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1. 发明授权

US09557326B2 Sample analyzing device and sample analyzing method 有权
标题翻译：样品分析装置和样品分析方法
公开(公告)号：US09557326B2
公开(公告)日：2017-01-31
申请号：US13702175
申请日：2011-06-07
申请人： Toru Inaba , Shinya Matsuoka , Taku Sakazume , Yoshihiro Yamashita , Masafumi Shimada , Osamu Kogi , Yushi Harada
发明人： Toru Inaba , Shinya Matsuoka , Taku Sakazume , Yoshihiro Yamashita , Masafumi Shimada , Osamu Kogi , Yushi Harada
IPC分类号： G01N33/543 , G01N33/53 , B03C1/033 , B03C1/28 , B03C1/01 , G01N33/574 , G01N35/00
CPC分类号： G01N33/5306 , B03C1/01 , B03C1/033 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/22 , B03C2201/24 , B03C2201/26 , G01N33/54326 , G01N33/57438 , G01N33/57484 , G01N35/0098
摘要： This invention provides a sample analyzing device and sample analyzing method designed to suppress nonuniform capture of magnetic particles (10) and detect a desired substance with higher accuracy. The sample analyzing device includes a flow channel (15) that conducts thereinto a sample which contains the magnetic particles (10), and magnetic field generating means (12) that generates magnetic fields for capturing the magnetic particles (10) in a magnetic particles capturing region of the flow channel (15); wherein the flow channel has at least one of structural characteristics that a cross-sectional area of the flow channel, at a downstream end of the magnetic particles capturing region, is larger than a cross-sectional area of the flow channel, at an upstream end of the magnetic particles capturing region, and that the magnetic fields generated by the magnetic field generating means (12) have a greater magnitude at a downstream side of the magnetic particles capturing region than at an upstream side thereof.
摘要翻译：本发明提供了一种设计用于抑制磁性颗粒（10）的不均匀捕获并以更高精度检测所需物质的样品分析装置和样品分析方法。样品分析装置包括：导入包含磁性粒子（10）的样品的流路（15）;以及磁场产生装置（12），其产生用于在磁性粒子捕获中捕获磁性粒子（10）的磁场流通道（15）的区域; 其中所述流动通道具有以下结构特征中的至少一个：所述流动通道的在所述磁性粒子捕获区域的下游端处的横截面面积大于所述流动通道的横截面积，在上游端并且由磁场产生装置（12）产生的磁场在磁性颗粒捕获区域的下游侧具有比在其上游侧更大的量值。

2. 发明申请

US20130143234A1 SAMPLE ANALYZING DEVICE AND SAMPLE ANALYZING METHOD 有权
标题翻译：样品分析装置和样品分析方法
公开(公告)号：US20130143234A1
公开(公告)日：2013-06-06
申请号：US13702175
申请日：2011-06-07
申请人： Toru Inaba , Shinya Matsuoka , Taku Sakazume , Yoshihiro Yamashita , Masafumi Shimada , Osamu Kogi , Yushi Harada
发明人： Toru Inaba , Shinya Matsuoka , Taku Sakazume , Yoshihiro Yamashita , Masafumi Shimada , Osamu Kogi , Yushi Harada
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , B03C1/01 , B03C1/033 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/22 , B03C2201/24 , B03C2201/26 , G01N33/54326 , G01N33/57438 , G01N33/57484 , G01N35/0098
摘要： This invention provides a sample analyzing device and sample analyzing method designed to suppress nonuniform capture of magnetic particles (10) and detect a desired substance with higher accuracy. The sample analyzing device includes a flow channel (15) that conducts thereinto a sample which contains the magnetic particles (10), and magnetic field generating means (12) that generates magnetic fields for capturing the magnetic particles (10) in a magnetic particles capturing region of the flow channel (15); wherein the flow channel has at least one of structural characteristics that a cross-sectional area of the flow channel, at a downstream end of the magnetic particles capturing region, is larger than a cross-sectional area of the flow channel, at an upstream end of the magnetic particles capturing region, and that the magnetic fields generated by the magnetic field generating means (12) have a greater magnitude at a downstream side of the magnetic particles capturing region than at an upstream side thereof.
摘要翻译：本发明提供了一种设计用于抑制磁性颗粒（10）的不均匀捕获并以更高精度检测所需物质的样品分析装置和样品分析方法。样品分析装置包括：导入包含磁性粒子（10）的样品的流路（15）;以及磁场产生装置（12），其产生用于在磁性粒子捕获中捕获磁性粒子（10）的磁场流通道（15）的区域; 其中所述流动通道具有以下结构特征中的至少一个：所述流动通道的在所述磁性粒子捕获区域的下游端处的横截面面积大于所述流动通道的横截面积，在上游端并且由磁场产生装置（12）产生的磁场在磁性颗粒捕获区域的下游侧具有比在其上游侧更大的量值。

3. 发明申请

US20060233665A1 Test chip and test chip system 审中-公开
标题翻译：测试芯片和测试芯片系统
公开(公告)号：US20060233665A1
公开(公告)日：2006-10-19
申请号：US11327481
申请日：2006-01-09
申请人： Yasuhiko Sasaki , Osamu Kogi , Hiroshi Kishida , Toru Inaba , Masaomi Uchida
发明人： Yasuhiko Sasaki , Osamu Kogi , Hiroshi Kishida , Toru Inaba , Masaomi Uchida
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2200/143 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487
摘要： A test chip, which allows a number of solution delivery steps much faster and accurate is provided. The test chip incorporates a sample flow path for containing a sample solution, a reaction flow path for inducing a predetermined reaction with the sample solution, a waste drain path for receiving the used sample, and the washing solution flow paths for containing washing solutions. The reaction flow path contains a plurality of beads having probes of mutually different types fixed thereon. The sample flow path, washing solution flow paths, and sample waste drain path have their respective solution detector units. The solution detector unit detects whether the solution is fed to the path. The detector units adjoiningly provided in the adjacent paths are arranged collinearly.
摘要翻译：提供了一种测试芯片，其允许许多解决方案传送步骤更快速和准确。测试芯片包括用于容纳样品溶液的样品流动路径，用于诱导与样品溶液的预定反应的反应流动路径，用于接收使用的样品的废液排放路径和用于容纳洗涤溶液的洗涤液流路。反应流路包含多个具有固定在其上的相互不同类型的探针的珠。样品流动路径，洗涤液流动路径和样品废物排放路径具有它们各自的溶液检测器单元。溶液检测器单元检测溶液是否被供给到路径。邻接设置在相邻路径中的检测器单元共线布置。

4. 发明申请

US20070243522A1 INSPECTION CHIP FOR BIOLOGICAL MATERIAL 审中-公开
标题翻译：生物材料检验芯片
公开(公告)号：US20070243522A1
公开(公告)日：2007-10-18
申请号：US11679214
申请日：2007-02-27
申请人： Yasuhiko Sasaki , Toru Inaba , Hiroshi Kishida , Osamu Kogi , Masaomi Uchida
发明人： Yasuhiko Sasaki , Toru Inaba , Hiroshi Kishida , Osamu Kogi , Masaomi Uchida
IPC分类号： G01N33/00 , C12M1/00
CPC分类号： B01L3/50273 , B01L2200/027 , B01L2300/0636 , B01L2300/0825 , B01L2300/0877 , B01L2300/14 , B01L2400/0487
摘要： There is provided an inspection chip capable of performing a number of solution feeding processes promptly and accurately. The inspection chip has one continuous flow path comprising a reaction flow path for accommodating a plurality of beads with immobilized probes of types different each other, a first and second solution holding flow path for holding a plurality of solutions each separated by an air gap. The solution is moved from one solution holding flow path to other solution holding flow path via a reaction flow path by utilizing pressure difference.
摘要翻译：提供了能够及时且准确地进行多个溶液供给处理的检查芯片。检查芯片具有一个连续的流动路径，其包括用于容纳具有彼此不同类型的固定化探针的多个珠粒的反应流动路径，用于保持由气隙隔开的多个溶液的第一和第二溶液保持流动路径。通过利用压差将解决方案通过反应流动路径从一个溶液保持流动路径移动到另一溶液保持流动路径。

5. 发明申请

US20050079552A1 Beads with immobilized amphiphilic molecules, method of fabrication thereof, and method of arraying beads for capillary beads-array 审中-公开
标题翻译：具有固定的两亲分子的珠，其制造方法和用于毛细管珠阵列的珠的排列方法
公开(公告)号：US20050079552A1
公开(公告)日：2005-04-14
申请号：US10928345
申请日：2004-08-30
申请人： Osamu Kogi
发明人： Osamu Kogi
IPC分类号： G01N33/53 , B01J19/00 , B05D1/20 , G01N37/00 , G01N33/543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00646 , B01J2219/00657 , B01J2219/00677 , B01J2219/0072 , B05D1/202
摘要： A capillary beads-array attractive to users is provided by immobilizing amphiphilic molecules on the surface of beads in uniform orientation and arraying the beads in a capillary formed on a soft resin. A monomolecular layer of the amphiphilic molecules is formed on the bead surface by putting beads having hydrophilic portions on the surface in water phase, dropping amphiphilic molecules containing a hydrophilic portion and a hydrophobic portion onto the water phase, pouring an oil lighter than water to form a monomolecular film of the amphiphilic molecules at an oil/water interface, capturing a single bead with the tip of a bead picker, lifting up the tip of the bead picker to allow the bead to reach the oil/water interface, and allowing to form a covalent bond between a functional group in the hydrophilic portion on the bead surface and a functional group in the hydrophilic portion of the amphiphilic molecules.
摘要翻译：通过将两亲分子固定在均匀取向的珠粒表面上并将珠粒排列在形成在软树脂上的毛细管中来提供对使用者有吸引力的毛细管珠阵列。通过将具有亲水部分的珠粒在水相中放置在表面上，将含有亲水部分和疏水部分的两亲性分子滴入水相中，将两性分子的单分子层形成在珠粒表面上，浇注比水更轻的油形成在油/水界面处的两亲分子的单分子膜，用珠子拾取器的尖端捕获单个珠粒，提起珠子拾取器的末端以允许珠子到达油/水界面，并且允许形成珠粒表面上的亲水部分中的官能团与两亲性分子的亲水部分中的官能团之间的共价键。

6. 发明申请

US20070003945A1 Method for manufacturing a biosensor element and for testing the same 审中-公开
标题翻译：生物传感器元件的制造方法及其检测方法
公开(公告)号：US20070003945A1
公开(公告)日：2007-01-04
申请号：US11270612
申请日：2005-11-10
申请人： Miwako Nakahara , Takashi Inoue , Tomonori Saeki , Osamu Kogi , Noriko Ban
发明人： Miwako Nakahara , Takashi Inoue , Tomonori Saeki , Osamu Kogi , Noriko Ban
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34 , G06F19/00
CPC分类号： G01B11/2441 , G01B11/0675
摘要： When a biomolecule and a biochemical reactant are detected, a white interference method is used to conduct a noncontact and nondestructive detection, and further to conduct efficient and accurate detection. This method is applied to a biosensor element, whereby non-labeled and noncontact quality control can be achieved.
摘要翻译：当检测到生物分子和生物化学反应物时，使用白色干涉法进行非接触和非破坏性检测，并进一步进行有效和准确的检测。该方法应用于生物传感器元件，由此可以实现非标记和非接触质量控制。

7. 发明申请

US20060180734A1 Beads alignment structure, production method thereof, and bead alignment method for capillary beads array 审中-公开
公开(公告)号：US20060180734A1
公开(公告)日：2006-08-17
申请号：US11399409
申请日：2006-04-07
申请人： Osamu Kogi , Hiroshi Kishida
发明人： Osamu Kogi , Hiroshi Kishida
IPC分类号： B29C33/00
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B82Y30/00 , C40B40/06 , Y10T428/2982
摘要： A method for producing a capillary bead array comprises the steps of: dispensing beads into a liquid pool, outside a capillary, having a depth of almost the same length as the particle diameter of a bead; leveling the excessive beads by moving a leveling member which is in contact with and relatively capable of be moved to the liquid pool to remove excessive beads that the liquid pool cannot contain; aligning the beads in the liquid pool one- or two-dimensionally; bonding adjacent individual beads to each other; producing a structure having the plurality of beads bonded and aligned one- or two-dimensionally; removing the structure from the liquid pool; and disposing the structure in the capillary formed of soft resin, so that the beads comprising the plurality of beads retaining the one- or two-dimensional alignment can be introduced simultaneously into the capillary. This method reduces the time and cost necessary for bead array production and retains the bead alignment in the capillary, resulting in improved accuracy and reliability in experiments using the capillary array.

8. 发明申请

US20050250130A1 Method for detecting location of probe bead in capillary bead array 审中-公开
标题翻译：用于检测毛细管珠阵列中探针珠位置的方法
公开(公告)号：US20050250130A1
公开(公告)日：2005-11-10
申请号：US11041262
申请日：2005-01-25
申请人： Osamu Kogi
发明人： Osamu Kogi
IPC分类号： G01N21/64 , C12Q1/68 , G01N21/05 , G01N21/75 , G01N21/78 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/551 , G01N33/58
CPC分类号： G01N21/6456 , G01N21/6428 , G01N33/54313 , G01N33/582 , G01N2021/052 , G01N2021/6439 , G01N2021/751
摘要： It is an object to provide a method for accurately identifying the order of probe beads, namely, the types of probes bound to the probe beads, by readily and precisely detecting the locations of all the beads in a capillary bead array using a fluorescence reading apparatus. It is also an object to significantly improve the reliability of results of biochemical or immunological inspection in which a capillary bead array is used. Probe beads 102 are arranged in a capillary 101. A solution that includes fluorescence-labeled target biomolecules is introduced into the capillary 101. A fluorescence image that includes the fluorescence spot 108 of a probe bead 105 that captured the biomolecules is obtained by the fluorescence reading apparatus. A solution that includes fluorescent material for staining all the beads is introduced into the capillary 101. A fluorescence image that includes the fluorescence spot area 114 of all the probe beads 113 is obtained by the fluorescence reading apparatus. The location and the order of the probe bead 105 that has captured the biomolecules is accurately determined by overlaying the fluorescence image that includes the fluorescence spot 108 of the probe bead that has captured the biomolecules and the fluorescence image that includes the fluorescence spot area 114 of all the probe beads 113.
摘要翻译：本发明的目的是提供一种用于通过使用荧光读取装置容易且精确地检测毛细管珠阵列中的所有珠粒的位置来精确地识别探针珠的顺序，即与探针珠结合的探针的类型的方法。还有一个目的是显着提高使用毛细管珠阵列的生化或免疫检查结果的可靠性。探针珠102布置在毛细管101中。将包含荧光标记的靶生物分子的溶液引入毛细管101中。通过荧光读取装置获得包含捕捉生物分子的探针珠105的荧光斑108的荧光图像。将包括用于染色所有珠粒的荧光材料的溶液引入毛细管101中。通过荧光读取装置获得包含所有探针珠113的荧光斑区域114的荧光图像。捕获生物分子的探针珠105的位置和顺序通过覆盖包含捕获生物分子的探针珠的荧光斑108和包含荧光斑区域114的荧光图像的荧光图像来准确地确定所有探针珠113。

9. 发明申请

US20070264726A1 Microchannel array component, microchannel array for recovering biomolecules, and method for recovering biomolecules 审中-公开
标题翻译：微通道阵列组件，用于回收生物分子的微通道阵列，以及用于回收生物分子的方法
公开(公告)号：US20070264726A1
公开(公告)日：2007-11-15
申请号：US11819558
申请日：2007-06-28
申请人： Osamu Kogi
发明人： Osamu Kogi
IPC分类号： G01N33/00
CPC分类号： B01L3/502753 , B01J19/0046 , B01J2219/00454 , B01J2219/00511 , B01J2219/00657 , B01J2219/00659 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , C40B50/14 , G01N1/04 , G01N2001/2873 , G01N2035/00158
摘要： Various types of biomolecules as the objects of recovery included in a sample solution in minute amounts are separated in accordance with their affinity for various types of probe molecules and readily recovered. A sample solution 8 including biomolecules 7 as the objects of recovery are poured into a microchannel array 6. After the biomolecules 7 are bound to probe molecules which are fixed on the wall of a microchannel in the form of spots and which have a high affinity for the biomolecules 7, a second substrate having periodic protrusions is removed from the microchannel array 6. A portion of the microchannel array 6 that includes a spot in which the probe molecules that are bound to the biomolecules 7, which are the objects of recovery for the first substrate, are fixed is cut with a sharp cutting knife, for example, thereby obtaining a piece that retains on the surface the probe molecules that are bound to the biomolecules 7.
摘要翻译：根据其对各种类型的探针分子的亲和力，分离作为包含在微量样品溶液中的回收对象的各种类型的生物分子，并容易回收。将包括作为回收对象的生物分子7的样品溶液8倒入微通道阵列6中。在生物分子7与斑点形式的固定在微通道壁上的探针分子结合，并且对生物分子7具有高亲和力之后，从微通道阵列6去除具有周期性突起的第二基底。例如，使用尖锐的切割刀切割包括与作为第一基板的回收对象的生物分子7结合的探针分子固定的部位的微通道阵列6的一部分，在表面上保留与生物分子7结合的探针分子的片段。

10. 发明申请

US20060068504A1 Functional particle array and method of use thereof 审中-公开
标题翻译：功能性粒子阵列及其使用方法
公开(公告)号：US20060068504A1
公开(公告)日：2006-03-30
申请号：US11232900
申请日：2005-09-23
申请人： Osamu Kogi
发明人： Osamu Kogi
IPC分类号： G01N33/543
CPC分类号： G01N33/582 , B01J19/0046 , B01J20/28014 , B01J20/28016 , B01J20/28057 , B01J20/3242 , B01J2219/00466 , B01J2219/005 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00657 , C12Q1/00 , G01N33/54313 , G01N2030/524
摘要： In a capillary bead array, a method for retaining stably in a capillary an agent, enzyme, and fluorescent labeling agent necessary for a chemical reaction performed therein by functional particles and eluting the agent or the like in the capillary is provided. Further, a method for adsorbing and separating various target molecules contained in a sample on the functional particles based on physicochemical properties of the target molecules and eluting them is provided. By adding a solution having a temperature and composition according to the kind of a capsule shell material and an agent corresponding to core substance of a microcapsule into a capillary arrayed with the microcapsule together with probe beads, it is possible to induce the release of the agent and fill the capillary with a solution of the agent. Thus, a composition of the agent eluted in the capillary and timing of the elution can be controlled.
摘要翻译：在毛细管珠阵列中，提供了一种在毛细管中稳定地保持其中由功能性颗粒进行的化学反应所需的试剂，酶和荧光标记试剂并在毛细管中洗脱等的方法。此外，提供了基于目标分子的物理化学性质并对其进行洗脱来吸附和分离包含在功能颗粒上的样品中的各种靶分子的方法。通过将具有根据胶囊壳材料的种类的温度和组成的溶液和与微胶囊的核心物质相对应的试剂加入到与微胶囊一起排列的毛细管和探针珠的溶液中，可以诱导试剂的释放并用该试剂的溶液填充毛细管。因此，可以控制在毛细管中洗脱的试剂的组成和洗脱的时间。

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