bacteria or their vicinity. Such compounds include nucleotides, proteins (including, for example, toxins), liposomes, and small molecule pharmaceuticals. The compositions are also useful in identifying bacterial cell surface markers to which the compositions bind.
摘要翻译：提供了结合沙门菌的组合物和方法。组合物包含以高特异性结合沙门氏菌的肽序列。该组合物可用于鉴定，检测和分离沙门氏菌。所述组合物还可用于将多种化合物递送至沙门氏菌或其附近。这些化合物包括核苷酸，蛋白质（包括例如毒素），脂质体和小分子药物。组合物还可用于鉴定组合物结合的细菌细胞表面标志物。

2. 发明申请

US20050074904A1 Magnetostrictive ligand sensor 有权
标题翻译：磁致伸缩配体传感器
公开(公告)号：US20050074904A1
公开(公告)日：2005-04-07
申请号：US10923414
申请日：2004-08-20
申请人： Bryan Chin , Zhongyang Cheng , Vitaly Vodyanoy , James Barbaree , Valery Petrenko , Tung-Shi Huang , Howard Wikle
发明人： Bryan Chin , Zhongyang Cheng , Vitaly Vodyanoy , James Barbaree , Valery Petrenko , Tung-Shi Huang , Howard Wikle
IPC分类号： G01N33/543 , G01N33/553
CPC分类号： G01N27/745 , G01N33/5434
摘要： A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target ligand binds thereto. A driver is also provided to emit a varying magnetic field such that the MSP produces a resonance response detectable by a measurement device configured to receive and detect changes in the resonance response that are due to alterations of the binding element. The MLSD and assays find use in identifying and quantitating ligands as well as chemicals and environmental conditions in a sample or patient.
摘要翻译：提供了具有至少一个磁致伸缩颗粒（MSP）的磁致伸缩配体传感器装置（MLSD），系统和方法，其结合至少一个结合元件。 MSP可以分散在含有靶配体的样品中，使得靶配体与其结合。还提供驱动器以发射变化的磁场，使得MSP产生由测量装置可检测的共振响应，该测量装置被配置为接收和检测由于绑定元件的改变而引起的共振响应的变化。 MLSD和测定法用于鉴定和定量配体以及样品或患者中的化学物质和环境条件。

3. 发明申请

US20060172332A1 Use of protective natural polymers to isolate and preserve biological material 失效
标题翻译：使用保护性天然聚合物来分离和保存生物材料
公开(公告)号：US20060172332A1
公开(公告)日：2006-08-03
申请号：US11341152
申请日：2006-01-27
申请人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
发明人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
IPC分类号： C12Q1/68 , G01N33/53 , G01N1/30
CPC分类号： G01N33/548 , A01N1/02 , A01N1/0221 , G01N1/30
摘要： Compositions and methods for the reversible preservation of biological samples are provided. The compositions include natural polymers such as pullulan or acacia gum, including derivations and modifications thereof, which are usefull as a reversible preservation solution. A method is provided for using pullulan or Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.
摘要翻译：提供了可逆保存生物样品的组合物和方法。组合物包括天然聚合物，例如支链淀粉或阿拉伯树胶，包括其衍生和修饰，其作为可逆保存溶液是有用的。提供了一种使用支链淀粉或相思胶来隔离和可逆地将室温下的休眠状态的生物样品长时间保持在最小损伤标本的方法。所公开的组合物和方法也可用于产生用于生物传感器的可逆保存的生物标本和生物受体。

4. 发明申请

US20050148019A1 Use of Acacia Gum to isolate and preserve the biological receptor on a biosensor 有权
标题翻译：使用相思胶在生物传感器上分离和保存生物受体
公开(公告)号：US20050148019A1
公开(公告)日：2005-07-07
申请号：US11073963
申请日：2005-03-07
申请人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
发明人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
IPC分类号： A01N1/02 , G01N1/30 , G01N33/548 , C12Q1/68 , C12M1/34 , G01N33/53
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0231 , G01N1/30 , G01N33/548
摘要： Compositions and methods for the reversible preservation of biological samples are provided. The compositions include Acacia Gum, including derivations and modifications thereof which are useful as a reversible preservation solution. A method is provided for using Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.
摘要翻译：提供了可逆保存生物样品的组合物和方法。组合物包括相思胶，包括其可用作可逆保存溶液的衍生物和修饰物。提供了一种方法，使用相思胶在室温下分离并可逆地保存在休眠状态的生物样品延长的时间，同时对样品的损伤最小。所公开的组合物和方法也可用于产生用于生物传感器的可逆保存的生物标本和生物受体。

5. 发明申请

US20070128642A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 有权
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20070128642A1
公开(公告)日：2007-06-07
申请号：US11601423
申请日：2006-11-16
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： G01N33/5002
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

6. 发明申请

US20070122799A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 有权
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20070122799A1
公开(公告)日：2007-05-31
申请号：US11523250
申请日：2006-09-19
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/553 , G01N33/6893 , G01N33/6896 , G01N2510/00 , G01N2800/2828
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）被称为“蛋白质成核中心”（PNC）的金属纳米簇周围的错误折叠或部分错误折叠的蛋白质。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。

7. 发明申请

US20050142611A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 审中-公开
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20050142611A1
公开(公告)日：2005-06-30
申请号：US11005416
申请日：2004-12-06
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C07K14/00 , C12P21/06 , G01N33/53
CPC分类号： G01N33/68
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

8. 发明申请

US20070072308A1 Methods of forming monolayers of phage-derived products and uses thereof 失效
标题翻译：形成噬菌体衍生产物的单层的方法及其用途
公开(公告)号：US20070072308A1
公开(公告)日：2007-03-29
申请号：US11604537
申请日：2006-11-27
申请人： Valery Petrenko , Vitaly Vodyanoy , Jennifer Sykora
发明人： Valery Petrenko , Vitaly Vodyanoy , Jennifer Sykora
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y30/00
摘要： Methods and compositions for identifying and characterizing the affinity of one or more ligands of a peptide are provided. In particular, a “stripped phage ligand sensor device” (SPLSD) is provided comprising a sensor coupled to a binding element of interest. Binding elements of the invention comprise phage which in most embodiments express a peptide of interest on the phage surface. Assays using the SPLSD allow detection and quantitation of ligands. Also provided are improved methods for forming monolayers using phage. In particular, methods for the formation of monolayers using “stripped phage” are provided. Further provided are monolayers and Langmuir-Blodgett films formed by the methods of the invention as well as substrates having deposited thereon the films of the invention. The monolayers, films and substrates of the invention are useful as components of biosensors and/or chemosensors.
摘要翻译：提供了用于鉴定和表征肽的一个或多个配体的亲和力的方法和组合物。特别地，提供了“剥离的噬菌体配体传感器装置”（SPLSD），其包括耦合到感兴趣的结合元件的传感器。本发明的结合元件包含噬菌体，其在大多数实施方案中在噬菌体表面上表达感兴趣的肽。使用SPLSD的测定允许检测和定量配体。还提供了使用噬菌体形成单层的改进方法。特别地，提供了使用“剥离噬菌体”形成单层的方法。还提供了通过本发明的方法形成的单层和Langmuir-Blodgett膜以及在其上沉积有本发明的膜的基底。本发明的单层，薄膜和底物可用作生物传感器和/或化学传感器的组分。

9. 发明授权

US07138238B2 Ligand sensor devices and uses thereof 有权
公开(公告)号：US07138238B2
公开(公告)日：2006-11-21
申请号：US10068570
申请日：2002-02-06
申请人： Vitaly Vodyanoy , Alexandre M. Samoylov , Tatiana I. Samoylova , Suram T. Pathirana
发明人： Vitaly Vodyanoy , Alexandre M. Samoylov , Tatiana I. Samoylova , Suram T. Pathirana
IPC分类号： G01N33/53
CPC分类号： C40B30/04 , C12N15/1037 , C40B40/02 , G01N29/022 , G01N33/54353 , G01N33/54373 , G01N33/5438 , G01N33/54393 , G01N33/545 , G01N33/6842 , G01N33/6845 , G01N2291/014 , G01N2291/02466 , G01N2291/02475 , G01N2291/0256 , G01N2291/0426
摘要： Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.

10. 发明申请

US20070014002A1 Microscope illumination device and adapter 有权
标题翻译：显微镜照明设备和适配器
公开(公告)号：US20070014002A1
公开(公告)日：2007-01-18
申请号：US11487551
申请日：2006-07-14
申请人： Vitaly Vodyanoy , Oleg Pustovyy , Arnold Vainrub
发明人： Vitaly Vodyanoy , Oleg Pustovyy , Arnold Vainrub
IPC分类号： G02B21/06
CPC分类号： G02B21/125
摘要： The present invention is a dark field illumination system including a light source which is fixed on an entrance slit of a condenser and an objective aligned with the condenser such that the objective and the condenser are adjusted to find a focus spot on a sample. The present invention essentially uses structured illumination to achieve an improved illumination system. The present invention also includes a system and method wherein the objective is coupled to an iris and aligned with the condenser such that when the iris is closed only dark field images are produced, and when the iris is open, direct entrance of light is allowed into the objective and bright field illumination is produced.
摘要翻译：本发明是一种暗场照明系统，其包括固定在冷凝器的入口狭缝上的光源和与冷凝器对准的物镜，使得调节物镜和聚光镜以在样品上找到焦点。本发明基本上使用结构照明来实现改进的照明系统。本发明还包括一种系统和方法，其中物镜耦合到虹膜并与冷凝器对准，使得当虹膜闭合时，仅产生暗场图像，并且当虹膜打开时，允许光直接进入产生客观和明亮的场景照明。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式