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1. 发明授权

US5026905A Fluorescent dyes 失效
标题翻译：荧光染料
公开(公告)号：US5026905A
公开(公告)日：1991-06-25
申请号：US234361
申请日：1988-08-19
申请人： Thomas L. Tarnowski , Mae W. Hu , Maureen Laney , John S. Pease , Vartan Ghazarossian
发明人： Thomas L. Tarnowski , Mae W. Hu , Maureen Laney , John S. Pease , Vartan Ghazarossian
IPC分类号： G01N33/53 , C09B23/00 , C09B57/00 , G01N1/30 , G01N33/50 , G01N33/533 , G01N33/542 , G01N33/555 , G01N33/80
CPC分类号： G01N1/30 , C09B57/007 , G01N33/5094 , G01N33/533 , G01N33/542 , G01N33/555 , G01N33/80
摘要： The present invention describes a class of dyes for use in staining cell samples and methods of making such dyes. A preferred class of dyes known as detergent dyes which possess the ability to stain cells in whole blood and are only slowly leached or lost from the stained cells over time are described. The present invention has application, for example, to blood typing for the determination of the presence of blood group antigens A, B, AB, O, and D (Rh.sub.o) and antibodies to such antigens.
摘要翻译：本发明描述了一类用于染色细胞样品的染料和制备这种染料的方法。已知洗涤剂染料的一类优选的染料，其具有在全血中染色细胞并随时间缓慢浸出或从染色的细胞中丢失的能力。本发明例如可用于血型分析，用于确定血型抗原A，B，AB，O和D（Rho）的存在以及对这些抗原的抗体。

2. 发明授权

US5145774A Fluorescent dyes 失效
标题翻译：荧光染料
公开(公告)号：US5145774A
公开(公告)日：1992-09-08
申请号：US680635
申请日：1991-04-01
申请人： Thomas L. Tarnowski , Mae W. L. Hu , Maureen Laney , John S. Pease , Vartan Ghazarossian
发明人： Thomas L. Tarnowski , Mae W. L. Hu , Maureen Laney , John S. Pease , Vartan Ghazarossian
IPC分类号： C09B57/00 , C12N5/08 , G01N1/30 , G01N33/50 , G01N33/533 , G01N33/542 , G01N33/555 , G01N33/80
CPC分类号： G01N33/555 , C09B57/007 , G01N1/30 , G01N33/5094 , G01N33/533 , G01N33/542 , G01N33/80 , Y10S436/80
摘要： The present invention describes a class of dyes for use in staining cell samples and methods of making such dyes. A preferred class of dyes known as detergent dyes which possess the ability to stain cells in whole blood and are only slowly leached or lost from the stained cells over time are described. The present invention has application, for example, to blood typing for the determination of the presence of blood group antigens A, B, AB, O, and D (Rh.sub.o) and antibodies to such antigens.
摘要翻译：本发明描述了一类用于染色细胞样品的染料和制备这种染料的方法。已知洗涤剂染料的一类优选的染料，其具有在全血中染色细胞并随时间缓慢浸出或从染色的细胞中丢失的能力。本发明例如可用于血型分析，用于确定血型抗原A，B，AB，O和D（Rho）的存在以及对这些抗原的抗体。

3. 发明授权

US06417965B1 Optical amplifier control system 有权
标题翻译：光放大器控制系统
公开(公告)号：US06417965B1
公开(公告)日：2002-07-09
申请号：US09784086
申请日：2001-02-16
申请人： Jun Ye , John S. Pease , Michael J. Gassner
发明人： Jun Ye , John S. Pease , Michael J. Gassner
IPC分类号： H01S300
CPC分类号： H04B10/2942
摘要： An optical amplifier control system provides real-time control of an optical amplifier in response to an analog signal having a large dynamic range. The optical amplifier control system uses a non-linear analog-to-digital converter, such as a logarithmic-scale analog-to-digital converter to achieve low relative quantization error. The amplifier control system may also use multiple analog-to-digital converters.
摘要翻译：光放大器控制系统响应于具有大动态范围的模拟信号，提供光放大器的实时控制。光放大器控制系统使用诸如对数尺度模数转换器之类的非线性模数转换器来实现低相对量化误差。放大器控制系统也可以使用多个模数转换器。

4. 发明授权

US07365665B2 Photodiode digitizer with fast gain switching 失效
标题翻译：具有快速增益切换的光电二极管数字化仪
公开(公告)号：US07365665B2
公开(公告)日：2008-04-29
申请号：US11644518
申请日：2006-12-22
申请人： John S. Pease
发明人： John S. Pease
IPC分类号： H03M1/00
CPC分类号： H04B10/66
摘要： An optical receiver and method of operating therfor. A photodiode converts a received optical signal to an electrical signal, which is provided to both high gain and low gain signal paths. First analog-to-digital converter ADC) circuitry is coupled to convert a high gain output signal into a first plurality of digital signals, while second ADC circuitry converts a low gain output signal into a second plurality of digital signals. A control unit is configured to monitor the amplitude of at least one of the low gain and high gain output signals. If the amplitude of the monitored signal falls below a predetermined threshold, the control unit is configured to select data provided by the first ADC circuitry. Otherwise, data provided by the second ADC circuitry is selected.
摘要翻译：一种光接收机及其操作方法。光电二极管将接收到的光信号转换为提供给高增益和低增益信号路径的电信号。第一模数转换器ADC）电路被耦合以将高增益输出信号转换为第一多个数字信号，而第二ADC电路将低增益输出信号转换为第二多个数字信号。控制单元被配置为监视低增益和高增益输出信号中的至少一个的振幅。如果监视信号的振幅降到预定阈值以下，则控制单元被配置为选择由第一ADC电路提供的数据。否则，选择由第二ADC电路提供的数据。

5. 发明授权

US06406913B1 Assay method utilizing induced luminescence 失效
标题翻译：利用诱导发光的测定方法
公开(公告)号：US06406913B1
公开(公告)日：2002-06-18
申请号：US08471130
申请日：1995-06-06
申请人： Edwin F. Ullman , Hrair Kirakossian , John S. Pease , Yuri Daniloff , Daniel B. Wagner
发明人： Edwin F. Ullman , Hrair Kirakossian , John S. Pease , Yuri Daniloff , Daniel B. Wagner
IPC分类号： G01T1161
CPC分类号： C07D265/30 , C07D279/12 , C07D327/06 , G01N33/54313 , G01N33/5436 , G01N33/58 , G01N33/582 , G01N33/585 , G01N33/586 , Y10S435/81 , Y10S435/968 , Y10S435/971 , Y10S435/973 , Y10S435/975 , Y10S436/829
摘要： Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a photosensitizer and a chemiluminescent compound to come into close proximity. The photosensitizer generates singlet oxygen and activates the chemiluminescent compound when it is in close proximity. The activated chemiluminescent compound subsequently produces light. The amount of light produced is related to the amount of analyte in the medium. Preferably, at least one of the photosensitizer and chemiluminescent compound is associated with a surface which is usually a suspendible particle, and a specific binding pair member is bound thereto. Compositions and kits are also disclosed.
摘要翻译：公开了用于确定怀疑含有分析物的介质中的分析物的方法。一种方法包括在允许分析物（如果存在）使光敏剂和化学发光化合物接近的条件下处理疑似含有分析物的介质。光敏剂产生单线态氧并在化学发光化合物接近时激活化学发光化合物。活化的化学发光化合物随后产生光。所产生的光量与介质中分析物的量有关。优选地，光敏剂和化学发光化合物中的至少一种与通常是悬浮颗粒的表面相关联，并且特异性结合对成员结合到其上。还公开了组合物和试剂盒。

6. 发明授权

US5618732A Method of calibration with photoactivatable chemiluminescent matrices 失效
标题翻译：用光活化化学发光基质校准的方法
公开(公告)号：US5618732A
公开(公告)日：1997-04-08
申请号：US434617
申请日：1995-05-04
申请人： John S. Pease , Hrair Kirakossian , Daniel B. Wagner , Edwin F. Ullman
发明人： John S. Pease , Hrair Kirakossian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33/532 , G01N21/78 , G01N33/58 , G01N21/64 , G01N21/76
CPC分类号： G01N33/582 , Y10S435/81 , Y10S436/829 , Y10S436/905 , Y10T436/10
摘要： Methods for labeling a material are disclosed. The methods comprise combining with the material (a) a photosensitizer capable upon irradiation of generating singlet oxygen and (b) a chemiluminescent compound capable of being activated by singlet oxygen wherein the photosensitizer and the chemiluminescent compound are incorporated in a particulate matrix or a non-particulate solid matrix. The particulate matrix can be solid or fluid. The methods allow for generating delayed luminescence, which can be realized upon irradiation of the matrix. The methods have application to the determination of an analyte in a medium suspected of containing the analyte. One method comprises subjecting a medium suspected of containing an analyte to conditions under which a complex of specific binding pair (sbp) members is formed in relation to the presence of the analyte and determining whether the sbp member complex has formed by employing as a label a single composition having both chemiluminescent and photosensitizer properties. Upon activation of the photosensitizer property singlet oxygen is generated and activates the chemiluminescent property. Compositions and kits are also disclosed.
摘要翻译：公开了标记材料的方法。所述方法包括与材料（a）结合，所述光敏剂能够在产生单线态氧的照射时和（b）能够被单线态氧活化的化学发光化合物，其中光敏剂和化学发光化合物掺入颗粒基质或非均相中，颗粒状固体基质。颗粒基质可以是固体或流体。这些方法允许产生延迟发光，这可以在照射基质时实现。该方法可用于确定怀疑含有分析物的介质中的分析物。一种方法包括使怀疑含有分析物的培养基相对于分析物的存在形成特异性结合对（sbp）成员的复合物的条件，以及通过使用标记a来确定sbp成员复合物是否形成具有化学发光和光敏剂性质的单一组合物。激活光敏剂时，产生单线态氧并激活化学发光性能。还公开了组合物和试剂盒。

7. 发明授权

US06703248B1 Particles for diagnostic and therapeutic use 有权
公开(公告)号：US06703248B1
公开(公告)日：2004-03-09
申请号：US09465065
申请日：1999-12-15
申请人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
发明人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33553
CPC分类号： G01N33/587 , C12Q1/6816 , Y10T436/10 , C12Q2563/155 , C12Q2523/319
摘要： Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the intensity of light emission at any time during a 20-fold decrease in the intensity is proportional to the intensity of the light emission. In one embodiment the polymeric matrix is comprised of particles of about 20 nm to about 100 &mgr;m in diameter to which is bound a specific binding pair member. The particles generally comprise a polymeric matrix having dissolved therein about 1 to about 20% by weight of a dopant. The compositions may be used in methods for determining an analyte. A combination is provided comprising (1) a medium suspected of containing the analyte, (2) and the aforementioned composition. The photoactive substance is activated and the effect of the activating on the optical properties of the combination is detected. The presence and amount of the effect is related to the presence and amount of the analyte in the medium. Also disclosed are kits for use in an assay.

8. 发明授权

US5709994A Photoactivatable chemiluminescent matrices 失效
标题翻译：光活化化学发光基质
公开(公告)号：US5709994A
公开(公告)日：1998-01-20
申请号：US470862
申请日：1995-06-06
申请人： John S. Pease , Hrair Kirakossian , Daniel B. Wagner , Edwin F. Ullman
发明人： John S. Pease , Hrair Kirakossian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33/532 , G01N21/78 , G01N33/58 , G01N33/52 , C09K11/00 , C12Q1/00 , C12Q1/68
CPC分类号： G01N33/582 , Y10S435/81 , Y10S436/829 , Y10S436/905 , Y10T436/10
摘要： Methods for labeling a material are disclosed. The methods comprise combining with the material (a) a photosensitizer capable upon irradiation of generating singlet oxygen and (b) a chemiluminescent compound capable of being activated by singlet oxygen wherein the photosensitizer and the chemiluminescent compound are incorporated in a particulate matrix or a non-particulate solid matrix. The particulate matrix can be solid or fluid. The methods allow for generating delayed luminescence, which can be realized upon irradiation of the matrix. The methods have application to the determination of an analyte in a medium suspected of containing the analyte. One method comprises subjecting a medium suspected of containing an analyte to conditions under which a complex of specific binding pair (sbp) members is formed in relation to the presence of the analyte and determining whether the sbp member complex has formed by employing as a label a single composition having both chemiluminescent and photosensitizer properties. Upon activation of the photosensitizer property singlet oxygen is generated and activates the chemiluminescent property. Compositions and kits are also disclosed.
摘要翻译：公开了标记材料的方法。所述方法包括与材料（a）结合，所述光敏剂能够在产生单线态氧的照射时和（b）能够被单线态氧活化的化学发光化合物，其中光敏剂和化学发光化合物掺入颗粒基质或非均相中，颗粒状固体基质。颗粒基质可以是固体或流体。这些方法允许产生延迟发光，这可以在照射基质时实现。该方法可用于确定怀疑含有分析物的介质中的分析物。一种方法包括使怀疑含有分析物的培养基相对于分析物的存在形成特异性结合对（sbp）成员的复合物的条件，以及通过使用标记a来确定sbp成员复合物是否形成具有化学发光和光敏剂性质的单一组合物。激活光敏剂时，产生单线态氧并激活化学发光性能。还公开了组合物和试剂盒。

9. 发明授权

US5340716A Assay method utilizing photoactivated chemiluminescent label 失效
标题翻译：使用光活化化学发光标记的测定方法
公开(公告)号：US5340716A
公开(公告)日：1994-08-23
申请号：US718490
申请日：1991-06-20
申请人： Edwin F. Ullman , Hrair Kirakossian , John S. Pease , Yuri Daniloff , Daniel B. Wagner
发明人： Edwin F. Ullman , Hrair Kirakossian , John S. Pease , Yuri Daniloff , Daniel B. Wagner
IPC分类号： G01N33/569 , G01N33/58 , C12Q1/00
CPC分类号： G01N33/582 , G01N33/56977 , G01N33/58 , G01N33/585
摘要： Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) a medium suspected of containing the analyte, (2) a label reagent comprising a first specific binding pair (sbp) member associated with a photochemically activatable chemiluminescent compound wherein the first sbp member is capable of binding to the analyte or to a second sbp member to form a complex related to the presence of the analyte. The method further comprises photochemically activating the chemiluminescent compound. The amount of luminescence generated by the chemiluminescent compound is detected. The amount thereof is related to the amount of analyte in the medium. Compositions and kits are also disclosed.
摘要翻译：公开了用于确定怀疑含有分析物的介质中的分析物的方法。一种方法包括提供（1）怀疑含有分析物的培养基，（2）标记试剂，其包含与光化学活化的化学发光化合物相关的第一特异性结合对（sbp）成员，其中第一sbp成员能够结合分析物或第二sbp成员以形成与分析物的存在有关的复合物。该方法还包括光化学活化化学发光化合物。检测由化学发光化合物产生的发光量。其量与培养基中分析物的量有关。还公开了组合物和试剂盒。

10. 发明授权

US07709273B2 Particles for diagnostic and therapeutic use 有权
标题翻译：用于诊断和治疗用途的颗粒
公开(公告)号：US07709273B2
公开(公告)日：2010-05-04
申请号：US11273275
申请日：2005-11-14
申请人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
发明人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33/543 , G01N31/00
CPC分类号： G01N33/587 , C12Q1/6816 , Y10T436/10 , C12Q2563/155 , C12Q2523/319
摘要： Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the intensity of light emission at any time during a 20-fold decrease in the intensity is proportional to the intensity of the light emission. In one embodiment the polymeric matrix is comprised of particles of about 20 nm to about 100 μm in diameter to which is bound a specific binding pair member. The particles generally comprise a polymeric matrix having dissolved therein about 1 to about 20% by weight of a dopant. The compositions may be used in methods for determining an analyte. A combination is provided comprising (1) a medium suspected of containing the analyte, (2) and the aforementioned composition. The photoactive substance is activated and the effect of the activating on the optical properties of the combination is detected. The presence and amount of the effect is related to the presence and amount of the analyte in the medium. Also disclosed are kits for use in an assay.
摘要翻译：公开了方法，组合物和试剂盒。组合物是发光的并且包含其中溶解有光敏化合物的聚合物基质。该组合物具有以下特征：在光活性化合物活化后，强度降低20倍的任何时间的发光强度的降低率与发光强度成比例。在一个实施方案中，聚合物基质包含直径约20nm至约100μm的颗粒，其与特定结合对构件结合。颗粒通常包含其中溶解约1至约20重量％的掺杂剂的聚合物基质。该组合物可用于测定分析物的方法中。提供的组合包括（1）怀疑含有分析物的介质，（2）和上述组合物。光活性物质被激活，并且检测到激活对组合的光学性质的影响。影响的存在和数量与介质中分析物的存在和数量有关。还公开了用于测定的试剂盒。

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