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1. 发明授权

US07308303B2 Thrombolysis and chronic anticoagulation therapy 失效
标题翻译：溶栓和慢性抗凝治疗
公开(公告)号：US07308303B2
公开(公告)日：2007-12-11
申请号：US10285803
申请日：2002-11-01
申请人： Todd K Whitehurst , Kelly H McClure , James R Thacker
发明人： Todd K Whitehurst , Kelly H McClure , James R Thacker
IPC分类号： A61N1/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
摘要翻译：本发明的血栓溶解和/或抗凝治疗包括将导管的放电部分和可选的一个或多个电极植入在待刺激的邻近组织上。刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。刺激部位包括冠状动脉，冠状动脉，脑动脉，其他血管，心脏腔，肠系膜血管，腿部深血管等位置。公开的治疗包括用于慢性治疗和/或预防血栓栓塞性疾病，用于急性治疗血栓栓塞症，用于急性治疗血栓形成的药物及其组合的药物。本发明减少或消除了血栓栓塞性疾病和相关疾病的发生，改善了血栓栓塞性疾病引起的症状，并改善了患者的生活质量。

2. 发明授权

US07155284B1 Treatment of hypertension 有权
标题翻译：治疗高血压
公开(公告)号：US07155284B1
公开(公告)日：2006-12-26
申请号：US10346538
申请日：2003-01-16
申请人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
发明人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/37205 , A61N1/37211 , A61N1/3787
摘要： Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.
摘要翻译：高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。微型激励器也可以/替代地递送电刺激脉冲。刺激部位包括颈动脉窦和颈动脉体等。治疗包括用于急性和/或慢性治疗高血压的药物。在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。

3. 发明授权

US07904162B2 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US07904162B2
公开(公告)日：2011-03-08
申请号：US11246719
申请日：2005-10-07
申请人： Todd K Whitehurst , James P McGivern , Kelly H McClure , Goran N Marnfeldt , James R Thacker
发明人： Todd K Whitehurst , James P McGivern , Kelly H McClure , Goran N Marnfeldt , James R Thacker
IPC分类号： A61N1/08
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

4. 发明授权

US07877137B2 Thrombolysis and chronic anticoagulation therapy 失效
标题翻译：溶栓和慢性抗凝治疗
公开(公告)号：US07877137B2
公开(公告)日：2011-01-25
申请号：US11949752
申请日：2007-12-03
申请人： Todd K Whitehurst , Kelly H McClure , James R Thacker
发明人： Todd K Whitehurst , Kelly H McClure , James R Thacker
IPC分类号： A61N1/08
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a catheter, configuring one or more stimulation parameters to treat at least one of a myocardial infarction, a stroke, and a pulmonary embolism, programming the stimulator with the one or more stimulation parameters, delivering with the stimulator via the catheter at least one drug to at least one tissue in accordance with the one or more stimulation parameters, and limiting perfusion of the at least one tissue by delivering electrical stimulation with the stimulator via the at least one electrode to the at least one tissue.
摘要翻译：用心肌梗死，中风和肺栓塞中的至少一种治疗患者的方法和系统包括提供耦合到至少一个电极和导管的刺激器，配置一个或多个刺激参数以治疗下列中的至少一个：心肌梗塞，中风和肺栓塞，用一个或多个刺激参数对刺激器进行编程，根据该一个或多个刺激参数，通过导管将至少一种药物通过导管递送至至少一个组织，并限制通过将所述刺激器经由所述至少一个电极递送到所述至少一个组织的电刺激来灌注所述至少一个组织。

5. 发明授权

US07321794B2 Method and system for treating atrial fibrillation 失效
标题翻译：治疗房颤的方法和系统
公开(公告)号：US07321794B2
公开(公告)日：2008-01-22
申请号：US10713511
申请日：2003-11-14
申请人： James R Thacker , Kelly H McClure , Todd K Whitehurst , Philip H Lee
发明人： James R Thacker , Kelly H McClure , Todd K Whitehurst , Philip H Lee
IPC分类号： A61N1/368
CPC分类号： A61N1/3622
摘要： An atrial, anti-arrhythmia system and method are provided. The system comprises: at least two electrodes attached to the atrium for providing independently controlled stimulus through each electrode; detection circuitry that can sense atrial fibrillation or the cardiac cycle; and stimulus generator that can deliver stimulation through at least two electrodes to stop atrial fibrillation. The method for treating atrial fibrillation has three possible modes: a first mode for detecting ongoing atrial fibrillation and stopping it; a second mode for detecting the cardiac cycle and delivering stimuli to the atrium after it has already begun to contract in order to suppress the onset of atrial fibrillation; and a third mode which applies pacing pulses to the atrium in a timed sequence to pace and contract the atrium faster than the native rate to preempt the initiation of atrial fibrillation.
摘要翻译：提供心房，抗心律失常系统和方法。该系统包括：至少两个连接到心房的电极，用于通过每个电极提供独立控制的刺激; 可以感测心房颤动或心动周期的检测电路; 和刺激发生器，其可以通过至少两个电极传递刺激以停止心房颤动。治疗心房颤动的方法有三种可能的模式：用于检测持续性心房颤动并停止的第一种模式; 用于检测心脏周期并在其已经开始收缩之后向心房递送刺激以抑制心房颤动发生的第二模式; 以及第三种模式，其以定时序列将起搏脉搏应用于心房，以使起搏和收缩心房比天然速率更快地抢占心房颤动的开始。

6. 发明授权

US07776029B2 Microminiature infusion pump 有权
标题翻译：微型输液泵
公开(公告)号：US07776029B2
公开(公告)日：2010-08-17
申请号：US10057144
申请日：2002-01-24
申请人： Todd K Whitehurst , Kelly H McClure , James P McGivern
发明人： Todd K Whitehurst , Kelly H McClure , James P McGivern
IPC分类号： A61K9/22
CPC分类号： A61M5/14276 , A61M5/14224 , A61M5/14228 , A61M2005/14208 , A61M2205/0244 , A61M2205/054 , A61M2205/3523 , A61N1/32 , A61N1/36071
摘要： An implantable microminiature infusion device includes a reservoir for holding a therapeutic fluid or other substance and a driver, e.g., a pump, that delivers the therapeutic fluid or substance to a patient within whom the device is implanted. The device further includes at least two electrodes coupled to pulse generation circuitry, thereby allowing therapeutic electrical stimulation to also be delivered to the patient.
摘要翻译：植入式微型灌注装置包括用于保持治疗流体或其他物质的储存器以及将治疗流体或物质输送到装置内的患者的驱动器，例如泵。该装置还包括耦合到脉冲发生电路的至少两个电极，从而允许治疗性电刺激也被递送给患者。

7. 发明授权

US07151961B1 Treatment of movement disorders by brain stimulation 有权
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US07151961B1
公开(公告)日：2006-12-19
申请号：US10428744
申请日：2003-05-02
申请人： Todd K Whitehurst , James P McGivern , Kelly H McClure
发明人： Todd K Whitehurst , James P McGivern , Kelly H McClure
IPC分类号： A61N1/00 , A61K9/22 , A61M31/00
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Introducing one or more stimulating drugs to the brain and/or applying electrical stimulation to the brain is used to treat movement disorders. At least one implantable system control unit (SCU) produces electrical pulses delivered via electrodes implanted in the brain and/or drug infusion pulses delivered via a catheter implanted in the brain. The stimulation is delivered to targeted brain structures to adjust the activity of those structures. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.
摘要翻译：将一种或多种刺激性药物引入脑中和/或对脑施加电刺激来用于治疗运动障碍。至少一个可植入系统控制单元（SCU）产生通过植入在脑中的电极传送的电脉冲和/或通过植入在脑中的导管递送的药物输注脉冲。刺激被传递到目标脑结构以调节这些结构的活性。在一些实施例中，使用一个或多个感测到的条件来调整刺激参数。

8. 发明授权

US07110823B2 RF telemetry link for establishment and maintenance of communications with an implantable device 有权
公开(公告)号：US07110823B2
公开(公告)日：2006-09-19
申请号：US10447336
申请日：2003-05-29
申请人： Todd K Whitehurst , Kelly H McClure , Salomo S Murtonen
发明人： Todd K Whitehurst , Kelly H McClure , Salomo S Murtonen
IPC分类号： A61N1/00
CPC分类号： A61N1/372
摘要： Communication between an implantable device(s), such as a neural stimulator, and an external remote device(s), e.g., a computer in a clinician's office, a computer in a patient's home, or a handheld patient remote control, is performed entirely via an RF link. In order to conserve power, the RF telemetry system of the implant is only activated periodically; with the period of activation being sufficiently short so as to allow a reasonably prompt response of the implant to a request for a communication session by the external device. In order to assure reliable communication, the RF information may be encoded, as appropriate, with error correction codes.

9. 发明授权

US07054692B1 Fixation device for implantable microdevices 有权
标题翻译：可植入微型装置的固定装置
公开(公告)号：US07054692B1
公开(公告)日：2006-05-30
申请号：US10146332
申请日：2002-05-15
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/37205 , A61N1/3756
摘要： A fixation device fixes the position of an implantable microminiature device residing proximally to a target site such as a nerve or a muscle. In one embodiment, the device comprises a sheath and a means for attaching the device to adjacent tissue. The means for attaching may be any one of several embodiments including one or more grasping members, a combination of grasping members and one or more helices, or an extension adapted to accept a suture. In another embodiment, the fixation device comprises an assembly residing in the implantation pathway, behind the stimulation device, thus preventing retreat of the stimulation device in the pathway. In a preferred use, the fixation device fixes the position of a microstimulator component of a Peripheral Nerve Stimulation (PNS) system.
摘要翻译：固定装置将位于近端的可植入微型装置的位置固定到诸如神经或肌肉的目标部位。在一个实施例中，该装置包括护套和用于将该装置附接到相邻组织的装置。用于附接的装置可以是包括一个或多个抓握构件，抓握构件和一个或多个螺旋的组合的几个实施例中的任一个或适于接纳缝合线的延伸部。在另一个实施例中，固定装置包括驻留在植入通路中的组件，位于刺激装置后面，从而防止刺激装置在路径中的后退。在优选的使用中，固定装置固定外围神经刺激（PNS）系统的微型激励器部件的位置。

10. 发明授权

US07167751B1 Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation 有权
标题翻译：使用完全可植入的微型神经刺激器进行迷走神经刺激的方法
公开(公告)号：US07167751B1
公开(公告)日：2007-01-23
申请号：US10993989
申请日：2004-11-19
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/08
CPC分类号： A61N1/3605 , A61N1/36082 , A61N1/36114 , A61N1/37205
摘要： A method of using a small implantable stimulator(s) with at least two electrodes small enough to have the electrodes located adjacent to the vagus nerve. The small stimulator provides a means of stimulating the vagus nerve when desired, and may be implanted via a minimal surgical procedure.
摘要翻译：使用具有足够小的至少两个电极的小型可植入刺激器的方法，以使电极位于与迷走神经相邻的位置。小刺激器在需要时提供刺激迷走神经的手段，并且可以通过最小的外科手术植入。

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