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1. 发明授权

US4966855A New redox indicators 失效
标题翻译：新的氧化还原指标
公开(公告)号：US4966855A
公开(公告)日：1990-10-30
申请号：US751367
申请日：1985-07-02
申请人： Ulfert Deneke , Werner Guthlein , Wolfgang Weckerle , Hans Wielinger
发明人： Ulfert Deneke , Werner Guthlein , Wolfgang Weckerle , Hans Wielinger
IPC分类号： C07D263/32 , C07D277/22 , C07D277/28 , C07D277/72 , C07D413/04 , C07D413/06 , C07D413/14 , C07D455/04 , C07F9/60 , C07F9/653 , C07F9/655 , C12Q1/26 , C12Q1/28 , G01N33/50 , G01N33/52
CPC分类号： C07D413/04 , C07D263/32 , C07D277/28 , C07D413/06 , C07D413/14 , C07D455/04 , C07F9/60 , C07F9/653 , C07F9/65505 , C12Q1/26 , C12Q1/28 , G01N33/525 , C12Q2326/00 , Y10S435/807 , Y10S436/904 , Y10T436/206664
摘要： The invention provides new redox indicators and uses for these redox compounds (I): ##STR1## Wherein X is oxygen or sulphur, R.sub.1 is julolidine or tetrahydroquinoline, which can carry an alkyl radical on the nitrogen atom which, in turn, can be substituted by a sulphuric, phosphonic or carboxylic acid residues, or is (II); wherein R.sub.4 is hydroxyl or a mono- or dialkylated amino group, R.sub.5 and R.sub.6, which can be the same or different, are hydrogen, alkyl or alkoxy, R.sub.2 is hydrogen or alkyl, julolidine or tetrahydroquinoline, which can carry an alkyl on the nitrogen atom which alkyl can be substituted by sulphuric, phosphonic or carboxylic acids, or is III; wherein R.sub.5 and R.sub.6 are the same as in R.sub.1 and R'.sub.4 is hydroxyl, an amino or a mono-or dialkylated amino group, whereby the alkyl radicals can be substituted one or more times by hydroxyl, alkoxy, halogen, morpholine or a sulphuric, carboxylic or phosphonic acid residue, which acids can also be esterified, and R.sub.3 is the same as R.sub.2 or is an alkyl substituted by hydroxyl, alkoxy, dialkylamino or phenyl, or is cycloalkyl, phenyl or pyridyl; as well as the salts thereof.
摘要翻译：本发明为这些氧化还原化合物（I）提供了新的氧化还原指示剂和用途：其中X是氧或硫，R1是可乐兰或四氢喹啉，其可以携带或者是（II）的氮原子上的烷基，其又可以被硫酸，膦酸或羧酸残基取代。其中R4是羟基或单烷基化或二烷基化氨基，可以相同或不同的R5和R6是氢，烷基或烷氧基，R2是氢或可以在氮上带有烷基的烷基，多环糊精或四氢喹啉这个烷基可以被硫酸，膦酸或羧酸取代，或者是III; 其中R5和R6与R1相同，R'4是羟基，氨基或单或二烷基化氨基，其中烷基可以被羟基，烷氧基，卤素，吗啉或硫酸取代一次或多次羧酸或膦酸残基，该酸也可以被酯化，R3与R2相同或是被羟基，烷氧基，二烷基氨基或苯基取代的烷基，或是环烷基，苯基或吡啶基; 以及它们的盐。

2. 发明授权

US4665023A Imidazole derivatives as redox indicators 失效
标题翻译：咪唑衍生物作为氧化还原指标
公开(公告)号：US4665023A
公开(公告)日：1987-05-12
申请号：US717511
申请日：1985-03-29
申请人： Ulfert Deneke , Werner Guthlein , Manfred Kuhr , Hartmut Merdes , Hans-Rudiger Murawski , Hans Wielinger
发明人： Ulfert Deneke , Werner Guthlein , Manfred Kuhr , Hartmut Merdes , Hans-Rudiger Murawski , Hans Wielinger
IPC分类号： C07D233/60 , A61K49/00 , C07D233/54 , C07D233/61 , C07D233/64 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D455/04 , C07F9/6506 , C12Q1/28 , G01N33/50 , G01N33/68
CPC分类号： C07D233/64 , C07D403/04 , C07D405/04 , C07D455/04 , C12Q1/28 , C12Q2326/00 , Y10T436/206664
摘要： The present invention provides imidazole derivatives of the general formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are defined hereinbelow. The present invention is also concerned with processes for the preparation of these imidazole derivatives and with the use thereof as redox indicators.
摘要翻译：本发明提供以下通式的咪唑衍生物：其中R，R 1和R 2定义如下。本发明还涉及制备这些咪唑衍生物的方法，并将其用作氧化还原指示剂。

3. 发明授权

US5786164A Method for separating non-high density lipoproteins from lipoprotein containing body fluid samples 失效
标题翻译：从含有脂蛋白的体液样品中分离非高密度脂蛋白的方法
公开(公告)号：US5786164A
公开(公告)日：1998-07-28
申请号：US661833
申请日：1996-06-11
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q1/60 , G01N33/52 , G01N33/92
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDL-s are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译：本发明涉及从含有它们的生物液体中分离非高密度脂蛋白（称为“非HDL”）的方法。提供含有非HDL沉淀剂的多孔载体。只需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL-不再存在于待测样品中。该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。

4. 发明授权

US5162200A Method for determination of a peroxidate-acting substance with a diarylimidazole compound 失效
标题翻译：用二胺咪唑化合物测定过氧化物作用物质的方法
公开(公告)号：US5162200A
公开(公告)日：1992-11-10
申请号：US530661
申请日：1990-05-30
申请人： Hans-Peter Braun , Ulfert Deneke , Werner Guethlein , Rolf Nagel
发明人： Hans-Peter Braun , Ulfert Deneke , Werner Guethlein , Rolf Nagel
IPC分类号： G01N31/22 , C07D233/54 , C07D233/64 , C07D455/04 , C12Q1/26 , C12Q1/28 , C12Q1/50
CPC分类号： C07D233/64 , C12Q1/28 , C12Q1/50 , C12Q2326/00
摘要： Diarylimidazoles of the general formula: ##STR1## wherein R.sup.1 is a radical of the general formula: ##STR2## in which R.sup.3 and R.sup.6 are hydrogen atoms, R.sup.4 and R.sup.5, which can be the same or different, are lower alkyl radicals or R.sup.3 /R.sup.4 and/or R.sup.5 /R.sup.6 in each case together represent a lower alkylene radical and R.sup.2 is a lower alkyl radical, and/or of a salt thereof, are used as redox indicators in the colorimetric diarylimidazoles are not influenced by the presence of a SH group-containing substance. The peroxidate-acting substance can be used to determine the presence of creatine kinase.
摘要翻译：具有以下通式的二芳基咪唑：其中R 1是具有以下通式的基团：其中R 3和R 6是氢原子，R 4和R 5可以相同或不同，在各种情况下，低级烷基或R 3 / R 4和/或R 5 / R 6一起代表低级亚烷基，R 2为低级烷基，和/或其盐用作比色二芳基咪唑中的氧化还原指示剂不受影响通过存在含SH基团的物质。过氧化物作用物质可用于测定肌酸激酶的存在。

5. 发明授权

US06171849B2 Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 有权
$Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step$
标题翻译：通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法
公开(公告)号：US06171849B2
公开(公告)日：2001-01-09
申请号：US09481664
申请日：2000-01-12
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12M100
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.
摘要翻译：公开了一种包括用于评估生物流体样品的第一多孔载体和第二多孔载体的装置。该装置用于从身体样品中的脂蛋白分离非高密度脂蛋白（非HDL），并用于测定身体样品中HDL和非高密度脂蛋白（非HDL）中的高密度脂蛋白（HDL）胆固醇。

6. 发明授权

US5426030A Apparatus for determination of HDL cholesterol 失效
标题翻译：用于测定HDL胆固醇的装置
公开(公告)号：US5426030A
公开(公告)日：1995-06-20
申请号：US572875
申请日：1990-08-24
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q1/60 , G01N33/52 , G01N33/92 , G01N21/00
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to an apparatus and a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译：本发明涉及一种用于从含有它们的生物液体中分离非高密度脂蛋白（被称为“非HDL”）的装置和方法。提供含有非HDL沉淀剂的多孔载体。仅需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL不再存在于待测样品中。该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。

7. 发明授权

US5374546A Process for stabilizing 1-methylhydantoinase, use and method of it for determining an analyte and agents suitable for this 失效
标题翻译：用于稳定1-甲基乙内酰脲酶的方法，其用于测定分析物的用途和方法以及适用于此的试剂
公开(公告)号：US5374546A
公开(公告)日：1994-12-20
申请号：US822176
申请日：1992-01-16
申请人： Rolf Nagel , Ulfert Deneke , Jurgen Mistele
发明人： Rolf Nagel , Ulfert Deneke , Jurgen Mistele
IPC分类号： C12N9/86 , C12N9/96 , C12Q1/26 , C12Q1/28 , C12Q1/34 , C12N9/78
CPC分类号： C12N9/86 , C12Q1/34 , G01N2333/986
摘要： The invention concerns a process for stabilizing the enzyme 1-methylhydantoinase (NMHase) which is characterized in that the NMHase is treated with divalent metal ions, a nucleoside triphosphate and a complexing agent which complexes these divalent metal ions. In addition the invention concerns the use of an enzyme stabilized in this way in a method for the determination of an analyte in which 1-methylhydantoin is converted, as well as a corresponding reagent.
摘要翻译：本发明涉及一种稳定酶1-甲基乙内酰脲酶（NMHase）的方法，其特征在于用二价金属离子，核苷三磷酸和与这些二价金属离子复合的络合剂处理NMHase。此外，本发明涉及以这种方式稳定的酶用于测定其中转化有1-甲基乙内酰脲的分析物以及相应试剂的方法。

8. 发明授权

US4591553A Process and analytical agent for the determination of the activity of glutamate-oxalacetate-transaminase 失效
标题翻译：用于测定谷氨酸 - 乙酸肝素 - 转氨酶活性的方法和分析试剂
公开(公告)号：US4591553A
公开(公告)日：1986-05-27
申请号：US500111
申请日：1983-06-01
申请人： Ulfert Deneke , Wolfgang Gruber , Hans-Georg Batz
发明人： Ulfert Deneke , Wolfgang Gruber , Hans-Georg Batz
IPC分类号： G01N33/52 , C12Q1/00 , C12Q1/26 , C12Q1/48 , C12Q1/52
CPC分类号： C12Q1/52 , Y10S435/805
摘要： The present invention provides a process for the determination of the activity of glutamateoxalacetate-transaminase (GOT) in aqueous solutions in which(a) .alpha.-ketoglutarate is reacted with alanine-sulphinic acid, catalyzed by GOT, to give pyruvate, sulphur dioxide and glutamate,(b) the resultant pyruvate is reacted with phosphate and oxygen, catalyzed by pyruvate oxidase, to give acetyl phosphate, carbon dioxide and hydrogen peroxide,(c) the hydrogen peroxide and a chromogen is reacted, catalyzed by a peroxidase, to give a dyestuff and water and(d) the amount of dyestuff formed is determined, wherein the chromogen used is N-(3'-sulphonyl-4'-hydroxy-5'-chlorophenyl)-4-aminoantipyrine (SHYC-AA), 4,5-bis-[4-dimethylaminophenyl]-2-[3,5-dimethoxy-4-hydroxyphenyl]-imidazole (B-DDH-imidazole) or a related substance.The present invention also provides an analytical agent for the determination of the activity of GOT, comprising .alpha.-ketoglutarate, alanine-sulphinic acid, a chromogen, peroxidase, pyruvate oxidase, soluble phosphate, buffer and water, wherein the chromogen is N-(3'-sulphonyl-4'-hydroxy-5'-chlorophenyl)-4-aminoantipyrine (SHYC-AA) or 4,5-bis-[4-dimethylaminophenyl]-2-[3,5-dimethoxy-4-hydroxyphenyl]-imidazole (B-DDH-imidazole).
摘要翻译：本发明提供了一种测定谷氨酸酰乙酰转氨酶（GOT）在水溶液中的活性的方法，其中（a）α-酮戊二酸与由GOT催化的丙氨酸 - 亚磺酸反应得到丙酮酸，二氧化硫和谷氨酸，（b）所得丙酮酸盐与磷酸盐和氧气反应，由丙酮酸氧化酶催化，得到乙酰磷酸盐，二氧化碳和过氧化氢，（c）过氧化氢和色原反应，由过氧化物酶催化，得到染料和水，（d）确定形成的染料的量，其中使用的色原是N-（3'-磺酰基-4'-羟基-5'-氯苯基）-4-氨基安替比林（SHYC-AA） 5-双 - [4-二甲基氨基苯基] -2- [3,5-二甲氧基-4-羟基苯基] - 咪唑（B-DDH-咪唑）或相关物质。本发明还提供了用于测定GOT的活性的分析剂，其包括α-酮戊二酸，丙氨酸 - 亚磺酸，色原，过氧化物酶，丙酮酸氧化酶，可溶性磷酸盐，缓冲液和水，其中色原为N-（3 4-磺基-4'-羟基-5'-氯苯基）-4-氨基安替比林（SHYC-AA）或4,5-双 - [4-二甲基氨基苯基] -2- [3,5-二甲氧基-4-羟基苯基] 咪唑（B-DDH-咪唑）。

9. 发明授权

US4563422A Method and composition for the removal of ascorbic acid from aqueous liquids 失效
标题翻译：从含水液体中除去抗坏血酸的方法和组合物
公开(公告)号：US4563422A
公开(公告)日：1986-01-07
申请号：US380804
申请日：1982-05-21
申请人： Ulfert Deneke , Hans Lange , Walter Rittersdorf
发明人： Ulfert Deneke , Hans Lange , Walter Rittersdorf
IPC分类号： C02F3/34 , A23L2/70 , C02F3/00 , C12P1/00 , C12Q1/26 , C12Q1/54 , G01N33/493 , C12Q1/30 , C12Q1/28
CPC分类号： C12Q1/54 , C12Q1/26 , Y10S435/805 , Y10S435/81 , Y10T436/142222 , Y10T436/25125
摘要： The present invention provides a process for removing ascorbic acid from aqueous solutions by the addition of ascorbate oxidase, wherein catalase and hydrogen peroxide are also added to the solution.The present invention also provides an agent for the removal of ascorbic acid from aqueous solutions, based on a solid carrier material impregnated with ascorbate oxidase, wherein the carrier material also contains catalase and hydrogen peroxide and optionally also a stabilizer and/or buffer substance.
摘要翻译：本发明提供了通过加入抗坏血酸氧化酶从水溶液中除去抗坏血酸的方法，其中还向溶液中加入过氧化氢酶和过氧化氢。本发明还提供了一种基于浸渍有抗坏血酸氧化酶的固体载体材料从水溶液中除去抗坏血酸的试剂，其中载体材料还含有过氧化氢酶和过氧化氢以及任选的稳定剂和/或缓冲物质。

10. 发明授权

US4544631A Process and reagent for the determination of .alpha.-amylase 失效
标题翻译：用于测定α-淀粉酶的方法和试剂
公开(公告)号：US4544631A
公开(公告)日：1985-10-01
申请号：US311856
申请日：1981-10-16
申请人： Elli Rauscher , Ulrich Neumann , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruber , Joachim Ziegenhorn , Eugen Schaich , Ulfert Deneke , Gerhard Michal , Gunter Weimann
发明人： Elli Rauscher , Ulrich Neumann , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruber , Joachim Ziegenhorn , Eugen Schaich , Ulfert Deneke , Gerhard Michal , Gunter Weimann
IPC分类号： G01N33/50 , C07H15/04 , C07H15/203 , C12Q1/40 , C12Q1/54 , C12Q1/32 , C12Q1/34 , C12Q1/48
CPC分类号： C12Q1/40 , C12Q2334/10 , Y10S435/805 , Y10S435/81
摘要： .alpha.-Amylase is determined by the enzymatic splitting of an .alpha.-amylase substrate and measurement of a fission product, wherein there is used as a substrate a maltoheptaose compound of the formula ##STR1## wherein R is a glucoside, phenylglucoside, mononitrophenylglucoside, dinitrophenylglucoside, sorbitol or gluconic acid group. Reagents comprising such a substrate and a system for the determination of a fission product formed from the amylase substrate by .alpha.-amylase, are also provided.
摘要翻译： α-淀粉酶通过α-淀粉酶底物的酶裂解和裂变产物的测定来确定，其中用作底物的麦芽麦角糖化合物，其中R是葡萄糖苷，苯基葡糖苷，单硝基苯基葡糖苷，二硝基苯基葡糖苷，山梨糖醇或葡萄糖酸基团。还提供了包含这种底物的试剂和用于通过α-淀粉酶测定由淀粉酶底物形成的裂变产物的系统。

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