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1. 发明授权

US06559440B2 Method for calibrating a radiation detection system 有权
公开(公告)号：US06559440B2
公开(公告)日：2003-05-06
申请号：US10027759
申请日：2001-12-21
申请人： Stephen T. Yarnall , Jerome E. Gormley
发明人： Stephen T. Yarnall , Jerome E. Gormley
IPC分类号： G01T1161
CPC分类号： G01T1/161 , A61B6/4258
摘要： An automatic and intuitive calibration method is provided for calibrating a radiation detection system for processing counts from a known radiation source. A probe is positioned near the radiation source, which may be the surgical injection site of a radionucleide. A control unit generates audible and/or visual feedback signals to cue the operator as to where to position the probe relative to the radiation source, in order to obtain a pulse frequency (count rate) in an optimal range for processing. The control unit then automatically identifies a peak energy level and sets an energy acceptance window having a mathematical relationship to the peak energy level, whereby the radiation detection system thereinafter processes only counts corresponding to energy levels falling within the energy acceptance window.

2. 发明授权

US06218669B1 Surgical probe apparatus 有权
标题翻译：手术探针仪
公开(公告)号：US06218669B1
公开(公告)日：2001-04-17
申请号：US09167420
申请日：1998-10-06
申请人： John D. Call
发明人： John D. Call
IPC分类号： G01T1161
CPC分类号： G01T1/161 , A61B6/4258
摘要： A surgical probe apparatus incorporates a probe structure with a handle component and forward crystal mount wherein a cadmium-telluride crystal is rigidly mounted against movement. A cup-shaped window assembly is provided having an internal cylindrical tungsten shield which extends forwardly from the front face of the crystal to define an air gap as well as to support an aluminum window. The window assembly is threadably mounted upon the handle at a transition region forming an outwardly extending ramp. This ramp is used in conjunction with a polymeric retainer component with legs containing dog structures which hold a cylindrical tungsten collimator in biased position against the window when attached.
摘要翻译：手术探针装置结合了具有手柄部件的探针结构和正向晶体安装座，其中刚性地安装碲化镉晶体以防止运动。提供了一种杯形窗组件，其具有从晶体的前表面向前延伸的内圆柱形钨屏蔽，以限定气隙以及支撑铝窗。窗组件在形成向外延伸的斜坡的过渡区域上螺纹安装在手柄上。该斜坡与聚合物保持器组件一起使用，其中腿部包含狗结构，当附着时将圆柱形准直器保持在偏置的位置。

3. 发明授权

US06583420B1 Device and system for improved imaging in nuclear medicine and mammography 有权
标题翻译：用于改善核医学和乳腺摄影术成像的装置和系统
公开(公告)号：US06583420B1
公开(公告)日：2003-06-24
申请号：US09590089
申请日：2000-06-07
申请人： Robert S. Nelson , William Bert Nelson
发明人： Robert S. Nelson , William Bert Nelson
IPC分类号： G01T1161
CPC分类号： A61B6/502 , A61B6/037 , A61B6/4028 , A61B6/4233 , A61B6/4258 , A61B6/4291 , A61B6/4488 , A61B6/548 , G01T1/1644 , G01T1/243 , G01T1/244 , G01T1/2928
摘要： A method and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for radiographic imaging, and nuclear medicine and x-ray mammography in particular, and material composition analysis are described. A detection system employs fixed or configurable arrays of one or more detector modules comprising detector arrays which may be electronically manipulated through a computer system. The detection system, by providing the ability for electronic manipulation, permits adaptive imaging. Detector array configurations include familiar geometries, including slit, slot, plane, open box, and ring configurations, and customized configurations, including wearable detector arrays, that are customized to the shape of the patient. Conventional, such as attenuating, rigid geometry, and unconventional collimators, such as x-ray optic, configurable, Conpton scatter modules, can be selectively employed with detector modules and radiation sources. The components of the imaging chain can be calibrated or corrected using processes of the invention. X-ray mammography and scintimammography are enhanced by utilizing sectional compression and related imaging techniques.
摘要翻译：描述了用于检测放射线成像的X射线，γ射线和粒子辐射以及核医学和X射线乳腺摄影的辐射的方法和装置，以及材料成分分析。检测系统采用一个或多个检测器模块的固定或可配置阵列，其包括可以通过计算机系统电子操作的检测器阵列。检测系统通过提供电子操纵的能力，允许自适应成像。检测器阵列配置包括熟悉的几何形状，包括狭缝，槽，平面，开箱和环形配置，以及根据患者形状定制的定制配置，包括可穿戴式检测器阵列。常规的，例如衰减的刚性几何形状和非常规准直器，例如x射线光学器件，可配置的康普顿散射模块，可以选择性地与检测器模块和辐射源一起使用。可以使用本发明的方法校准或校正成像链的部件。通过利用截面压缩和相关成像技术增强X射线乳腺摄影和闪烁扫描。

4. 发明授权

US06242744B1 Miniaturized gamma camera with very high spatial resolution 有权
标题翻译：具有非常高的空间分辨率的小型化伽马相机
公开(公告)号：US06242744B1
公开(公告)日：2001-06-05
申请号：US09202894
申请日：1998-12-22
申请人： Alessandro Soluri , Roberto Pani
发明人： Alessandro Soluri , Roberto Pani
IPC分类号： G01T1161
CPC分类号： G01T1/1642 , A61B6/4258 , G01T1/161
摘要： The miniaturized gamma camera has all specific functionalities of gamma cameras, with extremely high spatial resolution (about 1-2 mm) and dimensions of about 22 mm×22 mm of active area and total size of about 35 mm×35 mm, such as to fit in one of the surgeon's hands and to be handled with absolute ease.
摘要翻译：小型化伽马照相机具有伽马照相机的所有特定功能，具有极高的空间分辨率（约1-2毫米）和尺寸约为22毫米×22毫米的有效面积和总尺寸约35毫米×35毫米，例如适合外科医生的手，绝对容易处理。

5. 发明授权

US06229145B1 Dedicated apparatus and method emission mammography 失效
标题翻译：专用仪器和方法放射乳腺摄影术
公开(公告)号：US06229145B1
公开(公告)日：2001-05-08
申请号：US09415979
申请日：1999-10-12
申请人： Irving Weinberg
发明人： Irving Weinberg
IPC分类号： G01T1161
CPC分类号： A61B6/0414 , A61B6/4258 , A61B6/502 , A61B6/547 , G01T1/1642
摘要： The present invention is an apparatus for examining a body part. The apparatus comprises a mechanism for immobilizing and compressing the body part. The apparatus also comprises a mechanism for providing an internal anatomical image of the body part and a mechanism for detecting single gamma-rays emitted by a radiotracer infiltrated into the body part. The detecting mechanism is disposed in an adjacent relationship with the mechanism for providing an internal anatomic image so that the body part remains in the same position during and between anatomic and radiotracer imaging. In one embodiment, the detecting mechanism includes a detector module disposed on one side of the immobilizing mechanism. The detector module preferably has at least one array of gamma ray sensitive material in communication with a position detector. In another embodiment, the detecting mechanism includes a pair of detector modules disposed one on each side of the immobilizing mechanism. The present invention is also an apparatus for examining a body part which comprises a mechanism for immobilizing and compressing the body part and a mechanism for providing a stereotactic internal anatomical image of the body part. The apparatus also comprises a mechanism for providing a stereotactic physiological image of the body part in an adjacent relationship with the mechanism for providing an internal anatomic image such that the body part remains in the same position during and between stereotactic anatomic and radiotracer imaging.
摘要翻译：本发明是用于检查身体部位的装置。该装置包括用于固定和压缩身体部分的机构。该装置还包括用于提供身体部分的内部解剖图像的机构和用于检测由渗透入身体部位的放射性示踪器发射的单个γ射线的机构。检测机构与用于提供内部解剖图像的机构相邻地设置，使得身体部分在解剖和放射性示踪器成像期间和之间保持在相同的位置。在一个实施例中，检测机构包括设置在固定机构一侧的检测器模块。检测器模块优选地具有与位置检测器连通的至少一个伽马射线敏感材料阵列。在另一个实施例中，检测机构包括一对在固定机构的每一侧上设置的检测器模块。本发明还是一种用于检查身体部位的装置，其包括用于固定和压缩身体部位的机构以及用于提供身体部位的立体定向内部解剖图像的机构。该装置还包括用于提供与用于提供内部解剖图像的机构相邻关系的身体部位的立体定向生理图像的机构，使得身体部分在立体定向解剖和放射性示踪剂成像期间和之间保持在相同的位置。

6. 发明授权

US06740875B1 Gamma watermarking 失效
标题翻译：伽玛水印
公开(公告)号：US06740875B1
公开(公告)日：2004-05-25
申请号：US09502859
申请日：2000-02-11
申请人： Muriel Y. Ishikawa , Lowell L. Wood , Ronald W. Lougheed , Kenton J. Moody , Tzu-Fang Wang
发明人： Muriel Y. Ishikawa , Lowell L. Wood , Ronald W. Lougheed , Kenton J. Moody , Tzu-Fang Wang
IPC分类号： G01T1161
CPC分类号： B41M3/14
摘要： A covert, gamma-ray “signature” is used as a “watermark” for property identification. This new watermarking technology is based on a unique steganographic or “hidden writing” digital signature, implemented in tiny quantities of gamma-ray-emitting radioisotopic material combinations, generally covertly emplaced on or within an object. This digital signature may be readily recovered at distant future times, by placing a sensitive, high energy-resolution gamma-ray detecting instrument reasonably precisely over the location of the watermark, which location may be known only to the object's owner; however, the signature is concealed from all ordinary detection means because its exceedingly low level of activity is obscured by the natural radiation background (including the gamma radiation naturally emanating from the object itself, from cosmic radiation and material surroundings, from human bodies, etc.). The “watermark” is used in object-tagging for establishing object identity, history or ownership. It thus may serve as an aid to law enforcement officials in identifying stolen property and prosecuting theft thereof. Highly effective, potentially very low cost identification-on demand of items of most all types is thus made possible.
摘要翻译：隐蔽的伽马射线“签名”被用作属性识别的“水印”。这种新的水印技术基于独特的隐写或“隐藏书写”数字签名，其实施在少量的伽马射线发射放射性同位素材料组合中，通常隐蔽地放置在物体上或物体内。通过将敏感的高能量分辨率γ射线检测仪器合理地精确地放置在水印的位置上，该位置可能仅对物体的所有者可知，该数字签名可以在远距离的未来时间容易地恢复; 然而，由于其极低的活动水平被自然辐射背景遮蔽（包括自然辐射的物体本身，宇宙辐射和物质环境，人体等）的伽马辐射，所有这些标志都被隐藏起来。）。 “水印”用于建立对象标识，历史或所有权的对象标签。因此，这可能有助于执法人员查明被盗财产和起诉盗窃。因此，大多数所有类型的物品的高效，可能非常低成本的识别都是可能的。

7. 发明授权

US06630675B2 X-ray scintillator compositions for X-ray imaging applications 有权
标题翻译：用于X射线成像应用的X射线闪烁体组合物
公开(公告)号：US06630675B2
公开(公告)日：2003-10-07
申请号：US09876579
申请日：2001-06-06
申请人： Farhad Abbasi Ghelmansarai
发明人： Farhad Abbasi Ghelmansarai
IPC分类号： G01T1161
CPC分类号： C09K11/7771 , G01T1/2023
摘要： An x-ray imaging system includes a praseodymium (Pr) doped gadolinium oxysulfide (Gd2O2S) scintillator and a detector array positioned adjacent to the scintillator. The scintillator is particularly suited for x-ray imaging applications in which fast scan times are desired.
摘要翻译： X射线成像系统包括镨（Pr）掺杂的硫化钆（Gd 2 O 2 S）闪烁体和与闪烁体相邻的检测器阵列。闪烁体特别适用于需要快速扫描时间的x射线成像应用。

8. 发明授权

US06406913B1 Assay method utilizing induced luminescence 失效
标题翻译：利用诱导发光的测定方法
公开(公告)号：US06406913B1
公开(公告)日：2002-06-18
申请号：US08471130
申请日：1995-06-06
申请人： Edwin F. Ullman , Hrair Kirakossian , John S. Pease , Yuri Daniloff , Daniel B. Wagner
发明人： Edwin F. Ullman , Hrair Kirakossian , John S. Pease , Yuri Daniloff , Daniel B. Wagner
IPC分类号： G01T1161
CPC分类号： C07D265/30 , C07D279/12 , C07D327/06 , G01N33/54313 , G01N33/5436 , G01N33/58 , G01N33/582 , G01N33/585 , G01N33/586 , Y10S435/81 , Y10S435/968 , Y10S435/971 , Y10S435/973 , Y10S435/975 , Y10S436/829
摘要： Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a photosensitizer and a chemiluminescent compound to come into close proximity. The photosensitizer generates singlet oxygen and activates the chemiluminescent compound when it is in close proximity. The activated chemiluminescent compound subsequently produces light. The amount of light produced is related to the amount of analyte in the medium. Preferably, at least one of the photosensitizer and chemiluminescent compound is associated with a surface which is usually a suspendible particle, and a specific binding pair member is bound thereto. Compositions and kits are also disclosed.
摘要翻译：公开了用于确定怀疑含有分析物的介质中的分析物的方法。一种方法包括在允许分析物（如果存在）使光敏剂和化学发光化合物接近的条件下处理疑似含有分析物的介质。光敏剂产生单线态氧并在化学发光化合物接近时激活化学发光化合物。活化的化学发光化合物随后产生光。所产生的光量与介质中分析物的量有关。优选地，光敏剂和化学发光化合物中的至少一种与通常是悬浮颗粒的表面相关联，并且特异性结合对成员结合到其上。还公开了组合物和试剂盒。

9. 发明授权

US06380540B1 Radiation imaging using simultaneous emission and transmission 失效
标题翻译：使用同时发射和透射的辐射成像
公开(公告)号：US06380540B1
公开(公告)日：2002-04-30
申请号：US09355720
申请日：1999-10-21
申请人： Dov Maor , Alex Silberklang , Aharon Peretz , Alex Natanzon
发明人： Dov Maor , Alex Silberklang , Aharon Peretz , Alex Natanzon
IPC分类号： G01T1161
CPC分类号： G01T1/1615 , G01T1/1642 , G01T1/2985
摘要： A gamma camera (70), comprising: at least one emission detector (72), which receives radiation emitted from the body of a subject (26) and generates signals responsive thereto; a radiation source (74), which directs radiation toward the body; at least one transmission detector (76), having a long dimension, which receives radiation transmitted through the body (26) from the radiation source (74) and generates signals responsive thereto, wherein the transmission detector (76) translates in a direction generally perpendicular to the long dimension.
摘要翻译：一种伽马照相机（70），包括：至少一个发射检测器（72），其接收从对象（26）的身体发射的辐射并响应于此产生信号; 辐射源（74），其将辐射引向身体; 具有长尺寸的至少一个传输检测器（76），其接收从所述辐射源（74）传输通过所述主体（26）的辐射并产生响应于此的信号，其中所述传输检测器（76）沿大致垂直的方向到长的维度。

10. 发明授权

US06835935B2 System and method for calibrating and tuning a gamma camera 有权
公开(公告)号：US06835935B2
公开(公告)日：2004-12-28
申请号：US10224322
申请日：2002-08-21
申请人： John C. Engdahl , James F. Caruba
发明人： John C. Engdahl , James F. Caruba
IPC分类号： G01T1161
CPC分类号： G01T1/1642 , A61B6/4258 , G01T1/1648
摘要： A gamma camera having a system for performing a quality control procedure with minimal to no intervention from a user of the camera. In one aspect, the gamma camera includes a relatively weak radioactive source positioned at a fixed or known location relative to the gamma camera scintillation crystal and positioned so that the entrance window side of the crystal is facing the source, wherein the photons emitted from the source have an energy that is below the energy of photons used for diagnostic imaging. The response of the gamma camera photo-multiplier tubes to the absorption events caused by the radioactive source when the camera is idle can be compared to a baseline response to determine whether one or more of the PMTs need to be adjusted.

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