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1. 发明申请

US20070107514A1 Integrated sensor arrangement 审中-公开
标题翻译：集成传感器布置
公开(公告)号：US20070107514A1
公开(公告)日：2007-05-17
申请号：US11545778
申请日：2006-10-10
申请人： Ulrich Sieben , Holger Klapproth , Mirko Lehmann
发明人： Ulrich Sieben , Holger Klapproth , Mirko Lehmann
IPC分类号： G01F15/14
CPC分类号： G01N21/6454
摘要： An integrated sensor array has a substrates, at least one sensor element, and a signal processing device integrated in the substrate and connected or capable of being connected with the sensor elements. A layer having a measuring surface is capable of being detachably bonded to the substrate so that a signal emitted from the measuring surface is capable of being processed by the signal processing device when the layer is bonded to the substrate. The substrate has at least one feedthrough hole abutting with the layer, which feedthrough hole is connected or capable of being connected to a vacuum generating device in order to bond the layer to the substrate by suction.
摘要翻译：集成传感器阵列具有基板，至少一个传感器元件和集成在基板中并连接或能够与传感器元件连接的信号处理装置。具有测量表面的层能够可拆卸地结合到基板，使得当该层与基板结合时，从测量表面发射的信号能够被信号处理装置处理。衬底具有与该层邻接的至少一个馈通孔，所述馈通孔连接或能够连接到真空产生装置，以便通过抽吸将层粘合到衬底。

2. 发明申请

US20050176064A1 Method for determining the number of receptors on a carrier 审中-公开
标题翻译：确定载体上受体数目的方法
公开(公告)号：US20050176064A1
公开(公告)日：2005-08-11
申请号：US10520039
申请日：2003-06-30
申请人： Holger Klapproth , Ulrich Sieben
发明人： Holger Klapproth , Ulrich Sieben
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N33/542 , G01N33/543 , G01N33/551 , G01N33/566 , G01N33/58 , G01N33/53
CPC分类号： G01N33/54306 , B01J19/0046 , B01J2219/00385 , B01J2219/00527 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/00677 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N33/542 , G01N33/543 , G01N33/551 , G01N33/566 , G01N33/582
摘要： The invention relates to a method for determining the number of receptors on a carrier, in addition to a biosensor, especially a protein sensor, which can be produced using the method.
摘要翻译：本发明涉及一种用于确定载体上的受体数量的方法，除了可以使用该方法生产的生物传感器，特别是蛋白质传感器。

3. 发明申请

US20050158848A1 Method for immobolizing molecules on surfaces 审中-公开
标题翻译：表面上固定分子的方法
公开(公告)号：US20050158848A1
公开(公告)日：2005-07-21
申请号：US10511192
申请日：2003-04-10
申请人： Ulrich Sieben , Ingo Freund , Holger Klapproth
发明人： Ulrich Sieben , Ingo Freund , Holger Klapproth
IPC分类号： B01J20/32 , C09D125/06 , C09D179/08 , C09D201/00 , G01N33/543 , G01N37/00 , C12M1/34 , B05D3/00
CPC分类号： B01J20/3204 , B01J20/103 , B01J20/28011 , B01J20/3257 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/3289 , G01N33/54393
摘要： In a method for immobilizing molecules on a surface, a layer of a hydrophobic, e.g., a non-swelling polymer, may be applied to the surface and molecules are immobilized on a surface of the polymer layer. The hydrophobic polymers may be polyimide or polystyrene, and the surface to which the polymer layer is applied may be made of an inorganic material, e.g., a semiconductor material (silicon), a semiconducting oxide (silicon dioxide), glass, nitride, or ceramic. Hydrophobic polymers such as polyimide or polystyrene can be applied to the surface of an inorganic support with conventional methods. Further, they electrically insulate the support with respect to the molecules applied to the surface of the polymer layer or substances associated with these molecules. Thus, electrical sensors and processor circuits can be integrated into the support without any detrimental effect on their function due to molecules and substances applied to the surface of the polymer layer.
摘要翻译：在将分子固定在表面上的方法中，可以将一层疏水的，例如不溶胀的聚合物施加到表面上，并将分子固定在聚合物层的表面上。疏水聚合物可以是聚酰亚胺或聚苯乙烯，并且施加聚合物层的表面可以由无机材料制成，例如半导体材料（硅），半导体氧化物（二氧化硅），玻璃，氮化物或陶瓷。疏水性聚合物如聚酰亚胺或聚苯乙烯可以用常规方法施加到无机载体的表面上。此外，它们相对于施加到聚合物层的表面上的分子或与这些分子相关联的物质将载体电绝缘。因此，电传感器和处理器电路可以集成到支撑件中，而不会由于施加到聚合物层表面的分子和物质而对它们的功能产生不利影响。

4. 发明申请

US20090017505A1 Process and device for mixing microdroplets 审中-公开
标题翻译：混合微滴的方法和装置
公开(公告)号：US20090017505A1
公开(公告)日：2009-01-15
申请号：US11805242
申请日：2007-05-22
申请人： Ulrich Sieben , Holger Klapproth
发明人： Ulrich Sieben , Holger Klapproth
IPC分类号： C12P19/34 , C12M1/40 , C12M1/34
CPC分类号： B01L3/0262 , B01F13/0071 , B01F13/0084 , B01F15/06 , B01L3/5085 , B01L3/5088 , B01L3/563 , B01L2200/025 , B01L2200/143 , B01L2300/0819 , B01L2300/1822
摘要： In a process for mixing microdroplets (2a, 2b, 2c), at least two carriers (3a, 3b) are provided whose surfaces (4a, 4b) are each structured in such a way that at least one hydrophilic surface domain (5a, 5b) is delimited by at least one hydrophobic surface domain (6a, 6b). A first microdroplet (2a, 2b, 2c) is disposed on a hydrophilic surface domain (5a) of a first carrier (3a), and a second microdroplet (2a, 2b, 3c) is disposed on a hydrophilic surface domain (5b) of a second carrier (3b). The carriers (3a, 3b), with their first and second hydrophilic surfaces (4a, 4b) facing each other, are positioned adjacent to each other and sufficiently close to each other by being moved toward each other that the microdroplets (2a, 2b, 2c) come into contact with each other.
摘要翻译：在混合微滴（2a，2b，2c）的方法中，提供至少两个载体（3a，3b），其表面（4a，4b）各自构造成使得至少一个亲水性表面区域（5a，5b））由至少一个疏水性表面结构域（6a，6b）界定。第一微滴（2a，2b，2c）设置在第一载体（3a）的亲水性表面区域（5a）上，第二微滴（2a，2b，3c）设置在亲水性表面区域第二载体（3b）。其第一和第二亲水表面（4a，4b）彼此面对的载体（3a，3b）通过彼此移动彼此相邻并且彼此靠近彼此，使得微滴（2a，2b， 2c）相互接触。

5. 发明申请

US20080286882A1 Method and Apparatus for Measuring the Concentration of a Ligand Contained in a Sample That Is To Be Tested 审中-公开
标题翻译：用于测量待测试样品中的配体浓度的方法和装置
公开(公告)号：US20080286882A1
公开(公告)日：2008-11-20
申请号：US11960090
申请日：2007-12-19
申请人： Ulrich Sieben , Holger Klapproth
发明人： Ulrich Sieben , Holger Klapproth
IPC分类号： G01N33/543 , B01J19/00
CPC分类号： G01N33/54366
摘要： In a method for measuring the concentration of a ligand contained in a sample that is to be tested, at a plurality of test sites that are located on the surface of at least one substrate, in each case at least one receptor that is suitable upon contact with the ligand for specifically binding to said ligand, is immobilized. The sample is brought into contact for a predetermined time with the test sites in such a way that in the sample differently sized diffusion volumes are adjacent to the receptors from which at least one ligand can diffuse to the respective receptor during the predetermined time. After the predetermined time has passed, for each test site a measured signal for the number or density of the binding events at the test site is acquired.
摘要翻译：在用于测量待测试样品中所含配体浓度的方法中，在位于至少一个底物表面上的多个测试位点，在每种情况下至少一种适合接触的受体与特异性结合所述配体的配体被固定化。使样品与测试位置接触预定时间，使得在样品中不同尺寸的扩散体积与受体相邻，在预定时间内至少一种配体可以从该受体扩散到相应的受体。在预定时间过去之后，对于每个测试站点，获取测试点处的绑定事件的数量或密度的测量信号。

6. 发明申请

US20080028477A1 Chip with Power Supply Device 审中-公开
标题翻译：带电源的芯片
公开(公告)号：US20080028477A1
公开(公告)日：2008-01-31
申请号：US11579213
申请日：2005-02-02
申请人： Mirko Lehmann , Ulrich Sieben
发明人： Mirko Lehmann , Ulrich Sieben
IPC分类号： G06F1/26 , G08B29/16
CPC分类号： H01M8/02 , G06K19/0702 , G06K19/073 , G06K19/07381 , H01L23/576 , H01L2924/0002 , H01M8/04559 , H01M8/04917 , H01M8/04947 , H01M8/2475 , H01M2250/00 , H01M2250/30 , Y02B90/18 , H01L2924/00
摘要： A chip includes a memory that stores confidential data, a power supply device to apply a voltage and/or or a current, and an interface to transfer the data from and/or to another device. To secure the data in the memory, the power supply device is an integrated component of the chip. The power supply device is equipped with a limited, non-replenishable fuel reservoir so that data can be maintained in the memory over a limited service life. In other embodiments, voltage provided by the power supply device can also be employed actively to delete data in the memory in the event of unauthorized access to the chip.
摘要翻译：芯片包括存储秘密数据的存储器，用于施加电压和/或电流的电源装置，以及将数据从和/或传送到另一装置的接口。为了保护存储器中的数据，电源设备是芯片的集成组件。电源设备配备有限的，不可补充的燃料储存器，以便数据可在有限的使用寿命内保持在存储器中。在其他实施例中，在未经授权的访问芯片的情况下，还可以主动地采用由电源装置提供的电压来删除存储器中的数据。

7. 发明授权

US06288440B1 Chip arrangement 失效
标题翻译：芯片布置
公开(公告)号：US06288440B1
公开(公告)日：2001-09-11
申请号：US09342697
申请日：1999-06-29
申请人： Ulrich Sieben , Günter Igel , Mirko Lehmann , Hans-Jürgen Gahle , Bernhard Wolf , Werner Baumann , Ralf Ehret
发明人： Ulrich Sieben , Günter Igel , Mirko Lehmann , Hans-Jürgen Gahle , Bernhard Wolf , Werner Baumann , Ralf Ehret
IPC分类号： H01L23495
CPC分类号： H01L23/5385 , A61B5/14532 , A61B5/1473 , G01N33/48707 , H01L2924/0002 , H01L2924/00
摘要： A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).
摘要翻译：芯片装置（1）具有带有开口（3）的基板（2），其中插入有载体芯片（4），其具有电或电子结构部件（5）。至少一个导体路径（7）集成到载体芯片（4）中，其将结构部件（5）连接到电连接触点（8）。载体芯片（4）以这样的方式插入到开口（3）中，使得其端部突出超过衬底板（2）的相对面对的平坦表面（9,9'），从而形成突出部（10,10'）。这里，结构部件布置在突出超过一个表面（9）的伸出部（10）上，并且连接触点（8）布置在突出超过另一个表面（9'）的伸出部（10'）上，并且连接结构部件（5）和连接触点（8）的导体路径（7）穿过开口（3）。在基板（2）和载体芯片（4）之间设置密封件。

8. 发明授权

US06368851B1 Method and apparatus for measuring a state variable 有权
标题翻译：用于测量状态变量的方法和装置
公开(公告)号：US06368851B1
公开(公告)日：2002-04-09
申请号：US09321458
申请日：1999-05-27
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12M142
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.
摘要翻译：提供了一种用于测量位于营养介质（2）中并被支撑并附着到支撑区域（5）上的生物体（3）的状态变量的方法。在电池（3）的支撑区域（5）内并且距离支撑区域边缘一定距离处，在电池（3）的膜中形成开口。围绕开口并附着到支撑区域（5）的细胞膜的边缘将从细胞（3）内发现的液体与营养培养基（2）密封。通过打开状态变量（2）进行测量。还提供了一种用于执行该方法的装置。

9. 发明授权

US07501276B2 Apparatus for intracellular manipulation of a biological cell 失效
标题翻译：用于细胞内操作生物细胞的装置
公开(公告)号：US07501276B2
公开(公告)日：2009-03-10
申请号：US10202419
申请日：2002-07-23
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12M1/42 , C12N15/87
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.
摘要翻译：提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封在一起，并使细胞液体抵抗培养物中等（2）。电池（3）的内部通过开口被操纵。还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

10. 发明申请

US20060233662A1 Support element for use in the analysis of substances 审中-公开
标题翻译：用于物质分析的支持元素
公开(公告)号：US20060233662A1
公开(公告)日：2006-10-19
申请号：US10569329
申请日：2004-08-19
申请人： Mirko Lehmann , Ulrich Sieben
发明人： Mirko Lehmann , Ulrich Sieben
IPC分类号： G01N31/22
CPC分类号： B01L3/502707 , B01J2219/00378 , B01J2219/00527 , B01J2219/00545 , B01J2219/00549 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00677 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01L2300/0636 , B01L2300/0654 , C40B40/06 , C40B40/10 , G01N21/78 , G01N33/54366
摘要： In a carrier medium having at least two defined regions, biological and/or chemical substances are applied to the regions of the carrier medium for analyzing an analyte. The carrier medium is also provided with a stored code that indicates which biological and/or chemical substance is located in which defined region. The application of multiple biological and/or chemical substances to one carrier medium enables multiple analyses to be performed simultaneously on the analyte. This approach reduces the required quantities of the biological and/or chemical substances needed to perform the desired analyses of the analyte. The carrier medium itself does not reveal which biological and/or chemical substance is located in which region; this information may instead be provided by the code.
摘要翻译：在具有至少两个限定区域的载体介质中，将生物和/或化学物质施加到载体介质的区域以分析分析物。载体介质还具有指示哪个生物和/或化学物质位于哪个限定区域的存储代码。将多种生物和/或化学物质应用于一种载体介质使得能够在分析物上同时进行多次分析。该方法减少了对分析物进行所需分析所需的生物和/或化学物质所需的量。载体介质本身不显露哪个生物和/或化学物质位于哪个区域; 该信息可以由代码提供。

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