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1. 发明申请

US20080058310A1 High-density lipoprotein-cholesterol level elevating agent 审中-公开
标题翻译：高密度脂蛋白胆固醇水平升高剂
公开(公告)号：US20080058310A1
公开(公告)日：2008-03-06
申请号：US11810887
申请日：2007-06-07
申请人： Tomoyuki Nishimoto , Ryuichi Tozawa , Masakuni Kori , Yuichiro Amano
发明人： Tomoyuki Nishimoto , Ryuichi Tozawa , Masakuni Kori , Yuichiro Amano
IPC分类号： A61K31/553 , A61P3/00
CPC分类号： C07D267/14 , A61K31/553
摘要： A novel high-density lipoprotein(HDL)-cholesterol level elevating agent containing a compound which has a squalene synthase inhibitory activity.
摘要翻译：一种含有具有角鲨烯合酶抑制活性的化合物的新型高密度脂蛋白（HDL） - 胆固醇水平升高剂。

2. 发明申请

US20090209510A1 Novel Method of Treating Hyperlipidemia 审中-公开
标题翻译：治疗高脂血症的新方法
公开(公告)号：US20090209510A1
公开(公告)日：2009-08-20
申请号：US11921422
申请日：2006-05-31
申请人： Tomoyuki Nishimoto , Ryuichi Tozawa , Takeo Wada , Eiichiro Ishikawa , Toshiya Nishi , Hiroko Yamakawa
发明人： Tomoyuki Nishimoto , Ryuichi Tozawa , Takeo Wada , Eiichiro Ishikawa , Toshiya Nishi , Hiroko Yamakawa
IPC分类号： A61K31/397 , A61K31/553 , C07D413/02 , A61P3/06
CPC分类号： A61K45/06 , A61K31/00 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/553 , A61K2300/00
摘要： A pharmaceutical composition useful for a prevention and/or treatment of hyperlipidemia, which comprises combining an effective amount of squalene synthase inhibitor and HMG-CoA reductase inhibitor is provided.
摘要翻译：提供了可用于预防和/或治疗高脂血症的药物组合物，其包括组合有效量的角鲨烯合酶抑制剂和HMG-CoA还原酶抑制剂。

3. 发明申请

US20090118255A1 Crp Lowering Agent 审中-公开
标题翻译： Crp降剂
公开(公告)号：US20090118255A1
公开(公告)日：2009-05-07
申请号：US11659941
申请日：2005-08-08
申请人： Yoshimi Imura , Ryuichi Tozawa , Tomoyuki Nishimoto
发明人： Yoshimi Imura , Ryuichi Tozawa , Tomoyuki Nishimoto
IPC分类号： A61K31/553 , C07D413/02
CPC分类号： A61K31/553 , A61K31/00
摘要： The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
摘要翻译：本发明提供一种新的药物，其可用作涉及CRP水平升高，特别是炎性疾病和癌症的各种疾病的预防和/或治疗剂，其包含对角鲨烯合酶或其盐具有抑制活性的化合物或其前药。

4. 发明申请

US20080113965A1 Skeletal muscle protecting agent 审中-公开
标题翻译：骨骼肌保护剂
公开(公告)号：US20080113965A1
公开(公告)日：2008-05-15
申请号：US12006506
申请日：2008-01-03
申请人： Ryuichi Tozawa , Tomoyuki Nishimoto
发明人： Ryuichi Tozawa , Tomoyuki Nishimoto
IPC分类号： A61K31/553
CPC分类号： C07D267/14
摘要： The present invention provides a novel drug which is useful as a skeletal muscle protecting agent comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
摘要翻译：本发明提供了可用作骨骼肌保护剂的新型药物，其包含对角鲨烯合酶或其盐具有抑制活性的化合物或其前药。

5. 发明申请

US20060052362A1 Skeletal muscle protecting agent 审中-公开
标题翻译：骨骼肌保护剂
公开(公告)号：US20060052362A1
公开(公告)日：2006-03-09
申请号：US10542322
申请日：2004-01-15
申请人： Ryuichi Tozawa , Tomoyuki Nishimoto
发明人： Ryuichi Tozawa , Tomoyuki Nishimoto
IPC分类号： A61K31/553
CPC分类号： C07D267/14
摘要： The present invention provides a novel drug which is useful as a skeletal muscle protecting agent comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
摘要翻译：本发明提供了可用作骨骼肌保护剂的新型药物，其包含对角鲨烯合酶或其盐具有抑制活性的化合物或其前药。

6. 发明授权

US09175282B2 Cellobiose 2-epimerase, its preparation and uses 有权
标题翻译：纤维二糖2-差向异构酶，其制备和用途
公开(公告)号：US09175282B2
公开(公告)日：2015-11-03
申请号：US13590460
申请日：2012-08-21
申请人： Hikaru Watanabe , Masahiro Yagi , Tomoyuki Nishimoto , Hiroto Chaen , Shigeharu Fukuda
发明人： Hikaru Watanabe , Masahiro Yagi , Tomoyuki Nishimoto , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/02 , C12P19/12 , C12N9/90
CPC分类号： C12N9/90 , C12P19/02 , C12P19/12
摘要： The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme.
摘要翻译：本发明的目的是提供一种耐热纤维二糖2-差向异构酶，其制备和用途。本发明通过提供热稳定性纤维二糖2-差向异构酶，编码该酶的DNA，重组DNA和包含该DNA的转化体，该酶的制备方法和使用该酶生产异构化糖的方法来实现上述目的。

7. 发明授权

US08524889B2 Highly-branched starch, its production and uses 有权
标题翻译：高分支淀粉，其生产和用途
公开(公告)号：US08524889B2
公开(公告)日：2013-09-03
申请号：US13443296
申请日：2012-04-10
申请人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C07H1/06 , C08B31/00
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着抗退行性的具有6-α-麦芽糖基 - 和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种生产支化淀粉而不降低分子量的方法的材料淀粉及其用途。

8. 发明申请

US20070154996A1 Method for transferring a glucosyl residue 审中-公开
标题翻译：转移葡糖基残基的方法
公开(公告)号：US20070154996A1
公开(公告)日：2007-07-05
申请号：US10587711
申请日：2005-01-27
申请人： Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/04
CPC分类号： C12P19/18 , C12P19/44
摘要： An object of the present invention is to provide novel methods for forming glucosyl-transferred polyalcohols, glucosyl-transferred glucuronic acid, and glucosyl-transferred derivatives of glucose whose C-6 hydroxyl group bound to a saccharide by using an enzymatic reaction. The present invention solves the above object by providing a method for transferring a glucosyl residue to polyalcohols, glucuronic acid and/or derivatives of glucose whose C-6 hydroxyl group bound to a saccharide, comprising a step of: allowing a trehalose phosphorylase to act on a saccharide containing glucose as a component sugar and one or more polyalcohols selected from the group consisting of inositol, ribitol, erythritol, and glycerol; glucuronic acid and/or a salt thereof; and/or one or more derivatives of glucose whose C-6 hydroxyl group bound to a saccharide selected from the group consisting of isomaltose, gentiobiose, melibiose, isomaltotriose, and isopanose.
摘要翻译：本发明的目的是提供通过酶促反应形成C-6羟基与糖结合的葡萄糖转移的多元醇，葡糖基转移的葡萄糖醛酸和葡萄糖转移的葡萄糖转移衍生物的新方法。本发明通过提供一种将葡糖基残基转移到多糖，葡糖醛酸和/或其C-6羟基与糖结合的葡萄糖的衍生物的方法，包括以下步骤：使海藻糖磷酸化酶作用于含有葡萄糖作为组分糖和一种或多种选自肌醇，核糖醇，赤藓糖醇和甘油的多元醇的糖; 葡萄糖醛酸和/或其盐; 和/或一种或多种C-6羟基结合于选自异麦芽糖，龙胆糖，蜜二糖，异麦芽三糖和异丙糖的糖的葡萄糖衍生物。

9. 发明授权

US07192746B2 α-Isomaltosyltransferase, process for producing the same and use thereof 有权
标题翻译： α-异麦芽糖基转移酶，其制备方法和用途
公开(公告)号：US07192746B2
公开(公告)日：2007-03-20
申请号：US10296153
申请日：2001-05-22
申请人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
发明人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18 , C12N9/10 , C12N1/20
CPC分类号： A23G1/423 , A21D2/181 , A23C9/005 , A23C9/1307 , A23G1/40 , A23G1/56 , A23G3/346 , A23G4/10 , A23G2200/06 , A23L2/60 , A23L9/12 , A23L11/07 , A23L13/428 , A23L15/30 , A23L19/01 , A23L27/33 , A23L29/35 , A61K8/60 , A61K8/66 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C07H3/06 , C12N9/1048 , C12P19/18
摘要： The object of the present invention is to provide an α-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→} from a saccharide having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end; microorganisms which produce the enzyme; process for producing the enzyme; cyclotetrasaccharide or saccharide compositions comprising the same; and uses thereof.
摘要翻译：本发明的目的是提供一种α-异麦芽糖基转移酶，其形成具有环{ - > 6）-al-D-glucopyranosyl-（1-> 3）-al-D-glucopyranosyl- （1-> 6）-α-D-吡喃葡萄糖基 - （1-> 3）-alpha-D-吡喃葡萄糖基 - （1->}，其葡萄糖聚合度至少为3，并具有α-1 ，6个糖苷键作为非还原末端的连接键和除非还原末端之间的连接以外的α-1,4糖苷键;产生该酶的微生物;产生该酶的方法;环四糖或糖组合物，其包含相同;及其用途。

10. 发明授权

US06140487A DNA encoding kojibiose phosphorylase obtainable from thermoanaerobium, ' its preparation and uses 有权
标题翻译：编码由热酵母获得的曲霉糖磷酸化酶的DNA，其制备和用途
公开(公告)号：US06140487A
公开(公告)日：2000-10-31
申请号：US188404
申请日：1998-11-10
申请人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K8/60 , A61K38/00 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C07H21/04 , C12N9/12
CPC分类号： A61K8/60 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N9/1051 , C12P19/18 , A61K38/00
摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from .beta.-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using .beta.-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from natural sources such as microorganisms of the genus Thermoanaerobium, and obtainable by recombinant technology.
摘要翻译：在无机磷酸存在下水解曲霉糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸的曲霉糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸，并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移到其他糖类上。该酶可从天然来源例如Thermoanaerobium属的微生物获得，可通过重组技术获得。

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