专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4719207A CNS active substituted azetidinone compounds 失效
标题翻译： CNS活性取代的氮杂环丁酮化合物
公开(公告)号：US4719207A
公开(公告)日：1988-01-12
申请号：US747018
申请日：1985-06-20
申请人： Toshinari Tamura , Makoto Yoshida , Shin-ichi Tsukamoto , Hidenori Iwamoto , Minoru Yamamoto , Soichi Kagami
发明人： Toshinari Tamura , Makoto Yoshida , Shin-ichi Tsukamoto , Hidenori Iwamoto , Minoru Yamamoto , Soichi Kagami
IPC分类号： C07D205/08 , C07D205/085 , C07F7/10 , C07K5/097 , A61K31/415 , C07D403/12 , C07D403/14
CPC分类号： C07K5/0821 , C07D205/08 , C07D205/085 , C07F7/10
摘要： Substituted azetidinone compounds are provided which have the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 represents a substituted lower alkyl group, an azido group, an amino group, a lower acylamino group, a mercapto group or a lower alkylthio group and the other represents a hydrogen group, or, both represent hydrogen atoms or lower alkyl groups; R.sup.3 represents a hydrogen atom or a group shown by formula: ##STR2## (wherein X represents ##STR3## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group) and Y represents a hydroxy group, a lower alkoxy group, an amino group, a mono- or di-lower alkylamino group); R.sup.4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a group shown by formula: --CH.sub.2 CO--A (wherein A represents an amino group or a group shown by formula: ##STR4## (wherein X and Y are as defined above), provided that when R.sup.1 and R.sup.2 are both hydrogen atoms, at least R.sup.4 represents a group other than a hydrogen atom and provided that either R.sup.3 or R.sup.4 represents a group other than a hydrogen atom. The compounds have strong CNS action.
摘要翻译：提供具有下式的取代的氮杂环丁酮化合物：其中R 1和R 2之一表示取代的低级烷基，叠氮基，氨基，低级酰氨基，巯基或低级烷硫基另一个表示氢基团，或者都表示氢原子或低级烷基; R3表示氢原子或由下式表示的基团：其中X表示（其中R5表示氢原子或低级烷基），Y表示羟基，低级烷氧基，氨基，一或二低级烷基氨基）; R 4表示氢原子，取代或未取代的低级烷基或由式-CH 2 CO-A（其中A表示氨基或由下式表示的基团：其中X和Y如上所定义）），条件是当R 1和R 2均为氢原子时，至少R 4表示氢原子以外的基团，只要R 3或R 4表示除氢原子以外的基团，则该化合物具有强CNS作用。

2. 发明授权

US4636567A 4-substituted-2-azetidinone compound 失效
标题翻译： 4-取代-2-氮杂环丁酮化合物
公开(公告)号：US4636567A
公开(公告)日：1987-01-13
申请号：US785169
申请日：1985-10-07
申请人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
发明人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
IPC分类号： C07D403/14 , C07D205/08 , C07D403/12 , C07K5/078 , C07K5/097
CPC分类号： C07D403/12 , C07D205/08 , C07K5/06147
摘要： A novel-4-substituted-2-azetidinone compound shown by the general formula ##STR1## and salts thereof. The compounds of this invention have a strong CNS activity and are useful for improving a disturbance of consciousness in schizophrenia, a head injury, etc., or improving hypobulia, memory loss, etc.

3. 发明授权

US4610821A 4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds 失效
标题翻译： 4-取代-2-氮杂环丁酮化合物，制备该化合物的方法和含有这些化合物的药物
公开(公告)号：US4610821A
公开(公告)日：1986-09-09
申请号：US785168
申请日：1985-10-07
申请人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
发明人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
IPC分类号： C07D403/14 , C07D205/08 , C07D403/12 , C07K5/078 , C07K5/097 , C07D413/12
CPC分类号： C07D403/12 , C07D205/08 , C07K5/06147
摘要： A novel 4-substituted-2-azetidinone compound shown by the general formula ##STR1## and salts thereof. The compounds of this invention have a strong CNS activity and are useful for improving a disturbance of consciousness in shizophrenia, a head injury, etc., or improving hypobulia, memory loss, etc.

4. 发明授权

US4564609A 4-Substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds 失效
标题翻译： 4-取代-2-氮杂环丁酮化合物，制备该化合物的方法和含有这些化合物的药物
公开(公告)号：US4564609A
公开(公告)日：1986-01-14
申请号：US592866
申请日：1984-03-23
申请人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
发明人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
IPC分类号： C07D403/14 , C07D205/08 , C07D403/12 , C07K5/078 , C07K5/097 , A61K37/00
CPC分类号： C07D403/12 , C07D205/08 , C07K5/06147
摘要： A novel 4-substituted-2-azetidinone compound shown by the general formula ##STR1## and salts thereof. The compounds of this invention have a strong CNS activity and are useful for improving a disturbance of consciousness in schizophrenia, a head injury, etc., or improving hypobulia, memory loss, etc.
摘要翻译：由通式表示的新型4-取代-2-氮杂环丁酮化合物及其盐。本发明化合物具有较强的CNS活性，可用于改善精神分裂症意识障碍，头部损伤等，或改善低血压，记忆力丧失等。

5. 发明授权

US08507485B2 Cyclic compound having pyrimidinylalkylthio group 有权
标题翻译：具有嘧啶基烷硫基的环状化合物
公开(公告)号：US08507485B2
公开(公告)日：2013-08-13
申请号：US12931072
申请日：2011-01-24
申请人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
发明人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
IPC分类号： A61K31/5377 , A61K31/506
CPC分类号： C07D401/14 , C07D239/42 , C07D401/12 , C07D409/12
摘要： A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.
摘要翻译：通过施用治疗有效量的由式（1）表示的化合物或其盐来治疗与血管生成相关的疾病的方法，其中环X表示R 1和R 2独立地表示氢原子，烷基，芳基或芳香杂环; R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基芳硫基，烷基亚磺酰基或非芳族杂环; A1表示硫原子，亚磺酰基或磺酰基; A2表示亚烷基。

6. 发明申请

US20120323350A1 SUPPORT SYSTEM FOR SETTING EQUIPMENT PARAMETERS 审中-公开
标题翻译：用于设置设备参数的支持系统
公开(公告)号：US20120323350A1
公开(公告)日：2012-12-20
申请号：US13055334
申请日：2010-06-16
申请人： Minoru Yamamoto , Tatsushi Imori , Shinobu Hirano
发明人： Minoru Yamamoto , Tatsushi Imori , Shinobu Hirano
IPC分类号： G05B19/18
CPC分类号： G05B11/42 , G05B13/042 , G05B17/02
摘要： An object is to provide an equipment parameter setting support system for supporting the setting of parameters in various processing equipment. The equipment parameter setting support system has an execution results acquisition unit for acquiring, from an equipment controller or EES of the equipment design and manufacturing support system, execution results of a real equipment at any two points in time; a parameter calculation unit for calculating PID parameters at each time point on the basis of the acquired execution results; a difference calculation unit for calculating the difference between the calculated PID parameters; and a variation value calculation unit for calculating a variation value for a unit interval in relation to the calculated difference, wherein, in the equipment design and manufacturing support system, the calculated variation value and a PID parameters stored in the equipment simulator are computed to calculate a new PID parameter, and PID control is executed in the equipment simulator using the new PID parameter.
摘要翻译：目的是提供一种用于支持各种处理设备中参数设置的设备参数设置支持系统。设备参数设置支持系统具有执行结果获取单元，用于从设备控制器或设备设计制造支持系统的EES获取任意两点的实际设备的执行结果; 参数计算单元，用于基于所获取的执行结果来计算每个时间点的PID参数; 差分计算单元，用于计算所计算的PID参数之间的差; 以及变化值计算单元，用于计算与计算出的差异相关的单位间隔的变化值，其中，在设备设计和制造支持系统中，计算计算的变化值和存储在设备模拟器中的PID参数，以计算使用新的PID参数在设备模拟器中执行新的PID参数和PID控制。

7. 发明授权

US08288380B2 Thiophenediamine derivative having urea structure 有权
标题翻译：具有尿素结构的噻吩并二胺衍生物
公开(公告)号：US08288380B2
公开(公告)日：2012-10-16
申请号：US13448674
申请日：2012-04-17
申请人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
发明人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
IPC分类号： A61K31/5377 , A61K31/4436 , A61K31/381 , A61K31/496 , A61K31/4439 , A61K31/444 , C07D409/14 , C07D409/12 , C07D413/12 , C07D333/36 , C07D417/14 , A61P27/02 , A61P27/06
CPC分类号： C07D333/36 , C07D409/12
摘要： A compound of formula (1): wherein R1 and R2 represent hydrogen, lower alkyl, lower alkenyl, lower alkynyl or R3 represents hydroxyl, lower alkoxy, lower cycloalkyloxy, aryloxy, carboxy, lower alkoxycarbonyl, or NRaRb of the formula R4 and R5 represent halogen, lower alkyl, hydroxyl, or lower alkoxy; R6 represents halogen, lower alkyl, aryl, heterocyclic, hydroxy, lower alkoxy, mercapto, lower alkylthio, lower alkylcarbonyl, amino, nitro or cyano; R7 represents lower alkyl, hydroxyl or lower alkoxy; Ra and Rb represent hydrogen or lower alkyl; ring A represents a cyclic hydrocarbon or a heterocyclic ring; ring B represents a heterocyclic ring; X represents lower alkylene; Z represents a single bond or lower alkylene; Y represents lower alkylene and W1—W2 represents CH—CH, or Y represents a single bond and W1—W2 represents N—CH, CH—N or CH—CH; and 1, m, n and o represent 0, 1, 2, or 3.
摘要翻译：式（1）的化合物：其中R 1和R 2表示氢，低级烷基，低级烯基，低级炔基或R 3表示羟基，低级烷氧基，低级环烷氧基，芳氧基，羧基，低级烷氧基羰基或NR 4 R b R 5表示卤素，低级烷基，羟基或低级烷氧基; R6表示卤素，低级烷基，芳基，杂环，羟基，低级烷氧基，巯基，低级烷硫基，低级烷基羰基，氨基，硝基或氰基; R7表示低级烷基，羟基或低级烷氧基; Ra和Rb代表氢或低级烷基; 环A表示环状烃或杂环; 环B表示杂环; X表示低级亚烷基; Z表示单键或低级亚烷基; Y表示低级亚烷基，W1-W2表示CH-CH，或Y表示单键，W1-W2表示N-CH，CH-N或CH-CH; 和1，m，n和o表示0,1,2或3。

8. 发明授权

US08258242B2 Compatibilizing agent for polymer alloy, polymer alloy, and master batch for preparation of polymer alloy 失效
标题翻译：用于聚合物合金，聚合物合金和母料的增容剂用于制备聚合物合金
公开(公告)号：US08258242B2
公开(公告)日：2012-09-04
申请号：US12310314
申请日：2007-08-16
申请人： Ryoichi Hiroi , Minoru Yamamoto
发明人： Ryoichi Hiroi , Minoru Yamamoto
IPC分类号： C08G65/321
CPC分类号： C08L77/00 , C08J3/226 , C08K3/22 , C08K7/00 , C08L23/06 , C08L23/083 , C08L23/30 , C08L67/07 , C08L69/00 , C08L71/12 , C08L81/02 , C08L101/00 , C08L81/00 , C08L2666/02
摘要： Disclosed are: a compatibilizing agent for a polymer alloy, which can increase the compatibility with a variety of polymers; a polymer alloy using the compatibilizing agent; and master batch for a polymer alloy. Specifically disclosed is a compatibilizing agent which is used for the preparation of a polymer alloy by blending at least one polymer (A) selected from the group consisting of a polyphenylene sulfide, a polyphenylene ether and a polyamide with a polymer (B) of a different type from the polymer (A) at such a ratio that the amount of the polymer (A) blended is the same as or more than that of the polymer (B). The compatibilizing agent comprises a nanosheet-shaped layered titanic acid which is produced by intercalate an organic basic compound between the layers of a layered titanic acid.
摘要翻译：公开了一种用于聚合物合金的相容剂，其可以增加与各种聚合物的相容性; 使用相容剂的聚合物合金; 和聚合物合金的母料。具体公开了一种相容剂，其通过将选自聚苯硫醚，聚苯醚和聚酰胺的至少一种聚合物（A）与不同的聚合物（B）共混而用于制备聚合物合金以聚合物（A）的配合量与聚合物（B）相同或更多的比例从聚合物（A）中加入。相容剂包括通过在层状钛酸的层之间插入有机碱性化合物而制备的纳米片状层状钛酸。

9. 发明授权

US08017775B2 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity 有权
标题翻译：具有糖皮质激素受体结合活性的1-2-二氢喹啉衍生物
公开(公告)号：US08017775B2
公开(公告)日：2011-09-13
申请号：US11992088
申请日：2006-09-14
申请人： Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Masato Nagatsuka , Sachiko Kobayashi , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Tomoko Oda
发明人： Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Masato Nagatsuka , Sachiko Kobayashi , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Tomoko Oda
IPC分类号： C07D215/38
CPC分类号： C07D215/14 , C07D215/20 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S(O)R8 or S(O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.
摘要翻译：本发明的目的是研究新型1,2-二氢喹啉衍生物的合成，并找到衍生物的药理作用。由通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面是有效的。在该式中，环X表示苯环或吡啶环; R1表示卤素原子，烷基，羟基，烷氧基，氨基等; p表示0〜5的整数， R2表示卤素原子，烷基，羟基等; q表示0〜2的整数， R3表示氢原子，烷基，烯基等; R4和R5表示氢原子等; R6表示氢原子等; A表示亚烷基等; 并且R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8或S（O）2 R 8，其中R 8表示芳基，杂环基等，R 9表示氢原子等。

10. 发明申请

US20110124668A1 NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP 失效
标题翻译：新加坡衍生产品有限公司，卡巴集团，乌代组和替代氧化集团
公开(公告)号：US20110124668A1
公开(公告)日：2011-05-26
申请号：US13054041
申请日：2009-07-14
申请人： Kenji Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
发明人： Kenji Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
IPC分类号： A61K31/404 , C07D209/42 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/4439 , C07D405/10 , A61P29/00 , A61P27/06 , A61P17/00 , A61P27/02 , A61P35/00 , A61P3/00 , A61P25/00 , A61P37/06 , A61P31/00 , A61P37/08
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D403/12 , C07D405/04
摘要： The present invention relates to synthetic studies on novel indole derivatives having a carbamoyl group, a ureido group and a substituted oxy group or a salt thereof, and pharmaceutical actions of the derivatives. The compound and a salt thereof represented by the general formula (1) has an IKKβ inhibitory activity and is useful as a preventive and/or therapeutic agent for diseases considered to be associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group which may have a substituent, a hydroxy group, or a lower alkoxy group which may have a substituent, or the like; R2 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, or a heterocyclic group which may have a substituent, or the like; R3 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or the like; m represents 0, 1, 2, or the like.
摘要翻译：本发明涉及具有氨基甲酰基，脲基和取代的氧基或其盐的新型吲哚衍生物的合成研究以及衍生物的药物作用。由通式（1）表示的化合物及其盐具有IKK＆bgr; 抑制活性，并且可用作被认为与IKK＆bgr相关的疾病的预防和/或治疗剂。式中，R 1表示氢原子，可以具有取代基的低级烷基，羟基或可具有取代基的低级烷氧基等。 R2表示氢原子，可以具有取代基的低级烷基，可以具有取代基的低级环烷基，可以具有取代基的芳基或可以具有取代基的杂环基等。 R3表示卤原子，可以具有取代基的低级烷基，可以具有取代基的低级烯基，可以具有取代基的低级炔基，可以具有取代基的低级环烷基，可以具有取代基的低级环烷基，可以具有取代基，可以具有取代基的杂环基等; m表示0,1,2等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式