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1. 依法登记的发明

USH1638H Use of the polypeptide compound 失效
标题翻译：多肽化合物的用途
公开(公告)号：USH1638H
公开(公告)日：1997-03-04
申请号：US311434
申请日：1994-09-26
申请人： Takahisa Furuta , Toshiro Iwamoto , Akihiko Fujie , Kumiko Nitta , Yasuhisa Tsurumi , Nobuharu Shigematsu , Chiyoshi Kasahara , Motohiro Hino , Masakuni Okuhara
发明人： Takahisa Furuta , Toshiro Iwamoto , Akihiko Fujie , Kumiko Nitta , Yasuhisa Tsurumi , Nobuharu Shigematsu , Chiyoshi Kasahara , Motohiro Hino , Masakuni Okuhara
IPC分类号： A61K38/12 , C07K7/56 , A61K38/00
CPC分类号： A61K38/12 , C07K7/56
摘要： A pharmaceutical composition comprising an amount of a polypeptide of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group, R.sup.2 is hydroxy or an acyloxy group, R.sup.3 is hydrogen, hydroxy or hydroxysulfonyloxy, R.sup.4 is hydrogen or carbamoyl, and R.sup.5 and R.sup.6 are each hydrogen or hydroxy, with the proviso that (i) R.sup.2 is acyloxy when R.sup.3 is hydrogen, and (ii) R.sup.5 is hydrogen when R.sup.6 is hydrogen, or a pharmaceutically acceptable salt thereof, is useful in the prevention or treatment of Pneumocystis carinii infection.
摘要翻译：一种药物组合物，其包含一定量下式的多肽：其中R 1是氢或酰基，R 2是羟基或酰氧基，R 3是氢，羟基或羟基磺酰氧基，R 4是氢或氨基甲酰基，和R 5和 R6各自为氢或羟基，条件是当R 3为氢时，（ⅰ）R 2为酰氧基，和（ⅱ）R 6为氢时R 5为氢或其药学上可接受的盐可用于预防或治疗肺孢子虫卡利尼病感染。

2. 发明授权

US5502033A Antimicrobial polypeptide compound a pharmaceutical composition comprising the same, and a method for treating infectious diseases 失效
标题翻译：抗微生物多肽化合物，包含其的药物组合物和治疗感染性疾病的方法
公开(公告)号：US5502033A
公开(公告)日：1996-03-26
申请号：US218883
申请日：1994-03-28
申请人： Toshiro Iwamoto , Akihiko Fujie , Kumiko Nitta , Yasuhisa Tsurumi , Nobuharu Shigematsu , Chiyoshi Kasahara , Motohiro Hino , Masakuni Okuhara
发明人： Toshiro Iwamoto , Akihiko Fujie , Kumiko Nitta , Yasuhisa Tsurumi , Nobuharu Shigematsu , Chiyoshi Kasahara , Motohiro Hino , Masakuni Okuhara
IPC分类号： C12N1/14 , A61K38/00 , A61P31/04 , A61P31/10 , C07K1/20 , C07K5/12 , C07K7/56 , C07K14/195 , C07K14/41 , C12P21/04 , C12R1/645 , C07K7/00 , C07K7/06
CPC分类号： C07K7/56 , A61K38/00
摘要： A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.
摘要翻译：具有以下通式的抗微生物活性的化合物：其中R 1是氢或羟基，R 2是氢或羟基，R 3是羟基或羟基磺酰氧基，条件是当R 1是氢时，R 2是氢或药学上可接受的盐其中。该化合物可用于治疗由病原微生物引起的感染性疾病的方法。

3. 发明授权

US5376634A Polypeptide compound and a process for preparation thereof 失效
标题翻译：多肽化合物及其制备方法
公开(公告)号：US5376634A
公开(公告)日：1994-12-27
申请号：US715961
申请日：1991-06-17
申请人： Toshiro Iwamoto , Akihiko Fujie , Kumiko Nitta , Yasuhisa Tsurumi , Nobuharu Shigematsu , Chiyoshi Kasahara , Motohiro Hino , Masakuni Okuhara , Kazuo Sakane , Kohji Kawabata , Hidenori Ohki
发明人： Toshiro Iwamoto , Akihiko Fujie , Kumiko Nitta , Yasuhisa Tsurumi , Nobuharu Shigematsu , Chiyoshi Kasahara , Motohiro Hino , Masakuni Okuhara , Kazuo Sakane , Kohji Kawabata , Hidenori Ohki
IPC分类号： A61K38/00 , A61K38/12 , A61P31/04 , A61P31/10 , C07C309/43 , C07K1/06 , C07K7/56 , C07K7/64 , C12P21/04 , C12R1/645 , C07K5/12 , A61K37/02 , C07K7/06
CPC分类号： C07K7/56 , A61K38/00
摘要： A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,R.sup.3 is hydroxysulfonyloxy, andR.sup.4 is hydrogen or carbamoyl,with proviso thatR.sup.1 is not palmitoyl, when R.sup.2 is hydroxy,R.sup.3 is hydroxysulfonyloxy andR.sup.4 is carbamoyl,and a pharmaceutically acceptable salt thereof.
摘要翻译：具有以下通式的抗微生物活性的多肽化合物：其中R1是氢或酰基，R2是羟基或酰氧基，R3是羟基磺酰氧基，R4是氢或氨基甲酰基，条件是R1不是棕榈酰基，当R2 是羟基，R3是羟基磺酰氧基，R4是氨基甲酰基，及其药学上可接受的盐。

4. 发明授权

US6110933A Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor 失效
标题翻译：氨基酸衍生物及其作为磷脂酶A2抑制剂的用途
公开(公告)号：US6110933A
公开(公告)日：2000-08-29
申请号：US669395
申请日：1996-11-12
申请人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
发明人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
IPC分类号： C07D295/20 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/27 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P1/16 , A61P3/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C227/02 , C07C227/08 , C07C229/22 , C07C235/08 , C07C235/12 , C07C237/04 , C07C237/22 , C07C271/22 , C07C271/54 , C07C275/14 , C07C275/16 , C07C311/19 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/75 , C07D213/78 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/54 , C07D233/64 , C07D241/14 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/22 , C07D295/28 , C07D317/58 , C07D471/04 , A61K31/325 , A61K31/16 , C07D215/02 , C07D217/00
CPC分类号： C07D213/40 , C07C235/08 , C07C235/12 , C07C271/22 , C07C271/54 , C07C275/16 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/64 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/32 , C07D317/58 , C07D471/04
摘要： The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
摘要翻译： PCT No.PCT / JP95 / 00068 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1995年1月23日PCT PCT。第WO95 / 19959号公报日期：1995年7月27日本发明涉及下式的新型脂肪酸衍生物：其中R1为酰基等; R2是酰基（低级）烷基; R3是低级烷基等; R4是氢等; X为-O-等; 和其药学上可接受的盐，其可用作药物; 所述脂肪酸衍生物或其盐的制备方法; 包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物; 等等

5. 发明授权

US5043354A Pharmaceutically useful 5-hydroxy-2,3-dihydro-benzofurans and 5-hydroxy-benzofurans 失效
标题翻译：药用有用的5-羟基-2,3-二氢 - 苯并呋喃和5-羟基 - 苯并呋喃
公开(公告)号：US5043354A
公开(公告)日：1991-08-27
申请号：US520061
申请日：1990-05-03
申请人： Eisaku Tsujii , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Teruo Oku , Masashi Hashimoto
发明人： Eisaku Tsujii , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Teruo Oku , Masashi Hashimoto
IPC分类号： A61K31/34 , A61K31/343 , A61P43/00 , C07D307/79 , C07D307/80 , C12N1/14 , C12P17/04 , C12R1/79
CPC分类号： C07D307/79 , C07D307/80 , C12N1/14 , C12P17/04
摘要： A compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each lower alkyl, R.sup.4 is hydrogen or hydroxy, and a heavy solid line means a double bond when R.sup.4 is hydrogen and a single bond when R.sup.4 is hydroxy is useful in the treatment of diseases caused by reactive oxygen species and organic radicals.

6. 发明授权

US4910017A New compounds WF 2015 A and B 失效
标题翻译：新化合物WF 2015 A和B
公开(公告)号：US4910017A
公开(公告)日：1990-03-20
申请号：US261929
申请日：1988-10-25
申请人： Takanao Otsuka , Toshihiro Shibata , Hiroshi Terano , Yasuhisa Tsurumi , Masakuni Okuhara
发明人： Takanao Otsuka , Toshihiro Shibata , Hiroshi Terano , Yasuhisa Tsurumi , Masakuni Okuhara
IPC分类号： A61K35/74 , A61K36/06 , A61P35/00 , C07G11/00 , C12N1/14 , C12P1/02 , C12R1/645
CPC分类号： C12P1/02 , Y10S435/911
摘要： This invention relates to new compounds WF 2015 A and B which have immunosuppressing activity and antitumor activity, to a process for producing WF 2015 A and B by culturing a WF 2015 A and/or B-producing strain belonging to the genus Scolecobasidium in a nutrient medium, and to a pharmaceutical composition comprising the same.

7. 发明授权

US5447854A Production of cyclosporin A and/or C with a strain of NECTRIA 失效
标题翻译：用NECTRIA菌株生产环孢菌素A和/或C
公开(公告)号：US5447854A
公开(公告)日：1995-09-05
申请号：US90138
申请日：1993-11-10
申请人： Toshio Goto , Toru Kino , Masakuni Okuhara , Hirokazu Tanaka , Yasuhisa Tsurumi , Shigehiro Takase
发明人： Toshio Goto , Toru Kino , Masakuni Okuhara , Hirokazu Tanaka , Yasuhisa Tsurumi , Shigehiro Takase
IPC分类号： C07K7/64 , C12P21/04 , C12N1/14
CPC分类号： C12R1/645 , C07K7/645
摘要： The invention relates to a method of producing cyclosporin A and/or C which is characterized by culturing a cyclosporin A and/or C-producing strain of microorganism belonging to the genus Nectria (e.g. Nectria sp. F-4908) and recovering cyclosporin A and/or C from the resulting cultured broth.
摘要翻译： PCT No.PCT / JP92 / 00047 Sec。 371日期：1993年11月10日 102（e）日期1993年11月10日PCT 1992年1月22日PCT PCT。公开号WO92 / 13094 本发明涉及一种生产环孢菌素A和/或C的方法，其特征在于培养属于Nectria属的微生物的环孢菌素A和/或C产生菌株（例如Nectria sp.F- 4908），并从得到的培养肉汤中回收环孢菌素A和/或C。

8. 发明授权

US06730776B1 WF14573 or its salt, production thereof and use thereof 失效
标题翻译： WF14573或其盐，其制备及其用途
公开(公告)号：US06730776B1
公开(公告)日：2004-05-04
申请号：US09646342
申请日：2000-09-18
申请人： Yasuhiro Hori , Shigehiro Takase , Yasuhisa Tsurumi , Michizane Hashimoto , Motohiro Hino
发明人： Yasuhiro Hori , Shigehiro Takase , Yasuhisa Tsurumi , Michizane Hashimoto , Motohiro Hino
IPC分类号： C07K750
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573A and/or B-producing microorganism in a nutrient medium and recovering WF14573A and/or B from the resultant cultured broth or (b) deacylating WF14573A and/or B in the presence of a microbial substance which is capable of deacylating WF14573A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microorganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microorganisms.
摘要翻译：本发明提供了一种新的抗微生物化合物WF14573，以及（a）在营养培养基中培养WF14573A和/或产生B生物的微生物并从所得培养液中回收WF14573A和/或B或（b）生产WF14573的方法，在能够脱酰基WF14573A和/或B的微生物物质存在下脱酰基WF14573A和/或B。还提供了包含WF14573和载体的抗微生物剂，包含有效量的WF14573和药学上可接受的药物组合物载体，通过向微生物施用WF14573杀死微生物的方法，以及使用WF14573来治疗由病原微生物引起的感染性疾病。

9. 发明授权

US06521600B1 Compound, WF002, production thereof and use thereof 失效
标题翻译：化合物，WF002，其制备及其用途
公开(公告)号：US06521600B1
公开(公告)日：2003-02-18
申请号：US09720331
申请日：2001-01-18
申请人： Yasuhiro Hori , Masami Ezaki , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
发明人： Yasuhiro Hori , Masami Ezaki , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
IPC分类号： A61K317028
CPC分类号： C12R1/645 , C07J63/008 , C12P19/60 , Y10S435/911
摘要： The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.
摘要翻译：本发明提供了具有抗病原微生物的抗微生物活性的新的式（I）生物活性化合物及其生产方法。还提供了包含该化合物和药学上可接受的载体的药物组合物，该WF002作为药物的用途以及该化合物用于制备用于治疗感染性疾病的药物的用途。

10. 发明授权

US06656905B1 Cyclic tetrapeptide compound and use thereof 失效
标题翻译：环状四肽化合物及其用途
公开(公告)号：US06656905B1
公开(公告)日：2003-12-02
申请号：US09806500
申请日：2001-05-04
申请人： Hiroaki Mori , Kazutoshi Sakamoto , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
发明人： Hiroaki Mori , Kazutoshi Sakamoto , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
IPC分类号： A61K3807
CPC分类号： A61K38/12 , C07K5/126
摘要： A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.
摘要翻译：一种环状四肽化合物及其用途。特别地，化合物WF27082是通过在营养培养基中培养属于顶孢菌属的WF27082产生菌株并从培养液中回收化合物，将含有该化合物作为活性成分的药物组合物生产化合物的方法，与药学上可接受的，基本上无毒的载体或赋形剂的相关联，用作药物的化合物，该化合物用于制备用于抑制组蛋白脱乙酰酶的药物的用途，该化合物用于制备用于治疗或预防炎性疾病，糖尿病，糖尿病并发症，纯合地中海贫血，纤维化，肝硬化，急性早幼粒细胞白血病（APL），原生动物感染，器官移植排斥，自身免疫疾病或肿瘤，组蛋白脱乙酰酶抑制剂作为免疫抑制剂或抗肿瘤剂的用途，以及使用组蛋白脱乙酰酶抑制剂来制造用于治疗或预防的药物描述器官移植排斥，自身免疫性疾病或肿瘤。

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