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1. 发明申请

US20070014002A1 Microscope illumination device and adapter 有权
标题翻译：显微镜照明设备和适配器
公开(公告)号：US20070014002A1
公开(公告)日：2007-01-18
申请号：US11487551
申请日：2006-07-14
申请人： Vitaly Vodyanoy , Oleg Pustovyy , Arnold Vainrub
发明人： Vitaly Vodyanoy , Oleg Pustovyy , Arnold Vainrub
IPC分类号： G02B21/06
CPC分类号： G02B21/125
摘要： The present invention is a dark field illumination system including a light source which is fixed on an entrance slit of a condenser and an objective aligned with the condenser such that the objective and the condenser are adjusted to find a focus spot on a sample. The present invention essentially uses structured illumination to achieve an improved illumination system. The present invention also includes a system and method wherein the objective is coupled to an iris and aligned with the condenser such that when the iris is closed only dark field images are produced, and when the iris is open, direct entrance of light is allowed into the objective and bright field illumination is produced.
摘要翻译：本发明是一种暗场照明系统，其包括固定在冷凝器的入口狭缝上的光源和与冷凝器对准的物镜，使得调节物镜和聚光镜以在样品上找到焦点。本发明基本上使用结构照明来实现改进的照明系统。本发明还包括一种系统和方法，其中物镜耦合到虹膜并与冷凝器对准，使得当虹膜闭合时，仅产生暗场图像，并且当虹膜打开时，允许光直接进入产生客观和明亮的场景照明。

2. 发明申请

US20050260133A1 Strategy for designing patient-specific anti-cancer drugs 失效
标题翻译：设计患者特异性抗癌药物的策略
公开(公告)号：US20050260133A1
公开(公告)日：2005-11-24
申请号：US11132879
申请日：2005-05-19
申请人： Tatiana Samoylova , Henry Baker , Nancy Cox , Vitaly Vodyanoy , Ludmila Globa , Nancy Morrison
发明人： Tatiana Samoylova , Henry Baker , Nancy Cox , Vitaly Vodyanoy , Ludmila Globa , Nancy Morrison
IPC分类号： A61K38/17 , A61K51/00 , C10G20060101 , G01N33/50 , G01N33/574
CPC分类号： G01N33/574 , G01N33/5011 , G01N2500/10
摘要： A diagnostic technique for matching anti-cancer peptide drugs to the molecular profiles of individual cancer tumors, and a method using the technique for a patient-specific treatment of tumors in mammals. This strategy matches anti-cancer peptide drugs to the molecular profiles of individual tumors, and includes the development of two banks, both of which use the same targeting peptides. Targeting peptides are identified using biopsies or other tissue materials from multiple cancer patients and placed into two banks. For a bank of probes, targeting peptides are linked to a label such as a fluorescent or a radioisotope. For a bank of drugs, targeting peptides are linked to a cytotoxic peptide to form a “targeting peptide drug”. Peptide probes are used to establish molecular profiles of individual tumors. Based on these molecular profiles, a patient-specific combination of targeting drugs from the bank of peptide drugs is prepared and the patient is treated. Any currently used cytotoxic agent that can be linked to targeting peptides may be used in place of cytotoxic peptides.
摘要翻译：将抗癌肽药物与个体癌症肿瘤的分子特征匹配的诊断技术，以及使用该技术用于哺乳动物肿瘤患者特异性治疗的方法。这种策略将抗癌肽药物与单个肿瘤的分子谱相匹配，并且包括两个银行的发展，两个银行都使用相同的靶向肽。使用来自多个癌症患者的活组织检查或其他组织材料鉴定靶向肽，并将其置于两个组中。对于一组探针，靶向肽与标记如荧光或放射性同位素连接。对于一批药物，靶向肽与细胞毒肽连接以形成“靶向肽药物”。肽探针用于建立单个肿瘤的分子谱。基于这些分子谱，制备来自肽药物库的靶向药物的患者特异性组合，并对患者进行治疗。可以使用任何目前使用的可以与靶向肽连接的细胞毒性剂来代替细胞毒性肽。

3. 发明申请

US20050074904A1 Magnetostrictive ligand sensor 有权
标题翻译：磁致伸缩配体传感器
公开(公告)号：US20050074904A1
公开(公告)日：2005-04-07
申请号：US10923414
申请日：2004-08-20
申请人： Bryan Chin , Zhongyang Cheng , Vitaly Vodyanoy , James Barbaree , Valery Petrenko , Tung-Shi Huang , Howard Wikle
发明人： Bryan Chin , Zhongyang Cheng , Vitaly Vodyanoy , James Barbaree , Valery Petrenko , Tung-Shi Huang , Howard Wikle
IPC分类号： G01N33/543 , G01N33/553
CPC分类号： G01N27/745 , G01N33/5434
摘要： A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target ligand binds thereto. A driver is also provided to emit a varying magnetic field such that the MSP produces a resonance response detectable by a measurement device configured to receive and detect changes in the resonance response that are due to alterations of the binding element. The MLSD and assays find use in identifying and quantitating ligands as well as chemicals and environmental conditions in a sample or patient.
摘要翻译：提供了具有至少一个磁致伸缩颗粒（MSP）的磁致伸缩配体传感器装置（MLSD），系统和方法，其结合至少一个结合元件。 MSP可以分散在含有靶配体的样品中，使得靶配体与其结合。还提供驱动器以发射变化的磁场，使得MSP产生由测量装置可检测的共振响应，该测量装置被配置为接收和检测由于绑定元件的改变而引起的共振响应的变化。 MLSD和测定法用于鉴定和定量配体以及样品或患者中的化学物质和环境条件。

4. 发明申请

US20070128642A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 有权
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20070128642A1
公开(公告)日：2007-06-07
申请号：US11601423
申请日：2006-11-16
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： G01N33/5002
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

5. 发明授权

US07138238B2 Ligand sensor devices and uses thereof 有权
公开(公告)号：US07138238B2
公开(公告)日：2006-11-21
申请号：US10068570
申请日：2002-02-06
申请人： Vitaly Vodyanoy , Alexandre M. Samoylov , Tatiana I. Samoylova , Suram T. Pathirana
发明人： Vitaly Vodyanoy , Alexandre M. Samoylov , Tatiana I. Samoylova , Suram T. Pathirana
IPC分类号： G01N33/53
CPC分类号： C40B30/04 , C12N15/1037 , C40B40/02 , G01N29/022 , G01N33/54353 , G01N33/54373 , G01N33/5438 , G01N33/54393 , G01N33/545 , G01N33/6842 , G01N33/6845 , G01N2291/014 , G01N2291/02466 , G01N2291/02475 , G01N2291/0256 , G01N2291/0426
摘要： Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.

6. 发明申请

US20070242336A1 Applications for mixing and combining light utilizing a transmission filter, iris, aperture apparatus 审中-公开
标题翻译：利用透射滤光片，虹膜，光圈装置混合和组合光的应用
公开(公告)号：US20070242336A1
公开(公告)日：2007-10-18
申请号：US11708781
申请日：2007-02-20
申请人： Vitaly Vodyanoy , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B26/02 , G02B27/10 , G02B5/22
CPC分类号： G01N21/6458 , G02B5/22 , G02B21/06 , G02B26/008 , G02B26/023 , G02B27/0905 , G02B27/0994
摘要： The present invention involves methods to combine light and apparatuses to accomplish the same. In some embodiments of the present invention, light from two light sources is combined to achieve multiple functions within one application. In some embodiments of the present invention, light from the light source is filtered using traditional high-contrast filters, transmission filters or the like. In some embodiments of the present invention, novel low contrast filters and variable contrast filters are used. These filters allow passing a light with a narrow frequency band of large intensity, while the broad spectrum light of smaller intensity is still passing through the filter. In some embodiments of the present invention, a strobing effect is used to combine light.
摘要翻译：本发明涉及组合光和装置以完成相同的方法。在本发明的一些实施例中，来自两个光源的光被组合以在一个应用中实现多个功能。在本发明的一些实施例中，使用传统的高对比度滤波器，透射滤波器等对来自光源的光进行滤波。在本发明的一些实施例中，使用新颖的低对比度滤光片和可变对比度滤光片。这些滤光片允许通过具有较大强度的窄频带的光，而较小强度的广谱光仍然通过滤光片。在本发明的一些实施例中，使用选通效果来组合光。

7. 发明申请

US20070139764A1 Simultaneous observation of darkfield images and fluorescence using filter and diaphragm 有权
标题翻译：使用过滤器和隔膜同时观察暗场图像和荧光
公开(公告)号：US20070139764A1
公开(公告)日：2007-06-21
申请号：US11636107
申请日：2006-12-08
申请人： Vitaly Vodyanoy , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B21/06
CPC分类号： G02B21/10 , G01N21/6458 , G01N2021/8822 , G02B5/005 , G02B21/16
摘要： An annular diaphragm and filter used for the simultaneous observation of darkfield images and fluorescence. The diaphragm has a variable diameter controlled by a lever and a removable filter. The diaphragm is used to adjust the amount of unfiltered incident light which produces darkfield images when directed on a sample. The removable filter is used to filter light to a particular frequency for producing fluorescence images. An Acousto-Optical Tunable Filter, or other such tunable filter may be used with the diaphragm. A method of using the diaphragm and filter is also disclosed.
摘要翻译：用于同时观察暗场图像和荧光的环形光阑和滤光片。隔膜具有由杠杆和可移除过滤器控制的可变直径。光阑用于调整在过滤后的入射光量，当入射到样品时会产生暗场图像。可拆卸的过滤器用于将光过滤到特定频率以产生荧光图像。声光调节滤光器或其他这样的可调滤光片可以与隔膜一起使用。还公开了使用隔膜和过滤器的方法。

8. 发明申请

US20060153015A1 CD-ROM based optical biosensors 审中-公开
标题翻译：基于光盘的光学生物传感器
公开(公告)号：US20060153015A1
公开(公告)日：2006-07-13
申请号：US11149869
申请日：2005-06-10
申请人： Vitaly Vodyanoy , Alexei Samoylov , Timothy Moore
发明人： Vitaly Vodyanoy , Alexei Samoylov , Timothy Moore
IPC分类号： G11B7/00
CPC分类号： G01N33/54366 , G01N1/2214 , G01N1/2273 , G01N21/75 , G01N33/54373 , G01N35/00069
摘要： A CD-ROM based optical biosensor, system and method of sensing biological samples in the air includes treating the surface of a CD-ROM medium with a receptor capable of binding with a targeted biological sample. While continuous reading of the CD-ROM is conducted by a CD-ROM drive, an air-flow is directed through the CD-ROM drive, over and around the CD-ROM such that any targeted biological samples present in the air will bind with the receptors. The laser reader of the CD-ROM device detects these biological samples as they obstruct the data blocks present on the CD-ROM. A processor of the CD-ROM drive determines whether an output signal is required, and if so, appropriately sends one to an output device.
摘要翻译：基于CD-ROM的光学生物传感器，系统和感测空气中的生物样品的方法包括用能够与靶向生物样品结合的受体处理CD-ROM培养基的表面。当CD-ROM的连续读取由CD-ROM驱动器进行时，气流被引导通过CD-ROM驱动器，CD-ROM上方和周围，使得存在于空气中的任何目标生物样品将与受体。 CD-ROM设备的激光读取器在它们阻挡CD-ROM上存在的数据块时检测这些生物样本。 CD-ROM驱动器的处理器确定是否需要输出信号，如果是，则将其适当地发送到输出设备。

9. 发明申请

US20050168810A1 High-resolution optical microscope 有权
公开(公告)号：US20050168810A1
公开(公告)日：2005-08-04
申请号：US11068223
申请日：2005-02-28
申请人： Vitaly Vodyanoy , William Neely
发明人： Vitaly Vodyanoy , William Neely
IPC分类号： G01J3/44 , G01N21/65 , G02B21/06 , G02B21/16 , G02B21/18 , G02B21/36 , G02B21/00
CPC分类号： G01J3/44 , G01N21/65 , G02B21/06 , G02B21/16 , G02B21/18 , G02B21/36
摘要： A direct-view optical microscope system is provided which uses high-energy light from a phenomenon known as non-resonant Raman scattering to illuminate a living biological specimen. One embodiment of the system combines two discrete light sources to form a combined incident light source for the microscope. The system includes a method and apparatus for modulating the intensity of the scattered light when two light waves are combined to produce the incident light. By varying the frequency of the two source light waves, the intensity of the combined Raman-scattered light can be modulated to achieve finer resolution.

10. 发明申请

US20050148019A1 Use of Acacia Gum to isolate and preserve the biological receptor on a biosensor 有权
标题翻译：使用相思胶在生物传感器上分离和保存生物受体
公开(公告)号：US20050148019A1
公开(公告)日：2005-07-07
申请号：US11073963
申请日：2005-03-07
申请人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
发明人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
IPC分类号： A01N1/02 , G01N1/30 , G01N33/548 , C12Q1/68 , C12M1/34 , G01N33/53
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0231 , G01N1/30 , G01N33/548
摘要： Compositions and methods for the reversible preservation of biological samples are provided. The compositions include Acacia Gum, including derivations and modifications thereof which are useful as a reversible preservation solution. A method is provided for using Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.
摘要翻译：提供了可逆保存生物样品的组合物和方法。组合物包括相思胶，包括其可用作可逆保存溶液的衍生物和修饰物。提供了一种方法，使用相思胶在室温下分离并可逆地保存在休眠状态的生物样品延长的时间，同时对样品的损伤最小。所公开的组合物和方法也可用于产生用于生物传感器的可逆保存的生物标本和生物受体。

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