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1. 发明申请

US20070048796A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20070048796A1
公开(公告)日：2007-03-01
申请号：US11508904
申请日：2006-08-24
申请人： Toshiaki Kubo , Toshihide Ezoe , Hirohiko Tsuzuki , Morihito Ikeda
发明人： Toshiaki Kubo , Toshihide Ezoe , Hirohiko Tsuzuki , Morihito Ikeda
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要： It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting the interaction of a physiologically active substance with a test substance and a non-detection surface that does not detect said interaction, wherein the detection surface and non-detection surface are modified in such a way that the physiologically active substance can be immobilized thereon.
摘要翻译：本发明的目的是提供一种与生理活性物质相互作用的测试物质的回收率提高的生物传感器。本发明提供一种生物传感器，其具有形成在基板上的流路，该流路由用于检测生理活性物质与检测物质的相互作用的检测面和不检测所述相互作用的非检测面构成，检测表面和非检测表面以使生理活性物质固定在其上的方式被修饰。

2. 发明申请

US20070122308A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20070122308A1
公开(公告)日：2007-05-31
申请号：US11604698
申请日：2006-11-28
申请人： Morihito Ikeda , Taisei Nishimi , Hirohiko Tsuzuki , Toshihide Ezoe
发明人： Morihito Ikeda , Taisei Nishimi , Hirohiko Tsuzuki , Toshihide Ezoe
IPC分类号： G01N31/22
CPC分类号： G01N21/553 , B82Y15/00 , B82Y30/00 , G01N33/54373 , G01N33/544 , G01N2610/00
摘要： An object of the present invention is to provide a biosensor having high capability for suppressing nonspecific protein adsorption and high capability for extracting a target protein. The present invention provides a biosensor which comprises a flow channel that is formed on a substrate and is composed of a detection plane for detecting interaction between a physiologically active substance and a test substance and a non-detection plane where said interaction is not detected, wherein the substrate is a metal surface or a metal film and the surfaces of the detection plane and the non-detection plane are modified with a self-assembled monolayer (SAM) having a hydroxy group and a functional group for binding with a physiologically active substance.
摘要翻译：本发明的目的是提供一种能够抑制非特异性蛋白质吸附的能力高，提取目标蛋白质的能力高的生物传感器。本发明提供一种生物传感器，其包括形成在基板上的流路，其由用于检测生理活性物质与检测物质之间的相互作用的检测面以及未检测到相互作用的非检测面构成，基板是金属表面或金属膜，检测面和非检测面的表面用具有羟基和官能团的自组装单层（SAM）修饰，用于与生理活性物质结合。

3. 发明申请

US20070134730A1 Screening method, screening program and screening device 审中-公开
标题翻译：筛选方法，筛选程序和筛选装置
公开(公告)号：US20070134730A1
公开(公告)日：2007-06-14
申请号：US11637837
申请日：2006-12-13
申请人： Toshihide Ezoe , Takayuki Yamada , Hirohiko Tsuzuki
发明人： Toshihide Ezoe , Takayuki Yamada , Hirohiko Tsuzuki
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G01N33/553 , G01N2500/04
摘要： The invention provides a screening method for selecting a particular candidate molecule by using binding amount data between a target molecule and the candidate molecule, the data being obtained by supplying the candidate molecule of study to a measurement region composed of an immobilization membrane on which the target molecule is immobilized, the screening method comprising: obtaining the binding amount data during activity by supplying the candidate molecule to a measurement region in which the target molecule not subjected to activity lowering treatment that lowers physiological activity is immobilized, obtaining the binding amount data during low activity by supplying the candidate molecule to a measurement region in which the target molecule that is subjected to activity lowering treatment that lowers physiological activity is immobilized, and extracting a candidate molecule having a specified difference between the binding amount data during the activity and the binding amount data during the low activity.
摘要翻译：本发明提供了通过使用目标分子与候选分子之间的结合量数据来选择特定候选分子的筛选方法，该方法通过将候选分析物提供给由固定化膜构成的测定区域而获得的数据，分子被固定化，所述筛选方法包括：通过将候选分子提供给其中未进行活性降低治疗的目标分子的测定区域来获得活性期间的结合量数据，其降低生理活性被固定，在低浓度期间获得结合量数据通过将候选分子供给到固定有降低生理活性的进行活性降低处理的目标分子的测定区域，提取活性中的结合量数据与结合量之间具有规定差异的候选分子的活性低活动期间的数据。

4. 发明授权

US08585972B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08585972B2
公开(公告)日：2013-11-19
申请号：US12778555
申请日：2010-05-12
申请人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo , Hidetoshi Tomita
发明人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo , Hidetoshi Tomita
IPC分类号： G01N33/53
CPC分类号： G01N33/54353 , G01N33/54373
摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.
摘要翻译：本发明的一个目的是提供一种生物传感器及其生产方法，通过该生物传感器及其生产方法，可以使用安全的原料方便地生产能够固定生理活性物质的水凝胶。本发明提供一种生物传感器，其包括在其表面具有金属层的基材，其中具有能够与生理活性物质的羟基或氨基反应的反应性官能团的亲水性聚合物直接结合到金属层或间接经由中间层。

5. 发明申请

US20060211137A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20060211137A1
公开(公告)日：2006-09-21
申请号：US11362354
申请日：2006-02-27
申请人： Toshihide Ezoe , Toshiaki Kubo , Masashi Hakamata
发明人： Toshihide Ezoe , Toshiaki Kubo , Masashi Hakamata
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N33/54373
摘要： It is an object of the present invention to provide a biosensor wherein a reference unit and a measurement unit can be prepared by performing only a single operation for immobilizing a physiologically active substance and wherein unnecessary electric charge does not remain in the reference unit. The present invention provides a biosensor which comprises a substrate composed of a metal surface or metal film coated with a hydrophilic polymer compound, and which has a surface for retaining a physiologically active substance and a surface that does not retain a physiologically active substance on a single plane of the substrate.
摘要翻译：本发明的目的是提供一种生物传感器，其中通过仅执行用于固定生理活性物质的单一操作并且其中不必要的电荷不残留在参考单元中，可以制备参考单元和测量单元。本发明提供了一种生物传感器，其包括由涂覆有亲水性高分子化合物的金属表面或金属膜构成的基板，并且具有用于保持生理活性物质的表面和不保留生理活性物质的表面基板的平面。

6. 发明申请

US20060040410A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20060040410A1
公开(公告)日：2006-02-23
申请号：US11205183
申请日：2005-08-17
申请人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo
发明人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo
IPC分类号： C12M1/34 , G01N33/553
CPC分类号： G01N33/54393 , G01N33/54373
摘要： It is an object of the present invention to provide a technique of converting carboxylic acid into an active ester with no generation of air bubbles and a technique of stabilizing the obtained active ester. The present invention provides a biosensor wherein a carboxyl group existing on the surface of a substrate thereof is activated with any one compound selected from an uronium salt, a phosphonium salt or a triazine derivative which are defined in the present application, so as to form a carboxylic acid amide group.
摘要翻译：本发明的目的是提供一种不产生气泡而将羧酸转化成活性酯的技术，以及稳定所得活性酯的技术。本发明提供一种生物传感器，其中存在于其底物表面上的羧基由选自本申请中定义的铀盐，鏻盐或三嗪衍生物的任何一种化合物活化，从而形成羧酸酰胺基。

7. 发明授权

US5447820A Silver halide photographic light-sensitive material 失效
标题翻译：卤化银照相感光材料
公开(公告)号：US5447820A
公开(公告)日：1995-09-05
申请号：US262322
申请日：1994-06-17
申请人： Hiroshi Hayakawa , Toshihide Ezoe , Toshiaki Kubo
发明人： Hiroshi Hayakawa , Toshihide Ezoe , Toshiaki Kubo
IPC分类号： G03C1/06
CPC分类号： G03C1/061
摘要： Disclosed is a silver halide photographic light-sensitive material for plate making which has an excellent rapid processing performance and a high processing stability. The silver halide photographic light-sensitive material comprises a support having provided thereon at least one silver halide light-sensitive emulsion layer, wherein at least one of (i) the at least one emulsion layer and (ii) another hydrophilic colloid layers(s) contains a compound represented by Formula (I).
摘要翻译：公开了一种用于制版的卤化银照相感光材料，其具有优异的快速加工性能和高的加工稳定性。卤化银照相感光材料包括其上提供有至少一个卤化银感光乳剂层的载体，其中（i）至少一个乳剂层和（ii）另一亲水胶体层中的至少一个，含有式（I）表示的化合物。

8. 发明授权

US5744279A Silver halide photographic material 失效
标题翻译：卤化银照相材料
公开(公告)号：US5744279A
公开(公告)日：1998-04-28
申请号：US595478
申请日：1996-02-01
申请人： Toshihide Ezoe , Toshiaki Kubo , Hiroshi Takeuchi , Kazunobu Katoh , Shigeo Hirano , Kazuki Yamazaki , Takashi Hoshimiya , Minoru Sakai , Tetsuo Yoshida
发明人： Toshihide Ezoe , Toshiaki Kubo , Hiroshi Takeuchi , Kazunobu Katoh , Shigeo Hirano , Kazuki Yamazaki , Takashi Hoshimiya , Minoru Sakai , Tetsuo Yoshida
IPC分类号： G03C1/06 , G03C1/295 , G03C5/30
CPC分类号： G03C1/295 , G03C1/061 , G03C5/30
摘要： A silver halide photographic material is disclosed, comprising a support having provided thereon at least one silver halide emulsion layer, at least one layer of the emulsion layer and other hydrophilic colloid layers containing at least one hydrazine-type nucleating agent having, in the vicinity of the hydrazine group, an anionic group or a nonionic group which forms an intramolecular hydrogen bond with a hydrogen atom of the hydrazine, and also containing at least one of the onium salt compounds represented by formulae (a), (b) and (c), or at least one of the amine compounds represented by formulae (d), (e), (f), (g), (h), (i) and (j). Also disclosed is a method for processing, after exposure, the silver halide photographic material described above with a developer containing a reductone-type developing agent and having a pH of 12 or less.
摘要翻译：公开了一种卤化银照相材料，其包括在其上设置有至少一个卤化银乳剂层的支撑体，至少一层乳剂层和其它含有至少一种肼型成核剂的亲水胶体层，所述肼型成核剂在肼基，与肼的氢原子形成分子内氢键的阴离子基团或非离子基团，还含有由式（a），（b）和（c）表示的至少一种鎓盐化合物，，或者由式（d），（e），（f），（g），（h），（i）和（j）表示的至少一种胺化合物。还公开了一种在曝光后用含有还原酮型显影剂并且pH为12以下的显影剂处理上述卤化银照相材料的方法。

9. 发明授权

US07501289B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07501289B2
公开(公告)日：2009-03-10
申请号：US11020254
申请日：2004-12-27
申请人： Toshiaki Kubo , Toshihide Ezoe
发明人： Toshiaki Kubo , Toshihide Ezoe
IPC分类号： G01N33/543
CPC分类号： G01N21/553 , Y10S436/805
摘要： It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types of different surfaces in a region coated with a hydrophobic polymer.
摘要翻译：本发明的目的是提供一种不受基线波动的显着影响并抑制非特异性吸附的生物传感器。本发明提供了一种生物传感器，其包括涂覆有疏水性聚合物的金属表面或金属膜，并且在涂覆有疏水性聚合物的区域中具有两种或更多种不同的表面。

10. 发明申请

US20060257933A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20060257933A1
公开(公告)日：2006-11-16
申请号：US11378380
申请日：2006-03-20
申请人： Taisei Nishimi , Toshiaki Kubo , Toshihide Ezoe
发明人： Taisei Nishimi , Toshiaki Kubo , Toshihide Ezoe
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54373
摘要： It is an object of the present invention to provide a biosensor used to easily produce a hydrogel capable of immobilizing a physically active substance, using safe materials; and a method for producing the same. The present invention provides a biosensor which comprises a substrate having a metal layer on the surface thereof, wherein an acetoacetyl group-containing hydrophilic polymer is bound to said metal layer directly or via an intermediate layer.
摘要翻译：本发明的目的是提供一种用于容易地生产能够使用安全的材料固定活性物质的水凝胶的生物传感器。及其制造方法。本发明提供一种生物传感器，其包括其表面具有金属层的基板，其中含有乙酰乙酰基的亲水性聚合物直接或经由中间层与所述金属层结合。

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