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1. 发明授权

US5480484A Cytology centrifuge apparatus 失效
标题翻译：细胞离心机
公开(公告)号：US5480484A
公开(公告)日：1996-01-02
申请号：US204608
申请日：1994-03-01
申请人： Thomas F. Kelley , Alton D. Floyd
发明人： Thomas F. Kelley , Alton D. Floyd
IPC分类号： B04B5/04 , G01N1/28 , B05C13/00
CPC分类号： B04B5/0407 , G01N1/2813 , B04B2007/025 , G01N2001/2846 , Y10T436/111666 , Y10T436/112499
摘要： Improved cytology centrifuge apparatus includes single or multiple well cell concentrators for being rotated by a centrifugal spinner. A rotor is removably supported by the spinner for rotation and is adapted to receive two or four cell concentrators. The rotor supports the cell concentrators in an unrestrained manner, thereby enhancing the ease of use and flexibility of the apparatus. Each cell concentrator includes a chamber having a top surface in which at least one fluid receiving aperture is disposed and a front surface in which at least one fluid expulsion aperture is disposed. A backing plate is provided with protruding top and bottom edges to vertically align a microscope slide with the chamber so that the fluid expulsion aperture is adjacent to a central portion of the slide. Retention clips secure the chamber to the backing plate with the slide sandwiched therebetween in horizontal alignment. The cell concentrator is shaped to rest stably on a planar surface in a tilted manner so that a fluid specimen contained therein is prevented from contacting the slide prior to centrifugation. The concentrator is also well suited for use as a staining chamber and the backing plate has a viewing aperture aligned with the fluid expulsion aperture to enable viewing of cells on the slide during a staining process.
摘要翻译：改进的细胞学离心机装置包括用于通过离心旋转器旋转的单孔或多孔细胞集中器。旋转器可移动地由旋转器支撑以旋转，并且适于接收两个或四个电池集中器。转子以无限制的方式支撑细胞集中器，从而增强了装置的易用性和灵活性。每个细胞浓缩器包括具有顶表面的腔室，其中设置有至少一个流体接收孔口以及设置有至少一个流体排出孔口的前表面。背板设置有突出的顶部和底部边缘，以使显微镜载玻片与腔室垂直对准，使得流体排出孔口邻近载玻片的中心部分。保持夹将水箱对准的夹子固定在背板上。细胞集中器被成形为以倾斜的方式稳定地平放在平坦表面上，使得其中容纳的流体样品在离心之前被防止与载玻片接触。浓缩器也非常适合用作染色室，并且背板具有与流体排出孔对准的观察孔，以使得能够在染色过程中观察载玻片上的细胞。

2. 发明授权

US5326398A Compact slide spinner using a disposable slide holder 失效
标题翻译：紧凑型滑块旋转器使用一次性滑动架
公开(公告)号：US5326398A
公开(公告)日：1994-07-05
申请号：US918491
申请日：1992-07-22
申请人： Thomas F. Kelley , Larry E. Shephard , Robert L. Scott
发明人： Thomas F. Kelley , Larry E. Shephard , Robert L. Scott
IPC分类号： G01N1/28 , B05C11/02 , B05C5/00 , B05C13/02
CPC分类号： G01N1/2813
摘要： A compact slide spinner is disclosed. In the preferred embodiment, the compact slide spinner is used to prepare smears for microscopic evaluation. The spinner incorporates a disposable or reusable slide holder which encases a portion of a slide onto which the material to be smeared is placed. The holder containing the slide is then accelerated by spinning. Specimen fluid not adhering to the slide is contained within the slide holder which is discarded following preparation of the smear. Using this low-cost device, a uniform quality smear is quickly and easily prepared, while reducing the risk that laboratory personnel will be exposed to aerosol borne contagions.
摘要翻译：公开了一种紧凑的滑动旋转器。在优选实施例中，使用紧凑型滑动旋转器来制备用于显微镜评估的涂片。旋转器包含一次性或可重复使用的滑动夹持器，其将一部分幻灯片包裹在待涂抹的材料上。然后通过旋转加速器包含载玻片。未附着在载玻片上的样品液被包含在载玻片保持器内，在制备涂片后被丢弃。使用这种低成本设备，可以快速，轻松地准备均匀的质量涂抹，同时降低实验室人员将暴露于气溶胶传播的风险。

3. 发明授权

US4299794A Analytical system for analyzing CO.sub.2 content of a fluid 失效
标题翻译：用于分析液体二氧化碳含量的分析系统
公开(公告)号：US4299794A
公开(公告)日：1981-11-10
申请号：US161375
申请日：1980-06-20
申请人： Thomas F. Kelley , Dinesh I. Mody , Charles F. Mountain
发明人： Thomas F. Kelley , Dinesh I. Mody , Charles F. Mountain
IPC分类号： G01N7/18 , G01N7/14 , G01N33/483 , G01N33/84 , G01N33/50 , G01N1/10
CPC分类号： G01N33/84 , G01N7/14 , Y10T436/204998
摘要： A total carbon dioxide analyzer system has a reaction chamber that includes a tube and a piston mounted for sliding movement in the tube to change the volume of the chamber. A valve coupled to the chamber has a sample inlet port and a reagent inlet port, and is movable between a first state in which the sample inlet port is connected to the chamber, a second state in which the reagent inlet port is connected to the chamber, and a third state in which the reaction chamber is sealed. A system controller coordinately operates the valve and moves the piston to increase the volume of said chamber to draw sample into the chamber for mixing with an acid reagent in the chamber, and then seals the chamber and increases the volume of the chamber to facilitate the release of carbon dioxide. A transducer then senses the pressure of carbon dioxide in the reaction chamber.
摘要翻译：总的二氧化碳分析仪系统具有包括管和活塞的反应室，该活塞安装成用于在管中滑动以改变腔的体积。联接到所述室的阀具有样品入口和试剂入口，并且可以在样品入口与腔室连接的第一状态和第二状态之间移动，其中试剂入口连接到腔室和第三状态，其中反应室被密封。系统控制器协调地操作阀并移动活塞以增加所述室的体积以将样品抽入室中以与室中的酸试剂混合，然后密封室并增加室的体积以便于释放的二氧化碳。传感器然后感测反应室中二氧化碳的压力。

4. 发明授权

US4846974A Centrifuge system and fluid container therefor 失效
标题翻译：离心机系统及流体容器
公开(公告)号：US4846974A
公开(公告)日：1989-07-11
申请号：US797873
申请日：1985-11-14
申请人： Thomas F. Kelley , Robert L. Scott
发明人： Thomas F. Kelley , Robert L. Scott
IPC分类号： B04B5/04 , G01N33/49 , G01N35/00
CPC分类号： B04B5/0407 , G01N33/491 , G01N2035/00495
摘要： A disk shaped cassette for centrifugal fluid separation, particularly blood separation, and a drive system for high speed rotation of the cassette. The cassette is driven at speeds which permit very rapid separation of the blood in times on the order of seven (7) to twenty (20) seconds by an automated control. The cassette is supported by a flexible support coupling and mounting system that permits the entire rotating mass to spin about the center of mass unique to the particular cassette as filled. The cassette typically includes a peripheral collection chamber which may be either annular, lobed or channel shaped. A cassette enabled to hold plural separation tubes is also shown. A gel can be placed in the cassette with a density between the fluid components to separated and after centrifuging maintains the component separation that centrifuging creates. Because the cassette disperses the fluid components, markings may be molded into the cassette or placed against it to permit volumetric gauging of the centrifuged components. The cassette is provided in various configurations to provide control over the exchange of fluid between collection chambers and to facilitate the separation functions.
摘要翻译：用于离心流体分离的盘形盒，特别是血液分离，以及用于盒的高速旋转的驱动系统。磁带盒以通过自动控制在七（7）至二十（20）秒的时间内非常快速地分离血液的速度被驱动。盒式磁带由柔性支撑联轴器和安装系统支撑，允许整个旋转质量块围绕填充的特定磁带盒独特的质心旋转。盒式磁带通常包括可以是环形，叶形或通道形状的外围收集室。还示出了能够容纳多个分离管的盒。凝胶可以放置在盒中，流体组分之间的密度要分离，离心后保持离心分离产生的组分分离。因为盒分散了流体组分，所以标记可以模制到盒中或放置在其中以允许离心组分的体积测量。该盒具有各种构造以提供对收集室之间的流体交换的控制，并且便于分离功能。

5. 发明授权

US5257984A Blood collector 失效
标题翻译：血液收集器
公开(公告)号：US5257984A
公开(公告)日：1993-11-02
申请号：US771054
申请日：1991-10-02
申请人： Thomas F. Kelley
发明人： Thomas F. Kelley
IPC分类号： B01L3/14 , B01L99/00 , A61B5/14
CPC分类号： B01L3/0293 , B01L3/5021
摘要： Apparatus for transferring a blood specimen from a droplet source to a collection tube via a capillary tube. A glass anticoagulant-coated or an untreated capillary tube and a collection tube with a stopper having an X-slit membrane for admission of the capillary tube into the collection tube with the stopper on. A separating gel may be located in the collection tube to provide plasma and serum separation when the collection tube is centrifuged.
摘要翻译：用于通过毛细管将血液样本从液滴源转移到收集管的装置。玻璃抗凝剂涂布或未经处理的毛细管和具有塞子的收集管，其具有用于将毛细管进入收集管中的塞子的X形狭缝膜。当收集管离心时，分离凝胶可以位于收集管中以提供血浆和血清分离。

6. 发明授权

US4981585A Centrifuge system and fluid container therefor 失效
标题翻译：离心机系统及流体容器
公开(公告)号：US4981585A
公开(公告)日：1991-01-01
申请号：US372874
申请日：1989-06-28
申请人： Thomas F. Kelley , Robert L. Scott
发明人： Thomas F. Kelley , Robert L. Scott
IPC分类号： B04B5/04 , G01N33/49 , G01N35/00
CPC分类号： B04B5/0407 , G01N33/491 , G01N2035/00495
摘要： A disk shaped cassette for centrifugal fluid separation, particularly blood separation, and a drive system for high speed rotation of the cassette. The cassette is driven at speeds which permit very rapid separation of the blood in times on the order of seven (7) to twenty (20) seconds by an automated control. The cassette is supported by a flexible support coupling and mounting system that permits the entire rotating mass to spin about the center of mass unique to the particular cassette as filled. The cassette typically includes a peripheral collection chamber which may be either annular, lobed or channel shaped. A cassette enabled to hold plural separation tubes is also shown. A gel can be placed in the cassette with a density between the fluid components to be separated and after centrifuging maintains the component separation that centrifuging creates. Because the cassette disperses the fluid components, markings may be molded into the cassette or placed against it to permit volumetric gauging of the centrifuged components. The cassette is provided in various configurations to provide control over the exchange of fluid between collection chambers and to facilitate the separation functions.
摘要翻译：用于离心流体分离的盘形盒，特别是血液分离，以及用于盒的高速旋转的驱动系统。磁带盒以通过自动控制在七（7）至二十（20）秒的时间内非常快速地分离血液的速度被驱动。盒式磁带由柔性支撑联轴器和安装系统支撑，允许整个旋转质量块围绕填充的特定磁带盒独特的质心旋转。盒式磁带通常包括可以是环形，叶形或通道形状的外围收集室。还示出了能够容纳多个分离管的盒。凝胶可以放置在盒中，待分离的流体组分之间的密度和离心后保持离心分离产生的组分分离。因为盒分散了流体组分，所以标记可以模制到盒中或放置在其中以允许离心组分的体积测量。该盒具有各种构造以提供对收集室之间的流体交换的控制，并且便于分离功能。

7. 发明授权

US4884827A Partially transparent label 失效
标题翻译：部分透明标签
公开(公告)号：US4884827A
公开(公告)日：1989-12-05
申请号：US146965
申请日：1988-01-22
申请人： Thomas F. Kelley
发明人： Thomas F. Kelley
IPC分类号： G09F3/02 , G09F3/10
CPC分类号： G09F3/10 , G09F3/0295 , Y10T428/1481
摘要： A plastic adhesive label for microsample collection tubes has opaque end portions for receipt of identifying markings, and a transparent middle portion to permit viewing of the contents of the collection tube. In use, the transparent portion of the label is wrapped around and adhered to a collection tube and the end portions of the label are brought together in adhesion, the end portions forming a flag which carries the identifying information. With the transparent portion of the label surrounding the collection tube, the contents of the tube are still visible to an observer for confirmation at the same time the identifying information is displayed on the label.
摘要翻译：用于微样品收集管的塑料粘合剂标签具有用于接收识别标记的不透明端部和用于允许观察收集管的内容物的透明中间部分。在使用中，标签的透明部分被卷绕并附着在收集管上，标签的端部粘合在一起，端部形成携带标识信息的标记。随着标签周围收集管的透明部分，管子的内容对于观察者仍然是可见的，用于确认，同时标识信息显示在标签上。

8. 发明授权

US5679154A Cytology centrifuge apparatus 失效
标题翻译：细胞离心机
公开(公告)号：US5679154A
公开(公告)日：1997-10-21
申请号：US576679
申请日：1995-12-21
申请人： Thomas F. Kelley , Henry A. Petithory , Todd W. Soares
发明人： Thomas F. Kelley , Henry A. Petithory , Todd W. Soares
IPC分类号： B04B5/04 , G01N1/28 , B05C13/00
CPC分类号： B04B5/0407 , G01N1/2813 , B04B2007/025 , G01N2001/2846 , Y10T436/112499
摘要： Removed cytology centrifuge apparatus includes single or multiple well cell concentrators for being rotated by a centrifugal spinner. A rotor is removably supported by the spinner for rotation and is adapted to receive two or four cell concentrators. The rotor supports the cell concentrators in an unrestrained manner, thereby enhancing the ease of use and flexibility of the apparatus. The cell concentrator is shaped to rest stably on a planar surface in a tilted manner so that a fluid specimen contained therein is prevented from contacting the slide prior to centrifugation. Each cell concentrator includes a chamber having at least one fluid receiving aperture and at least one fluid expulsion aperture. The chamber is secured to a backing plate by a fastening mechanism, with the slide sandwiched therebetween. In one embodiment, the chamber is hinged to the backing plate. Also described is a bibulous pad interposed between the chamber and the slide in order to absorb excess sample fluid.
摘要翻译：移除的细胞学离心机设备包括用于通过离心旋转器旋转的单孔或多孔细胞集中器。旋转器可移动地由旋转器支撑以旋转，并且适于接收两个或四个电池集中器。转子以无限制的方式支撑细胞集中器，从而增强了装置的易用性和灵活性。细胞集中器被成形为以倾斜的方式稳定地平放在平坦表面上，使得其中容纳的流体样品在离心之前被防止与载玻片接触。每个细胞浓缩器包括具有至少一个流体接收孔和至少一个流体排出孔的室。腔室通过紧固机构固定到背板上，其间夹有滑动件。在一个实施例中，腔室铰接到背板。还描述了插入室和载玻片之间的吸收垫，以吸收多余的样品流体。

9. 发明授权

US5549750A Disposable slide holder 失效
标题翻译：一次性滑轨架
公开(公告)号：US5549750A
公开(公告)日：1996-08-27
申请号：US270041
申请日：1994-07-01
申请人： Thomas F. Kelley , Larry E. Shephard , Robert L. Scott
发明人： Thomas F. Kelley , Larry E. Shephard , Robert L. Scott
IPC分类号： G01N1/28 , B05C13/02
CPC分类号： G01N1/2813
摘要： A compact slide spinner is disclosed. In the preferred embodiment, the compact slide spinner is used to prepare smears for microscopic evaluation. The spinner incorporates a disposable or reusable slide holder which encases a portion of a slide onto which the material to be smeared is placed. The holder containing the slide is then accelerated by spinning. Specimen fluid not adhering to the slide is contained within the slide holder which is discarded following preparation of the smear. Using this low-cost device, a uniform quality smear is quickly and easily prepared, while reducing the risk that laboratory personnel will be exposed to aerosol borne contagions.
摘要翻译：公开了一种紧凑的滑动旋转器。在优选实施例中，使用紧凑型滑动旋转器来制备用于显微镜评估的涂片。旋转器包含一次性或可重复使用的滑动夹持器，其将一部分幻灯片包裹在待涂抹的材料上。然后通过旋转加速器包含载玻片。未附着在载玻片上的样品液被包含在载玻片保持器内，在制备涂片后被丢弃。使用这种低成本设备，可以快速，轻松地准备均匀的质量涂抹，同时降低实验室人员将暴露于气溶胶传播的风险。

10. 发明授权

US4399362A Liquid handling apparatus 失效
标题翻译：液体处理设备
公开(公告)号：US4399362A
公开(公告)日：1983-08-16
申请号：US239025
申请日：1981-02-27
申请人： Alan D. Cormier , John D. Czaban , Thomas J. Schillinger , Kenneth D. Legg , Thomas F. Kelley
发明人： Alan D. Cormier , John D. Czaban , Thomas J. Schillinger , Kenneth D. Legg , Thomas F. Kelley
IPC分类号： G01N35/08 , G01N21/01
CPC分类号： G01N35/08
摘要： A clinical analyzer system flows a small volume (less than 200 microliters) of liquid sample to be analyzed from an inlet port past a sensor array to a series of analysis chambers. The sensor array includes two optical sensor units that are spaced a fixed distance apart, and each sensor unit transmits a beam of infrared radiation through the flow tube for sensing by a detector. Each detector output has a low value when blood is in the flow tube, an intermediate value when air is in the flow tube, and a high value when a clear liquid is in the flow tube. Control logic senses changes in the outputs of the detectors and accurately indicates gas-liquid interface transitions. The noninvasive system accurately locates leading and trailing edges of samples of biological fluids to be analyzed, monitors the integrity of those samples, and distinguishes between types of sample liquids processed by the analyzer.
摘要翻译：临床分析仪系统将小分子量（小于200微升）的液体样品从入口通过传感器阵列流向一系列分析室。传感器阵列包括间隔开固定距离的两个光学传感器单元，每个传感器单元透过一束红外线辐射通过流管，以便由检测器检测。当血液在流管中时，每个检测器输出值都较低，空气在流管中时的中间值，而当流管中有透明液体时，其值为高值。控制逻辑检测检测器输出的变化并准确地指示气 - 液界面转变。非侵入性系统准确地定位要分析的生物流体样品的前缘和后缘，监测这些样品的完整性，并区分由分析仪处理的样品液体的类型。

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