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1. 发明授权

US08585972B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08585972B2
公开(公告)日：2013-11-19
申请号：US12778555
申请日：2010-05-12
申请人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo , Hidetoshi Tomita
发明人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo , Hidetoshi Tomita
IPC分类号： G01N33/53
CPC分类号： G01N33/54353 , G01N33/54373
摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.
摘要翻译：本发明的一个目的是提供一种生物传感器及其生产方法，通过该生物传感器及其生产方法，可以使用安全的原料方便地生产能够固定生理活性物质的水凝胶。本发明提供一种生物传感器，其包括在其表面具有金属层的基材，其中具有能够与生理活性物质的羟基或氨基反应的反应性官能团的亲水性聚合物直接结合到金属层或间接经由中间层。

2. 发明申请

US20060040410A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20060040410A1
公开(公告)日：2006-02-23
申请号：US11205183
申请日：2005-08-17
申请人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo
发明人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo
IPC分类号： C12M1/34 , G01N33/553
CPC分类号： G01N33/54393 , G01N33/54373
摘要： It is an object of the present invention to provide a technique of converting carboxylic acid into an active ester with no generation of air bubbles and a technique of stabilizing the obtained active ester. The present invention provides a biosensor wherein a carboxyl group existing on the surface of a substrate thereof is activated with any one compound selected from an uronium salt, a phosphonium salt or a triazine derivative which are defined in the present application, so as to form a carboxylic acid amide group.
摘要翻译：本发明的目的是提供一种不产生气泡而将羧酸转化成活性酯的技术，以及稳定所得活性酯的技术。本发明提供一种生物传感器，其中存在于其底物表面上的羧基由选自本申请中定义的铀盐，鏻盐或三嗪衍生物的任何一种化合物活化，从而形成羧酸酰胺基。

3. 发明申请

US20060257933A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20060257933A1
公开(公告)日：2006-11-16
申请号：US11378380
申请日：2006-03-20
申请人： Taisei Nishimi , Toshiaki Kubo , Toshihide Ezoe
发明人： Taisei Nishimi , Toshiaki Kubo , Toshihide Ezoe
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54373
摘要： It is an object of the present invention to provide a biosensor used to easily produce a hydrogel capable of immobilizing a physically active substance, using safe materials; and a method for producing the same. The present invention provides a biosensor which comprises a substrate having a metal layer on the surface thereof, wherein an acetoacetyl group-containing hydrophilic polymer is bound to said metal layer directly or via an intermediate layer.
摘要翻译：本发明的目的是提供一种用于容易地生产能够使用安全的材料固定活性物质的水凝胶的生物传感器。及其制造方法。本发明提供一种生物传感器，其包括其表面具有金属层的基板，其中含有乙酰乙酰基的亲水性聚合物直接或经由中间层与所述金属层结合。

4. 发明申请

US20060240478A1 Biosensor 审中-公开
公开(公告)号：US20060240478A1
公开(公告)日：2006-10-26
申请号：US11358107
申请日：2006-02-22
申请人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo , Hidetoshi Tomita
发明人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo , Hidetoshi Tomita
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54353 , G01N33/54373
摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.

5. 发明申请

US20080188010A1 BIOSENSOR SUBSTRATE 审中-公开
标题翻译：生物传感器基板
公开(公告)号：US20080188010A1
公开(公告)日：2008-08-07
申请号：US12022606
申请日：2008-01-30
申请人： Yukou Saitoh , Toshihide Ezoe , Taisei Nishimi
发明人： Yukou Saitoh , Toshihide Ezoe , Taisei Nishimi
IPC分类号： G01N33/551 , B01J19/00
CPC分类号： G01N33/54373
摘要： It is an object of the present invention to provide a biosensor substrate that prevents non-specific adsorption and is used for immobilizing a physiologically active substance. The present invention provides a biosensor substrate which comprises an inorganic oxide film and a hydrophilic polymer having a physiologically active substance-immobilizing group on the substrate, wherein the hydrophilic polymer is bound to the inorganic oxide film through a low molecular compound.
摘要翻译：本发明的目的是提供一种防止非特异性吸附并用于固定生理活性物质的生物传感器基板。本发明提供一种生物传感器基板，其包含无机氧化物膜和在基板上具有生理活性物质固定基团的亲水性聚合物，其中亲水性聚合物通过低分子化合物与无机氧化物膜结合。

6. 发明申请

US20060246512A1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US20060246512A1
公开(公告)日：2006-11-02
申请号：US11377554
申请日：2006-03-17
申请人： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
发明人： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： C12Q1/002 , G01N21/553 , G01N21/554 , G01N33/5438 , Y10S436/805
摘要： It is an object of the present invention to provide a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The present invention provides a biosensor which comprises a substrate having at least two types of surfaces on a single plane, wherein at least one of said surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to said surface that does not retain a physiologically active substance.
摘要翻译：本发明的目的是提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。本发明提供了一种生物传感器，其包括在单个平面上具有至少两种类型的表面的基底，其中所述表面中的至少一个不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物结合到不保留生理活性物质的所述表面。

7. 发明授权

US07964414B2 Biosensor with suppressed non-specific adsorption 有权
标题翻译：抑制非特异性吸附的生物传感器
公开(公告)号：US07964414B2
公开(公告)日：2011-06-21
申请号：US11377554
申请日：2006-03-17
申请人： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
发明人： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： C12Q1/002 , G01N21/553 , G01N21/554 , G01N33/5438 , Y10S436/805
摘要： The present invention provides a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The biosensor of the invention includes a substrate having at least two types of surfaces on a single plane, wherein at least one of the surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to the surface that does not retain a physiologically active substance.
摘要翻译：本发明提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。本发明的生物传感器包括在单个平面上具有至少两种类型的表面的基底，其中至少一个表面不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物被结合到没有保留生理活性物质的表面。

8. 发明授权

US07563623B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07563623B2
公开(公告)日：2009-07-21
申请号：US11708637
申请日：2007-02-21
申请人： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
发明人： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
IPC分类号： G01N33/551
CPC分类号： G01N33/54353 , Y10S435/808 , Y10S436/805
摘要： It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM compound having high water solubility and good performance in terms of supply. The present invention provides a biosensor comprising a substrate on which a hydrophilic polymer having a reactive group capable of binding to a physiologically active substance is immobilized via a compound represented by the following formula (1), said compound at a concentration of 1 mM being dissolved in water at 25° C.: X-L-Y (1) wherein X represents a group capable of binding to metal, L represents a linking group, and Y represents a functional group to which the hydrophilic polymer is bound.
摘要翻译：本发明的目的是提供一种生物传感器，其中可以固定大量的蛋白质，并且通过使用具有高水溶性的SAM化合物和在供给方面的良好性能，不太可能发生非特异性吸附。本发明提供了一种生物传感器，其包括通过下式（1）表示的化合物固定具有能够结合生理活性物质的反应性基团的亲水性聚合物的基材，所述化合物浓度为1mM时溶解在25°C的水中：<？in-line-formula description =“In-line Formulas”end =“lead”？> XLY（1）<？in-line-formula description =“In-line Formulas”end =“尾”→其中X表示能够与金属结合的基团，L表示连接基团，Y表示亲水性聚合物结合的官能团。

9. 发明申请

US20080187977A1 METHOD FOR PRODUCTION OF PHYSIOLOGICALLY ACTIVE SUBSTANCE-IMMOBILIZED SUBSTRATE 审中-公开
标题翻译：用于生产生理活性物质固定基质的方法
公开(公告)号：US20080187977A1
公开(公告)日：2008-08-07
申请号：US12022608
申请日：2008-01-30
申请人： Yukou Saitoh , Koji Kuruma , Taisei Nishimi , Hiroyuki Ohta , Toshihide Ezoe
发明人： Yukou Saitoh , Koji Kuruma , Taisei Nishimi , Hiroyuki Ohta , Toshihide Ezoe
IPC分类号： C12N11/08 , G01N1/31
CPC分类号： G01N33/553 , G01N33/54373
摘要： An object of the present invention is to provide a method for production of a physiologically active substance-immobilized substrate, which can prevent the inactivation of a physiologically active substance and/or can immobilize a physiologically active substance at a high concentration onto a substrate surface without use of electrostatic attraction. The present invention provides a method for production of a physiologically active substance-immobilized substrate, which comprises steps of: applying, to a metal substrate having a layer for immobilizing a physiologically active substance, a solution containing a physiologically active substance capable of forming a covalent bond with a molecule constituting the layer for immobilizing a physiologically active substance; and then drying the solution.
摘要翻译：本发明的目的是提供一种制备生理活性物质固定化基质的方法，其可以防止生理活性物质的失活和/或可以将高浓度的生理活性物质固定在基材表面上而无需使用静电吸引。本发明提供一种生产生物活性物质固定化基质的方法，其包括以下步骤：将具有固定生理活性物质的层的金属基材施加到含有可形成共价的生理活性物质的溶液中与构成用于固定生理活性物质的层的分子结合; 然后干燥溶液。

10. 发明申请

US20070258866A1 Method for producing a biosensor 有权
标题翻译：生物传感器的制造方法
公开(公告)号：US20070258866A1
公开(公告)日：2007-11-08
申请号：US11604260
申请日：2006-11-27
申请人： Taisei Nishimi , Toshihide Ezoe , Koji Kuruma , Masayuki Kawakami
发明人： Taisei Nishimi , Toshihide Ezoe , Koji Kuruma , Masayuki Kawakami
IPC分类号： B01J14/00
CPC分类号： G01N33/54393 , B01D15/361 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3221 , B01J20/3257 , B01J20/3272 , B01J20/3289 , B01J47/016 , B82Y15/00 , B82Y30/00 , G01N33/54373
摘要： An object of the present invention is to provide a biosensor comprising a hydrogel capable of immobilizing a physiologically active substance thereon, which can be produced conveniently by use of a safe material, and a method for producing the same. The present invention provides a method for producing a biosensor, which comprises bringing a polymer containing an activated carboxyl group into contact with a substrate surface coated with an organic layer having an amino group to thereby bind the polymer to the organic layer.
摘要翻译：本发明的目的是提供一种生物传感器及其制造方法，该生物传感器包括能够使其上生理活性物质固定的水凝胶，其可以通过使用安全材料方便地制备。本发明提供一种生物传感器的制造方法，其包括使含有活性羧基的聚合物与涂布有氨基的有机层的基材表面接触，从而将聚合物与有机层结合。

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