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1. 发明授权

US09429572B2 Complex formation method and separation method 有权
标题翻译：复杂形成方法和分离方法
公开(公告)号：US09429572B2
公开(公告)日：2016-08-30
申请号：US11991170
申请日：2006-08-24
申请人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
发明人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
IPC分类号： G01N33/48 , G01N33/50 , G01N33/561 , C12M1/00 , G06F19/00 , G06F19/18 , C12M3/06 , G01N33/53 , G01N33/536 , G01N33/537
CPC分类号： G01N33/561 , C12M23/16 , C12M45/07 , G01N33/5306 , G01N33/536 , G01N33/5375 , G06F19/18 , G06F19/702 , Y10S977/705
摘要： An object of the present invention is to provide a method for forming a complex between an analyte or an analog thereof, and a substance formable the complex with said analyte or said analog thereof (the complex forming substance), in a short time and in high reaction efficiency, and a method for separating a complex formed, and a complex forming substance not involved in formation of said complex or an analog not involved in formation of said complex rapidly, simply and in high accuracy, along with a method for measuring an analyte in a sample in high sensitivity.
摘要翻译：本发明的目的是提供一种用于在分析物或其类似物之间形成络合物的方法，以及在短时间内和高温下与所述分析物或其类似物（复合物形成物质）形成复合物的物质反应效率以及分离所形成的络合物的方法，以及不涉及形成所述络合物的复合物形成物质或不涉及形成所述复合物的类似物，并且简单且高精度地连同测定分析物的方法在高灵敏度的样品中。

2. 发明申请

US20090280573A1 Structure for Introducing a Plurality of Solutions, Micro Fluidic Device Having Said Structure and Method for Introducing Solution 有权
标题翻译：引入多种解决方案的结构，具有所述结构的微流体装置和引入解决方案的方法
公开(公告)号：US20090280573A1
公开(公告)日：2009-11-12
申请号：US12226017
申请日：2007-04-11
申请人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
发明人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
IPC分类号： G01N27/26 , B01J19/00 , B01D57/02 , G01N1/28
CPC分类号： G01N27/44791 , B01F13/0059 , B01F15/0404 , B01L3/5027 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C12N5/0605 , C12N5/063 , C12N2500/25 , C12N2501/105 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/135 , C12N2501/15 , C12N2502/094 , C12N2506/025 , G01N27/44743 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel (1) of a micro fluidic device, said channel (1) comprising not less than three side channels (2) for drain and not less than two side channels (3) for introducing a sample or a reagent solution.
摘要翻译：本发明涉及一种溶液导入结构，用于将高精度体积的多个溶液（样品和/或试剂溶液）以大量简单的方式引入微流体装置的通道（1）中，所述通道（1）包括用于排出的不少于三个侧通道（2）和用于引入样品或试剂溶液的不少于两个侧通道（3）。

3. 发明授权

US07910380B2 Structure for introducing a plurality of solutions, micro fluidic device having said structure and method for introducing solution 有权
标题翻译：用于引入多种溶液的结构，具有所述结构的微流体装置和用于引入溶液的方法
公开(公告)号：US07910380B2
公开(公告)日：2011-03-22
申请号：US12899838
申请日：2010-10-07
申请人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
发明人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
IPC分类号： G01N1/18 , G01N1/10 , G01N35/00 , B01L3/02
CPC分类号： G01N27/44791 , B01F13/0059 , B01F15/0404 , B01L3/5027 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C12N5/0605 , C12N5/063 , C12N2500/25 , C12N2501/105 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/135 , C12N2501/15 , C12N2502/094 , C12N2506/025 , G01N27/44743 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity.
摘要翻译：本发明涉及一种用于将高精度体积的多个溶液（样品和/或试剂溶液）以高量和简单的方式引入通道，特别是通道中的结构（溶液引入结构）微流体装置，具有所述结构的微流体装置，使用所述装置引入溶液的方法，分离物质的方法以及分离物或其类似物之间的复合物的分离方法和结合所述装置的物质的方法分析物或其类似物（以下简称为复合物形成物质或CFS），其通过使由它们引入的多种溶液和所述CFS或类似物不参与所述复合物的形成而快速，简单且高精度地获得以及以高灵敏度测量样品中的分析物或其类似物的方法。

4. 发明申请

US20110027902A1 STRUCTURE FOR INTRODUCING A PLURALITY OF SOLUTIONS, MICRO FLUIDIC DEVICE HAVING SAID STRUCTURE AND METHOD FOR INTRODUCING SOLUTION 有权
标题翻译：引入多种解决方案的结构，具有结构的微流体装置和引入解决方案的方法
公开(公告)号：US20110027902A1
公开(公告)日：2011-02-03
申请号：US12899838
申请日：2010-10-07
申请人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
发明人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
IPC分类号： G01N1/00
CPC分类号： G01N27/44791 , B01F13/0059 , B01F15/0404 , B01L3/5027 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C12N5/0605 , C12N5/063 , C12N2500/25 , C12N2501/105 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/135 , C12N2501/15 , C12N2502/094 , C12N2506/025 , G01N27/44743 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity.
摘要翻译：本发明涉及一种用于将高精度体积的多个溶液（样品和/或试剂溶液）以高量和简单的方式引入通道，特别是通道中的结构（溶液引入结构）微流体装置，具有所述结构的微流体装置，使用所述装置引入溶液的方法，分离物质的方法以及分离物或其类似物之间的复合物的分离方法和结合所述装置的物质的方法分析物或其类似物（以下简称为复合物形成物质或CFS），其通过使由它们引入的多种溶液和所述CFS或类似物不参与所述复合物的形成而快速，简单且高精度地获得以及以高灵敏度测量样品中的分析物或其类似物的方法。

5. 发明申请

US20090152114A1 Complex formation method and separation method 有权
标题翻译：复杂形成方法和分离方法
公开(公告)号：US20090152114A1
公开(公告)日：2009-06-18
申请号：US11991170
申请日：2006-08-24
申请人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
发明人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
IPC分类号： C25B7/00
CPC分类号： G01N33/561 , C12M23/16 , C12M45/07 , G01N33/5306 , G01N33/536 , G01N33/5375 , G06F19/18 , G06F19/702 , Y10S977/705
摘要： An object of the present invention is to provide a method for forming a complex between an analyte or an analogue thereof, and a substance formable the complex with said analyte or said analogue thereof (the complex forming substance), in a short time and in high reaction efficiency, and a method for separating a complex formed, and a complex forming substance not involved in formation of said complex or an analogue not involved in formation of said complex rapidly, simply and in high accuracy, along with a method for measuring an analyte in a sample in high sensitivity.
摘要翻译：本发明的目的是提供一种在分析物或其类似物之间形成复合物的方法，以及在短时间内和高温下与所述分析物或其类似物（复合物形成物质）形成复合物的物质反应效率的方法和形成的络合物的方法以及不涉及所述络合物的形成的复合物形成物质或不涉及快速形成所述复合物的类似物，以及用于测定分析物的方法在高灵敏度的样品中。

6. 发明授权

US07833804B2 Structure for introducing a plurality of solutions, micro fluidic device having said structure and method for introducing solution 有权
标题翻译：用于引入多种溶液的结构，具有所述结构的微流体装置和用于引入溶液的方法
公开(公告)号：US07833804B2
公开(公告)日：2010-11-16
申请号：US12226017
申请日：2007-04-11
申请人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
发明人： Tomohisa Kawabata , Shinji Satomura , Henry Garrett Wada
IPC分类号： G01N1/18 , G01N1/10 , G01N35/00 , B01L3/02
CPC分类号： G01N27/44791 , B01F13/0059 , B01F15/0404 , B01L3/5027 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C12N5/0605 , C12N5/063 , C12N2500/25 , C12N2501/105 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/135 , C12N2501/15 , C12N2502/094 , C12N2506/025 , G01N27/44743 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel (1) of a micro fluidic device, said channel (1) comprising not less than three side channels (2) for drain and not less than two side channels (3) for introducing a sample or a reagent solution.
摘要翻译：本发明涉及一种溶液导入结构，用于将高精度体积的多个溶液（样品和/或试剂溶液）以大量简单的方式引入微流体装置的通道（1）中，所述通道（1）包括用于排出的不少于三个侧通道（2）和用于引入样品或试剂溶液的不少于两个侧通道（3）。

7. 发明授权

US07842175B2 Electrophoresis 有权
标题翻译：电泳
公开(公告)号：US07842175B2
公开(公告)日：2010-11-30
申请号：US10472753
申请日：2002-04-03
申请人： Tomohisa Kawabata , Kenji Nakamura , Shinji Satomura
发明人： Tomohisa Kawabata , Kenji Nakamura , Shinji Satomura
IPC分类号： G01N27/447
CPC分类号： G01N33/532 , C12Q1/68 , G01N27/44726 , C12Q2565/125 , C12Q2563/179
摘要： The invention relates to a method for separating a target for measurement utilizing electrophoresis, particularly capillary electrophoresis efficiently in high sensitivity and in a short period of time. It also relates to a method for measuring said target separated by said method for separation. The invention provides a method for separating a target for measurement and a method for measuring said target separated by said method for separation, characterized by using a substance to which is bound a nucleic acid chain labeled by a marker and which has an affinity for said target for measurement.
摘要翻译：本发明涉及一种利用电泳，特别是高灵敏度和短时间内有效毛细管电泳分离测定靶的方法。本发明还涉及一种用于分离由所述分离方法分离的所述靶的测量方法。本发明提供了一种用于分离测量目标的方法和由所述分离方法分离的用于测量所述靶的方法，其特征在于使用结合由标记物标记的核酸链的物质，所述核酸链对所述靶标具有亲和力用于测量。

8. 发明授权

US07198702B1 Method for separating substances using dielectrophoretic forces 有权
标题翻译：使用介电电泳力分离物质的方法
公开(公告)号：US07198702B1
公开(公告)日：2007-04-03
申请号：US09670399
申请日：2000-09-27
申请人： Masao Washizu , Tomohisa Kawabata
发明人： Masao Washizu , Tomohisa Kawabata
IPC分类号： B01D57/02 , G01N27/447 , G01N33/53 , G01N33/543 , G01N33/566 , G01N1/10 , G01N35/08 , G01N37/00 , B03C5/00 , C12N15/09 , C12Q1/68 , C12M1/00
CPC分类号： B03C5/005
摘要： The present invention has an object of providing a method by which two kinds or more of molecules can be separated each other by using dielectrophoretic forces. The present invention comprises two methods. The first method is a method comprising forming a complex substance of a “specific molecule” containing in a sample, and a “substance capable of changing dielectrophoretic properties of the specific molecule”, which binds to the “specific molecule” contained therein, and thereby separating the complex substance and the molecules other than the specific molecule in the sample from each other. The second method is a method comprising placing a solution in which two kinds or more of molecules are dissolved under a strong electric field strength, that is, under a nonuniform electric field having an electric field strength of 500 KV/m or higher, by using dielectrophoretic forces.
摘要翻译：本发明的目的是提供一种通过使用介电电泳力将两种以上的分子彼此分离的方法。本发明包括两种方法。第一种方法包括形成包含在样品中的“特定分子”的复合物质和与其中所含的“特定分子”结合的“能够改变特定分子的介电电泳性质的物质”，从而将样品中的特定分子之外的复合物质和分子彼此分离。第二种方法是通过使用在强电场强度下，即在电场强度为500KV / m以上的不均匀电场下，将两种以上的分子溶解的溶液，通过使用介电电泳力。

9. 发明申请

US20100108514A1 METHOD OF CONTROLLING TEMPERATURE 审中-公开
标题翻译：控制温度的方法
公开(公告)号：US20100108514A1
公开(公告)日：2010-05-06
申请号：US12593875
申请日：2008-03-28
申请人： Yoshihiro Seto , Tomohisa Kawabata , Chungsoo Charles Park
发明人： Yoshihiro Seto , Tomohisa Kawabata , Chungsoo Charles Park
IPC分类号： G01N27/26
CPC分类号： G01N27/44708
摘要： To suppress temperature variations of sample fluids within flow channels for electrophoresis, in a method for controlling temperatures within micro flow channels. When controlling the temperatures of sample fluids within micro flow channels of electrophoresis chips, in which flow channels through which electrophoresis occurs by application of electrical potential differences can be switched, temperature variations of the sample fluids within the micro flow channels, caused by differences in heat generated by the sample fluids prior to and following the switching of the flow channels, are predicted. Control properties for temperature control in order to cancel the temperature variations are changed during the switching of the flow channels.
摘要翻译：为了抑制用于电泳的流动通道内的样品流体的温度变化，用于控制微流动通道内的温度的方法。当控制电泳芯片的微流通道内的样品流体的温度，其中可以切换通过施加电势差而发生电泳的流动通道时，由微热流通道中的热差导致的样品流体的温度变化预测在流动通道切换之前和之后由样品流体产生的。为了消除温度变化，温度控制的控制特性在流道切换期间发生变化。

10. 发明授权

US06875329B2 Method for separating substances using a dielectrophoretic apparatus 失效
标题翻译：使用介电电泳设备分离物质的方法
公开(公告)号：US06875329B2
公开(公告)日：2005-04-05
申请号：US09833566
申请日：2001-04-13
申请人： Masao Washizu , Tomohisa Kawabata
发明人： Masao Washizu , Tomohisa Kawabata
IPC分类号： B03C5/02 , G01N27/447
CPC分类号： B03C5/026
摘要： To provide An electrode for a dielectrophoretic apparatus in which a background detected by reflecting an excited light on an electrode present under the substance (molecule) is reduced and an S/N ratio is enhanced. Also, there is provided an dielectrophoretic apparatus, in an apparatus in which a liquid containing substances to be separated is present in a non-uniform electric field formed by a dielectrophoretic electrode, and separation is carried out by a dielectrophoretic force exerting on the substances, wherein the collecting ability of substances is enhanced. The present invention is characterized in that a vacant space is provided in an electrode whereby substances subjected to influence by a negative dielectrophoretic force can be concentrated in said vacant space of an electrode, or above or below portion of the space.
摘要翻译：提供一种用于介电电泳装置的电极，其中通过在物质（分子）下存在的电极上反射激发光而检测到的背景降低，并且提高S / N比。另外，在由介电泳电极形成的不均匀电场中存在含有待分离物质的液体的设备中，提供了介电泳设备，并且通过对该物质施加的介电电泳力进行分离，其中物质的收集能力得到提高。本发明的特征在于，在电极中设置空白空间，由此受到负介电电泳力的影响的物质可以集中在电极的空间空间中，或者在空间的上方或下方。

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