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1. 发明授权

US09745278B2 Group of STAT3 pathway inhibitors and cancer stem cell pathway inhibitors 有权
公开(公告)号：US09745278B2
公开(公告)日：2017-08-29
申请号：US12677513
申请日：2008-09-10
申请人： Chiang Jia Li , Harry Rogoff , Youzhi Li , Jifeng Liu , Wei Li
发明人： Chiang Jia Li , Harry Rogoff , Youzhi Li , Jifeng Liu , Wei Li
IPC分类号： A61K31/655 , C07D307/92 , A61K31/38 , C07D333/74
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regimen; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds.

2. 发明授权

US09730909B2 Methods for targeting cancer stem cells 有权
公开(公告)号：US09730909B2
公开(公告)日：2017-08-15
申请号：US13634694
申请日：2011-03-21
申请人： Chiang Jia Li , David Leggett , Youzhi Li , Wei Li
发明人： Chiang Jia Li , David Leggett , Youzhi Li , Wei Li
IPC分类号： A61K31/343 , A61P35/00 , A61K9/14
CPC分类号： A61K31/343
摘要： The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.

3. 发明授权

US09138183B2 Combined physiological sensor systems and methods 有权
标题翻译：组合生理传感器系统和方法
公开(公告)号：US09138183B2
公开(公告)日：2015-09-22
申请号：US13020704
申请日：2011-02-03
申请人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
发明人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/01 , A61B5/0205 , A61B5/024 , A61B5/16
CPC分类号： A61B5/02055 , A61B5/01 , A61B5/0205 , A61B5/02433 , A61B5/14552 , A61B5/165 , A61B5/6814 , A61B5/6826 , A61B5/6838 , A61B5/7203 , A61B5/7257 , A61B5/726
摘要： A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (EPS), a pulse transit time (PTT), body temperature associated with the subject, a depth of consciousness (DOC) measurement, any other suitable physiological parameter, and any suitable combination thereof. The combined sensor may include a variety of individual sensors, such as electrodes, optical detectors, optical emitters, temperature sensors, and/or other suitable sensors. The sensors may be advantageously positioned in accordance with a number of different geometries. The combined sensor may also be coupled to a monitoring device, which may receive and/or process one or more output signals from the individual sensors to display information about the medical condition of the subject. In addition, several techniques may be employed to prevent or limit interference between the individual sensors and their associated input and/or output signals.
摘要翻译：提供组合的生理传感器和用于检测受试者的一种或多种生理特征的方法。组合的传感器（例如，前额传感器）可用于检测和/或计算脉搏血氧饱和度水平，区域血氧饱和度水平，呼吸速率，血压，电生理信号（EPS ），脉搏传播时间（PTT），与受试者相关的体温，意识深度（DOC）测量，任何其它合适的生理参数及其任何合适的组合。组合的传感器可以包括各种单独的传感器，例如电极，光学检测器，光发射器，温度传感器和/或其它合适的传感器。可以根据多个不同的几何形状有利地定位传感器。组合的传感器还可以耦合到监视设备，监视设备可以接收和/或处理来自各个传感器的一个或多个输出信号以显示关于对象的医疗状况的信息。此外，可以采用几种技术来防止或限制各个传感器及其相关的输入和/或输出信号之间的干扰。

4. 发明授权

US09072433B2 Method and apparatus for noninvasive blood pressure measurement using pulse oximetry 有权
标题翻译：使用脉搏血氧仪进行无创血压测量的方法和装置
公开(公告)号：US09072433B2
公开(公告)日：2015-07-07
申请号：US13030385
申请日：2011-02-18
申请人： Bo Chen , Youzhi Li , Daniel Lisogurski
发明人： Bo Chen , Youzhi Li , Daniel Lisogurski
IPC分类号： A61B5/02 , A61B5/022 , A61B5/024 , A61B5/021
CPC分类号： A61B5/02255 , A61B5/02108 , A61B5/022 , A61B5/02422
摘要： Embodiments of the present disclosure relate to a system and method for determining a physiologic parameter of a patient. Specifically, embodiments provided herein include blood pressure cuffs that are adapted to be used in conjunction with a photoplethysmography sensor. The cuff as provided may be configured to be placed over the sensor and/or aligned in a specific manner relative to the sensor. Alternatively, the cuffs may include integral optical components.
摘要翻译：本公开的实施例涉及用于确定患者的生理参数的系统和方法。具体地，本文提供的实施例包括适于与光电容积描记传感器结合使用的血压袖带。所提供的袖带可以被配置为放置在传感器上方和/或以相对于传感器的特定方式对准。或者，袖带可以包括一体的光学部件。

5. 发明授权

US08603003B2 Trachea pressure determination method and device 有权
标题翻译：气管压力测定方法及装置
公开(公告)号：US08603003B2
公开(公告)日：2013-12-10
申请号：US12477636
申请日：2009-06-03
申请人： Lockett E. Wood , Sarah Hayman , Youzhi Li
发明人： Lockett E. Wood , Sarah Hayman , Youzhi Li
IPC分类号： A61B5/08
CPC分类号： A61B5/036 , A61B5/08 , A61B5/085 , A61B5/7278 , A61B5/742 , A61M16/0051 , A61M16/0057 , A61M16/024 , A61M16/0434 , A61M16/044 , A61M16/0459 , A61M16/0816 , A61M2016/0027 , A61M2205/70 , G06F19/00
摘要： According to various embodiments, methods and systems for determining pressure in the lungs may employ intracuff pressure measurements. The intracuff pressure measurements may calibrated or adjusted based on a set of calibration coefficients or a set of calibration curves, which may reflect patient parameters and cuff/tube geometry factors. The resulting calibration may be used to determine a more accurate estimate of lung pressure, which in turn may be used to control a ventilator and provide breathing assistance to a patient. Also provided are tracheal tubes with couplers or other memory devices for storing calibration information. Such tubes may allow calibration at the level of an individual tracheal tube to account for changes in tube geometry and individual patient factors.
摘要翻译：根据各种实施例，用于确定肺中的压力的方法和系统可采用耳内压测量。可以基于一组校准系数或一组校准曲线校准或调整脉管内压力测量值，这可以反映患者参数和袖套/管几何因素。所得到的校准可用于确定肺压力的更准确的估计，其进而可以用于控制呼吸机并向患者提供呼吸辅助。还提供了具有耦合器或用于存储校准信息的其它存储器装置的气管管。这样的管可以允许在单个气管管的水平处的校准来解释管几何形状和个体患者因素的变化。

6. 发明授权

US08457716B2 Time of flight based tracheal tube placement system and method 有权
标题翻译：基于时间的气管插管系统及方法
公开(公告)号：US08457716B2
公开(公告)日：2013-06-04
申请号：US12434770
申请日：2009-05-04
申请人： Youzhi Li , Edward McKenna , Andy Lin , Sarah Hayman
发明人： Youzhi Li , Edward McKenna , Andy Lin , Sarah Hayman
IPC分类号： A61B5/00 , A61M16/04
CPC分类号： A61M16/0488 , A61B1/267 , A61B5/0084 , A61B5/065 , A61B5/72 , A61B5/742 , A61B5/746 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M16/0486 , A61M2205/3306 , A61M2205/502 , A61M2205/6018 , G01S7/481 , G01S17/10 , G01S17/88
摘要： According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure, such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include time of flight techniques.
摘要翻译：根据各种实施例，气管插管可以采用光学感测技术来确定插入的管和解剖结构之间的距离，例如小孔。距离信息可以提供关于气管管是否适当地放置在气管内的指示。光学技术可以包括飞行时间技术。

7. 发明申请

US20130109948A1 METHODS AND SYSTEMS FOR DETERMINING PHYSIOLOGICAL PARAMETERS USING TWO PHOTOACOUSTIC PEAKS 审中-公开
标题翻译：使用两个光电峰确定生理参数的方法和系统
公开(公告)号：US20130109948A1
公开(公告)日：2013-05-02
申请号：US13284545
申请日：2011-10-28
申请人： Youzhi Li
发明人： Youzhi Li
IPC分类号： A61B8/00 , A61B6/00 , A61B5/145
CPC分类号： A61B5/0095 , A61B5/021
摘要： A patient monitoring system may use photoacoustic sensing to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure, response generated by the application and absorption of light, which may include two peaks. The peaks may correspond to surfaces of a feature such as a blood vessel, and the peak information may allow determination of physiological information. For example, the two peaks may be analyzed and an effective attenuation coefficient may be determined, from which hemoglobin concentration, blood oxygen saturation, or other physiological parameters may be derived.
摘要翻译：患者监视系统可以使用光声感测来确定受试者的一个或多个生理参数。该系统可以检测声压，由应用产生的响应和光的吸收，其可以包括两个峰。峰可以对应于诸如血管的特征的表面，并且峰值信息可以允许确定生理信息。例如，可以分析两个峰，并且可以确定有效衰减系数，从中可以导出血红蛋白浓度，血氧饱和度或其他生理参数。

8. 发明申请

US20130028944A1 NOVEL METHODS FOR TARGETING CANCER STEM CELLS 有权
标题翻译：用于靶向癌细胞的新方法
公开(公告)号：US20130028944A1
公开(公告)日：2013-01-31
申请号：US13634694
申请日：2011-03-21
申请人： Chiang Jia Li , David Leggett , Youzhi Li , Wei Li
发明人： Chiang Jia Li , David Leggett , Youzhi Li , Wei Li
IPC分类号： A61K31/343 , A61P35/00 , A61K9/14
CPC分类号： A61K31/343
摘要： The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.
摘要翻译：本发明提供了萘并呋喃化合物，萘并呋喃化合物的多晶型物，颗粒形式的萘并呋喃化合物，含有一种或多种萘并呋喃化合物的纯化组合物，含有一种或多种粒状萘并呋喃化合物的纯化组合物，制备这些萘并呋喃化合物的方法，组合物和/或颗粒形式，以及使用这些萘并呋喃化合物，多晶型物，纯化组合物和/或颗粒形式来治疗有需要的受试者的方法。

9. 发明授权

US08299106B2 Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases 有权
标题翻译：激酶抑制剂的组成及其用于治疗与激酶相关的癌症和其它疾病的用途
公开(公告)号：US08299106B2
公开(公告)日：2012-10-30
申请号：US12676869
申请日：2008-09-05
申请人： Chiang Jia Li , Ji-Feng Liu , Youzhi Li , Wei Li , Harry Rogoff
发明人： Chiang Jia Li , Ji-Feng Liu , Youzhi Li , Wei Li , Harry Rogoff
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K45/06 , C07D417/04
摘要： The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
摘要翻译：本发明涉及新型噻唑取代的二氢吲哚-2-酮作为CSCPK和相关激酶的抑制剂; 涉及通过使用激酶抑制剂抑制癌症干细胞的方法; 含有这些化合物的药物组合物; 以及使用这些化合物治疗哺乳动物中蛋白激酶相关病症的方法; 以及制备这些化合物及其中间体的方法。

10. 发明申请

US20120252763A1 NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS 有权
标题翻译： STAT3途径抑制剂和癌症干细胞途径抑制剂
公开(公告)号：US20120252763A1
公开(公告)日：2012-10-04
申请号：US12677513
申请日：2008-09-10
申请人： Chiang Jia Li , Zhiwei Jiang , Harry Rogoff , Youzhi Li , Jifeng Liu , Wei Li
发明人： Chiang Jia Li , Zhiwei Jiang , Harry Rogoff , Youzhi Li , Jifeng Liu , Wei Li
IPC分类号： A61K31/343 , A61K31/665 , A61P35/00 , C12N5/095 , C07F9/655
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regimen; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds.
摘要翻译：本发明涉及新型癌症干细胞途径（CSCP）抑制剂的应用; 涉及使用这些化合物治疗顽固性，复发性或转移性癌症的方法; 通过使用具有特定给药方案的这种化合物选择性杀死癌细胞的方法; 通过抑制Stat3途径靶向癌症干细胞的方法; 涉及使用新化合物治疗与异常Stat3途径活性相关的哺乳动物中的病症或病症的方法; 以及制备这些化合物及其中间体的方法，以及相关化合物的药物组合物以及这些化合物的具体给药方法。

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