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1. 发明公开

US20230228750A1 CELL PROCESSING USING MAGNETIC PARTICLES 审中-公开
公开(公告)号：US20230228750A1
公开(公告)日：2023-07-20
申请号：US18120295
申请日：2023-03-10
申请人： Inguran, LLC
发明人： Kristie Krug
IPC分类号： G01N33/569 , G01N15/10 , G01N33/543 , B03C1/01 , B03C1/28 , G01N33/537 , C12N13/00
CPC分类号： G01N33/56966 , G01N15/10 , G01N33/54333 , B03C1/01 , B03C1/288 , G01N33/5434 , G01N33/54346 , G01N33/5438 , G01N33/5375 , C12N13/00 , G01N2015/1081 , G01N2015/1006 , B03C2201/18 , B03C2201/26
摘要： The present invention relates to compositions comprising magnetic particles, the methods of using these compositions in processing animal sperm, the resulting sperm and embryo products, and the methods of use of these compositions to increase the efficiency, efficacy and/or speed of cell processing and artificial insemination techniques.

2. 发明授权

US10072068B2 Method for altering the binding specificity of plasma proteins by oxidation 有权
公开(公告)号：US10072068B2
公开(公告)日：2018-09-11
申请号：US14923945
申请日：2015-10-27
申请人： REDOX-REACTIVE REAGENTS, LLC
发明人： John A. McIntyre
IPC分类号： C07K16/00 , C07K16/18 , G01N33/53 , G01N33/537 , G01N33/564 , G01N33/68
CPC分类号： C07K16/00 , C07K16/18 , C07K2317/21 , G01N33/5306 , G01N33/5375 , G01N33/564 , G01N33/6854 , Y10S424/81 , Y10S436/825 , Y10S530/868
摘要： The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.

3. 发明申请

US20170307627A1 HIGH RESOLUTION IMAGING OF TISSUE PROTEINS 审中-公开
公开(公告)号：US20170307627A1
公开(公告)日：2017-10-26
申请号：US15481141
申请日：2017-04-06
申请人： ARATOME, LLC , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： Gordon WANG , Jay TRAUTMAN
IPC分类号： G01N33/68 , G01N33/53 , G01N33/533 , G01N33/537
CPC分类号： G01N33/6803 , C07K19/00 , C12Q1/6804 , C12Q1/6816 , G01N33/53 , G01N33/533 , G01N33/5375
摘要： The present invention provides labeling method for Array Tomography (AT) and immunohistochemistry (IHC) that enables automated analysis many tens-to-hundreds of proteins in a manner that minimizes tissue degradation, increases data fidelity, and substantially increases throughput and reduces cost. Also included are methods for automated acquisition of AT and IHC data.

4. 发明授权

US09714934B2 Multiphase systems and uses thereof 有权
公开(公告)号：US09714934B2
公开(公告)日：2017-07-25
申请号：US13817976
申请日：2011-08-22
申请人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
发明人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
IPC分类号： G01N33/00 , G01N33/49 , B03B5/28 , B03B5/44 , B03D3/00 , G01N33/537 , G01N33/574 , G01N33/18
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.

5. 发明授权

US09018017B2 Reagents for reducing leukocyte interference in immunoassays 有权
标题翻译：用于减少免疫测定中白细胞干扰的试剂
公开(公告)号：US09018017B2
公开(公告)日：2015-04-28
申请号：US13862632
申请日：2013-04-15
申请人： Abbott Point of Care Inc.
发明人： John Lewis Emerson Campbell , Graham Davis , John Emegbero Omakor , Adam Roger Moss , Ganesh Guhados
IPC分类号： G01N33/543 , G01N33/537 , G01N33/53
CPC分类号： G01N33/54393 , G01N33/5306 , G01N33/5375 , G01N33/74 , G01N2333/475 , Y10T436/25125 , Y10T436/25375
摘要： Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors.
摘要翻译：提供了用于减少分析物免疫测定中白细胞干扰的方法和装置。在一个实施方案中，提供了一种方法，其包括以下步骤：将生物样品例如全血样品与一种或多种减少或消除白细胞的代谢活性的白细胞介素试剂进行修饰，并对经修订的样品进行免疫测定以确定浓度的样品中的分析物。优选地，用一种或多种酶和任选的一种或多种酶底物和辅因子修饰样品。

6. 发明授权

US08999729B2 Device and analyzing system for conducting agglutination assays 有权
标题翻译：用于进行凝集测定的装置和分析系统
公开(公告)号：US08999729B2
公开(公告)日：2015-04-07
申请号：US13165134
申请日：2011-06-21
申请人： Isabelle Delafosse , Fabrice Ummel , Antonio Yanez
发明人： Isabelle Delafosse , Fabrice Ummel , Antonio Yanez
IPC分类号： G01N33/558 , G01N33/537 , G01N33/538 , B01L3/00 , G01N33/53 , B04B5/04 , B01L9/06
CPC分类号： B01L3/5085 , B01L3/5021 , B01L9/06 , B01L2300/069 , B01L2300/18 , B01L2400/0409 , B04B5/0421 , G01N33/5304 , G01N33/5375 , G01N33/538 , Y10S436/81
摘要： A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber for receiving fluids from the upper chamber, a closed end opposite to the end, and a matrix for separating agglutinates from non-agglutinates; wherein the device further comprises a rotating support able to rotate around an axis and holding pivotally the reaction vessels in a way to allow the reaction vessels to pivot about an axis essentially perpendicular to the rotation axis of the support when the latter is rotated, such that the fluids remain in the upper chamber when the support is not rotated, and can flow from the upper chamber to the lower chamber and into the matrix when the support is rotated.
摘要翻译：用于进行包含几个反应容器的凝集测定的装置，每个反应容器包括具有用于接收反应物和/或样品的开口的上室; 以及下室，其包括与所述上室连通的端部，用于从所述上室接收流体，与所述端部相对的封闭端，以及用于从非凝集物分离凝集物的基质; 其中所述装置还包括旋转支撑件，所述旋转支撑件能够围绕轴线旋转并且以使得所述反应容器在所述反应容器旋转时基本上垂直于所述支撑件的旋转轴线的轴线枢转地保持所述反应容器，使得当支撑件不旋转时，流体保留在上腔室中，并且当支撑件旋转时，流体可以从上腔室流到下腔室并进入基体。

7. 发明申请

US20140057282A1 SWITCHABLE AFFINITY BINDERS 审中-公开
标题翻译：可切换的亲属领带
公开(公告)号：US20140057282A1
公开(公告)日：2014-02-27
申请号：US14071805
申请日：2013-11-05
申请人： General Electric Company
发明人： Aaron Joseph Dulgar-Tulloch , Ernest William Kovacs , Evelina Roxana Loghin , Anup Sood
IPC分类号： G01N1/34 , C07K14/00
CPC分类号： G01N1/34 , C07K14/001 , C12N2539/10 , G01N33/5375 , G01N33/54333
摘要： Methods and kits for binding and releasing biological targets, comprising, a binder having an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target. In one embodiment, the binder is a pre-existing chemical sequence, composition, or structural configuration but unknown or unspecified and still viable as a binder for attaching a molecular switch.
摘要翻译：用于结合和释放生物靶的方法和试剂盒，包括具有环境反应性分子开关的粘合剂，所述粘合剂可以在高亲和力状态之间切换以将靶结合到低亲和性状态以释放靶。在一个实施方案中，粘合剂是预先存在的化学序列，组合物或结构构型，但是未知的或未指定的，并且作为用于连接分子开关的粘合剂仍然可行。

8. 发明申请

US20130273576A1 REAGENTS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS 审中-公开
标题翻译：用于减少免疫球蛋白中的低密度脂蛋白干扰的试剂
公开(公告)号：US20130273576A1
公开(公告)日：2013-10-17
申请号：US13862632
申请日：2013-04-15
申请人： Abbott Point of Care Inc.
发明人： John Lewis Emerson Campbell , Graham Davis , John Emegbero Omakor , Adam Roger Moss , Ganesh Guhados
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/5306 , G01N33/5375 , G01N33/74 , G01N2333/475 , Y10T436/25125 , Y10T436/25375
摘要： Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors.
摘要翻译：提供了用于减少分析物免疫测定中白细胞干扰的方法和装置。在一个实施方案中，提供了一种方法，其包括以下步骤：将生物样品例如全血样品与一种或多种减少或消除白细胞的代谢活性的白细胞介素试剂进行修饰，并对经修订的样品进行免疫测定以确定浓度的样品中的分析物。优选地，用一种或多种酶和任选的一种或多种酶底物和辅因子修饰样品。

9. 发明申请

US20130266930A1 ANTIBODY-LINKED IMMUNO-SEDIMENTATION AGENT AND METHOD OF ISOLATING A TARGET FROM A SAMPLE USING SAME 审中-公开
标题翻译：抗体连接的免疫定位试剂和使用相同样品从样品中分离目标的方法
公开(公告)号：US20130266930A1
公开(公告)日：2013-10-10
申请号：US13800495
申请日：2013-03-13
申请人： CYTOSED, INC.
发明人： Warren L. Dinges
IPC分类号： G01N33/539 , C07K16/00
CPC分类号： G01N33/539 , C07K16/00 , G01N33/5375 , G01N33/56966 , G01N33/56972 , G01N33/56988 , G01N2333/7051
摘要： The present disclosure is directed to antibody-linked immuno-sedimentation agent, the antibody being linked to a sedimentation agent by a non-antigen binding region of the antibody, and a method of isolating a target from a sample using the antibody-linked immuno-sedimentation agent. The methods involve forming a mixture including a sample with an antibody linked immuno-sedimentation agent and red blood cells under conditions sufficient to form red blood cell rouleaux and allow antibody-antigen binding.
摘要翻译：本公开涉及抗体连接的免疫沉降剂，所述抗体通过抗体的非抗原结合区连接到沉降剂，以及使用抗体连接的免疫沉淀作用从样品中分离靶的方法，沉淀剂。所述方法包括在足以形成红血球细胞并允许抗体 - 抗原结合的条件下，在含有抗体连接的免疫沉降剂和红细胞的条件下形成包含样品的混合物。

10. 发明授权

US08211714B2 Characterization of molecules 有权
标题翻译：分子的表征
公开(公告)号：US08211714B2
公开(公告)日：2012-07-03
申请号：US13110345
申请日：2011-05-18
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/536
CPC分类号： G01N33/5375 , G01N33/53 , G01N33/68 , Y10T436/10 , Y10T436/105831
摘要： The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity.
摘要翻译：本发明涉及获得物种（包括化学，生物或生物化学分子）的签名和/或物种之间的相互作用的签名，并使用它们来表征物种，表征相互作用，和/或识别可在各种设置中有用的物种。可以使用水性多相分配获得签名，并且可以用于预测用于药物发现的应用的分子相互作用。多个水性多相分配装置可以定义提供信息密集型签名的整体系统，从而使精度和灵敏度最大化。

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