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1. 发明授权

US07493171B1 Treatment of pathologic craving and aversion syndromes and eating disorders by electrical brain stimulation and/or drug infusion 有权
标题翻译：通过电脑刺激和/或药物输注治疗病理性渴望和厌恶综合征和进食障碍
公开(公告)号：US07493171B1
公开(公告)日：2009-02-17
申请号：US11140152
申请日：2005-05-27
申请人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
发明人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2005/1726 , A61M2205/054 , A61M2205/3523 , A61M2205/50 , A61M2210/06 , A61M2210/0693 , A61N1/00 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/36089
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to at least treat or prevent obesity and/or other eating disorders, as well as drug, nicotine and alcohol addiction, uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以至少治疗或预防肥胖症和/或其他进食障碍以及药物，尼古丁和酒精成瘾的系统和方法使用至少一个系统控制单元（SCU）产生通过植入在脑中的电极递送的电脉冲和/或产生药物输注脉冲，其中刺激性药物被递送到脑中的目标区域。

2. 发明授权

US07440806B1 Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion 有权
标题翻译：通过电脑刺激和/或药物输注治疗糖尿病的系统和方法
公开(公告)号：US07440806B1
公开(公告)日：2008-10-21
申请号：US11140126
申请日：2005-05-27
申请人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
发明人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
IPC分类号： A61N1/00
CPC分类号： A61M5/1723 , A61M5/14276 , A61M5/172 , A61M2205/054 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/08 , A61N1/36082 , A61N1/37205
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to at least treat or prevent diabetes uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以至少治疗或预防糖尿病的系统和方法使用至少一个系统控制单元（SCU），其产生通过植入脑内的电极递送的电脉冲和/或产生药物输注脉冲，其中刺激性药物被递送到脑中的目标区域。

3. 发明授权

US07203548B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US07203548B2
公开(公告)日：2007-04-10
申请号：US10176743
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

4. 发明授权

US07860570B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 有权
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US07860570B2
公开(公告)日：2010-12-28
申请号：US10178010
申请日：2002-06-20
申请人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
发明人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
IPC分类号： A61N1/375
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

5. 发明授权

US08452407B2 Methods for treating gastrointestinal disorders 有权
标题翻译：治疗胃肠道疾病的方法
公开(公告)号：US08452407B2
公开(公告)日：2013-05-28
申请号：US11192750
申请日：2005-07-29
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru
IPC分类号： A61N1/00 , A61N1/375 , A61N1/36
CPC分类号： A61N1/375 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： A small implantable stimulator(s) having at least two electrodes is implanted adjacent to a gastrointestinal nerve and/or muscle for the stimulation treatment of gastrointestinal disorders, including gastrointestinal motility, sphincteric disorders, and/or eating disorders. The stimulator provides a means of stimulating tissue at a stimulation site when desired, and may be implanted via a minimal surgical procedure.
摘要翻译：具有至少两个电极的小植入式刺激器邻近胃肠神经和/或肌肉植入，用于刺激治疗胃肠道疾病，包括胃肠蠕动，括肠功能障碍和/或进食障碍。刺激器提供了在需要时在刺激部位刺激组织的手段，并且可以通过最小的外科手术植入。

6. 发明授权

US07292890B2 Vagus nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：迷走神经刺激通过动作电位的单向传播
公开(公告)号：US07292890B2
公开(公告)日：2007-11-06
申请号：US10176722
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/08 , A61N1/36071 , Y10S128/903
摘要： Methods of stimulating a vagus nerve include providing at least one implantable stimulator with at least two electrodes, configuring the electrodes to apply stimulation that unidirectionally propagates action potentials along a vagus nerve, and applying the stimulation to the vagus nerve to effectively select afferent fibers, thereby treating at least one of epilepsy and depression while limiting side effects of bidirectional stimulation. At least one of the electrodes comprises a leadsless electrode.
摘要翻译：刺激迷走神经的方法包括提供至少一个可植入的刺激器，其具有至少两个电极，构造电极以施加沿着迷走神经单向传播动作电位的刺激，并将刺激应用于迷走神经以有效地选择传入纤维，从而治疗癫痫和抑郁症中的至少一种，同时限制双向刺激的副作用。至少一个电极包括无引线电极。

7. 发明授权

US07308303B2 Thrombolysis and chronic anticoagulation therapy 失效
标题翻译：溶栓和慢性抗凝治疗
公开(公告)号：US07308303B2
公开(公告)日：2007-12-11
申请号：US10285803
申请日：2002-11-01
申请人： Todd K Whitehurst , Kelly H McClure , James R Thacker
发明人： Todd K Whitehurst , Kelly H McClure , James R Thacker
IPC分类号： A61N1/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
摘要翻译：本发明的血栓溶解和/或抗凝治疗包括将导管的放电部分和可选的一个或多个电极植入在待刺激的邻近组织上。刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。刺激部位包括冠状动脉，冠状动脉，脑动脉，其他血管，心脏腔，肠系膜血管，腿部深血管等位置。公开的治疗包括用于慢性治疗和/或预防血栓栓塞性疾病，用于急性治疗血栓栓塞症，用于急性治疗血栓形成的药物及其组合的药物。本发明减少或消除了血栓栓塞性疾病和相关疾病的发生，改善了血栓栓塞性疾病引起的症状，并改善了患者的生活质量。

8. 发明授权

US07054692B1 Fixation device for implantable microdevices 有权
标题翻译：可植入微型装置的固定装置
公开(公告)号：US07054692B1
公开(公告)日：2006-05-30
申请号：US10146332
申请日：2002-05-15
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/37205 , A61N1/3756
摘要： A fixation device fixes the position of an implantable microminiature device residing proximally to a target site such as a nerve or a muscle. In one embodiment, the device comprises a sheath and a means for attaching the device to adjacent tissue. The means for attaching may be any one of several embodiments including one or more grasping members, a combination of grasping members and one or more helices, or an extension adapted to accept a suture. In another embodiment, the fixation device comprises an assembly residing in the implantation pathway, behind the stimulation device, thus preventing retreat of the stimulation device in the pathway. In a preferred use, the fixation device fixes the position of a microstimulator component of a Peripheral Nerve Stimulation (PNS) system.
摘要翻译：固定装置将位于近端的可植入微型装置的位置固定到诸如神经或肌肉的目标部位。在一个实施例中，该装置包括护套和用于将该装置附接到相邻组织的装置。用于附接的装置可以是包括一个或多个抓握构件，抓握构件和一个或多个螺旋的组合的几个实施例中的任一个或适于接纳缝合线的延伸部。在另一个实施例中，固定装置包括驻留在植入通路中的组件，位于刺激装置后面，从而防止刺激装置在路径中的后退。在优选的使用中，固定装置固定外围神经刺激（PNS）系统的微型激励器部件的位置。

9. 发明授权

US07167751B1 Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation 有权
标题翻译：使用完全可植入的微型神经刺激器进行迷走神经刺激的方法
公开(公告)号：US07167751B1
公开(公告)日：2007-01-23
申请号：US10993989
申请日：2004-11-19
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/08
CPC分类号： A61N1/3605 , A61N1/36082 , A61N1/36114 , A61N1/37205
摘要： A method of using a small implantable stimulator(s) with at least two electrodes small enough to have the electrodes located adjacent to the vagus nerve. The small stimulator provides a means of stimulating the vagus nerve when desired, and may be implanted via a minimal surgical procedure.
摘要翻译：使用具有足够小的至少两个电极的小型可植入刺激器的方法，以使电极位于与迷走神经相邻的位置。小刺激器在需要时提供刺激迷走神经的手段，并且可以通过最小的外科手术植入。

10. 发明授权

US07155284B1 Treatment of hypertension 有权
标题翻译：治疗高血压
公开(公告)号：US07155284B1
公开(公告)日：2006-12-26
申请号：US10346538
申请日：2003-01-16
申请人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
发明人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/37205 , A61N1/37211 , A61N1/3787
摘要： Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.
摘要翻译：高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。微型激励器也可以/替代地递送电刺激脉冲。刺激部位包括颈动脉窦和颈动脉体等。治疗包括用于急性和/或慢性治疗高血压的药物。在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。

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