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1. 发明授权

US07860570B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 有权
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US07860570B2
公开(公告)日：2010-12-28
申请号：US10178010
申请日：2002-06-20
申请人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
发明人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
IPC分类号： A61N1/375
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

2. 发明授权

US07292890B2 Vagus nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：迷走神经刺激通过动作电位的单向传播
公开(公告)号：US07292890B2
公开(公告)日：2007-11-06
申请号：US10176722
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/08 , A61N1/36071 , Y10S128/903
摘要： Methods of stimulating a vagus nerve include providing at least one implantable stimulator with at least two electrodes, configuring the electrodes to apply stimulation that unidirectionally propagates action potentials along a vagus nerve, and applying the stimulation to the vagus nerve to effectively select afferent fibers, thereby treating at least one of epilepsy and depression while limiting side effects of bidirectional stimulation. At least one of the electrodes comprises a leadsless electrode.
摘要翻译：刺激迷走神经的方法包括提供至少一个可植入的刺激器，其具有至少两个电极，构造电极以施加沿着迷走神经单向传播动作电位的刺激，并将刺激应用于迷走神经以有效地选择传入纤维，从而治疗癫痫和抑郁症中的至少一种，同时限制双向刺激的副作用。至少一个电极包括无引线电极。

3. 发明授权

US07203548B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US07203548B2
公开(公告)日：2007-04-10
申请号：US10176743
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

4. 发明授权

US07103408B2 Electrode assembly for a microstimulator 有权
标题翻译：用于微型激励器的电极组件
公开(公告)号：US07103408B2
公开(公告)日：2006-09-05
申请号：US10691201
申请日：2003-10-22
申请人： Matthew I Haller , Tom Xiaohai He , Jay Daulton
发明人： Matthew I Haller , Tom Xiaohai He , Jay Daulton
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An electrode assembly includes an electrode electrically connected to a capacitor with a wire. A method of assembly for attaching a wire to a capacitor and an electrode may include an assembly carrier for housing and securing the wire, capacitor, and electrode during assembly.
摘要翻译：电极组件包括电连接到具有导线的电容器的电极。用于将导线附接到电容器和电极的组装方法可以包括用于在组装期间容纳和固定线，电容器和电极的组件载体。

5. 发明授权

US08352046B1 Sound processing assembly for use in a cochlear implant system 有权
公开(公告)号：US08352046B1
公开(公告)日：2013-01-08
申请号：US12697028
申请日：2010-01-29
申请人： Matthew I Haller , Patrick T. Wong , Tracey Kruger , Lee F Hartley
发明人： Matthew I Haller , Patrick T. Wong , Tracey Kruger , Lee F Hartley
IPC分类号： A61N1/18
CPC分类号： A61N1/36032 , A61N1/36036 , H04R25/552 , H04R25/554 , H04R25/558
摘要： An exemplary cochlear implant system includes a sound processing assembly configured to be external to a patient and first and second extension members coupled to the sound processing assembly. The sound processing assembly includes a sound processing unit configured to process an audio signal and transmit one or more control parameters based on the audio signal to an implantable cochlear stimulator and a battery module configured to be electrically coupled to the sound processing unit and provide operating power to the sound processing unit. The first extension member has a distal portion configured to be coupled to a first ear of the patient and the second extension member has a distal portion configured to be coupled to a second ear of the patient. The first and second extension members typically extend back from the ears, thus positioning the sound processing assembly behind the patient's head.

6. 发明授权

US07904171B2 Voltage converter for implantable microstimulator using RF-powering coil 有权
标题翻译：使用RF供电线圈的可植入微型激励器的电压转换器
公开(公告)号：US07904171B2
公开(公告)日：2011-03-08
申请号：US12099474
申请日：2008-04-08
申请人： Jordi Parramon , Matthew I Haller
发明人： Jordi Parramon , Matthew I Haller
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/37205 , A61N1/3787
摘要： A combination, voltage converter circuit for use within an implantable device, such as a microstimulator, uses a coil, instead of capacitors, to provide a voltage step up and step down conversion functions. The output voltage is controlled, or adjusted, through duty-cycle modulation. In accordance with one aspect of the invention, applicable to implantable devices having an existing RF coil through which primary or charging power is provided, the existing RF coil is used in a time-multiplexing scheme to provide both the receipt of the RF signal and the voltage conversion function. This minimizes the number of components needed within the device, and thus allows the device to be packaged in a smaller housing or frees up additional space within an existing housing for other circuit components. In accordance with another aspect of the invention, the voltage up/down converter circuit is controlled by a pulse width modulation (PWM) low power control circuit. Such operation allows high efficiencies over a wide range of output voltages and current loads.
摘要翻译：在可植入装置（例如微型激励器）内使用的组合电压转换器电路使用线圈代替电容器来提供升压和降压转换功能。通过占空比调制来控制或调节输出电压。根据本发明的一个方面，可应用于具有通过其提供初级或充电功率的现有RF线圈的可植入装置，现有的RF线圈用于时间复用方案以提供RF信号的接收和电压转换功能。这使得器件中所需的部件的数量最小化，并因此允许将器件封装在较小的外壳中，或释放现有外壳内用于其他电路元件的额外空间。根据本发明的另一方面，电压上/下变频器电路由脉宽调制（PWM）低功率控制电路控制。这种操作允许在宽范围的输出电压和电流负载下实现高效率。

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