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1. 发明授权

US5783124A Cellulose acetate hemodialysis membrane 失效
标题翻译：乙酸纤维素血液透析膜
公开(公告)号：US5783124A
公开(公告)日：1998-07-21
申请号：US730599
申请日：1996-10-15
申请人： Tohru Uenishi , Isamu Yamamoto , Kazutake Okamoto , Hideo Sato , Yasuhiro Shiota , Hidehiko Sakurai , Seiji Watanuki , Mitsuru Suzuki
发明人： Tohru Uenishi , Isamu Yamamoto , Kazutake Okamoto , Hideo Sato , Yasuhiro Shiota , Hidehiko Sakurai , Seiji Watanuki , Mitsuru Suzuki
IPC分类号： B01D69/08 , B01D71/16 , B01D33/21
CPC分类号： B01D71/16 , B01D69/08
摘要： A cellulose acetate membrane composed of a mixture comprising a cellulose triacetate and a cellulose diacetate and having an improved heat stability, which does not substantially show a melting peak of cellulose diacetate but substantially shows a melting peak of cellulose triacetate, in a differential thermal analysis. By mixing a cellulose triacetate and a cellulose diacetate at an appropriate ratio, crystallization or orientational crystallization of each component due to a high pressure stream sterilization can be avoided and a cellulose acetate membrane with improved water permeability and sieving coefficient of myoglobin after a high pressure steam sterilization can be obtained.
摘要翻译：一种醋酸纤维素膜，由包含三乙酸纤维素和二乙酸纤维素并具有改进的热稳定性的混合物组成，其在差热分析中基本上不显示纤维素二乙酸酯的熔融峰，但基本上显示出三乙酸纤维素的熔融峰。通过以适当的比例混合三乙酸纤维素和二乙酸纤维素，可以避免由于高压流灭菌而导致的每种组分的结晶或取向结晶，以及在高压蒸汽之后具有改善的透水性和肌红蛋白的筛分系数的乙酸纤维素膜可以获得灭菌。

2. 发明授权

US5624561A Cellulose acetate hemodialysis membrane 失效
标题翻译：乙酸纤维素血液透析膜
公开(公告)号：US5624561A
公开(公告)日：1997-04-29
申请号：US272397
申请日：1994-07-26
申请人： Tohru Uenishi , Isamu Yamamoto , Kazutake Okamoto , Hideo Sato , Yasuhiro Shiota , Hidehiko Sakurai , Seiji Watanuki , Mitsuru Suzuki
发明人： Tohru Uenishi , Isamu Yamamoto , Kazutake Okamoto , Hideo Sato , Yasuhiro Shiota , Hidehiko Sakurai , Seiji Watanuki , Mitsuru Suzuki
IPC分类号： B01D69/08 , B01D71/16 , B01D39/00
CPC分类号： B01D71/16 , B01D69/08
摘要： A cellulose acetate membrane composed of a mixture comprising a cellulose triacetate and a cellulose diacetate and having an improved heat stability, which does not substantially show a melting peak of cellulose diacetate but substantially shows a melting peak of cellulose triacetate, in a differential thermal analysis. By mixing a cellulose triacetate and a cellulose diacetate at an appropriate ratio, crystallization or orientational crystallization of each component due to a high pressure steam sterilization can be avoided and a cellulose acetate membrane with improved water permeability and sieving coefficient of myoglobin after a high pressure steam sterilization can be obtained.
摘要翻译：一种醋酸纤维素膜，由包含三乙酸纤维素和二乙酸纤维素并具有改进的热稳定性的混合物组成，其在差热分析中基本上不显示纤维素二乙酸酯的熔融峰，但基本上显示出三乙酸纤维素的熔融峰。通过以适当的比例混合三乙酸纤维素和二乙酸纤维素，可以避免由于高压蒸汽灭菌而引起的每种组分的结晶或取向结晶，以及在高压蒸汽之后具有改善的透水性和肌红蛋白筛分系数的乙酸纤维素膜可以获得灭菌。

3. 发明授权

US08840788B2 Hollow fiber membrane, method for manufacturing the same, and blood purification module 有权
标题翻译：中空纤维膜，其制造方法和血液净化模块
公开(公告)号：US08840788B2
公开(公告)日：2014-09-23
申请号：US13147721
申请日：2010-02-02
申请人： Makoto Ohno , Isamu Yamamoto , Takahito Sagara , Kimihiro Mabuchi , Tohru Uenishi , Shinya Koyama
发明人： Makoto Ohno , Isamu Yamamoto , Takahito Sagara , Kimihiro Mabuchi , Tohru Uenishi , Shinya Koyama
IPC分类号： B01D69/08 , B01D63/02 , B01D71/68 , A61M1/16
CPC分类号： B01D69/087 , A61M1/1621 , B01D63/02 , B01D71/68 , B01D2313/04
摘要： The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module.
摘要翻译：本发明提供了一种中空纤维膜，其中确保了来自透析液一侧的膜强度和耐压性，在来自外部的反复压力负载之后的透水性保持率高，对外部的压力的耐受性优异，模块的组装性（粘附部分的低泄漏率）同时是令人满意的。本发明还提供了其制造方法和血液净化模块。

4. 发明申请

US20110290709A1 HOLLOW FIBER MEMBRANE, METHOD FOR MANUFACTURING THE SAME, AND BLOOD PURIFICATION MODULE 有权
标题翻译：中空纤维膜，其制造方法和血液净化模块
公开(公告)号：US20110290709A1
公开(公告)日：2011-12-01
申请号：US13147721
申请日：2010-02-02
申请人： Makoto Ohno , Isamu Yamamoto , Takahito Sagara , Kimihiro Mabuchi , Tohru Uenishi , Shinya Koyama
发明人： Makoto Ohno , Isamu Yamamoto , Takahito Sagara , Kimihiro Mabuchi , Tohru Uenishi , Shinya Koyama
IPC分类号： B01D71/68 , B01D69/08 , D01D5/06 , B01D63/02
CPC分类号： B01D69/087 , A61M1/1621 , B01D63/02 , B01D71/68 , B01D2313/04
摘要： The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module.An annealing spinning method was found where a spinning dope is discharged from a nozzle into a coagulation bath, an appropriate elongation is applied so as to enhance the membrane strength, an elongation is continued during a water-washing step so as not to relax the elongation, and no elongation is applied during drying whereby the strain is relaxed. By the annealing spinning, a hollow fiber membrane and a blood purification module can be obtained where although the water permeability is low, the efficiency is high, no risk of backfiltration is resulted, the pressure resistance and strength are enhanced due to elongation, the stability is enhanced due to annealing during drying, the safety and assembling property into module are excellent.
摘要翻译：本发明提供了一种中空纤维膜，其中确保了来自透析液一侧的膜强度和耐压性，在来自外部的反复压力负载之后的透水性保持率高，对外部的压力的耐受性优异，模块的组装性（粘附部分的低泄漏率）同时是令人满意的。本发明还提供了其制造方法和血液净化模块。发现退火纺丝法，其中纺丝原液从喷嘴排出到凝固浴中，施加适当的伸长率以提高膜强度，在水洗步骤期间持续延伸以便不使伸长率松弛，并且在干燥期间不施加伸长率，从而使应变松弛。通过退火纺丝，可以获得中空纤维膜和血液净化组件，其中透水性低，效率高，不会产生反渗透的风险，耐压性和强度由于伸长而提高，稳定性由于干燥过程中的退火而增强，模块的安全性和组装性优异。

5. 发明授权

US4886631A Cellulose ester hollow fiber membrane for plasma separation 失效
标题翻译：用于血浆分离的纤维素酯中空纤维膜
公开(公告)号：US4886631A
公开(公告)日：1989-12-12
申请号：US239686
申请日：1988-09-02
申请人： Mitsuru Suzuki , Makoto Ohno , Isamu Yamamoto
发明人： Mitsuru Suzuki , Makoto Ohno , Isamu Yamamoto
IPC分类号： A61M1/18 , B01D69/02 , B01D69/08 , B01D71/06 , B01D71/14 , D01D5/24 , D01F2/28
CPC分类号： D01D5/24 , B01D69/02 , B01D69/08 , B01D71/14 , D01F2/28
摘要： A hollow fiber membrane made of a cellulose ester having a membrane thickness of not more than 75 .mu.m, and having void volume (x, % by volume) of the membrane and a rate of ultrafiltration (y, ml/m.sup.2.hr.mmHg) satisfying the following formula:55x-2500.ltoreq.y.ltoreq.48x+600wherein x.gtoreq.60,and further has a .beta.-lipoprotein sieving coefficient (sc) of not less than 0.95, and preferably having further not more than 2% of change ratio in the axial direction and in the radial direction when dipped freely in water at 121.degree. C. for 20 minutes. Said hollow fiber membrane is useful for the medical use, such as the exchange of plasma in patients, collection of plasma from healthy donors, the pre-treatment of plasma for the collection and purification of valuable materials contained in plasma.
摘要翻译：由膜厚不大于75μm，膜的空隙体积（x，体积％）和超滤速度（y，ml / m2.hr.mmHg）的纤维素酯制成的中空纤维膜）满足下列公式：55x-2500 = = 60，并且还具有不小于0.95的β-脂蛋白筛分系数（sc），并且优选具有不超过在121℃下在水中自由浸渍20分钟时，在轴向和径向上的变化率的2％以上。所述中空纤维膜可用于医疗用途，例如患者血浆的交换，来自健康供体的血浆的收集，等离子体的预处理，用于收集和纯化血浆中包含的有价值物质。

6. 发明授权

US4808312A Cellulose ester hollow fiber membrane for plasma separation 失效
标题翻译：用于血浆分离的纤维素酯中空纤维膜
公开(公告)号：US4808312A
公开(公告)日：1989-02-28
申请号：US900584
申请日：1986-08-26
申请人： Mitsuru Suzuki , Makoto Ohno , Isamu Yamamoto
发明人： Mitsuru Suzuki , Makoto Ohno , Isamu Yamamoto
IPC分类号： A61M1/18 , B01D69/02 , B01D69/08 , B01D71/06 , B01D71/14 , D01D5/24 , D01F2/28 , B01D13/00 , B01D13/01
CPC分类号： D01D5/24 , B01D69/02 , B01D69/08 , B01D71/14 , D01F2/28
摘要： A hollow fiber membrane made of a cellulose ester having a membrane thickness of not more than 75 .mu.m, and having void volume (x, % by volume) of the membrane and a rate of ultrafiltration (y, ml/m.sup.2.hr.mmHg) satisfying the following formula:55x-2500.ltoreq.y.ltoreq.48x+600wherein x.gtoreq.60,and further has a .beta.-lipoprotein sieving coefficient (sc) of not less than 0.95, and preferably having further not more than 2% of change ratio in the axial direction and in the radial direction when dipped freely in water at 121.degree. C. for 20 minutes. Said hollow fiber membrane is useful for the medical use, such as the exchange of plasma in patients, collection of plasma from healthy donor, the pre-treatment of plasma for the collection and purification of valuable materials contained in plasma.
摘要翻译：由膜厚不大于75μm，膜的空隙体积（x，体积％）和超滤速度（y，ml / m2.hr.mmHg）的纤维素酯制成的中空纤维膜）满足下列公式：55x-2500 = = 60，并且还具有不小于0.95的β-脂蛋白筛分系数（sc），并且优选具有不超过在121℃下在水中自由浸渍20分钟时，在轴向和径向上的变化率的2％以上。所述中空纤维膜可用于医疗用途，例如患者血浆的交换，来自健康供体的血浆的收集，等离子体的预处理，用于收集和纯化血浆中包含的有价物质。

7. 发明授权

US08040408B2 Image signal processing apparatus, image capturing apparatus, and image signal processing method 失效
标题翻译：图像信号处理装置，图像捕获装置和图像信号处理方法
公开(公告)号：US08040408B2
公开(公告)日：2011-10-18
申请号：US12406159
申请日：2009-03-18
申请人： Yoshihiro Date , Yoshinari Hirohata , Isamu Yamamoto
发明人： Yoshihiro Date , Yoshinari Hirohata , Isamu Yamamoto
IPC分类号： H04N5/208 , H04N5/14 , H04N5/21 , G06K9/40
CPC分类号： H04N5/142 , G06T5/003 , G06T2207/20192 , H04N5/23212 , H04N5/23245 , H04N5/23293 , H04N9/646
摘要： An image signal processing apparatus is disclosed. A peaking signal generation section extracts and amplifies high frequency components contained in an input image signal to generate a peaking signal. An operation section allows a target area for which contour correction is to be performed using the peaking signal to be accepted. A control section generates an area gate signal describing position information corresponding to the designated target area. A mask processing section performs a mask process of outputting an image signal to which the peaking signal has been added to the target area designated through the operation section based on the area gate signal supplied from the control section. A scaling processing section converts pixels of the image signal for which the mask process has been performed is converted at a predetermined scaling ratio.
摘要翻译：公开了一种图像信号处理装置。峰化信号生成部提取并放大输入图像信号中包含的高频分量，生成峰值信号。操作部允许使用要被接受的峰值信号来执行轮廓校正的目标区域。控制部分生成描述与指定的目标区域相对应的位置信息的区域门信号。掩模处理部基于从控制部提供的区域门信号，执行将通过操作部指定的目标区域输出已经添加了峰化信号的图像信号的掩码处理。转换已经执行了掩模处理的图像信号的像素以缩放比例转换的缩放处理部分。

8. 发明授权

US06336971B1 Method and apparatus for producing silicon carbide single crystal 有权
标题翻译：生产碳化硅单晶的方法和装置
公开(公告)号：US06336971B1
公开(公告)日：2002-01-08
申请号：US09508427
申请日：2000-03-13
申请人： Nobuyuki Nagato , Kunio Komaki , Isamu Yamamoto , Naoki Oyanagi , Shigehiro Nishino
发明人： Nobuyuki Nagato , Kunio Komaki , Isamu Yamamoto , Naoki Oyanagi , Shigehiro Nishino
IPC分类号： C30B2936
CPC分类号： C30B23/00 , C30B29/36
摘要： A silicon carbide single crystal is produced by allowing a vapor evaporated from a silicon raw material to pass through a heated carbon member and then reach a seed crystal substrate on which a silicon carbide single crystal grows. For this production, an apparatus is used, which has a reaction tube, a heating device and a graphite crucible, wherein the lower part of the crucible constitutes a silicon raw material-charging part; a seed crystal substrate is situated at the top of the crucible; and a carbon member, through which the vapor evaporated from a silicon raw material in capable of passing, is disposed intermediately between the silicon raw material-charging part and the seed crystal. As the carbon member, a porous carbon structure, a carbon plate having a plurality of through holes and a carbon particle-packed layer can be mentioned.
摘要翻译：通过使从硅原料蒸发的蒸汽通过加热的碳构件，然后到达碳化硅单晶生长的晶种基板，制造碳化硅单晶。对于该生产，使用具有反应管，加热装置和石墨坩埚的装置，其中坩埚的下部构成硅原料充电部; 晶种基底位于坩埚顶部; 在硅原料充电部和晶种之间设置碳原子，通过该碳构件从硅原料蒸发的能够通过的蒸气。作为碳构件，可以提及多孔碳结构，具有多个通孔的碳板和碳粒子填充层。

9. 发明授权

US5063719A Column base structure 失效
标题翻译：柱状结构
公开(公告)号：US5063719A
公开(公告)日：1991-11-12
申请号：US282372
申请日：1988-12-09
申请人： Hideshige Matsuo , Isamu Yamamoto , Osamu Narishige , Michio Itoh , Kuniaki Sato , Yoshihiro Nakamura , Akio Tomita , Toshikazu Yamada , Yoshikazu Maeda
发明人： Hideshige Matsuo , Isamu Yamamoto , Osamu Narishige , Michio Itoh , Kuniaki Sato , Yoshihiro Nakamura , Akio Tomita , Toshikazu Yamada , Yoshikazu Maeda
IPC分类号： E04H12/22
CPC分类号： E04H12/2261
摘要： A column base structure having connected a pair of column-base metal fittings to the lower part of a column consisting of a pair of main column members disposed at predetermined intervals and connecting members disposed in such a manner as to integrally connect the main column members; the column base metal fittings being fixedly fitted to a concrete foundation via anchor bolts and nuts; characterized in that a horizontal member having a predetermined cross-sectional area is integrally and fixedly fitted between the main column members in the vicinity of the column base metal fitting.
摘要翻译：一种列底部结构，其将一对列基金属配件连接到由一对以预定间隔设置的主列构件和由主列构件一体连接而设置的连接构件构成的列的下部; 柱基金属配件通过地脚螺栓和螺母固定在混凝土基础上; 其特征在于，具有预定横截面积的水平构件整体地并且固定地配合在所述主柱构件之间的所述柱基础金属配件附近。

10. 发明授权

US4507500A Process for producing 2-mercaptoethylamine hydrohalides 失效
标题翻译： 2-巯基乙胺氢卤化物的制备方法
公开(公告)号：US4507500A
公开(公告)日：1985-03-26
申请号：US281091
申请日：1981-07-07
申请人： Shigenobu Nakayama , Eiichi Noda , Yoshiaki Noguchi , Isamu Yamamoto , Noboru Kawasaki
发明人： Shigenobu Nakayama , Eiichi Noda , Yoshiaki Noguchi , Isamu Yamamoto , Noboru Kawasaki
IPC分类号： C07C323/02 , A61K31/095 , A61K31/13 , A61K31/131 , C07C67/00 , C07C313/00 , C07C319/02 , C07C319/12 , C07C323/25 , C07C323/29 , C07C329/16 , C07C149/24
CPC分类号： C07C319/02 , C07C329/16
摘要： A process for producing 2-mercaptoethylamine hydrohalides of the general formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are identical or different, and each represents a hydrogen atom, a lower alkyl group, a hydroxy-substituted lower alkyl group or a phenyl group, and X represents a halogen atom,which comprises reacting a 2-mercaptothiazoline of the general formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, with a 2-halogenoethylamine hydrohalide of the general formula ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as defined above, in the presence of water.
摘要翻译：制备通式为（III）的2-巯基乙胺氢卤化物的方法，其中R 1，R 2，R 3和R 4相同或不同，各自表示氢原子，低级烷基，羟基取代的低级烷基或苯基，并且X表示卤素原子，其包括使通式为其中R 1，R 2，R 3和R 4如上定义的通式为其中R1，R2，R3和R4的2-巯基噻唑与2-卤代乙胺氢卤酸酯反应，在水的存在下，通式（II）其中R 1，R 2，R 3，R 4和X如上所定义。

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