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1. 发明授权

US07022529B2 Particles for diagnostic and therapeutic use 有权
公开(公告)号：US07022529B2
公开(公告)日：2006-04-04
申请号：US10745972
申请日：2003-12-24
申请人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
发明人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33/543
CPC分类号： G01N33/587 , C12Q1/6816 , Y10T436/10 , C12Q2563/155 , C12Q2523/319
摘要： Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the intensity of light emission at any time during a 20-fold decrease in the intensity is proportional to the intensity of the light emission. In one embodiment the polymeric matrix is comprised of particles of about 20 nm to about 100 μm in diameter to which is bound a specific binding pair member. The particles generally comprise a polymeric matrix having dissolved therein about 1 to about 20% by weight of a dopant. The compositions may be used in methods for determining an analyte. A combination is provided comprising (1) a medium suspected of containing the analyte, (2) and the aforementioned composition. The photoactive substance is activated and the effect of the activating on the optical properties of the combination is detected. The presence and amount of the effect is related to the presence and amount of the analyte in the medium. Also disclosed are kits for use in an assay.

2. 发明授权

US07709273B2 Particles for diagnostic and therapeutic use 有权
标题翻译：用于诊断和治疗用途的颗粒
公开(公告)号：US07709273B2
公开(公告)日：2010-05-04
申请号：US11273275
申请日：2005-11-14
申请人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
发明人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33/543 , G01N31/00
CPC分类号： G01N33/587 , C12Q1/6816 , Y10T436/10 , C12Q2563/155 , C12Q2523/319
摘要： Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the intensity of light emission at any time during a 20-fold decrease in the intensity is proportional to the intensity of the light emission. In one embodiment the polymeric matrix is comprised of particles of about 20 nm to about 100 μm in diameter to which is bound a specific binding pair member. The particles generally comprise a polymeric matrix having dissolved therein about 1 to about 20% by weight of a dopant. The compositions may be used in methods for determining an analyte. A combination is provided comprising (1) a medium suspected of containing the analyte, (2) and the aforementioned composition. The photoactive substance is activated and the effect of the activating on the optical properties of the combination is detected. The presence and amount of the effect is related to the presence and amount of the analyte in the medium. Also disclosed are kits for use in an assay.
摘要翻译：公开了方法，组合物和试剂盒。组合物是发光的并且包含其中溶解有光敏化合物的聚合物基质。该组合物具有以下特征：在光活性化合物活化后，强度降低20倍的任何时间的发光强度的降低率与发光强度成比例。在一个实施方案中，聚合物基质包含直径约20nm至约100μm的颗粒，其与特定结合对构件结合。颗粒通常包含其中溶解约1至约20重量％的掺杂剂的聚合物基质。该组合物可用于测定分析物的方法中。提供的组合包括（1）怀疑含有分析物的介质，（2）和上述组合物。光活性物质被激活，并且检测到激活对组合的光学性质的影响。影响的存在和数量与介质中分析物的存在和数量有关。还公开了用于测定的试剂盒。

3. 发明授权

US06703248B1 Particles for diagnostic and therapeutic use 有权
公开(公告)号：US06703248B1
公开(公告)日：2004-03-09
申请号：US09465065
申请日：1999-12-15
申请人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
发明人： Sharat Singh , John S. Pease , Jacqueline Sadakian , Daniel B. Wagner , Edwin F. Ullman
IPC分类号： G01N33553
CPC分类号： G01N33/587 , C12Q1/6816 , Y10T436/10 , C12Q2563/155 , C12Q2523/319
摘要： Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the intensity of light emission at any time during a 20-fold decrease in the intensity is proportional to the intensity of the light emission. In one embodiment the polymeric matrix is comprised of particles of about 20 nm to about 100 &mgr;m in diameter to which is bound a specific binding pair member. The particles generally comprise a polymeric matrix having dissolved therein about 1 to about 20% by weight of a dopant. The compositions may be used in methods for determining an analyte. A combination is provided comprising (1) a medium suspected of containing the analyte, (2) and the aforementioned composition. The photoactive substance is activated and the effect of the activating on the optical properties of the combination is detected. The presence and amount of the effect is related to the presence and amount of the analyte in the medium. Also disclosed are kits for use in an assay.

4. 发明申请

US20060121506A1 Particles for diagnostic and therapeutic use 有权
标题翻译：用于诊断和治疗用途的颗粒
公开(公告)号：US20060121506A1
公开(公告)日：2006-06-08
申请号：US11273275
申请日：2005-11-14
申请人： Sharat Singh , John Pease , Jacqueline Sadakian , Daniel Wagner , Edwin Ullman
发明人： Sharat Singh , John Pease , Jacqueline Sadakian , Daniel Wagner , Edwin Ullman
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： G01N33/587 , C12Q1/6816 , Y10T436/10 , C12Q2563/155 , C12Q2523/319
摘要： Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the intensity of light emission at any time during a 20-fold decrease in the intensity is proportional to the intensity of the light emission. In one embodiment the polymeric matrix is comprised of particles of about 20 nm to about 100 μm in diameter to which is bound a specific binding pair member. The particles generally comprise a polymeric matrix having dissolved therein about 1 to about 20% by weight of a dopant. The compositions may be used in methods for determining an analyte. A combination is provided comprising (1) a medium suspected of containing the analyte, (2) and the aforementioned composition. The photoactive substance is activated and the effect of the activating on the optical properties of the combination is detected. The presence and amount of the effect is related to the presence and amount of the analyte in the medium. Also disclosed are kits for use in an assay.
摘要翻译：公开了方法，组合物和试剂盒。组合物是发光的并且包含其中溶解有光敏化合物的聚合物基质。该组合物具有以下特征：在光活性化合物活化后，强度降低20倍的任何时间的发光强度的降低率与发光强度成比例。在一个实施方案中，聚合物基质包括直径约20nm至约100μm的颗粒，其与特定结合对成员结合。颗粒通常包含其中溶解约1至约20重量％的掺杂剂的聚合物基质。该组合物可用于测定分析物的方法中。提供的组合包括（1）怀疑含有分析物的介质，（2）和上述组合物。光活性物质被激活，并且检测到激活对组合的光学性质的影响。影响的存在和数量与介质中分析物的存在和数量有关。还公开了用于测定的试剂盒。

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