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1. 发明申请

US20070134730A1 Screening method, screening program and screening device 审中-公开
标题翻译：筛选方法，筛选程序和筛选装置
公开(公告)号：US20070134730A1
公开(公告)日：2007-06-14
申请号：US11637837
申请日：2006-12-13
申请人： Toshihide Ezoe , Takayuki Yamada , Hirohiko Tsuzuki
发明人： Toshihide Ezoe , Takayuki Yamada , Hirohiko Tsuzuki
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G01N33/553 , G01N2500/04
摘要： The invention provides a screening method for selecting a particular candidate molecule by using binding amount data between a target molecule and the candidate molecule, the data being obtained by supplying the candidate molecule of study to a measurement region composed of an immobilization membrane on which the target molecule is immobilized, the screening method comprising: obtaining the binding amount data during activity by supplying the candidate molecule to a measurement region in which the target molecule not subjected to activity lowering treatment that lowers physiological activity is immobilized, obtaining the binding amount data during low activity by supplying the candidate molecule to a measurement region in which the target molecule that is subjected to activity lowering treatment that lowers physiological activity is immobilized, and extracting a candidate molecule having a specified difference between the binding amount data during the activity and the binding amount data during the low activity.
摘要翻译：本发明提供了通过使用目标分子与候选分子之间的结合量数据来选择特定候选分子的筛选方法，该方法通过将候选分析物提供给由固定化膜构成的测定区域而获得的数据，分子被固定化，所述筛选方法包括：通过将候选分子提供给其中未进行活性降低治疗的目标分子的测定区域来获得活性期间的结合量数据，其降低生理活性被固定，在低浓度期间获得结合量数据通过将候选分子供给到固定有降低生理活性的进行活性降低处理的目标分子的测定区域，提取活性中的结合量数据与结合量之间具有规定差异的候选分子的活性低活动期间的数据。

2. 发明申请

US20070122308A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20070122308A1
公开(公告)日：2007-05-31
申请号：US11604698
申请日：2006-11-28
申请人： Morihito Ikeda , Taisei Nishimi , Hirohiko Tsuzuki , Toshihide Ezoe
发明人： Morihito Ikeda , Taisei Nishimi , Hirohiko Tsuzuki , Toshihide Ezoe
IPC分类号： G01N31/22
CPC分类号： G01N21/553 , B82Y15/00 , B82Y30/00 , G01N33/54373 , G01N33/544 , G01N2610/00
摘要： An object of the present invention is to provide a biosensor having high capability for suppressing nonspecific protein adsorption and high capability for extracting a target protein. The present invention provides a biosensor which comprises a flow channel that is formed on a substrate and is composed of a detection plane for detecting interaction between a physiologically active substance and a test substance and a non-detection plane where said interaction is not detected, wherein the substrate is a metal surface or a metal film and the surfaces of the detection plane and the non-detection plane are modified with a self-assembled monolayer (SAM) having a hydroxy group and a functional group for binding with a physiologically active substance.
摘要翻译：本发明的目的是提供一种能够抑制非特异性蛋白质吸附的能力高，提取目标蛋白质的能力高的生物传感器。本发明提供一种生物传感器，其包括形成在基板上的流路，其由用于检测生理活性物质与检测物质之间的相互作用的检测面以及未检测到相互作用的非检测面构成，基板是金属表面或金属膜，检测面和非检测面的表面用具有羟基和官能团的自组装单层（SAM）修饰，用于与生理活性物质结合。

3. 发明申请

US20070048796A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20070048796A1
公开(公告)日：2007-03-01
申请号：US11508904
申请日：2006-08-24
申请人： Toshiaki Kubo , Toshihide Ezoe , Hirohiko Tsuzuki , Morihito Ikeda
发明人： Toshiaki Kubo , Toshihide Ezoe , Hirohiko Tsuzuki , Morihito Ikeda
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要： It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting the interaction of a physiologically active substance with a test substance and a non-detection surface that does not detect said interaction, wherein the detection surface and non-detection surface are modified in such a way that the physiologically active substance can be immobilized thereon.
摘要翻译：本发明的目的是提供一种与生理活性物质相互作用的测试物质的回收率提高的生物传感器。本发明提供一种生物传感器，其具有形成在基板上的流路，该流路由用于检测生理活性物质与检测物质的相互作用的检测面和不检测所述相互作用的非检测面构成，检测表面和非检测表面以使生理活性物质固定在其上的方式被修饰。

4. 发明授权

US07449343B2 Method for measuring surface plasmon resonance 有权
标题翻译：表面等离子体共振测量方法
公开(公告)号：US07449343B2
公开(公告)日：2008-11-11
申请号：US11218656
申请日：2005-09-06
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N33/558 , G01N33/553
CPC分类号： G01N33/54373 , Y10S436/805
摘要： It is an object of the present invention to provide a measurement method which can suppress noise when a specific binding reaction between a physiologically active substance and a test substance is measured using a surface plasmon resonance measurement device. The present invention provides a method for measuring a change in surface plasmon resonance which comprises: using a surface plasmon resonance measurement device comprising a metal film, a light source for generating a light beam, an optical system for allowing the above-described light beam to enter the interface of the metal film so that total reflection conditions can be obtained at the interface thereof and so that various incidence angles can be included, a flow channel system comprising a cell formed on the above-described metal film, and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at the above interface, and exchanging the liquid contained in the above flow channel system with another liquid, wherein the liquid in the above-described flow channel system is exchanged with another liquid obtained by eliminating insoluble matters from a measurement solvent, and the change in surface plasmon resonance is then measured in a state where the flow of the liquid has been stopped.
摘要翻译：本发明的目的是提供一种测量方法，当使用表面等离子体共振测量装置测量生理活性物质和测试物质之间的特异性结合反应时，可以抑制噪声。本发明提供了一种用于测量表面等离子体共振的变化的方法，包括：使用表面等离子体共振测量装置，其包括金属膜，用于产生光束的光源，用于允许上述光束进入金属膜的界面，使得能够在其界面获得全反射条件，并且可以包括各种入射角，包括形成在上述金属膜上的单元的流路系统和光检测用于通过测量在上述界面全反射的光束强度来检测表面等离子体共振的状态的装置，以及将上述流道系统中所含的液体与另一种液体进行交换，其中上述流道系统与通过从测量溶剂中除去不溶物质而获得的另一种液体以及表面质膜的变化进行交换然后在液体的流动停止的状态下测量单次共振。

5. 发明申请

US20060187460A1 Method for measuring the surface plasmon resonance 审中-公开
标题翻译：测量表面等离子体共振的方法
公开(公告)号：US20060187460A1
公开(公告)日：2006-08-24
申请号：US11354839
申请日：2006-02-16
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： It is an object of the present invention to provide a method for obtaining a chromatogram using the SPR analysis method. The present invention provides a method for measuring the change in the surface plasmon resonance by using a surface plasmon resonance measurement device which comprises a metal film, a light source for generating a light beam, an optical system for allowing such a light beam to enter the interface of the metal film so that total reflection conditions can be obtained at the interface thereof and so that various incidence angles can be included, a flow channel system comprising a cell formed on said metal film, and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at said interface, and exchanging a liquid contained in the flow channel system; wherein the measurement is carried out by supplying a liquid at a liquid amount such that the absolute amount of molecules adsorbed on the metal film surface is lower than the saturated adsorption amount of said molecules on said metal film surface.
摘要翻译：本发明的目的是提供使用SPR分析方法获得色谱图的方法。本发明提供了一种用于通过使用表面等离子体共振测量装置来测量表面等离子体共振的变化的方法，所述表面等离子体共振测量装置包括金属膜，用于产生光束的光源，用于允许这种光束进入使得能够在其界面处获得全反射条件，并且可以包括各种入射角，包括形成在所述金属膜上的单元的流路系统和用于检测状态的光检测装置通过测量在所述界面处全反射的光束的强度，并且更换包含在所述流道系统中的液体的表面等离子体共振; 其中所述测量是通过以液体量供给液体来进行的，以使吸附在所述金属膜表面上的分子的绝对量低于所述金属膜表面上的所述分子的饱和吸附量。

6. 发明授权

US06274301B1 Photothermographic recording elements 失效
标题翻译：光热记录元件
公开(公告)号：US06274301B1
公开(公告)日：2001-08-14
申请号：US09174011
申请日：1998-10-16
申请人： Hisashi Okamura , Hirohiko Tsuzuki , Itsuo Fujiwara , Yoshiharu Yabuki
发明人： Hisashi Okamura , Hirohiko Tsuzuki , Itsuo Fujiwara , Yoshiharu Yabuki
IPC分类号： G03C1498
CPC分类号： G03C1/49863 , G03C1/002 , G03C1/04 , G03C1/34 , G03C1/49845 , G03C2200/22 , G03C2200/36
摘要： A photothermographic recording element having improved image tone and improved tone stability during storage is provided wherein at least one of constituent layers comprises (a) polymeric microparticulates containing a dyestuff, (b) microcapsules containing a dyestuff, and/or (c) an organic or inorganic pigment.
摘要翻译：提供了具有改善的图像色调并且在存储期间具有改善的色调稳定性的光热记录元件，其中至少一个构成层包含（a）含有染料的聚合物微粒，（b）含有染料的微胶囊和/或（c）有机或无机颜料。

7. 发明授权

US6093529A Imaging materials 失效
标题翻译：成像材料
公开(公告)号：US6093529A
公开(公告)日：2000-07-25
申请号：US60881
申请日：1998-04-16
申请人： Hirohiko Tsuzuki , Hisashi Okamura , Itsuo Fujiwara , Yoshiharu Yabuki , Masaki Noro
发明人： Hirohiko Tsuzuki , Hisashi Okamura , Itsuo Fujiwara , Yoshiharu Yabuki , Masaki Noro
IPC分类号： G03C1/498 , G03C1/490 , G03C1/815
CPC分类号： G03C1/49845 , G03C1/49872 , G03C1/49863
摘要： An imaging material is provided in the form of a photothermographic or thermographic image forming layer containing an organic silver salt on one surface of a support and further comprising a polyvalent metal ion and a phthalic acid compound on the image forming layer-bearing surface of the support. The imaging material has improved shelf stability before and after image formation and the ease of handling and produces high-quality blue black tone images.
摘要翻译：成像材料以支持体的一个表面上含有有机银盐的光热照相或热成像图像形式的形式提供，并且在载体的图像形成层承载表面上还包含多价金属离子和邻苯二甲酸化合物。成像材料在图像形成之前和之后具有改善的储存稳定性和易于处理并产生高质量的蓝黑色调图像。

8. 发明授权

US5922529A Photothermographic material 失效
标题翻译：光热成像材料
公开(公告)号：US5922529A
公开(公告)日：1999-07-13
申请号：US996914
申请日：1997-12-23
申请人： Hirohiko Tsuzuki , Hisashi Okada , Yoshio Inagaki
发明人： Hirohiko Tsuzuki , Hisashi Okada , Yoshio Inagaki
IPC分类号： C09B23/00 , G03C1/498 , G03C1/08 , G03C1/34
CPC分类号： G03C1/49854 , G03C1/49845
摘要： A photothermographic material has a photosensitive layer containing a binder, organic silver salt, reducing agent, and silver halide on one surface of a support. The photosensitive layer further contains a specific sulfur-containing compound and a merocyanine dye of specific structure and has an absorbance of 0.15-1.0 at an exposure wavelength. Sharpness, sensitivity, and aging stability are improved.
摘要翻译：光热敏成像材料在载体的一个表面上具有含有粘合剂，有机银盐，还原剂和卤化银的感光层。感光层还含有特定的含硫化合物和特定结构的部花青染料，并且在曝光波长下的吸光度为0.15-1.0。清晰度，灵敏度和老化稳定性得到提高。

9. 发明授权

US08236575B2 Carrier for analysis of an analyte and process for producing the same 有权
标题翻译：用于分析分析物的载体和用于制备分析物的方法
公开(公告)号：US08236575B2
公开(公告)日：2012-08-07
申请号：US12744311
申请日：2008-11-21
申请人： Koichi Minami , Hirohiko Tsuzuki
发明人： Koichi Minami , Hirohiko Tsuzuki
IPC分类号： G01N33/543
CPC分类号： G01N33/542 , G01N21/6428
摘要： A first reactant, which is provided with a reaction site for specific binding with an analyte, and a fluorescent label site, and a second reactant, which is provided with a reaction site for specific binding with the analyte, and a fluorescence recognition site for recognizing fluorescence produced by the fluorescent label site of the first reactant, are respectively fixed onto a support such that the first reactant and the second reactant have a positional relationship adapted for the binding with the analyte.
摘要翻译：提供有用于与分析物特异性结合的反应位点的第一反应物和荧光标记位点，以及第二反应物，其具有用于与分析物特异性结合的反应位点和用于识别的荧光识别位点由第一反应物的荧光标记位点产生的荧光分别固定在载体上，使得第一反应物和第二反应物具有适于与分析物结合的位置关系。

10. 发明授权

US07723122B2 Method for analyzing test substance by surface plasmon resonance analysis 有权
标题翻译：通过表面等离子体共振分析分析测试物质的方法
公开(公告)号：US07723122B2
公开(公告)日：2010-05-25
申请号：US11213716
申请日：2005-08-30
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N24/00 , G01N21/62 , G01N33/53
CPC分类号： G01N21/553 , G01N21/276 , Y10S436/805 , Y10T436/24
摘要： It is an object of the present invention to provide a method for analyzing the interaction of a test substance with a ligand by analyzing a phenomenon whereby multiple test substances are simultaneously adsorbed to a ligand. The present invention provides a method for analyzing the interaction of test substances with a ligand by measuring the change in the surface plasmon resonance using a surface plasmon resonance measurement device wherein the above-described method comprises: supplying a solution containing two or more types of test substances after supplying a solution containing no test substances; measuring the change in the surface plasmon resonance; and analyzing the difference between the change in the surface plasmon resonance that is predicted from the adsorption rate constant (ka) and dissociation rate constant (kd) of each of the test substances that had previously been measured and the change in the surface plasmon resonance that has actually been measured.
摘要翻译：本发明的目的是提供一种通过分析同时将多种测试物质吸附到配体上的现象来分析测试物质与配体的相互作用的方法。本发明提供了一种通过使用表面等离子体共振测量装置测量表面等离子体共振的变化来分析测试物质与配体的相互作用的方法，其中上述方法包括：提供含有两种或多种类型的测试的溶液提供不含检测物质的溶液后的物质; 测量表面等离子体共振的变化; 并分析从先前测量的每种测试物质的吸附速率常数（ka）和解离速率常数（kd）预测的表面等离子体共振的变化与表面等离子体共振的变化之间的差异，实际上已被测量。

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