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1. 发明申请

US20070014002A1 Microscope illumination device and adapter 有权
标题翻译：显微镜照明设备和适配器
公开(公告)号：US20070014002A1
公开(公告)日：2007-01-18
申请号：US11487551
申请日：2006-07-14
申请人： Vitaly Vodyanoy , Oleg Pustovyy , Arnold Vainrub
发明人： Vitaly Vodyanoy , Oleg Pustovyy , Arnold Vainrub
IPC分类号： G02B21/06
CPC分类号： G02B21/125
摘要： The present invention is a dark field illumination system including a light source which is fixed on an entrance slit of a condenser and an objective aligned with the condenser such that the objective and the condenser are adjusted to find a focus spot on a sample. The present invention essentially uses structured illumination to achieve an improved illumination system. The present invention also includes a system and method wherein the objective is coupled to an iris and aligned with the condenser such that when the iris is closed only dark field images are produced, and when the iris is open, direct entrance of light is allowed into the objective and bright field illumination is produced.
摘要翻译：本发明是一种暗场照明系统，其包括固定在冷凝器的入口狭缝上的光源和与冷凝器对准的物镜，使得调节物镜和聚光镜以在样品上找到焦点。本发明基本上使用结构照明来实现改进的照明系统。本发明还包括一种系统和方法，其中物镜耦合到虹膜并与冷凝器对准，使得当虹膜闭合时，仅产生暗场图像，并且当虹膜打开时，允许光直接进入产生客观和明亮的场景照明。

2. 发明授权

US07551349B2 High resolution optical microscope with cardioid condenser for brightfield and darkfield illumination 有权
标题翻译：高分辨率光学显微镜，用于明场和暗场照明的心形聚光镜
公开(公告)号：US07551349B2
公开(公告)日：2009-06-23
申请号：US11607369
申请日：2006-12-01
申请人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G01N21/6458 , G01N2021/8825
摘要： The present invention is an improved illumination system which achieves enhanced spatial resolution and contrast in the observation of small objects. The enhanced performance is achieved by using a metal-halide light source, a power conservative pre-condenser optics train, an annular diaphragm, a cardioid annular condenser, and an adjustable light-filtering iris. These features are also intended to be used with a direct-view light optical microscope. A method of manufacturing and using the improved illumination system is also disclosed.
摘要翻译：本发明是一种改进的照明系统，其在观察小物体时实现了增强的空间分辨率和对比度。通过使用金属卤化物光源，功率保守的预冷凝器光学系列，环形光阑，心形环形冷凝器和可调节的光过滤虹膜来实现增强的性能。这些特征也用于直视光学显微镜。还公开了一种制造和使用改进的照明系统的方法。

3. 发明申请

US20070127117A1 High resolution optical microscope 有权
标题翻译：高分辨率光学显微镜
公开(公告)号：US20070127117A1
公开(公告)日：2007-06-07
申请号：US11607369
申请日：2006-12-01
申请人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G01N21/6458 , G01N2021/8825
摘要： The present invention is an improved illumination system which achieves enhanced spatial resolution and contrast in the observation of small objects. The enhanced performance is achieved by using a metal-halide light source, a power conservative pre-condenser optics train, an annular diaphragm, a cardioid annular condenser, and an adjustable light-filtering iris. These features are also intended to be used with a direct-view light optical microscope. A method of manufacturing and using the improved illumination system is also disclosed.
摘要翻译：本发明是一种改进的照明系统，其在观察小物体时实现了增强的空间分辨率和对比度。通过使用金属卤化物光源，功率保守的预冷凝器光学系列，环形光阑，心形环形冷凝器和可调节的光过滤虹膜来实现增强的性能。这些特征也用于直视光学显微镜。还公开了一种制造和使用改进的照明系统的方法。

4. 发明申请

US20070128642A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 有权
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20070128642A1
公开(公告)日：2007-06-07
申请号：US11601423
申请日：2006-11-16
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： G01N33/5002
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

5. 发明申请

US20070242336A1 Applications for mixing and combining light utilizing a transmission filter, iris, aperture apparatus 审中-公开
标题翻译：利用透射滤光片，虹膜，光圈装置混合和组合光的应用
公开(公告)号：US20070242336A1
公开(公告)日：2007-10-18
申请号：US11708781
申请日：2007-02-20
申请人： Vitaly Vodyanoy , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B26/02 , G02B27/10 , G02B5/22
CPC分类号： G01N21/6458 , G02B5/22 , G02B21/06 , G02B26/008 , G02B26/023 , G02B27/0905 , G02B27/0994
摘要： The present invention involves methods to combine light and apparatuses to accomplish the same. In some embodiments of the present invention, light from two light sources is combined to achieve multiple functions within one application. In some embodiments of the present invention, light from the light source is filtered using traditional high-contrast filters, transmission filters or the like. In some embodiments of the present invention, novel low contrast filters and variable contrast filters are used. These filters allow passing a light with a narrow frequency band of large intensity, while the broad spectrum light of smaller intensity is still passing through the filter. In some embodiments of the present invention, a strobing effect is used to combine light.
摘要翻译：本发明涉及组合光和装置以完成相同的方法。在本发明的一些实施例中，来自两个光源的光被组合以在一个应用中实现多个功能。在本发明的一些实施例中，使用传统的高对比度滤波器，透射滤波器等对来自光源的光进行滤波。在本发明的一些实施例中，使用新颖的低对比度滤光片和可变对比度滤光片。这些滤光片允许通过具有较大强度的窄频带的光，而较小强度的广谱光仍然通过滤光片。在本发明的一些实施例中，使用选通效果来组合光。

6. 发明申请

US20070139764A1 Simultaneous observation of darkfield images and fluorescence using filter and diaphragm 有权
标题翻译：使用过滤器和隔膜同时观察暗场图像和荧光
公开(公告)号：US20070139764A1
公开(公告)日：2007-06-21
申请号：US11636107
申请日：2006-12-08
申请人： Vitaly Vodyanoy , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B21/06
CPC分类号： G02B21/10 , G01N21/6458 , G01N2021/8822 , G02B5/005 , G02B21/16
摘要： An annular diaphragm and filter used for the simultaneous observation of darkfield images and fluorescence. The diaphragm has a variable diameter controlled by a lever and a removable filter. The diaphragm is used to adjust the amount of unfiltered incident light which produces darkfield images when directed on a sample. The removable filter is used to filter light to a particular frequency for producing fluorescence images. An Acousto-Optical Tunable Filter, or other such tunable filter may be used with the diaphragm. A method of using the diaphragm and filter is also disclosed.
摘要翻译：用于同时观察暗场图像和荧光的环形光阑和滤光片。隔膜具有由杠杆和可移除过滤器控制的可变直径。光阑用于调整在过滤后的入射光量，当入射到样品时会产生暗场图像。可拆卸的过滤器用于将光过滤到特定频率以产生荧光图像。声光调节滤光器或其他这样的可调滤光片可以与隔膜一起使用。还公开了使用隔膜和过滤器的方法。

7. 发明申请

US20070242335A1 Translational filter, shutter, aperture apparatus for selecting and combining filtered and unfiltered light 审中-公开
标题翻译：平移滤光片，快门，孔径设备，用于选择和组合过滤和未过滤的光
公开(公告)号：US20070242335A1
公开(公告)日：2007-10-18
申请号：US11708877
申请日：2007-02-20
申请人： Thomas Hasling , Vitaly Vodyanoy , Oleg Pustovyy
发明人： Thomas Hasling , Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B26/02
CPC分类号： G01N21/6458 , G02B5/22 , G02B21/06 , G02B26/008 , G02B26/023 , G02B27/0905 , G02B27/0994
摘要： A method and apparatus for filtering and mixing light is provided. The apparatus comprises a translational filter, aperture and shutter. A light beam and the translational filter, aperture and shutter are moved relative to each other to precisely control the proportions of filtered, unobstructed and blocked light. A method for precisely controlling the proportions of filtered, unobstructed and blocked light is also provided. Optional accessories include additional translational filters, apertures and shutters, light guides, relay lenses, microscopes, computers, motors for controlling the positions of the components, focusing lenses, and mechanical shutters.
摘要翻译：提供了一种用于过滤和混合光的方法和装置。该装置包括平移滤光器，光圈和快门。光束和平移滤光器，光圈和快门相对于彼此移动以精确地控制滤光的，无障碍的和阻挡的光的比例。还提供了一种用于精确控制过滤，无障碍和阻挡光的比例的方法。可选配件包括附加的平移滤光片，孔和百叶窗，光导，中继透镜，显微镜，计算机，用于控制部件位置的电动机，聚焦透镜和机械百叶窗。

8. 发明授权

US07688505B2 Simultaneous observation of darkfield images and fluorescence using filter and diaphragm 有权
标题翻译：使用过滤器和隔膜同时观察暗场图像和荧光
公开(公告)号：US07688505B2
公开(公告)日：2010-03-30
申请号：US11636107
申请日：2006-12-08
申请人： Vitaly Vodyanoy , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/10 , G01N21/6458 , G01N2021/8822 , G02B5/005 , G02B21/16
摘要： An annular diaphragm and filter used for the simultaneous observation of darkfield images and fluorescence. The diaphragm has a variable diameter controlled by a lever and a removable filter. The diaphragm is used to adjust the amount of unfiltered incident light which produces darkfield images when directed on a sample. The removable filter is used to filter light to a particular frequency for producing fluorescence images. An Acousto-Optical Tunable Filter, or other such tunable filter may be used with the diaphragm. A method of using the diaphragm and filter is also disclosed.
摘要翻译：用于同时观察暗场图像和荧光的环形光阑和滤光片。隔膜具有由杠杆和可移除过滤器控制的可变直径。光阑用于调整在过滤后的入射光量，当入射到样品时会产生暗场图像。可拆卸的过滤器用于将光过滤到特定频率以产生荧光图像。声光调节滤光器或其他这样的可调滤光片可以与隔膜一起使用。还公开了使用隔膜和过滤器的方法。

9. 发明申请

US20070122799A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 有权
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20070122799A1
公开(公告)日：2007-05-31
申请号：US11523250
申请日：2006-09-19
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/553 , G01N33/6893 , G01N33/6896 , G01N2510/00 , G01N2800/2828
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）被称为“蛋白质成核中心”（PNC）的金属纳米簇周围的错误折叠或部分错误折叠的蛋白质。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。

10. 发明申请

US20050237605A1 Microscope illumination device and adapter therefor 有权
标题翻译：显微镜照明装置及适配器
公开(公告)号：US20050237605A1
公开(公告)日：2005-10-27
申请号：US11106819
申请日：2005-04-15
申请人： Vitaly Vodyanoy , Oleg Pustovyy , Thomas Hasling
发明人： Vitaly Vodyanoy , Oleg Pustovyy , Thomas Hasling
IPC分类号： G02B21/00 , G02B21/06 , G02B21/10 , G02B21/12 , G02B21/16
CPC分类号： G02B21/12 , G02B21/10 , G02B21/16
摘要： An illumination system for a microscope, including a light source for generating light to illuminate a sample for microscopic observation, at least one collimating lens for collimating light generated by the light source, and a darkfield condenser for receiving collimated light and directing a hollow cone of light onto the sample under observation. The system optionally includes an adapter for enhancing economy of light transmission from the light source to the specimen, the adapter having a centrally disposed spacer and a plurality of optical fibers surrounding the spacer, to generate a hollow cylinder of light for transmission to the darkfield condenser. The system provides improved resolution and contrast, and is well suited for adaptation to fluorescence microscopy techniques.
摘要翻译：一种用于显微镜的照明系统，包括用于产生用于照明用于显微镜观察的样品的光的光源，至少一个用于准直光源产生的光的准直透镜，以及用于接收准直光的暗场冷凝器，在观察下点亮样品。该系统可选地包括用于增强从光源到样本的光透射的经济性的适配器，适配器具有居中设置的间隔物和围绕间隔物的多个光纤，以产生中空圆柱形的光以传输到暗场冷凝器。该系统提供改进的分辨率和对比度，并且非常适合于适应荧光显微镜技术。

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