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1. 发明授权

US07501276B2 Apparatus for intracellular manipulation of a biological cell 失效
标题翻译：用于细胞内操作生物细胞的装置
公开(公告)号：US07501276B2
公开(公告)日：2009-03-10
申请号：US10202419
申请日：2002-07-23
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12M1/42 , C12N15/87
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.
摘要翻译：提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封在一起，并使细胞液体抵抗培养物中等（2）。电池（3）的内部通过开口被操纵。还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

2. 发明授权

US06916673B2 Method for producing an optical transmitting and receiving device and a transmitting and receiving device produced according to said method 失效
标题翻译：用于制造光发射和接收装置的方法和根据所述方法制造的发射和接收装置
公开(公告)号：US06916673B2
公开(公告)日：2005-07-12
申请号：US10169008
申请日：2000-12-19
申请人： Ulrich Sieben , Günter Igel
发明人： Ulrich Sieben , Günter Igel
IPC分类号： H01L31/12 , H01L31/173 , H01L21/00
CPC分类号： H01L31/173
摘要： The invention relates to a method for producing an optical transmitting and receiving device (1, 1a) comprising a light emitting transmission element (3, 3a) and a receiving element (4, 4a) which converts this light into an electrical magnitude. The transmission and receiving elements are inserted into a silicon substrate. The optical transmitting and receiving device (1) is preferably inserted in a monolithic manner into a common substrate, comprising a sequence of superimposed layers for the light emitting transmission element (3) and the light receiving element (4). An electrically insulating intermediate layer (9, 9a) is incorporated between the transmission and receiving element.
摘要翻译：本发明涉及一种用于制造光发射和接收装置（1,1a）的方法，该光发射和接收装置（1,1a）包括发光透射元件（3,3a）和接收元件（4,4a），其将该光转换成电量。将传输和接收元件插入到硅衬底中。光发送和接收装置（1）优选地以单片方式插入公共衬底中，包括用于发光透射元件（3）和光接收元件（4）的叠加层序列。电绝缘中间层（9,9a）结合在传输和接收元件之间。

3. 发明授权

US06765394B1 Capacitive magnetic field sensor 失效
标题翻译：电容式磁场传感器
公开(公告)号：US06765394B1
公开(公告)日：2004-07-20
申请号：US09868538
申请日：2001-11-26
申请人： Günter Igel , Ulrich Sieben , Jürgen Giehl
发明人： Günter Igel , Ulrich Sieben , Jürgen Giehl
IPC分类号： G01R2726
CPC分类号： G01R33/038
摘要： The invention relates to a capacitive magnetic field sensor. This sensor has a first electrode (2) and a second electrode (3), which are spaced apart from one another and which form a measurement capacitance. The first electrode (2) is situated on a first substrate body (4), and the second electrode (3) on a second substrate body (5). The second substrate body (5) is designed as a deformable membrane in the vicinity of the second electrode (3). A magnetic body (6) is situated in the vicinity of the second electrode (3) and the membrane, and is rigidly connected to the membrane and to the second electrode (3). As a result of this rigid connection, the influence of an external magnetic field on the magnetic body causes not only the magnetic body (6) to change its position but also causes the membrane and the second electrode (3) to change their position, since they are rigidly connected to said magnetic body. Because the second electrode (3) changes its position, its distance from the first electrode (2) changes, and thus the measurement capacitance, which acts as a measure of the externally applied magnetic field. This capacitive magnetic field sensor is distinguished by very small exterior dimensions, great mechanical stability, and low temperature dependence.
摘要翻译：本发明涉及电容式磁场传感器。该传感器具有彼此间隔开并形成测量电容的第一电极（2）和第二电极（3）。第一电极（2）位于第一基板主体（4）上，第二电极（3）位于第二基板主体（5）上。第二基板体（5）被设计为在第二电极（3）附近的可变形膜。磁体（6）位于第二电极（3）和膜附近，并且刚性地连接到膜和第二电极（3）。作为这种刚性连接的结果，外部磁场对磁体的影响不仅使磁体（6）改变其位置，而且还使膜和第二电极（3）改变其位置，因为它们刚性地连接到所述磁体。因为第二电极（3）改变其位置，所以其与第一电极（2）的距离改变，因此测量电容用作外部施加的磁场的量度。该电容式磁场传感器的外形尺寸非常小，机械稳定性好，温度依赖性低。

4. 发明授权

US06638743B2 Method for measuring a state variable 失效
公开(公告)号：US06638743B2
公开(公告)日：2003-10-28
申请号：US10119354
申请日：2002-04-09
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jörg Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jörg Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12N1300
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

5. 发明授权

US06475760B1 Method for intracellular manipulation of a biological cell 有权
标题翻译：细胞内操作生物细胞的方法
公开(公告)号：US06475760B1
公开(公告)日：2002-11-05
申请号：US09321051
申请日：1999-05-27
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12N1300
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.
摘要翻译：提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封并使细胞液体抵抗培养物中等（2）。电池（3）的内部通过开口被操纵。还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

6. 发明授权

US06413474B1 Measuring device 失效
标题翻译：测量工具
公开(公告)号：US06413474B1
公开(公告)日：2002-07-02
申请号：US09441769
申请日：1999-11-17
申请人： Günter Igel , Ulrich Sieben , Jürgen Giehl , Bernhard Wolf
发明人： Günter Igel , Ulrich Sieben , Jürgen Giehl , Bernhard Wolf
IPC分类号： G01N1506
CPC分类号： G01L19/147 , H01L2224/16225 , H01L2924/00014 , H01L2224/0401
摘要： A measuring device (1) has a semiconductor arrangement, which includes a semiconductor chip (2) connected to a carrier (4) having at least one through-hole (3). The semiconductor chip (2) has at least one sensor (6) with an active sensor surface (5) facing the through-hole (3). The semiconductor chip (2) has electrical terminal points (9), which are connected using flip-chip connections (10) to terminal contacts (11) facing the terminal points (9) and located on the carrier (4). The carrier (4) has electrical strip conductors (12), which connect the terminal contacts (11) to contact elements (13) located on the carrier. To the rear side of the carrier (4) having the contact elements (13) a strip conductor carrier (16) is provided, which has strip conductors (12) connected to opposing contacts (14). The opposing contacts (14) are each electrically connected using flip-chip connections (17), to a contact element (13), which are allocated to each of them. The semiconductor chip (2) and the carrier (4) enclose a measuring chamber. Between the carrier (4) and the semiconductor chip (2) a seal (7) is arranged, which is constructed to be porous or semi-porous, at least in certain areas, or is constructed as a selectively permeable membrane, for bringing a substance into the measuring chamber.
摘要翻译：测量装置（1）具有半导体装置，其包括连接到具有至少一个通孔（3）的载体（4）的半导体芯片（2）。半导体芯片（2）具有至少一个具有面向通孔（3）的有源传感器表面（5）的传感器（6）。半导体芯片（2）具有电气端点（9），它们使用倒装芯片连接（10）连接到面向终端点（9）并位于载体（4）上的端子触点（11）。载体（4）具有将端子触点（11）连接到位于载体上的接触元件（13）的电条导体（12）。在具有接触元件（13）的载体（4）的后侧设置带状导体载体（16），该带状导体载体（16）具有连接到相对触点（14）的带状导体（12）。每个相对的触点（14）都使用倒装芯片连接（17）电连接到分配给它们中的每一个的接触元件（13）。半导体芯片（2）和载体（4）包围测量室。在载体（4）和半导体芯片（2）之间，至少在某些区域中布置密封件（7），其被构造为多孔或半孔的，或被构造为选择性渗透膜，用于使物质进入测量室。

7. 发明授权

US06369435B1 Semiconductor component 失效
标题翻译：半导体元件
公开(公告)号：US06369435B1
公开(公告)日：2002-04-09
申请号：US09440913
申请日：1999-11-16
申请人： Günter Igel
发明人： Günter Igel
IPC分类号： H01L2984
CPC分类号： G01L19/142 , G01L19/146 , G01L19/147
摘要： A semiconductor component (1) has a pressure sensor and a semiconductor chip (2) with a semiconductor structure (3) for at least one additional function of the semiconductor component (1). The semiconductor chip (2) is connected to a casing (5) by means of an elastic carrier arrangement (4) and can be deflected relative to the casing (5) against the restoring force of the material of the carrier arrangement (4) on the whole. For indirect measurement of a pressure acting on the semiconductor chip (2) and causing the deflection of the semiconductor chip (2), at least one position sensor that works together with the semiconductor chip (2) is provided.
摘要翻译：半导体部件（1）具有用于半导体部件（1）的至少一个附加功能的具有半导体结构（3）的压力传感器和半导体芯片（2）。半导体芯片（2）通过弹性载体装置（4）连接到壳体（5），并且可以克服载体装置（4）的材料的恢复力而相对于壳体（5）偏转整体。为了间接测量作用在半导体芯片（2）上的压力并引起半导体芯片（2）的偏转，提供了与半导体芯片（2）一起工作的至少一个位置传感器。

8. 发明授权

US06964927B2 Method and production of a sensor 失效
标题翻译：传感器的方法和生产
公开(公告)号：US06964927B2
公开(公告)日：2005-11-15
申请号：US10149560
申请日：2001-12-07
申请人： Günter Igel , Markus Rogalla
发明人： Günter Igel , Markus Rogalla
IPC分类号： H01L21/56 , H01L31/0203 , H01L31/0232 , H01L21/302
CPC分类号： H01L31/0203 , H01L21/565 , H01L2924/0002 , H01L2924/00
摘要： The invention relates to a method for producing a sensor (1), wherein a carrier chip (2) is produced. Said chip is provided with a sensor structure (3) comprising an active sensor surface (4). A material (9) capable of flowing is applied onto carrier chips (2) in such a way that the sensor structure (3) has a thinner layer thickness on said active sensor surface (4) than on the area of the carrier chip (2) which borders on the active sensor surface (4). The material (9) which is capable of flowing is hardened thereafter. The hardened material (9) is subsequently removed by chemical means from the surface which faces said carrier chip (2) until the active sensor surface of the sensor structure is layed bare.
摘要翻译：本发明涉及一种制造传感器（1）的方法，其中制造了载体芯片（2）。所述芯片设置有包括有源传感器表面（4）的传感器结构（3）。将能够流动的材料（9）施加到载体芯片（2）上，使得传感器结构（3）在所述主动传感器表面（4）上具有比载体芯片（2）的区域更薄的层厚度），其接合在主动传感器表面（4）上。能够流动的材料（9）之后被硬化。随后通过化学方法从面向所述载体芯片（2）的表面去除硬化材料（9），直到传感器结构的有源传感器表面裸露。

9. 发明授权

US06572748B1 Reference electrode 失效
标题翻译：参考电极
公开(公告)号：US06572748B1
公开(公告)日：2003-06-03
申请号：US09623839
申请日：2001-11-26
申请人： Sigrun Herrmann , Heiner Kaden , Wolfram Oelssner , Günter Igel
发明人： Sigrun Herrmann , Heiner Kaden , Wolfram Oelssner , Günter Igel
IPC分类号： G01N2726
CPC分类号： G01N27/301
摘要： A reference electrode (1) for electrochemical measurements includes a metallic palladium-containing electrode component (3) which is covered by a layer (4) formed of or containing a palladium compound poorly soluble in aqueous media. Positioned on layer (4) is a reference electrolyte (5) which contains anions of this palladium compound in dissolved form (FIG. 4).
摘要翻译：用于电化学测量的参比电极（1）包括由不溶于水性介质的钯化合物形成或含有钯化合物的层（4）覆盖的金属含钯电极组分（3）。位于层（4）上的是参考电解质（5），其含有溶解形式的该钯化合物的阴离子（图4）。

10. 发明授权

US06191489B1 Micromechanical layer stack arrangement particularly for flip chip or similar connections 有权
标题翻译：微机械层堆叠布置，特别适用于倒装芯片或类似连接
公开(公告)号：US06191489B1
公开(公告)日：2001-02-20
申请号：US09506634
申请日：2000-02-18
申请人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
发明人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
IPC分类号： H01L2348
CPC分类号： H01L24/12 , H01L23/3192 , H01L24/11 , H01L2224/13018 , H01L2224/13022 , H01L2224/13099 , H01L2224/13144 , H01L2224/13147 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01022 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/19043 , H01L2924/351 , H01L2924/00
摘要： A process is provided for manufacturing a layer arrangement (1) having a bump for a flip chip or similar connection. The layer arrangement has a plurality of layers (2, 3, 4, 5, 6, 7, 11) made of solid material and stacked into a layer stack (8). A recess (10) that extends over several layers (2, 3, 4, 5, 6, 7, 11) is made in the layer stack (8) transverse to the coating planes of the layers (2, 3, 4, 5, 6, 7, 11). A bump material (14) is placed in the recess (10). A profiling is created on the lateral boundary wall of the recess (10) by removal of layer material of different layers (2, 3, 4, 5, 6, 7, 11) of the layer stack (8). The profiling, starting from the surface (9) of the layer stack (8) and progressing in layers to the inside of the recess (10), has at least two indentations (12) and at least one projection (13) located between them. After the production of the profiling, a bump material (14) is brought into the recess (10) in such a way that it grasps behind the indentations (12).
摘要翻译：提供了一种用于制造具有用于倒装芯片或类似连接的凸块的层布置（1）的工艺。层布置具有由固体材料制成并堆叠成层堆叠（8）的多个层（2,3,4,5,6,7,11）。在层叠体（8）中横跨多层（2,3,4,5,6,7,11）的层（2,3,4,5,11）的涂层平面（2,3,4,5），6,7,11）。凸起材料（14）放置在凹部（10）中。通过去除层叠（8）的不同层（2,3,4,5,6,7,11）的层材料，在凹槽（10）的侧边界壁上形成轮廓。从层叠体（8）的表面（9）开始并且分层进入凹部（10）的内部的成型具有至少两个凹口（12）和位于它们之间的至少一个突起（13）。在生产轮廓之后，将凸块材料（14）以这样一种方式被带到凹槽（10）中，使得它抓住压痕（12）的后面。

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