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1. 发明申请

US20070004027A1 Method for manufacturing a biosensor element 审中-公开
标题翻译：生物传感器元件的制造方法
公开(公告)号：US20070004027A1
公开(公告)日：2007-01-04
申请号：US11270456
申请日：2005-11-10
申请人： Miwako Nakahara , Takashi Inoue , Tomonori Saeki , Osamu Kogi , Noriko Ban
发明人： Miwako Nakahara , Takashi Inoue , Tomonori Saeki , Osamu Kogi , Noriko Ban
IPC分类号： C12M1/34
CPC分类号： G01N33/54393 , G01N33/54353
摘要： When probe biomolecules are immobilized on a substrate surface, a surfactant (phase transfer catalyst) is added for reaction, whereby immobilization efficiency of the probe biomolecules and coating uniformity thereof are improved. Consequently, it is possible to dramatically improve quantitativity and reproducibility of the biosensor element.
摘要翻译：当将探针生物分子固定在基材表面上时，加入表面活性剂（相转移催化剂）进行反应，从而提高了探针生物分子的固定效率和涂层均匀性。因此，可以显着提高生物传感器元件的定量性和再现性。

2. 发明申请

US20060270054A1 Method for inspecting the quality of probe beads 审中-公开
标题翻译：检测探针珠质量的方法
公开(公告)号：US20060270054A1
公开(公告)日：2006-11-30
申请号：US11435940
申请日：2006-05-18
申请人： Osamu Kogi , Noriko Ban
发明人： Osamu Kogi , Noriko Ban
IPC分类号： G01N31/22
CPC分类号： G01N15/1459 , G01N21/6428 , G01N2015/1486 , G01N2021/6417 , G01N2021/6439
摘要： In capillary bead arrays, the quality of each of a number of probe beads made by the batch process is non-destructively inspected. Only good probe beads, which are beads having a predetermined quantity of probes of a desired type immobilized on the surface thereof, are selected to be arranged in capillaries, whereby homogeneous and high-quality capillary bead arrays alone can be provided to users. Thus, the reproducibility of biochemical experiments involving capillary bead arrays is significantly increased. Probe beads 401 made by the batch process are one- or two-dimensionally arranged on the bottom surface of a container 402. The probe beads 401 are irradiated with excitation light 403, and the quality of the probe beads 401 arranged on the bottom surface of the container 402 is inspected by spectral analysis. Based on the quality inspection, probe beads judged as defective items are removed from all the probe beads 401, thereby leaving only probe beads judged as good items. The remaining good probe beads alone in the container 402 are provided in capillary bead arrays.
摘要翻译：在毛细管珠阵列中，通过批处理制造的多个探针珠中的每一个的质量是非破坏性检查的。仅选择具有预定量的固定在其表面上的期望类型的探针的珠粒的良好的探针珠被布置成毛细管，由此可以向用户提供单独的高质量毛细管珠阵列。因此，涉及毛细管珠阵列的生物化学实验的再现性显着增加。通过分批处理制造的探针珠401在容器402的底面上一维或二维地排列。探针珠401用激发光403照射，并且探针珠401的质量布置在通过光谱分析检查容器402。基于质量检查，从所有探针珠401中去除被判定为缺陷物品的探针珠，从而仅留下被判断为好物品的探针珠。在容器402中单独存在的剩余的良好探针珠设置在毛细管珠阵列中。

3. 发明申请

US20070003945A1 Method for manufacturing a biosensor element and for testing the same 审中-公开
标题翻译：生物传感器元件的制造方法及其检测方法
公开(公告)号：US20070003945A1
公开(公告)日：2007-01-04
申请号：US11270612
申请日：2005-11-10
申请人： Miwako Nakahara , Takashi Inoue , Tomonori Saeki , Osamu Kogi , Noriko Ban
发明人： Miwako Nakahara , Takashi Inoue , Tomonori Saeki , Osamu Kogi , Noriko Ban
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34 , G06F19/00
CPC分类号： G01B11/2441 , G01B11/0675
摘要： When a biomolecule and a biochemical reactant are detected, a white interference method is used to conduct a noncontact and nondestructive detection, and further to conduct efficient and accurate detection. This method is applied to a biosensor element, whereby non-labeled and noncontact quality control can be achieved.
摘要翻译：当检测到生物分子和生物化学反应物时，使用白色干涉法进行非接触和非破坏性检测，并进一步进行有效和准确的检测。该方法应用于生物传感器元件，由此可以实现非标记和非接触质量控制。

4. 发明申请

US20060024208A1 Apparatus and method for arraying beads 失效
公开(公告)号：US20060024208A1
公开(公告)日：2006-02-02
申请号：US11189931
申请日：2005-07-27
申请人： Noriko Ban , Hiroshi Kishida
发明人： Noriko Ban , Hiroshi Kishida
IPC分类号： B01L3/02
CPC分类号： B01L3/0289 , B01J19/0046 , B01J2219/00463 , B01J2219/005 , B01L2200/0668 , Y10T436/255
摘要： An apparatus and a method for arraying beads that allow a bead array having been difficult in mass production to be manufactured easily and accurately are provided. Beads are once arrayed in a separate container using an inclined bead array apparatus while controlling the number of beads to be inserted simply by the use of a bead control rod. When the whole arraying is completed, the arrayed beads are transferred onto a plate for use in an actual reaction.

5. 发明授权

US07550115B2 Apparatus and method for arraying beads 失效
标题翻译：用于排列珠的装置和方法
公开(公告)号：US07550115B2
公开(公告)日：2009-06-23
申请号：US11189931
申请日：2005-07-27
申请人： Noriko Ban , Hiroshi Kishida
发明人： Noriko Ban , Hiroshi Kishida
IPC分类号： B01L3/02 , G01N1/18 , G01N21/00
CPC分类号： B01L3/0289 , B01J19/0046 , B01J2219/00463 , B01J2219/005 , B01L2200/0668 , Y10T436/255
摘要： An apparatus and a method for arraying beads that allow a bead array having been difficult in mass production to be manufactured easily and accurately are provided. Beads are once arrayed in a separate container using an inclined bead array apparatus while controlling the number of beads to be inserted simply by the use of a bead control rod. When the whole arraying is completed, the arrayed beads are transferred onto a plate for use in an actual reaction.
摘要翻译：提供了容易且准确地制造允许大规模生产难以制造的珠阵列的珠的排列装置和方法。使用倾斜珠阵列装置将珠粒一次排列在单独的容器中，同时通过使用珠控制棒来控制要插入的珠的数量。当整个排列完成时，将排列的珠粒转移到板上用于实际反应。

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