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1. 发明公开

US20240230676A1 ESM1 MARKER PANELS FOR EARLY DETECTION OF SEPSIS 审中-公开
公开(公告)号：US20240230676A1
公开(公告)日：2024-07-11
申请号：US18558150
申请日：2022-04-29
申请人： Roche Diagnostics Operations, Inc.
发明人： Felix Gruenewald , Victor Johann Raul Jeger , Martin Klammer , Philipp Schuetz , Maria von Holtey , Stephen Weber , Heike Wegmeyer , Ursula-Henrike Wienhues-Thelen
IPC分类号： G01N33/68 , C12Q1/37 , C12Q1/52 , G01N33/72 , G16H50/20
CPC分类号： G01N33/6893 , C12Q1/37 , C12Q1/52 , G01N33/728 , G16H50/20 , G01N2333/4722 , G01N2333/8139 , G01N2333/91188 , G01N2800/26 , G01N2800/50
摘要： The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being ESM-1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is Creatinine or a Cystatin C, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being ESM-1 and a second biomarker being Creatinine or a Cystatin C or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

2. 发明授权

US11519918B2 Method for quantification of amino acids using cell-free protein synthesis system 有权
公开(公告)号：US11519918B2
公开(公告)日：2022-12-06
申请号：US16633805
申请日：2018-07-24
申请人： The Industry & Academic Cooperation in Chungnam National University (IAC)
发明人： Dong-Myung Kim , Tae Hyeon Yoo , Kyung-Ho Lee , Yeon-Jae Jang
IPC分类号： G01N33/68 , C12Q1/52
摘要： The present invention relates to a method for quantification of amino acids using a cell-free protein synthesis system. Specifically, the present invention relates to a method for quantification of amino acids, comprising: (a) preparing a reaction mixture for cell-free protein synthesis without target amino acids; (b) performing cell-free protein synthesis by mixing an assay sample containing target amino acids with the reaction mixture for cell-free protein synthesis; (c) measuring the signal intensity of the synthesized protein; and (d) calculating the concentration of the target amino acids by comparing the measured signal intensity with the standard concentration curve for each amino acid according to the protein signal produced using a standard sample, a method for providing information for diagnosing an amino acid metabolism-related disease using the same, a method for screening a material for prevention or treatment of an amino acid metabolism-related disease, and a method for screening a transaminase substrate. The method for quantification of amino acids according to the present invention can quantify amino acids in a short time at a low cost, and thus can be useful in various industries.

3. 发明申请

US20210310043A1 QUANTIFICATION METHOD OF ETHANOLAMINE PHOSPHATE, OXIDOREDUCTASE FOR QUANTIFICATION, COMPOSITION FOR QUANTIFICATION, KIT FOR QUANTIFICATION AND SENSOR FOR QUANTIFICATION 有权
公开(公告)号：US20210310043A1
公开(公告)日：2021-10-07
申请号：US17345187
申请日：2021-06-11
申请人： KIKKOMAN CORPORATION
发明人： Atsushi ICHIYANAGI , Yosuke MASAKARI , Haruka HIRAGUCHI
IPC分类号： C12Q1/52 , C12Q1/26 , C12N9/06
摘要： There is provided a novel quantification method for quantifying a concentration of EAP, which is a biomarker of depression, an enzyme for quantitation, a composition for quantitation, a kit for quantitation or a sensor for quantitation. There is provided a quantification method of ethanolamine phosphate by adding oxidoreductase to a sample containing ethanolamine phosphate. A mediator may be reduced by adding the oxidoreductase, and the reduced mediator may be reacted with a reagent to determine a concentration of ethanolamine phosphate. In addition, hydrogen peroxide produced by adding the oxidase as the oxidoreductase may be reacted with a reagent to determine a concentration of the ethanolamine phosphate.

4. 发明申请

US20210155971A1 METHODS OF DETECTING AMINO ACID DEFICIENCIES 有权
公开(公告)号：US20210155971A1
公开(公告)日：2021-05-27
申请号：US17047667
申请日：2019-04-16
申请人： PACIFIC NORTHWEST RESEARCH INSTITUTE
发明人： Amy Sirr , Adrian C. Scott , Aimee M. Dudley
IPC分类号： C12Q1/52 , C12N15/81 , C12Q1/02 , C12Q1/6883
摘要： The present application relates to a method of screening a subject (and/or treating a subject) for a disease. The application further relates to cells and kits for determination of a disease. Also contemplated are treatments, including those based on a personalized cell model system that determines a subject's threshold for a disease and their personalized treatment.

5. 发明授权

US11009516B2 Systems and methods for multi-analysis 有权
公开(公告)号：US11009516B2
公开(公告)日：2021-05-18
申请号：US14860048
申请日：2015-09-21
申请人： Theranos, Inc.
发明人： Elizabeth A. Holmes , Michael Chen , Pey-Jiun Ko
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B01L3/00 , B01L9/06 , B01L9/00 , G01N15/14 , B01L7/00 , C12Q1/6883 , C12Q1/70 , G01N33/569 , G01N33/80 , G01N21/25 , G01N33/543 , B01L3/02 , G01N21/27 , C12Q1/42 , C12Q1/52 , G01N33/62 , G01N33/68 , G01N33/92 , G01N33/50 , G01N15/00 , G01N15/10
摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

6. 发明授权

US10571466B2 Method for presymptomatic diagnosis of coeliac disease and gluten sensitivity 有权
公开(公告)号：US10571466B2
公开(公告)日：2020-02-25
申请号：US14395353
申请日：2013-04-17
申请人： Aesku.Diagnostics GmbH & Co. KG
发明人： Torsten Matthias , Sasha Pfeiffer , Kai Prager , Christian Meesters , Patricia Jeremias
IPC分类号： A61K39/00 , A61K39/05 , A61K39/35 , C12Q1/52 , G01N33/564 , G01N33/68
摘要： The invention relates to the use of an immunologically reactive microbial transglutaminase or its immunologically reactive parts or analogues, which are present in a complex with gliadin or its immunologically reactive parts or analogues, for the diagnosis and/or therapy control of coeliac disease or sprue as well as gluten sensitivity, and a kit for determining the diagnosis and/or therapy control of coeliac disease or sprue as well as of gluten sensitivity, by means of the previously mentioned complex.

7. 发明授权

US10557863B2 Systems and methods for multi-analysis 有权
公开(公告)号：US10557863B2
公开(公告)日：2020-02-11
申请号：US14789930
申请日：2015-07-01
申请人： Theranos, Inc.
发明人： Elizabeth A. Holmes , Michael Chen , John K. Frankovich , Samartha Anekal , Adrit Lath , Alexander Loo , Chinmay Pangarkar , Joy Roy , Timothy Smith , Daniel Young
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B01L3/00 , B01L9/06 , B01L9/00 , G01N15/14 , B01L7/00 , C12Q1/6883 , C12Q1/70 , G01N33/569 , G01N33/80 , G01N21/25 , G01N33/543 , B01L3/02 , G01N21/27 , C12Q1/42 , C12Q1/52 , G01N33/62 , G01N33/68 , G01N33/92 , G01N33/50 , G01N15/00 , G01N15/10
摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

8. 发明申请

US20190316175A1 BLOOD ANALYSIS METHOD AND BLOOD TEST KIT 审中-公开
公开(公告)号：US20190316175A1
公开(公告)日：2019-10-17
申请号：US16452553
申请日：2019-06-26
申请人： FUJIFILM Corporation
发明人： Hikaru URANO , Haruyasu NAKATSUGAWA , Tatsuya ISHIZAKA , Shinya SUGIMOTO , Isao YONEKUBO
IPC分类号： C12Q1/52 , B01L3/00 , G01N1/38 , G01N33/49
摘要： An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing a diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the diluent solution defines an amount of the normal component which is derived from the diluent solution and/or the members and may be contained in the diluent solution, and in which a volume of the blood sample is 50 μL or less, and a dilution factor of a blood plasma component in the blood sample is 14 times or more.

9. 发明申请

US20190062801A1 SYSTEMS AND METHODS FOR ELECTROCHEMICAL ASPARTATE TRANSAMINASE (AST) AND ALANINE TRANSAMINASE (ALT) DETECTION AND QUANTIFICATION 审中-公开
公开(公告)号：US20190062801A1
公开(公告)日：2019-02-28
申请号：US16176056
申请日：2018-10-31
申请人： Polymer Technology Systems, Inc.
发明人： Gary L. Hughes , Aniruddha Patwardhan
IPC分类号： C12Q1/52 , C12N9/02 , C12N9/88 , C12Q1/00
摘要： A system for electrochemically detecting AST and ALT includes a first sampler for producing pyruvate from ALT and a second sampler for producing pyruvate from AST. The system further includes an electrochemical test strip for receiving processed samples from the first and second samplers, the processed samples containing pyruvate. The system further includes a meter for reading the electrochemical test strip and indicating an amount of AST and ALT in the sample.

10. 发明申请

US20180119199A1 DEVICE FOR ONLINE MEASUREMENT OF NEUROTRANSMITTERS USING ENZYMATIC REACTORS 审中-公开
公开(公告)号：US20180119199A1
公开(公告)日：2018-05-03
申请号：US15847082
申请日：2017-12-19
申请人： Alberto Morales Villagran , Daniel Morales Rodriguez
发明人： Alberto Morales Villagran , Daniel Morales Rodriguez
IPC分类号： C12Q1/52 , G01N33/94 , C12Q1/44
CPC分类号： C12Q1/52 , C12Q1/44 , G01N33/9406
摘要： The invention relates to a device and a method for measuring neurotransmitters in the brain dialysate of mammals using enzymatic reactors specific to a certain neurotransmitter, which generate fluorescent derivatives when mixed. The mixture is introduced into an incubation chamber and passes through a temperature controlling system in order to set it to the optimum enzymatic reaction temperature, and the fluorescent derivative generated is passed through a flow fluorescence cell located inside the incubation chamber, where the liquid is impacted with a laser light source via an optical fiber. The fluorescence emitted is captured by a fluorescence detector that sends it to a processing system in order to obtain the corresponding values.

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