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1. 发明授权

US07860570B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 有权
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US07860570B2
公开(公告)日：2010-12-28
申请号：US10178010
申请日：2002-06-20
申请人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
发明人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
IPC分类号： A61N1/375
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

2. 发明授权

US07319906B2 Cochlear implant electrode and method of making same 有权
标题翻译：人工耳蜗植入电极及其制作方法
公开(公告)号：US07319906B2
公开(公告)日：2008-01-15
申请号：US10857389
申请日：2004-05-28
申请人： Janusz A Kuzma , Lani A Smith , Chuladatta Thenawara
发明人： Janusz A Kuzma , Lani A Smith , Chuladatta Thenawara
IPC分类号： A61N1/00
CPC分类号： A61N1/0541 , A61N1/36036 , Y10T29/49117
摘要： A cochlear stimulation lead and method of making an aggressively curved electrode array are provided. In one embodiment of the lead, while the curved section of the lead is curled further beyond the originally molded curvature and held in this position, a filling channel is filled up with a filling material that is hardened or cured in this held position. The resulting lead has a tip curvature that is more curved than the originally molded curvature.
摘要翻译：提供了一种人工耳蜗刺激引线和制造积极弯曲的电极阵列的方法。在引线的一个实施例中，当引线的弯曲部分被卷曲进一步超出原始模制曲率并保持在该位置时，填充通道填充有在该保持位置被硬化或固化的填充材料。所得到的引线具有比最初模制曲率更弯曲的尖端曲率。

3. 发明授权

US08224459B1 Insertion tool for paddle-style electrode 有权
标题翻译：桨式电极插入工具
公开(公告)号：US08224459B1
公开(公告)日：2012-07-17
申请号：US11117814
申请日：2005-04-29
申请人： Anne M Pianca , Janusz A Kuzma , Chuladatta Thenuwara
发明人： Anne M Pianca , Janusz A Kuzma , Chuladatta Thenuwara
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： The present disclosure describes various embodiments of an insertion tool that affords steerability of the paddle-style electrode during implantation without causing damage to the insulation and/or the contacts of the paddle-style electrode. One embodiment is described as having a “pin fork” configuration; another a “shovel” configuration; and yet another has tabs or a lumen on the paddle-style electrode for facilitating the insertion of a stylet. The various embodiments for the insertion tool allow for adjustments of the paddle-style electrode in both the medial/lateral and inferior/superior directions allowing the surgeon to steer the paddle-style electrode to the desired stimulation site within the epidural space of the spinal column.
摘要翻译：本公开描述了插入工具的各种实施例，其在植入期间提供桨式电极的可操纵性，而不会损坏桨式电极的绝缘体和/或触点。一个实施例被描述为具有“销叉”配置; 另一个“铲”配置; 并且另一个在桨式电极上具有翼片或腔，以便于插入探针。用于插入工具的各种实施例允许在内侧/外侧和下/上方向上调整桨式电极，从而允许外科医生将桨式电极转向脊柱硬膜外腔内的期望的刺激部位。

4. 发明授权

US07891085B1 Electrode array assembly and method of making same 有权
标题翻译：电极阵列组装及其制作方法
公开(公告)号：US07891085B1
公开(公告)日：2011-02-22
申请号：US11329907
申请日：2006-01-11
申请人： Janusz A Kuzma , Anne M Pianca
发明人： Janusz A Kuzma , Anne M Pianca
IPC分类号： H01R43/00 , A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553 , Y10T29/49117 , Y10T29/49204 , Y10T29/49208 , Y10T29/4922
摘要： A lead assembly and a method of making a lead are provided. The method of making a multi-contact lead assembly comprises providing conductive contacts located at an end of a lead body, disposing conductive wires in conductor lumens formed in the lead body, and connecting the conductive wires to the conductive contacts. The method further includes placing spacers between pairs of conductive contacts and inserting monofilament in at least a portion of at least one of the conductor lumens not occupied by the conductor wires. The method also includes reflowing at least one of the spacers or monofilament into at least one portion of at least one of the conductor lumens by heating the spacers and monofilament to a temperature to cause thermal flow or melting of at least one of the spacers or monofilament.
摘要翻译：提供引线组件和引线的方法。制造多接触导线组件的方法包括提供位于引线体的端部处的导电触点，将导线布置在形成在引线主体中的导体腔中，以及将导线连接到导电触头。该方法还包括将隔离物置于成对的导电触点之间，并将单丝插入到未被导线占据的导体流明中的至少一个的至少一部分上。该方法还包括通过将间隔物和单丝加热到使得至少一个间隔物或单丝的热流动或熔化的温度，将间隔物或单丝中的至少一个回流到至少一个导体内腔的至少一部分中。

5. 发明授权

US07174218B1 Lead extension system for use with a microstimulator 有权
标题翻译：引导延伸系统，用于微型激励器
公开(公告)号：US07174218B1
公开(公告)日：2007-02-06
申请号：US10915979
申请日：2004-08-11
申请人： Janusz A Kuzma
发明人： Janusz A Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/372 , A61N1/0556 , A61N1/37205 , A61N1/3752 , A61N1/3756 , Y10S439/909
摘要： An adapter system is provided for adapting and connecting a leadless microstimulator to a separate monopolar, bipolar, or tripolar electrode. Advantageously, the microstimulator does not need to be physically modified. The adapter system encloses the microstimulator and electrically connects the microstimulator to the selected, separate electrode via an extension lead or leads. The adapter has two forms: a monopolar adapter having a single opening or a bipolar adapter having two openings. The separate electrode is equipped with at least one extension lead having a connector that can be inserted into the opening of the monopolar adapter or the bipolar adapter and connect to the microstimulator that is placed within the monopolar or bipolar adapter.
摘要翻译：提供适配器系统，用于将无引线微型激励器适配并连接到单独的单极，双极或三极电极。有利地，微型激励器不需要进行物理修改。适配器系统封闭微型激励器，并通过延长引线或引线将微型激励器电连接到选定的独立电极。适配器具有两种形式：具有单个开口的单极适配器或具有两个开口的双极适配器。单独的电极配备有至少一个延伸引线，其具有可以插入单极适配器或双极适配器的开口中的连接器，并且连接到放置在单极或双极适配器内的微型激励器。

6. 发明授权

US07047081B2 Band type multicontact electrode and method of making the same 有权
公开(公告)号：US07047081B2
公开(公告)日：2006-05-16
申请号：US10600381
申请日：2003-06-20
申请人： Janusz A Kuzma
发明人： Janusz A Kuzma
IPC分类号： A61N1/04
CPC分类号： A61N1/0529 , A61N1/0551 , B29C33/126 , B29L2031/753
摘要： A multicontact electrode array suitable for implantation in living tissue includes a distal end having multiple spaced-apart ring or band electrode contacts carried on a flexible tube carrier. Each ring electrode contact is laser welded to a respective wire tip that has a multi-helix orientation on the inside of a separation tube. The center of the multi-helix wire defines a lumen wherein a positioning stylet, or other suitable positioning tool, may be removably inserted when the electrode array is implanted. The method of making the multicontact electrode array includes, as an initial step, winding lead wires around a suitable mandrel so as to form a multi-helix configuration. (Alternatively, the wire may be purchased in a multiwire pre-wound configuration that defines a lumen, in which case the mandrel is slipped inside the lumen.) Then, at a distal end of the electrode, each wire within the multi-helix winding is unwound so as to protrude out from the winding. Next, a non-conductive separation silicone tube which has a longitudinal slit along its length, is placed around the wound wires. Ring contacts are then placed over the silicone tube at a distal end of the electrode array and spaced apart as desired. These ring contacts also have a slit therein through which the protruding wire ends may exit. The silicone tube is used as a spacer to centrally locate the multi-helix wound wires with the ring contacts. A compressive die may be used to hold the pre-assembled ring contact, multi-helix wire, separation tube in their desired positions, and may be used to close the opening or slit of each ring contact through which the wire tips protrude. The wire tips are then individually trimmed to a suitable distance. A laser welding process may then be used to bond each lead wire to a corresponding ring contact. Finally, the preassembled electrode array is placed in a molding die, and a polymer filler is injected into the internal gaps of the electrode array components.

7. 发明授权

US08019439B2 Lead assembly and method of making same 有权
标题翻译：导线组装及其制作方法
公开(公告)号：US08019439B2
公开(公告)日：2011-09-13
申请号：US11689918
申请日：2007-03-22
申请人： Janusz A Kuzma , Anne M Pianca , Jeryle L Walter , Milad Girgis
发明人： Janusz A Kuzma , Anne M Pianca , Jeryle L Walter , Milad Girgis
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553
摘要： A lead assembly and a method of making a lead are provided. The lead comprises a terminal, proximal end having a plurality of terminal contacts and material separating the terminal contacts. In one embodiment of the lead, the terminal contacts are separated by a preformed spacer, that may be made from various hard materials such as polyurethane, PEEK and polysulfone. Epoxy may be used to fill spaces at the proximal lead end, including between the spacer and terminal contacts. In one embodiment of the lead, the terminal contacts are separated by epoxy only. The lead may include a plurality of conductor lumens that contain conductors. The lead may also include a stylet lumen for accepting a stylet.
摘要翻译：提供引线组件和引线的方法。引线包括端子，近端具有多个端子触头和分离端子触头的材料。在引线的一个实施例中，端子触点由预先形成的间隔物隔开，预定间隔件可以由各种硬质材料如聚氨酯，PEEK和聚砜制成。环氧树脂可以用于填充近端引线端的空间，包括间隔物和端子触点之间的空间。在引线的一个实施例中，端子触点仅由环氧树脂分离。引线可以包括包含导体的多个导体流明。引线还可以包括用于接受探针的探针管腔。

8. 发明授权

US07949412B1 Coated electrode array having uncoated electrode contacts 有权
标题翻译：具有未涂覆电极接触的涂覆电极阵列
公开(公告)号：US07949412B1
公开(公告)日：2011-05-24
申请号：US11421742
申请日：2006-06-01
申请人： William Vanbrooks Harrison , Michael S Colvin , Janusz A Kuzma , Thomas J Balkany
发明人： William Vanbrooks Harrison , Michael S Colvin , Janusz A Kuzma , Thomas J Balkany
IPC分类号： A61N1/372
CPC分类号： A61N1/0541 , A61N1/0551 , A61N1/0558
摘要： Implantable electrode leads, e.g. cochlear, spinal cord stimulation, or any type of neurostimulation leads, used in a patient's body to stimulate muscle or nerve tissue, provide enhanced stimulation for treating, e.g., hearing loss or chronic pain. One such lead includes, an implantable electrode array, adapted for insertion into a cochlea, which lead provides improved stability of electrode contact direction. In-line electrodes are spaced-apart along one side of a flexible carrier having non-conductive bumps coated with a bioresorbable material spaced apart between each electrode contact. Over time the bioresorbable material is absorbed thereby reducing chronic placement pressure caused during the insertion of the electrode array into the cochlea. The bioresorbable material may also serve as a carrier for drugs or other materials that would improve performance of the electrode for any type of lead.
摘要翻译：可植入电极引线，例如用于患者身体刺激肌肉或神经组织的耳蜗，脊髓刺激或任何类型的神经刺激引线，提供治疗，例如听力损失或慢性疼痛的增强刺激。一个这样的引线包括适于插入耳蜗的可植入电极阵列，该引线提供改善的电极接触方向的稳定性。在线电极沿柔性载体的一侧间隔开，所述柔性载体具有涂覆有在每个电极接触之间间隔开的生物可再吸收材料的非导电凸块。随着时间的推移，生物可吸收材料被吸收，从而减少在将电极阵列插入耳蜗期间引起的慢性放置压力。生物可再吸收材料还可以用作药物或其他材料的载体，这些材料将改善任何类型铅的电极的性能。

9. 发明授权

US07949395B2 Implantable microdevice with extended lead and remote electrode 有权
标题翻译：具有延长引线和远程电极的可植入微型设备
公开(公告)号：US07949395B2
公开(公告)日：2011-05-24
申请号：US10353101
申请日：2003-01-27
申请人： Janusz A Kuzma
发明人： Janusz A Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/37205
摘要： An implantable microdevice includes at least one electrode detachably connected to electronic circuitry housed in an hermetically-sealed micro housing. The micro housing has a length no more than about 10 mm. In one embodiment, the electrode is located at a distal end of an electrode lead, and a proximal end of the electrode lead is removably inserted into a connector that forms part of the micro housing.
摘要翻译：可植入微型装置包括至少一个可拆卸地连接到容纳在密封的微型壳体中的电子电路的电极。微型外壳的长度不得超过约10mm。在一个实施例中，电极位于电极引线的远端，并且电极引线的近端可移除地插入形成微型外壳的一部分的连接器中。

10. 发明授权

US07343205B1 System and method for insertion of a device into the brain 失效
标题翻译：将装置插入大脑的系统和方法
公开(公告)号：US07343205B1
公开(公告)日：2008-03-11
申请号：US10642851
申请日：2003-08-18
申请人： Anne M Pianca , Janusz A Kuzma
发明人： Anne M Pianca , Janusz A Kuzma
IPC分类号： A61N1/18
CPC分类号： A61N1/0534 , A61B90/11 , A61N1/0539
摘要： A deep brain stimulation lead system has a medical lead, or similar elongate medical insertion device, securable with a lead lock through a cannula slit, thereby allowing a lead to remain electrically operative and preventing movement of the lead during removal of a stylet, recording microelectrode, or cannula.
摘要翻译：深脑刺激引导系统具有医疗引线或类似的细长医疗插入装置，其通过插管狭缝具有引线锁定，从而允许引线保持电动操作并防止引线在移除探针时移动，记录微电极，或套管。

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