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1. 发明授权

US10274479B2 Method for sperm motility evaluation and screening and its microfluidic device 有权
公开(公告)号：US10274479B2
公开(公告)日：2019-04-30
申请号：US14117597
申请日：2012-06-01
申请人： Tian Qiu , Rui Ma , Chao Han , Lan Xie , Jing Cheng
发明人： Tian Qiu , Rui Ma , Chao Han , Lan Xie , Jing Cheng
IPC分类号： B01L3/00 , A61B17/43 , G01N33/50
摘要： The present invention provides a microfluidic device and its use for cell motility classification. The microfluidic device comprises a fluid inlet, a sample inlet and a channel connecting the fluid inlet and the sample inlet, wherein the channel comprises at least two sections of different sizes, and the channel allows fluid flow from the fluid inlet to the sample inlet.

2. 发明申请

US20140199720A1 METHOD FOR SPERM MOTILITY EVALUATION AND SCREENING AND ITS MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于动力学评估和筛选的方法及其微流体装置
公开(公告)号：US20140199720A1
公开(公告)日：2014-07-17
申请号：US14117597
申请日：2012-06-01
申请人： Tian Qiu , Rui Ma , Chao Han , Lan Xie , Jing Cheng
发明人： Tian Qiu , Rui Ma , Chao Han , Lan Xie , Jing Cheng
IPC分类号： G01N33/50 , A61B17/43
CPC分类号： G01N33/5005 , A61B17/43 , B01L3/502746 , B01L3/502761 , B01L2200/0652 , B01L2300/0825
摘要： The present invention provides a microfluidic device and its use for cell motility classification. The microfluidic device comprises a fluid inlet, a sample inlet and a channel connecting the fluid inlet and the sample inlet, wherein the channel comprises at least two sections of different sizes, and the channel allows fluid flow from the fluid inlet to the sample inlet.
摘要翻译：本发明提供一种微流体装置及其在细胞运动性分类中的应用。微流体装置包括流体入口，样品入口和连接流体入口和样品入口的通道，其中通道包括至少两个不同尺寸的区段，并且通道允许流体从流体入口流到样品入口。

3. 发明授权

US09511366B2 Microfluidic device and its use for positioning of cells or organisms 有权
标题翻译：微流体装置及其用于定位细胞或生物体的用途
公开(公告)号：US09511366B2
公开(公告)日：2016-12-06
申请号：US13991848
申请日：2012-01-13
申请人： Rui Ma , Lan Xie , Tian Qiu , Lei Wang , Wanli Xing , Jing Cheng
发明人： Rui Ma , Lan Xie , Tian Qiu , Lei Wang , Wanli Xing , Jing Cheng
IPC分类号： B01L3/00 , C12M3/00 , C12M1/32 , C12M3/06
CPC分类号： B01L3/5027 , C12M21/06 , C12M23/12 , C12M23/16
摘要： A micro fluidic device comprises one microstructure layer (5) and one cover layer (1), wherein the cover layer (1) is connected to the microstructure layer (5). The microstructure layer (5) comprises one bottom layer and a plurality of microstructures on it to position samples. The cover layer (1) comprises one top layer, one positioning well (6) and at least one inlet pool (4). The positioning well (6) is right above the microstructures and connected with each other. The inlet pools (4) and the positioning well (6) are connected by microchannels (3) which are formed between the microstructure layer (5) and the cover layer (1). The micro fluidic device can be applied in vitro fertilization, in determining how glial cells affect neurons, in constructing neural network and in detecting cell growth conditions.
摘要翻译：微流体装置包括一个微结构层（5）和一个覆盖层（1），其中覆盖层（1）连接到微结构层（5）。微结构层（5）包括一个底层和多个微结构，用于定位样品。覆盖层（1）包括一个顶层，一个定位孔（6）和至少一个入口池（4）。定位井（6）位于微结构的正上方并相互连接。入口池（4）和定位井（6）通过形成在微结构层（5）和覆盖层（1）之间的微通道（3）连接。微流体装置可以应用于体外受精，确定神经胶质细胞如何影响神经元，构建神经网络和检测细胞生长条件。

4. 发明申请

US20130244270A1 MICROFLUIDIC DEVICE FOR CELL MOTILITY SCREENING AND CHEMOTAXIS TESTING 审中-公开
标题翻译：用于细胞动力学筛选和化学检测的微流体装置
公开(公告)号：US20130244270A1
公开(公告)日：2013-09-19
申请号：US13814426
申请日：2011-08-10
申请人： Lan Xie , Rui Ma , Chao Han , Wanli Xing , Jing Cheng
发明人： Lan Xie , Rui Ma , Chao Han , Wanli Xing , Jing Cheng
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , B01L3/5027 , B01L2300/0816 , B01L2300/0864 , G01N33/5029
摘要： The present invention relates to a microfluidic device used for cell motility screening and chemotaxis testing which comprises microfluidic channels and chambers. Cells which can secret a chemoattractant or chemorepellent are selectively planted in the microfluidic device and a stable chemoattractant or chemorepellent gradient can be established in the channels.
摘要翻译：本发明涉及用于细胞运动筛选和趋化性测试的微流体装置，其包括微流体通道和腔室。可以将化学引诱物或化学引诱物分泌的细胞选择性地种植在微流体装置中，并且可以在通道中建立稳定的化学引诱物或化学增益梯度。

5. 发明授权

US09445840B2 Integrated microfluidic device for single oocyte trapping 有权
标题翻译：用于单卵母细胞捕获的集成微流体装置
公开(公告)号：US09445840B2
公开(公告)日：2016-09-20
申请号：US13805322
申请日：2011-06-17
申请人： Chao Han , Guoliang Huang , Jing Cheng
发明人： Chao Han , Guoliang Huang , Jing Cheng
IPC分类号： A61B17/43 , A61B17/435 , B01L3/00 , C12M3/00 , C12M3/06 , C12M1/00
CPC分类号： A61B17/43 , A61B17/435 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2300/0851 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M47/04
摘要： An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.
摘要翻译：提供集成的微流体装置及其用途。微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。

6. 发明申请

US20130204076A1 INTEGRATED MICROFLUIDIC DEVICE FOR SINGLE OOCYTE TRAPPING 有权
标题翻译：综合微流体装置，用于单个OOCYTE TRAPPING
公开(公告)号：US20130204076A1
公开(公告)日：2013-08-08
申请号：US13805322
申请日：2011-06-17
申请人： Chao Han , Guoliang Huang , Jing Cheng
发明人： Chao Han , Guoliang Huang , Jing Cheng
IPC分类号： A61B17/43
CPC分类号： A61B17/43 , A61B17/435 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2300/0851 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M47/04
摘要： An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.
摘要翻译：提供集成的微流体装置及其用途。微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。

7. 发明授权

US09512001B2 Fluorescent magnetic nanoparticles and process of preparation 有权
标题翻译：荧光磁性纳米颗粒及其制备方法
公开(公告)号：US09512001B2
公开(公告)日：2016-12-06
申请号：US12970688
申请日：2010-12-16
申请人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
发明人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
IPC分类号： G01N33/543 , B82Y15/00 , G01N33/58
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

8. 发明授权

US08784633B2 Automatic positioning and sensing microelectrode arrays 有权
标题翻译：自动定位和感应微电极阵列
公开(公告)号：US08784633B2
公开(公告)日：2014-07-22
申请号：US12667507
申请日：2007-07-04
申请人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
发明人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/4836 , B01J2219/00653 , B01J2219/00743 , B01L3/502707 , B01L2300/0645 , B01L2400/0421 , B01L2400/0424
摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.
摘要翻译：微电极感测装置包括基板和微电极传感器阵列。每个传感器包括至少部分地导电的第一导电层。第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。每个传感器还包括至少部分地传导电的第二导电层。第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

9. 发明申请

US20120202872A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND PROGNOSIS OF CERVICAL INTRAEPITHELIAL NEOPLASIA AND CERVICAL CANCER 有权
标题翻译：宫颈内膜和宫颈癌的诊断和预防的方法和组合
公开(公告)号：US20120202872A1
公开(公告)日：2012-08-09
申请号：US13389428
申请日：2010-08-06
申请人： Wenyan Qin , Peng Dong , Tuo Deng , Cailing Ma , Keith Richard Mitchelson , Hao Wen , Jing Cheng
发明人： Wenyan Qin , Peng Dong , Tuo Deng , Cailing Ma , Keith Richard Mitchelson , Hao Wen , Jing Cheng
IPC分类号： A61K31/713 , C07H21/02 , G01N33/53 , C40B40/06 , C40B30/04 , C12Q1/68 , C07H21/04 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The invention provides methods and compositions for the diagnosis and prognosis of cervical intraepithelial neoplasia and cervical cancer. The methods comprise the step of determining the expression levels or genetic status of specific miRNAs.
摘要翻译：本发明提供了用于宫颈上皮内瘤变和子宫颈癌的诊断和预后的方法和组合物。该方法包括确定特异性miRNA的表达水平或遗传状态的步骤。

10. 发明授权

US08003063B2 Microfluidic devices and methods for multiple analyte detection 有权
标题翻译：用于多分析物检测的微流体装置和方法
公开(公告)号：US08003063B2
公开(公告)日：2011-08-23
申请号：US12516999
申请日：2007-03-09
申请人： Xiaosheng Guan , Min Guo , Rong Zhang , Dong Dong , Yuming Hu , Ting Cui , Jing Cheng
发明人： Xiaosheng Guan , Min Guo , Rong Zhang , Dong Dong , Yuming Hu , Ting Cui , Jing Cheng
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/50273 , B01L7/52 , B01L2200/0605 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , G01N35/08 , G01N35/10 , G01N2035/00356 , G01N2035/1032 , G01N2035/1034 , Y10T137/0396 , Y10T436/2575
摘要： The invention is directed to microfluidic devices comprising at least two processing channels, wherein each of the processing channels comprises an inlet, an outlet, and a high-flow-resistant and hydrophilic conduit; a distributing channel, wherein the distributing channel comprises an upstream end and a downstream end, and is in fluid communication with each inlet of the processing channels via the high-flow-resistant and hydrophilic conduit; and a flushing channel, wherein the flushing channel comprises an upstream end and a downstream end, and is in fluid communication with each outlet of the processing channels. The invention also provides methods of using the microfluidic devices.
摘要翻译：本发明涉及包括至少两个处理通道的微流体装置，其中每个处理通道包括入口，出口和高流阻和亲水导管; 分配通道，其中所述分配通道包括上游端和下游端，并且经由所述高阻流和亲水导管与所述处理通道的每个入口流体连通; 和冲洗通道，其中所述冲洗通道包括上游端和下游端，并且与所述处理通道的每个出口流体连通。本发明还提供使用微流体装置的方法。

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