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1. 发明授权

US6103199A Capillary electroflow apparatus and method 失效
标题翻译：毛细管电流装置及方法
公开(公告)号：US6103199A
公开(公告)日：2000-08-15
申请号：US153566
申请日：1998-09-15
申请人： Torleif Ove Bjornson , Randy M. McCormick , David S. Soane
发明人： Torleif Ove Bjornson , Randy M. McCormick , David S. Soane
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , C40B60/14 , G01N27/447 , G01N30/28 , G01N30/46 , G01N30/60 , G01N35/00
CPC分类号： G01N27/44791 , B01J19/0046 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/5027 , B01L3/50273 , G01N27/44743 , B01J2219/00317 , B01J2219/00369 , B01J2219/00783 , B01J2219/00889 , B01J2219/00891 , B01L2200/10 , B01L2300/0829 , B01L2300/0838 , B01L2300/0883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , B01L2400/0442 , B01L2400/0481 , C40B60/14 , G01N2030/285 , G01N2035/00237 , G01N30/466 , G01N30/6095
摘要： The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates. The first plate comprises an array of sample receiving elements for receiving a plurality of samples from an array of sample containers and dispensing the samples. The second plate comprises a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. Also disclosed is a method for processing an array of samples. At least a portion of each sample in an array of sample wells is simultaneously transferred to a corresponding array of microfluidic networks of cavity structures and channels by means of a corresponding array of sample receiving elements that is in integral fluid communication with the array of microfluidic networks. The samples are then processed. Also disclosed is a device for conducting a microfluidic process wherein the device comprising a planar substrate having a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. A plurality of such devices may be present on a continuous sheet. The invention further includes kits for carrying out microfluidic processes comprising an apparatus as described above.
摘要翻译：本发明涉及用于进行微流程的装置。该装置包括集成的第一和第二板。第一板包括用于从样品容器阵列接收多个样品并分配样品的样品接收元件阵列。第二板包括用于进行微流程的空腔结构和通道的微流体网络的平面阵列。还公开了一种用于处理样本阵列的方法。样品孔阵列中的每个样品的至少一部分通过与微流控网络阵列整体流体连通的相应的样品接收元件阵列同时转移到腔结构和通道的相应阵列的微流体网络。然后处理样品。还公开了一种用于进行微流程过程的装置，其中该装置包括具有用于进行微流程的空腔结构和通道的微流体网络的平面阵列的平面基板。多个这样的装置可以存在于连续片材上。本发明还包括用于进行微流程工艺的试剂盒，其包括如上所述的装置。

2. 发明授权

US06399952B1 Multiplexed fluorescent detection in microfluidic devices 有权
标题翻译：微流体装置中多重荧光检测
公开(公告)号：US06399952B1
公开(公告)日：2002-06-04
申请号：US09569963
申请日：2000-05-12
申请人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01L3/5027 , B01L2200/14 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6478 , G01N2201/101
摘要： An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.
摘要翻译：提供了一种光学检测和取向装置，包括具有激发光源的壳体，用于将激发光反射到非球面透镜并透射由所述激发光激发的荧光团发射的光的光学元件，用于将发射的光聚焦到聚焦透镜用作共焦孔的光纤的进入以及用于相对于微流体装置中的通道在小的区域上精确地移动所述壳体的装置。光学检测和取向装置用于识别通道的中心并且在涉及荧光信号的操作期间检测通道中的荧光团。

3. 发明授权

US07479391B2 Pipetting apparatus with integrated liquid level and/or gas bubble detection 有权
标题翻译：具有集成液位和/或气泡检测的移液装置
公开(公告)号：US07479391B2
公开(公告)日：2009-01-20
申请号：US11009247
申请日：2004-12-10
申请人： Torleif Ove Bjornson , Robert Liebhard , Adi Zuppiger , Dirk Heerklotz
发明人： Torleif Ove Bjornson , Robert Liebhard , Adi Zuppiger , Dirk Heerklotz
IPC分类号： B01L3/02
CPC分类号： G01N35/1009 , G01F23/185 , Y10T436/119163 , Y10T436/2575
摘要： A pipetting apparatus (1) comprises a fluidic space (7), to which a pressure transducer (11) with a pressure sensor (12) is attached with a gas filled space (15). The fluidic space (7) is defined by a pipette tip (2), a first tubing (5) that connects the pipette tip (2) to a pump (4), and an active part (6) of the pump (4). The pipetting apparatus (1) according to the present invention is characterized in that the pipetting apparatus (1) further comprises an impulse generating means (16, 18, 19) that is in operative contact with a column (10) of system liquid (8) inside the fluidic space (7). The impulse generating means (16, 18, 19) is designed to induce a vertical movement in this system liquid column (10), which results in a pressure variation in the gas filled space (15) that is pneumatically connected with the fluidic space (7). This pressure variation—as recorded with the pressure transducer (11) and as processed by a first data processing unit (13) during utilization of this pipetting apparatus—is taken as an indicator for the detection of penetration or of quitting of a surface (17) of a liquid, with an orifice (3) of the pipette tip (2), of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid (8) contained in the fluidic space (7) of this pipetting apparatus.
摘要翻译：移液装置（1）包括流体空间（7），具有压力传感器（12）的压力传感器（11）与气体填充空间（15）连接在该流体空间上。流体空间（7）由移液管吸头（2），将移液管吸头（2）连接到泵（4）的第一管（5）和泵（4）的有源部分（6）。根据本发明的移液装置（1）的特征在于，移液装置（1）还包括与系统液体（8）的柱（10）有效接触的脉冲发生装置（16,18,19））在流体空间（7）内。脉冲发生装置（16,18,19）被设计成在该系统液柱（10）中引起垂直运动，这导致与流体空间气动连接的气体填充空间（15）中的压力变化（ 7）。该压力变化（如压力传感器11记录的）并且在利用该移液装置期间由第一数据处理单元（13）处理）被作为用于检测表面的穿透或退出的指示器（17 ），其具有移液器吸头（2）的孔口（3），其中液体的量将被吸入和分配。该压力变化也被用作检测包含在该移液装置的流体空间（7）中的系统液体（8）中是否存在气泡的指示器。

4. 发明授权

US06908594B1 Efficient microfluidic sealing 有权
标题翻译：高效的微流体密封
公开(公告)号：US06908594B1
公开(公告)日：2005-06-21
申请号：US09691957
申请日：2000-10-18
申请人： Samuel Benjamin Schaevitz , Travis Boone , Torleif Ove Bjornson
发明人： Samuel Benjamin Schaevitz , Travis Boone , Torleif Ove Bjornson
IPC分类号： B01L3/00 , B01L3/02 , B01L9/00 , B01L99/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/06 , B01L11/00
CPC分类号： B01L3/5025 , B01J2219/00315 , B01J2219/00317 , B01J2219/00331 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00804 , B01J2219/0086 , B01J2219/00869 , B01L3/502715 , B01L3/50853 , B01L2200/0689 , B01L2300/041 , B01L2300/0829 , B01L2400/0415 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/117497 , Y10T436/118339
摘要： Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The collars are protrusions extending from the surface of the devices and the internal walls of the collars generally aligned with the internal walls of the microstructure. Conformable and/or adhesive lids are employed for sealing the microstructures.
摘要翻译：通过向微观结构（例如储存器）提供围绕开口的套环来提供具有多个单元的微流体装置中用于微结构的改进的密封。套环是从装置的表面延伸的凸起，并且套环的内壁与微观结构的内壁大致对准。采用适形和/或粘合剂盖来密封微结构。

5. 发明授权

US06515753B2 Optical alignment in capillary detection using capillary wall scatter 有权
公开(公告)号：US06515753B2
公开(公告)日：2003-02-04
申请号：US09859749
申请日：2001-05-17
申请人： Kevin Maher , Torleif Ove Bjornson
发明人： Kevin Maher , Torleif Ove Bjornson
IPC分类号： G01B1114
CPC分类号： G01N27/44721 , G01N21/47 , G01N27/44791
摘要： The present invention provides for methods and apparatus for locating a capillary channel that is disposed within a lab chip. The method provides for scanning the channel with a light source, monitoring the resulting light at the edges of the lab chip, and interpreting this information whereby the light detected at the edges of the lab chip can be used as a means for characterizing the location of the side walls of the channel within the lab chip. The apparatus provides for a carriage system to which a light source and the lab chip are attached. It also provides for one or more scatter detectors directed towards the edges of the chip and connected to a computer processor for purposes of analysis.

6. 发明申请

US20130134039A1 DIGITAL MICROFLUIDICS SYSTEM WITH DISPOSABLE CARTRIDGES 有权
标题翻译：具有可拆卸盒的数字微流控系统
公开(公告)号：US20130134039A1
公开(公告)日：2013-05-30
申请号：US13304481
申请日：2011-11-25
申请人： Torleif Ove Bjornson , Marc Nathan Feiglin , Michael Benjamin Franklin , Anne R. Kopf-Sill , Travis Lee , Kailiang Wang
发明人： Torleif Ove Bjornson , Marc Nathan Feiglin , Michael Benjamin Franklin , Anne R. Kopf-Sill , Travis Lee , Kailiang Wang
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0673 , B01L2300/043 , B01L2300/044 , B01L2300/089 , B01L2300/123 , B01L2400/0427
摘要： A digital microfluidics system manipulates samples in liquid droplets within disposable cartridges and has disposable cartridges each with a bottom layer, a top layer and a gap therebetween. A base unit with cartridge accommodation sites and at least one electrode array with electrodes works with a cover plate at the sites and a control unit for controlling selection of the electrodes and for providing them with voltage pulses for manipulating liquid droplets within the cartridges by electrowetting. The cover plate has an electrically conductive material that extends parallel to the array. A selection of disposable cartridges and a method for manipulating samples in liquid droplets that adhere to a hydrophobic surface can be used with the system.
摘要翻译：数字微流体系统在一次性盒中操作液滴中的样品，并且具有每个底部层，顶层和间隙的一次性盒。具有盒容纳位置的基座单元和具有电极的至少一个电极阵列与位置处的盖板一起工作，以及控制单元，用于控制电极的选择并为其提供用于通过电润湿来操纵墨盒内的液滴的电压脉冲。盖板具有平行于阵列延伸的导电材料。可以使用一次性盒的选择和用于操纵粘附到疏水表面的液滴中的样品的方法。

7. 发明授权

US06627406B1 Sample evaporative control 有权
公开(公告)号：US06627406B1
公开(公告)日：2003-09-30
申请号：US09568786
申请日：2000-05-10
申请人： Sharat Singh , Vivian Xiao , Ian Gibbons , Travis Boone , Torleif Ove Bjornson , Herbert H. Hooper , Edwin F. Ullman
发明人： Sharat Singh , Vivian Xiao , Ian Gibbons , Travis Boone , Torleif Ove Bjornson , Herbert H. Hooper , Edwin F. Ullman
IPC分类号： G01N3353
CPC分类号： B01L3/5027 , B01F13/0059 , B01J19/16 , B01J2219/00317 , B01L3/5025 , B01L3/502723 , B01L2200/0642 , B01L2200/142 , B01L2300/0861 , B01L2400/0406 , B01L2400/0415 , B01L2400/0688 , C40B60/14 , G01N1/34 , G01N2035/00237 , G01N2035/00287
摘要： Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the atmosphere of a small volume in a zone, where a sample is placed in the zone where evaporation can occur. The zone is maintained in contact with a liquid medium that serves to replenish the liquid in the zone and maintain the composition of the mixture in the zone substantially constant. The diffusion of components in the zone is restricted during the course of the determination by the liquid flux into the zone.

8. 发明授权

US06284113B1 Apparatus and method for transferring liquids 有权
标题翻译：液体转移装置及方法
公开(公告)号：US06284113B1
公开(公告)日：2001-09-04
申请号：US09153814
申请日：1998-09-15
申请人： Torleif Ove Bjornson , Timothy F. Smith
发明人： Torleif Ove Bjornson , Timothy F. Smith
IPC分类号： G01N2726
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00358 , C40B60/14 , G01N35/1065 , G01N35/1074 , G01N2035/1037
摘要： The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.
摘要翻译：本发明涉及用于转移液体的装置，装置和方法。本发明的一个方面是包括具有多个转移元件的板的装置。每个传送元件包括板中的孔，其中孔能够被电激活。板具有用于将板连接到多孔板以形成除了转移元件的孔之外的密封系统的更多附接元件之一。通常，该装置适于密封附着到多孔板。在根据本发明的方法中，一定量的液体被设置在板的具有多个孔的板的第二面上。孔能够被电活动。除了板中的孔之外，液体存在于封闭的井中。为了同时从孔中排出液体，孔被电激活。还公开了包括根据本发明的装置的试剂盒。

9. 发明授权

US08821705B2 Digital microfluidics system with disposable cartridges 有权
标题翻译：带一次性墨盒的数字微流体系统
公开(公告)号：US08821705B2
公开(公告)日：2014-09-02
申请号：US13304481
申请日：2011-11-25
申请人： Torleif Ove Bjornson , Marc Nathan Feiglin , Michael Benjamin Franklin , Anne R. Kopf-Sill , Travis Lee , Kailiang Wang
发明人： Torleif Ove Bjornson , Marc Nathan Feiglin , Michael Benjamin Franklin , Anne R. Kopf-Sill , Travis Lee , Kailiang Wang
IPC分类号： G01N27/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0673 , B01L2300/043 , B01L2300/044 , B01L2300/089 , B01L2300/123 , B01L2400/0427
摘要： A digital microfluidics system manipulates samples in liquid droplets within disposable cartridges and has disposable cartridges each with a bottom layer, a top layer and a gap therebetween. A base unit with cartridge accommodation sites and at least one electrode array with electrodes works with a cover plate at the sites and a control unit for controlling selection of the electrodes and for providing them with voltage pulses for manipulating liquid droplets within the cartridges by electrowetting. The cover plate has an electrically conductive material that extends parallel to the array. A selection of disposable cartridges and a method for manipulating samples in liquid droplets that adhere to a hydrophobic surface can be used with the system.
摘要翻译：数字微流体系统在一次性盒中操作液滴中的样品，并且具有每个底部层，顶层和间隙的一次性盒。具有盒容纳位置的基座单元和具有电极的至少一个电极阵列与位置处的盖板一起工作，以及控制单元，用于控制电极的选择并为其提供用于通过电润湿来操纵墨盒内的液滴的电压脉冲。盖板具有平行于阵列延伸的导电材料。可以使用一次性盒的选择和用于操纵粘附到疏水表面的液滴中的样品的方法。

10. 发明授权

US08287806B2 Pipetting apparatus with integrated liquid level and/or gas bubble detection 有权
标题翻译：具有集成液位和/或气泡检测的移液装置
公开(公告)号：US08287806B2
公开(公告)日：2012-10-16
申请号：US12354322
申请日：2009-01-15
申请人： Torleif Ove Bjornson , Robert Liebhard , Adi Zuppiger , Dirk Heerklotz
发明人： Torleif Ove Bjornson , Robert Liebhard , Adi Zuppiger , Dirk Heerklotz
IPC分类号： B01L3/02
CPC分类号： G01N35/1009 , G01F23/185 , Y10T436/119163 , Y10T436/2575
摘要： A pipetting apparatus has a fluidic space to which a pressure transducer with a pressure sensor is attached with a gas filled space. The fluidic space is defined by a pipette tip, a first tubing that connects the pipette tip to a pump, and an active part of the pump. The pipetting apparatus further has an impulse generating mechanism that is in operative contact with a column of system liquid inside the fluidic space. The impulse generating mechanism induces a vertical movement in the system liquid column, which results in a pressure variation in the gas filled space that is pneumatically connected with the fluidic space. This pressure variation, as recorded with the pressure transducer and as processed by a first data processing unit during utilization of this pipetting apparatus, is taken as an indicator for the detection of penetration or of quitting of a surface of a liquid, with an orifice of the pipette tip, of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid contained in the fluidic space of this pipetting apparatus.
摘要翻译：移液装置具有流体空间，具有压力传感器的压力传感器与气体填充空间相连。流体空间由移液管尖端，将移液管尖端连接到泵的第一管和泵的有效部分限定。移液装置还具有脉冲发生机构，其与流体空间内的系统液体柱可操作地接触。脉冲产生机构在系统液柱中引起垂直运动，这导致与流体空间气动连接的气体填充空间中的压力变化。该压力变化记录在压力传感器中并且在利用该移液装置期间由第一数据处理单元处理，被作为用于检测液体的表面的渗透或退出的指示器，其中孔口移液管尖端，其中液体的量将被吸入和分配。该压力变化也被用作检测包含在该移液装置的流体空间中的系统液体中是否存在气泡的指标。

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