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1. 发明授权

US09375159B2 Device for indicator dilution measurements 有权
标题翻译：指示剂稀释测量装置
公开(公告)号：US09375159B2
公开(公告)日：2016-06-28
申请号：US12738073
申请日：2008-10-15
申请人： Ulf Borg , Reinhold Knoll , Frederic Michard , Ulrich Pfeiffer
发明人： Ulf Borg , Reinhold Knoll , Frederic Michard , Ulrich Pfeiffer
IPC分类号： A61B5/02 , A61B5/029 , A61B5/028 , A61B5/0275
CPC分类号： A61B5/029 , A61B5/02755 , A61B5/028
摘要： The invention relates to indicator dilution measurements of a central volume (V1) with a first site of injection (S1) upstream of the central volume (V1) a second site of detection (S2) of the diluted indicator downstream of the central volume (V1), wherein a first additional volume (V2) is defined between the first site (S1) and the central volume (V1) and a first additional branch (B2) is defined between the first site (S1) and the central volume (V1) and wherein a second additional volume (V3) is defined between the central volume (V1) and the second site (S2) and a second additional branch (B3) is defined between the central volume (V1) and the second site (S2) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V2, V3) and/or for the first and second additional branches (B2, B3).
摘要翻译：本发明涉及具有中心体积（V1）上游的第一注射部位（S1）的中心体积（V1）的指示剂稀释测量，第二中心体积（V1）下游的稀释指示的检测位置（S2）），其中在所述第一部位（S1）和所述中心体积（V1）之间限定第一附加体积（V2），并且在所述第一部位（S1）和所述中心体积（V1）之间限定第一附加分支（B2）并且其中在所述中心体积（V1）和所述第二部位（S2）之间限定第二附加体积（V3），并且在所述中心体积（V1）和所述第二部位（S2）之间限定第二附加分支（B3），其中针对第一和第二附加体积（V2，V3）和/或第一和第二附加分支（B2，B3）校正中心体积参数的结果。

2. 发明申请

US20110105911A1 Device for Indicator Dilution Measurements 有权
标题翻译：指示剂稀释测量装置
公开(公告)号：US20110105911A1
公开(公告)日：2011-05-05
申请号：US12738073
申请日：2008-10-15
申请人： Ulf Borg , Reinhold Knoll , Frederic Michard , Ulrich Pfeiffer
发明人： Ulf Borg , Reinhold Knoll , Frederic Michard , Ulrich Pfeiffer
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/02755 , A61B5/028
摘要： The invention relates to indicator dilution measurements of a central volume (V1) with a first site of injection (S1) upstream of the central volume (V1) a second site of detection (S2) of the diluted indicator downstream of the central volume (V1), wherein a first additional volume (V2) is defined between the first site (S1) and the central volume (V1) and a first additional branch (B2) is defined between the first site (S1) and the central volume (V1) and wherein a second additional volume (V3) is defined between the central volume (V1) and the second site (S2) and a second additional branch (B3) is defined between the central volume (V1) and the second site (S2) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V2, V3) and/or for the first and second additional branches (B2, B3).
摘要翻译：本发明涉及具有中心体积（V1）上游的第一注射部位（S1）的中心体积（V1）的指示剂稀释测量，第二中心体积（V1）下游的稀释指示的检测位置（S2）），其中在所述第一部位（S1）和所述中心体积（V1）之间限定第一附加体积（V2），并且在所述第一部位（S1）和所述中心体积（V1）之间限定第一附加分支（B2）并且其中在所述中心体积（V1）和所述第二部位（S2）之间限定第二附加体积（V3），并且在所述中心体积（V1）和所述第二部位（S2）之间限定第二附加分支（B3），其中针对第一和第二附加体积（V2，V3）和/或第一和第二附加分支（B2，B3）校正中心体积参数的结果。

3. 发明授权

US08506496B2 Method and apparatus to determine the end of the systolic part of a pressure curve 有权
标题翻译：确定压力曲线收缩部分末端的方法和装置
公开(公告)号：US08506496B2
公开(公告)日：2013-08-13
申请号：US12744772
申请日：2008-11-24
申请人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
发明人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/029 , A61B5/021
摘要： The invention relates to a method and an apparatus for determining the systolic phase interval (SP) of an arterial pressure curve with a starting point (t0) of the systolic phase interval (SP) and an end point (tN) of the systolic phase interval (SP) wherein a QT interval is defined as the start of the Q wave and the end of the T wave in the hearts electrical cycle and wherein the determination of the end point (tN) of the systolic phase interval (SP) is restricted to the measured points of arterial pressure which fulfill the condition that the difference in time between the end point (tN) to be determined of the systolic phase interval (SP) and the starting point (t0) of the systolic phase interval (SP) is smaller than the QT interval.
摘要翻译：本发明涉及用于确定动脉压曲线的收缩期间隔（SP）的方法和装置，其具有收缩期间隔（SP）的起始点（t0）和收缩相间期的终点（tN）（SP），其中QT间隔被定义为心脏电循环中Q波的开始和T波的结束，并且其中心脏收缩期间隔（SP）的终点（tN）的确定被限制为满足如下条件的动脉压的测量点，其中确定收缩期间隔（SP）的终点（tN）与收缩相间隔（SP）的起始点（t0）之间的时间差在较小比QT间隔。

4. 发明申请

US20110040195A1 METHOD AND APPARATUS TO DETERMINE THE END OF THE SYSTOLIC PART OF A PRESSURE CURVE 有权
标题翻译：确定压力曲线的相位部分的方法和装置
公开(公告)号：US20110040195A1
公开(公告)日：2011-02-17
申请号：US12744772
申请日：2008-11-24
申请人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
发明人： Reinhold Knoll , Ulf Borg , Ulrich Pfeiffer
IPC分类号： A61B5/021
CPC分类号： A61B5/029 , A61B5/021
摘要： The invention relates to a method and an apparatus for determining the systolic phase interval (SP) of an arterial pressure curve with a starting point (t0) of the systolic phase interval (SP) and an end point (tN) of the systolic phase interval (SP) wherein a QT interval is defined as the start of the Q wave and the end of the T wave in the hearts electrical cycle and wherein the determination of the end point (tN) of the systolic phase interval (SP) is restricted to the measured points of arterial pressure which fulfill the condition that the difference in time between the end point (tN) to be determined of the systolic phase interval (SP) and the starting point (t0) of the systolic phase interval (SP) is smaller than the QT interval.
摘要翻译：本发明涉及用于确定动脉压曲线的收缩期间隔（SP）的方法和装置，其具有收缩期间隔（SP）的起始点（t0）和收缩相间期的终点（tN）（SP），其中QT间隔被定义为心脏电循环中Q波的开始和T波的结束，并且其中心脏收缩期间隔（SP）的终点（tN）的确定被限制为满足如下条件的动脉压的测量点，其中确定收缩期间隔（SP）的终点（tN）与收缩相间隔（SP）的起始点（t0）之间的时间差在较小比QT间隔。

5. 发明申请

US20080045845A1 Apparatus and computer program for determining a patient's volemic status represented by cardiopulmonary blood volume 审中-公开
标题翻译：用于确定由心肺血容量表示的患者的血液状态的装置和计算机程序
公开(公告)号：US20080045845A1
公开(公告)日：2008-02-21
申请号：US11820785
申请日：2007-06-20
申请人： Ulrich Pfeiffer , Frederic Michard , Reinhold Knoll
发明人： Ulrich Pfeiffer , Frederic Michard , Reinhold Knoll
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/029 , A61B5/0295 , A61M16/021 , G16H50/20
摘要： An apparatus for determining a patient's volemic status can make use of a physiological heart-lung interaction during spontaneous breathing or mechanical ventilation. Further, a computer program for determining the patient's volemic status has instructions for carrying out the steps of generating data of a physiological heart-lung interaction during spontaneous breathing or mechanical ventilation, and determining the patient's volemic status when making use of the data of the physiological heart-lung interaction, when run on a computer.
摘要翻译：用于确定患者的血液状态的装置可以在自发呼吸或机械通气期间利用生理心肺相互作用。此外，用于确定患者的血液状态的计算机程序具有用于执行在自发呼吸或机械通气期间产生生理心肺相互作用的数据的步骤的指令，以及当使用生理学数据时确定患者的血液状态当在计算机上运行时，心肺相互作用。

6. 发明申请

US20070135716A1 Dilution apparatus, method and computer program 有权
标题翻译：稀释装置，方法和计算机程序
公开(公告)号：US20070135716A1
公开(公告)日：2007-06-14
申请号：US11637373
申请日：2006-12-12
申请人： Ulrich Pfeiffer , Reinhold Knoll
发明人： Ulrich Pfeiffer , Reinhold Knoll
IPC分类号： A61B5/02
CPC分类号： A61B5/0275 , A61B5/028 , A61B5/029 , A61B5/0295 , A61B5/7225 , A61B5/7239 , A61B5/7278
摘要： An apparatus for determining a patient's circulatory fill status is adapted to provide a dilution curve and is capable to derive the ratio between the patient's global end-diastolic volume GEDV and the patient's intra thoracic thermo volume ITTV from the dilution curve. Further, a computer program for determining a patient's circulatory fill status has instructions adapted to carry out the steps of generating the dilution curve on basis of provided measurement data of dilution versus time, deriving the ratio between the patient's global end-diastolic volume GEDV and the patient's intra thoracic thermo volume ITTV from the dilution curve, and determining the patient's circulatory fill status on basis of the ratio between the patient's global end-diastolic volume GEDV and the patient's intra thoracic thermo volume ITTV, when the computer program is run on a computer. A method is also provided.
摘要翻译：用于确定患者的循环充盈状态的装置适于提供稀释曲线，并且能够从稀释曲线导出患者的全身舒张末期容积GEDV与患者的胸内热体积ITTV之间的比率。此外，用于确定患者的循环填充状态的计算机程序具有适于执行基于所提供的稀释度与时间的测量数据产生稀释曲线的步骤的指令，导出患者的全身舒张末期容积GEDV与患者的胸腔内热量ITTV从稀释曲线，并且当计算机程序在计算机上运行时，基于患者的全身舒张末期容积GEDV与患者的胸内热体积ITTV之间的比率确定患者的循环填充状态。还提供了一种方法。

7. 发明授权

US5526817A Process for determining a patient's circulatory fill status 失效
标题翻译：确定患者循环灌注状态的过程
公开(公告)号：US5526817A
公开(公告)日：1996-06-18
申请号：US325347
申请日：1994-10-31
申请人： Ulrich Pfeiffer , Reinhold Knoll
发明人： Ulrich Pfeiffer , Reinhold Knoll
IPC分类号： A61B5/00 , A61B5/028
CPC分类号： A61B5/411 , A61B5/028
摘要： A process and a device for determining a patient's circulatory fill status, particularly the global end-diastolic volume of the heart (GEDV), intrathoracic blood volume (ITBV), pulmonary blood volume (PBV), extravascular lung water volume (EVLW), and/or global cardiac function index (CFI) by means of thermo-dilution; with this process intrathoracic thermo-volume (ITTV) and pulmonary thermo-volume (PTV), for example, are obtained and the global end-diastolic volume of the heart (GEDV) is determined from the equationGEDV=ITTV-PTV.The other volumes can be calculated by means of this parameter, which is specific for the fill status of the heart, as well as other species-specific characteristics (a, a', b, b').
摘要翻译： PCT No.PCT / EP93 / 01052 Sec。 371日期：1994年10月31日 102（e）日期1994年10月31日PCT 1993年4月30日PCT PCT。公开号WO93 / 21823 日期：1993年11月11日。一种用于确定患者的循环充盈状态，特别是心脏的全身舒张末期容积（GEDV），胸内血容量（ITBV），肺血容量（PBV），血管外肺水量（EVLW）和/或全身心脏功能指数（CFI）; 通过该过程获得例如胸腔内热量（ITTV）和肺热容积（PTV），并且从GEDV = ITTV-PTV等式确定心脏的全身舒张末期容积（GEDV）。其他体积可以通过该参数计算，该参数是针对心脏的填充状态，以及其他物种特异性特征（a，a'，b，b'）特有的。

8. 发明授权

US5305744A Calibrating reflector device for an optical measuring system 失效
标题翻译：用于光学测量系统的校准反射器装置
公开(公告)号：US5305744A
公开(公告)日：1994-04-26
申请号：US32862
申请日：1993-03-17
申请人： Ulrich Pfeiffer , Reinhold Knoll
发明人： Ulrich Pfeiffer , Reinhold Knoll
IPC分类号： G01N21/01 , A61B1/00 , A61B5/00 , G01M11/00 , G01N21/47 , G01N21/55 , G01N21/77 , G02B5/02
CPC分类号： G01N21/4785 , A61B5/1459 , A61B5/1495 , G01M11/30 , A61B2560/0233 , G01N21/7703 , G01N2201/066 , G01N2201/084
摘要： Calibrating reflector device to calibrate an optical measuring system having an optical fiber optics probe, for example, for measuring the oxygen saturation of blood. The calibrating reflector device comprises a housing that is open on one end, a reflecting device in the form of an opaque layer in which reflecting particles are embedded, as well as a positioning plug with a central bore, in which the fiber optics probe can be received with a certain frictional resistance. A transparent layer is disposed between the front end of fiber optics probe and the reflecting layer, on whose surface the front end of fiber optics probe can be arranged by the positioning plug.
摘要翻译：校准反射器装置来校准具有光纤光学探针的光学测量系统，例如用于测量血液的氧饱和度。校准反射器装置包括在一端开口的壳体，其中嵌入反射颗粒的不透明层形式的反射装置以及具有中心孔的定位插塞，光纤探针可以受到一定的摩擦阻力。透明层设置在光纤探针的前端和反射层之间，光纤探针前端可由定位插头排列。

9. 发明授权

US08998817B2 Blood pressure measuring device and method for measuring the blood pressure of a living being 有权
标题翻译：血压测量装置及测量生物体内血压的方法
公开(公告)号：US08998817B2
公开(公告)日：2015-04-07
申请号：US12870434
申请日：2010-08-27
申请人： Ulrich Pfeiffer , Tobias Thomamueller , Reinhold Knoll
发明人： Ulrich Pfeiffer , Tobias Thomamueller , Reinhold Knoll
IPC分类号： A61B5/02 , A61B5/022
CPC分类号： A61B5/02233 , A61B5/02225
摘要： A blood pressure measuring device includes a flexible element configured to at least partially surround a body part and having a stiffening element configured to stiffen the flexible element; and at least one pressure sensor element attached to the flexible element.
摘要翻译：血压测量装置包括柔性元件，该柔性元件构造成至少部分地围绕主体部分并且具有构造成加强柔性元件的加强元件; 以及附接到柔性元件的至少一个压力传感器元件。

10. 发明授权

US08920329B2 Disposable sensor device and monitoring system with trimming element 有权
标题翻译：一次性传感器装置和带修剪元件的监控系统
公开(公告)号：US08920329B2
公开(公告)日：2014-12-30
申请号：US12529010
申请日：2008-02-19
申请人： Reinhold Knoll , Frederic Michard , Matthias Fahle , Tobias Thomamüller , Ulrich Pfeiffer
发明人： Reinhold Knoll , Frederic Michard , Matthias Fahle , Tobias Thomamüller , Ulrich Pfeiffer
IPC分类号： A61B5/02 , A61B5/0215 , A61B5/00
CPC分类号： A61B5/02141 , A61B5/002 , A61B5/0215 , A61B2560/0214 , A61B2560/045 , A61B2562/227
摘要： The invention relates to a disposable sensor device (51) for patient monitoring comprising a sensor (52) for providing an electric quantity based on a quantity to be detected, a first signal terminal (54) for providing a tap for the electric quantity, a first supply terminal (53) for supplying the sensor with an electrical supply quantity, a first connector for accommodating the first signal terminal (54) and the first supply terminal (53), a second signal terminal (56) for providing a further tap for the electric quantity, and a second connector for accommodating at least the second signal terminal (56). The invention further relates to a disposable sensor device for patient monitoring comprising a sensor (7) for providing an electric quantity based on a quantity to be detected; a first signal terminal (22) for providing a tap for the electric quantity; a first connector (A) for accommodating the first signal terminal, wherein the first connector (A) is provided with a trimming element (R2) which simulates the influence of a selectively attachable first monitoring device (1) on a measuring of the electric quantity, wherein the trimming element (R2) is electrically effective depending on a connector structure of a corresponding further connector (B, C) to be coupled with the first connector (A).
摘要翻译：本发明涉及一种用于患者监测的一次性传感器装置（51），包括用于基于待检测的量提供电量的传感器（52），用于提供用于电量的抽头的第一信号端子（54）用于向传感器提供电源的第一供应端子（53），用于容纳第一信号端子（54）和第一供应端子（53）的第一连接器，用于提供另一分接头的第二信号端子以及用于容纳至少第二信号端子（56）的第二连接器。本发明还涉及一种用于患者监测的一次性传感器装置，其包括用于基于待检测量提供电量的传感器（7）用于为电量提供水龙头的第一信号端子（22）用于容纳所述第一信号端子的第一连接器（A），其中所述第一连接器（A）设置有修整元件（R2），所述修整元件（R2）模拟可选择地附接的第一监视装置（1）对所述电量的测量的影响，其中根据要与第一连接器（A）耦合的相应的另外的连接器（B，C）的连接器结构，修整元件（R2）是电学上有效的。

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