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1. 发明授权

US06231498B1 Combined catheter system for IABP and determination of thermodilution cardiac output 失效
公开(公告)号：US06231498B1
公开(公告)日：2001-05-15
申请号：US09338543
申请日：1999-06-23
申请人： Ulrich J. Pfeiffer , Steve Allen , Ulf Borg
发明人： Ulrich J. Pfeiffer , Steve Allen , Ulf Borg
IPC分类号： A61N1362
CPC分类号： A61B5/028 , A61B5/029 , A61M1/1008 , A61M1/106 , A61M1/1072 , A61M1/1086 , A61M1/125 , A61M2025/0003 , A61M2205/33 , A61M2205/3303 , A61M2205/3334 , A61M2205/3368
摘要： An intro-aortic balloon catheter system and method for determining cardiac output with the system including a distal end for insertion into an aorta and a proximal end opposed to the distal end, a balloon portion in proximity to the distal end which repeatedly expands and contracts so as to assist the pumping action of the heart, a catheter tube connected to the balloon portion with the catheter tube having a lumen introducing a pressurized gas into the balloon portion and leading the pressurized gas out from the balloon portion and a temperature sensor attached to the catheter tube and being electrically coupled to a connector at the proximal end of the catheter tube. The method includes inserting the temperature sensor into a lumen of the intra aortic balloon catheter system, advancing the temperature sensor until it projects freely into the aorta, injecting an injectate of a temperature different to that of the temperature of the patient's blood into the central vein of the patient, measuring the blood temperature profile versus time by means of the temperature sensor and calculating cardiac output and optionally the derived variables from the measured temperature profile.

2. 发明授权

US06746431B2 Combined catheter system for IABP and determination of thermodilution cardiac output 失效
标题翻译：用于IABP的组合导管系统和热稀释心输出量的测定
公开(公告)号：US06746431B2
公开(公告)日：2004-06-08
申请号：US09834905
申请日：2001-04-16
申请人： Ulrich J. Pfeiffer , Steve Allen , Ulf Borg
发明人： Ulrich J. Pfeiffer , Steve Allen , Ulf Borg
IPC分类号： A61M531
CPC分类号： A61B5/028 , A61B5/029 , A61M1/1008 , A61M1/106 , A61M1/1072 , A61M1/1086 , A61M1/125 , A61M2025/0003 , A61M2205/33 , A61M2205/3303 , A61M2205/3334 , A61M2205/3368
摘要： An intro-aortic balloon catheter system and method for determining cardiac output with the system including a distal end for insertion into an aorta and a proximal end opposed to the distal end, a balloon portion in proximity to the distal end which repeatedly expands and contracts so as to assist the pumping action of the heart, a catheter tube connected to the balloon portion with the catheter tube having a lumen introducing a pressurized gas into the balloon portion and leading the pressurized gas out from the balloon portion and a temperature sensor attached to the catheter tube and being electrically coupled to a connector at the proximal end of the catheter tube. The method includes inserting the temperature sensor into a lumen of the intra aortic balloon catheter system, advancing the temperature sensor until it projects freely into the aorta, injecting an injectate of a temperature different to that of the temperature of the patient's blood into the central vein of the patient, measuring the blood temperature profile versus time by means of the temperature sensor and calculating cardiac output and optionally the derived variables from the measured temperature profile.
摘要翻译：一种主动脉内气囊导管系统和方法，用于利用所述系统确定心输出量，所述系统包括用于插入主动脉的远端和与所述远端相对的近端，邻近所述远端的气囊部分反复膨胀和收缩为了辅助心脏的泵送动作，导管与血管部分连接，其中导管管具有将加压气体引入球囊部分并将加压气体从球囊部分引出并将温度传感器附接到导管管并且电耦合到导管管的近端处的连接器。该方法包括将温度传感器插入主动脉内主动脉球囊导管系统的内腔，推进温度传感器直到其自由伸入主动脉，将与患者血液温度不同的温度注射入中央静脉的患者，通过温度传感器测量血液温度分布与时间的关系，并根据测量的温度曲线计算心输出量和可选的导出变量。

3. 发明申请

US20110105911A1 Device for Indicator Dilution Measurements 有权
标题翻译：指示剂稀释测量装置
公开(公告)号：US20110105911A1
公开(公告)日：2011-05-05
申请号：US12738073
申请日：2008-10-15
申请人： Ulf Borg , Reinhold Knoll , Frederic Michard , Ulrich Pfeiffer
发明人： Ulf Borg , Reinhold Knoll , Frederic Michard , Ulrich Pfeiffer
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/02755 , A61B5/028
摘要： The invention relates to indicator dilution measurements of a central volume (V1) with a first site of injection (S1) upstream of the central volume (V1) a second site of detection (S2) of the diluted indicator downstream of the central volume (V1), wherein a first additional volume (V2) is defined between the first site (S1) and the central volume (V1) and a first additional branch (B2) is defined between the first site (S1) and the central volume (V1) and wherein a second additional volume (V3) is defined between the central volume (V1) and the second site (S2) and a second additional branch (B3) is defined between the central volume (V1) and the second site (S2) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V2, V3) and/or for the first and second additional branches (B2, B3).
摘要翻译：本发明涉及具有中心体积（V1）上游的第一注射部位（S1）的中心体积（V1）的指示剂稀释测量，第二中心体积（V1）下游的稀释指示的检测位置（S2）），其中在所述第一部位（S1）和所述中心体积（V1）之间限定第一附加体积（V2），并且在所述第一部位（S1）和所述中心体积（V1）之间限定第一附加分支（B2）并且其中在所述中心体积（V1）和所述第二部位（S2）之间限定第二附加体积（V3），并且在所述中心体积（V1）和所述第二部位（S2）之间限定第二附加分支（B3），其中针对第一和第二附加体积（V2，V3）和/或第一和第二附加分支（B2，B3）校正中心体积参数的结果。

4. 发明授权

US06989498B1 Method and device for locking 有权
标题翻译：锁定方法和装置
公开(公告)号：US06989498B1
公开(公告)日：2006-01-24
申请号：US10070720
申请日：2000-09-08
申请人： Hans Linder , Ulf Borg
发明人： Hans Linder , Ulf Borg
IPC分类号： H01R9/28
CPC分类号： H01H9/20 , H01H9/16 , H01H9/282
摘要： The present invention concerns a method and a device for locking a disconnecting breaker. During locking of a single-poled or multiple-poled disconnecting breaker, the actuator of the breaker is first locked both electrically and mechanically. When the breaker is in the open position, the distance between the contacts of the breaker comprises the conductor spacing for the isolation function. The electrical and mechanical locking of the actuator is indicated both electrically and mechanically. Subsequently, the link system of the breaker is mechanically locked. The link system is locked in the interlocked position. Locking of the link system is indicated by at least one indicator. Locking of the actuator of the breaker can be controlled manually via a key- and lock device, or remotely.
摘要翻译：本发明涉及一种用于锁定断路器的方法和装置。在单极或多极断路器的锁定期间，断路器的致动器首先被电和机械地锁定。当断路器处于打开位置时，断路器触点之间的距离包括用于隔离功能的导体间距。致动器的电气和机械锁定均以电气和机械方式显示。随后，断路器的连接系统被机械锁定。链接系统锁定在互锁位置。链接系统的锁定由至少一个指示符指示。断路器执行器的锁定可以通过钥匙和锁定装置或远程手动控制。

5. 发明申请

US20110040195A1 METHOD AND APPARATUS TO DETERMINE THE END OF THE SYSTOLIC PART OF A PRESSURE CURVE 有权
标题翻译：确定压力曲线的相位部分的方法和装置
公开(公告)号：US20110040195A1
公开(公告)日：2011-02-17
申请号：US12744772
申请日：2008-11-24
申请人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
发明人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
IPC分类号： A61B5/021
CPC分类号： A61B5/029 , A61B5/021
摘要： The invention relates to a method and an apparatus for determining the systolic phase interval (SP) of an arterial pressure curve with a starting point (t0) of the systolic phase interval (SP) and an end point (tN) of the systolic phase interval (SP) wherein a QT interval is defined as the start of the Q wave and the end of the T wave in the hearts electrical cycle and wherein the determination of the end point (tN) of the systolic phase interval (SP) is restricted to the measured points of arterial pressure which fulfill the condition that the difference in time between the end point (tN) to be determined of the systolic phase interval (SP) and the starting point (t0) of the systolic phase interval (SP) is smaller than the QT interval.
摘要翻译：本发明涉及用于确定动脉压曲线的收缩期间隔（SP）的方法和装置，其具有收缩期间隔（SP）的起始点（t0）和收缩相间期的终点（tN）（SP），其中QT间隔被定义为心脏电循环中Q波的开始和T波的结束，并且其中心脏收缩期间隔（SP）的终点（tN）的确定被限制为满足如下条件的动脉压的测量点，其中确定收缩期间隔（SP）的终点（tN）与收缩相间隔（SP）的起始点（t0）之间的时间差在较小比QT间隔。

6. 发明申请

US20070106181A1 Lumen measuring devices and methods 有权
标题翻译：流明测量装置及方法
公开(公告)号：US20070106181A1
公开(公告)日：2007-05-10
申请号：US11252363
申请日：2005-10-17
申请人： Eric Mangiardi , Jason Reynolds , Ulf Borg , Tony Alexander
发明人： Eric Mangiardi , Jason Reynolds , Ulf Borg , Tony Alexander
IPC分类号： A61B5/103 , A61M29/00 , G01B3/00
CPC分类号： A61B5/1076 , A61M25/0133
摘要： A lumen measuring device generally includes a central member dimensioned to extend into a lumen and an elongate outer member having a flexible region configured to flex outward from the central member in response to retraction of the central member. In measuring a lumen, the flexible region is caused to contact the lumen. The lumen may be contacted by linear segments that hinge or by members that bow arcuately. A polygon, such as a triangle, may be defined by portions of the outer member and the central member. A handle assembly may be provided by which the disposition of the central member relative to the outer member may be adjusted. Indicators may be defined by the central member and outer member by which the disposition of the central member and by which the diameter of a lumen may be determined.
摘要翻译：管腔测量装置通常包括尺寸适于延伸到内腔中的中心构件和具有柔性区域的细长外部构件，弹性区域构造成响应于中心构件的缩回而从中心构件向外弯曲。在测量管腔时，使柔性区域与内腔接触。内腔可以通过铰链或弓形弓形的线段相接触。诸如三角形的多边形可以由外部构件和中心构件的部分限定。可以提供手柄组件，通过该手柄组件可以调节中心构件相对于外部构件的布置。指示器可以由中心构件和外部构件限定，通过该构件可以确定中心构件的布置并且可以确定管腔的直径。

7. 发明授权

US06491640B1 Injection channel for a blood vessel catheter 有权
标题翻译：用于血管导管的注射通道
公开(公告)号：US06491640B1
公开(公告)日：2002-12-10
申请号：US09515218
申请日：2000-02-29
申请人： Rainer Schmalberger , Matthias Fahle , Ulf Borg , Ulrich Pfeiffer
发明人： Rainer Schmalberger , Matthias Fahle , Ulf Borg , Ulrich Pfeiffer
IPC分类号： A61B502
CPC分类号： A61B5/028
摘要： The present invention is directed to an apparatus and method for injecting an injectate fluid into a blood vessel of a patient for carrying out thermodilution or dye-dilution measurements in order to determine hemodynamic parameters of the patient. The apparatus includes sensing means for sensing a change of pressure and/or flow rate and/or temperature inside the injection channel, and a computer coupled to the sensing means for determining the time instants of start and finish of the injection process.
摘要翻译：本发明涉及一种用于将注射液注射到患者的血管中以进行热稀释或染料稀释测量以便确定患者的血液动力学参数的装置和方法。该装置包括用于感测喷射通道内的压力和/或流速和/或温度变化的感测装置，以及耦合到感测装置的计算机，用于确定喷射过程的开始和结束的时间。

8. 发明授权

US08506496B2 Method and apparatus to determine the end of the systolic part of a pressure curve 有权
标题翻译：确定压力曲线收缩部分末端的方法和装置
公开(公告)号：US08506496B2
公开(公告)日：2013-08-13
申请号：US12744772
申请日：2008-11-24
申请人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
发明人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/029 , A61B5/021
摘要： The invention relates to a method and an apparatus for determining the systolic phase interval (SP) of an arterial pressure curve with a starting point (t0) of the systolic phase interval (SP) and an end point (tN) of the systolic phase interval (SP) wherein a QT interval is defined as the start of the Q wave and the end of the T wave in the hearts electrical cycle and wherein the determination of the end point (tN) of the systolic phase interval (SP) is restricted to the measured points of arterial pressure which fulfill the condition that the difference in time between the end point (tN) to be determined of the systolic phase interval (SP) and the starting point (t0) of the systolic phase interval (SP) is smaller than the QT interval.
摘要翻译：本发明涉及用于确定动脉压曲线的收缩期间隔（SP）的方法和装置，其具有收缩期间隔（SP）的起始点（t0）和收缩相间期的终点（tN）（SP），其中QT间隔被定义为心脏电循环中Q波的开始和T波的结束，并且其中心脏收缩期间隔（SP）的终点（tN）的确定被限制为满足如下条件的动脉压的测量点，其中确定收缩期间隔（SP）的终点（tN）与收缩相间隔（SP）的起始点（t0）之间的时间差在较小比QT间隔。

9. 发明授权

US09186068B2 Methods and systems for photoacoustic monitoring using hypertonic and isotonic indicator dilutions 有权
标题翻译：使用高渗和等渗指示剂稀释的光声监测的方法和系统
公开(公告)号：US09186068B2
公开(公告)日：2015-11-17
申请号：US13310859
申请日：2011-12-05
申请人： Youzhi Li , Bo Chen , Lockett Wood , Ulf Borg
发明人： Youzhi Li , Bo Chen , Lockett Wood , Ulf Borg
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/029
CPC分类号： A61B5/0095 , A61B5/029
摘要： A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.
摘要翻译：患者监测系统可以基于指示剂稀释提供光声感测以确定受试者的一个或多个生理参数。该系统可以检测声压信号，其可以包括一个或多个热稀释响应，一个或多个血稀释响应或其组合。例如，可以使用热稀释指示剂和/或血稀释指示剂来确定一个或多个血液动力学参数。在另一个实例中，等渗指示剂和高渗指示剂可用于确定受试者的一个或多个血液动力学参数。

10. 发明授权

US08535366B2 Implantable device delivery system handle and method of use 有权
标题翻译：植入式装置输送系统手柄及使用方法
公开(公告)号：US08535366B2
公开(公告)日：2013-09-17
申请号：US10585430
申请日：2005-01-07
申请人： Eric Mangiardi , Jason Reynolds , Ulf Borg
发明人： Eric Mangiardi , Jason Reynolds , Ulf Borg
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9517
摘要： The present invention, in an exemplary embodiment, provides a delivery system and novel handle configuration for the delivery system that facilitates repeatable placement of implantable devices. In particular, in optical embodiments, the handle allows for the reversible coupling of scopes directly to the handle to enhance physician control during placement. The delivery system also allows for one-handed manipulation as finger action can be used to engage and disengage the scope as well as actuate the extent of implantable device deployment. Exemplary delivery systems are flexible, durable and/or assure proper installation of one or more implantable devices in a single procedure. Moreover, the preferred embodiments of the delivery system provides for the reloading of the delivery device with additional implantable devices for additional interventional procedures, resulting in a substantially reusable delivery device.
摘要翻译：本发明在示例性实施例中提供了一种用于输送系统的输送系统和新颖的手柄配置，其有利于可植入装置的可重复放置。特别地，在光学实施例中，手柄允许示波器可直接耦合到手柄以增强在放置期间的医师控制。输送系统还允许单手操作，因为可以使用手指动作来接合和脱离该范围，并且致动可植入装置部署的程度。示例性递送系统是灵活的，耐用的和/或确保在单个过程中正确安装一个或多个可植入装置。此外，递送系统的优选实施例提供了用于附加介入程序的附加可植入装置的输送装置的重新装载，从而产生基本上可重复使用的递送装置。

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