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1. 发明授权

US4399362A Liquid handling apparatus 失效
标题翻译：液体处理设备
公开(公告)号：US4399362A
公开(公告)日：1983-08-16
申请号：US239025
申请日：1981-02-27
申请人： Alan D. Cormier , John D. Czaban , Thomas J. Schillinger , Kenneth D. Legg , Thomas F. Kelley
发明人： Alan D. Cormier , John D. Czaban , Thomas J. Schillinger , Kenneth D. Legg , Thomas F. Kelley
IPC分类号： G01N35/08 , G01N21/01
CPC分类号： G01N35/08
摘要： A clinical analyzer system flows a small volume (less than 200 microliters) of liquid sample to be analyzed from an inlet port past a sensor array to a series of analysis chambers. The sensor array includes two optical sensor units that are spaced a fixed distance apart, and each sensor unit transmits a beam of infrared radiation through the flow tube for sensing by a detector. Each detector output has a low value when blood is in the flow tube, an intermediate value when air is in the flow tube, and a high value when a clear liquid is in the flow tube. Control logic senses changes in the outputs of the detectors and accurately indicates gas-liquid interface transitions. The noninvasive system accurately locates leading and trailing edges of samples of biological fluids to be analyzed, monitors the integrity of those samples, and distinguishes between types of sample liquids processed by the analyzer.
摘要翻译：临床分析仪系统将小分子量（小于200微升）的液体样品从入口通过传感器阵列流向一系列分析室。传感器阵列包括间隔开固定距离的两个光学传感器单元，每个传感器单元透过一束红外线辐射通过流管，以便由检测器检测。当血液在流管中时，每个检测器输出值都较低，空气在流管中时的中间值，而当流管中有透明液体时，其值为高值。控制逻辑检测检测器输出的变化并准确地指示气 - 液界面转变。非侵入性系统准确地定位要分析的生物流体样品的前缘和后缘，监测这些样品的完整性，并区分由分析仪处理的样品液体的类型。

2. 发明授权

US4531088A Blood analysis 失效
标题翻译：血液分析
公开(公告)号：US4531088A
公开(公告)日：1985-07-23
申请号：US405870
申请日：1982-08-06
申请人： John D. Czaban , Alan D. Cormier , Kenneth D. Legg
发明人： John D. Czaban , Alan D. Cormier , Kenneth D. Legg
IPC分类号： G01N27/416 , G01N27/28 , G01N33/487 , G01N33/49 , G01N27/00
CPC分类号： G01N33/4915
摘要： Rapid and accurate whole blood analysis measurements are made with analysis systems of the potentiometric type that employ restricted diffusion type liquid junctions where the whole blood sample is flowed past sensing electrode and liquid junction at a velocity of at least one centimeter per second during a data acquisition interval that is at least twenty-five milliseconds in duration.
摘要翻译：使用限制性扩散型液体接头的电位分析系统进行快速准确的全血分析测量，在数据采集期间，全血样以每秒至少一厘米的速度流过检测电极和液体接头间隔至少为25毫秒。

3. 发明授权

US4283262A Analysis system 失效
标题翻译：分析系统
公开(公告)号：US4283262A
公开(公告)日：1981-08-11
申请号：US165051
申请日：1980-07-01
申请人： Alan D. Cormier , Milo E. Webster , John D. Czaban , Neil D. Silverman , Lynn W. Noble
发明人： Alan D. Cormier , Milo E. Webster , John D. Czaban , Neil D. Silverman , Lynn W. Noble
IPC分类号： G01N27/38 , G01N33/483 , G01N35/08 , G01N27/28
CPC分类号： G01N35/08 , G01N27/38
摘要： A system for analyzing a biological fluid specimen or the like includes an analysis chamber and an electrochemical electrode measuring system connected in sensing relation to the analysis chamber. A flow network connects a sample inlet port and an auxiliary fluid reservoir to the analysis chamber. The flow network includes a sample line connected between the sample inlet port and the analysis chamber and an auxiliary manifold connected to the auxiliary fluid reservoir. A positive displacement pump is connected in the sample line between the analysis chamber and a waste outlet port. A valved T-connection is provided between the sample line and the manifold; an inlet isolation valve is in the sample flow path between the sample inlet and the valved T-connection; an analysis chamber isolation valve is in the sample flow path between the valved T-connection and the analysis chamber; and both the sample line and the manifold have a vent valve, the sample line vent valve being connected between the inlet and chamber isolation valves and the manifold vent valve being connected upstream of the auxiliary fluid reservoir. Coordinated operation of the several valves permits the pump to selectively flow fluid from the auxiliary reservoir or a sample through the analysis chamber, together with imposition of nonlaminar flow conditions by concurrent operation of the vent valves to provide effective cleaning of flow surfaces and analysis chambers.
摘要翻译：用于分析生物流体样本等的系统包括分析室和连接到分析室的感测关系的电化学电极测量系统。流动网络将样品入口端口和辅助流体容器连接到分析室。流动网络包括连接在样品入口和分析室之间的样品管线和连接到辅助流体储存器的辅助歧管。容积式泵连接在分析室和废物出口之间的样品管线中。在样品管线和歧管之间提供带阀的T形连接件; 入口隔离阀位于样品入口与阀门T型连接件之间的样品流动路径中; 分析室隔离阀位于带阀T连接和分析室之间的样品流动路径中; 并且样品管线和歧管都具有通气阀，样品管线排气阀连接在入口和室隔离阀之间，并且歧管排放阀连接在辅助流体储存器的上游。多个阀的协调操作允许泵选择性地将流体从辅助储存器或样品通过分析室，同时通过排气阀的并行操作来施加非层流流动条件，以提供对流动表面和分析室的有效清洁。

4. 发明授权

US4410631A Compensated reference liquid 失效
标题翻译：补偿参考液
公开(公告)号：US4410631A
公开(公告)日：1983-10-18
申请号：US271321
申请日：1981-06-15
申请人： John D. Czaban , Alan D. Cormier
发明人： John D. Czaban , Alan D. Cormier
IPC分类号： G01N27/416 , G01N27/26 , C09K3/00
CPC分类号： G01N27/4165 , G01N27/333 , G01N33/492 , Y10T436/10
摘要： A reference liquid system for use with a chemical analyzer that has a plurality of ion selective electrodes comprises a plurality of reference liquids, each of which has a first salt component such that ions of a first element to be measured are present in a predetermined concentration, a second salt component such that ions of a second element to be measured are present in a predetermined concentration, and an error compensation salt component present in a concentration effective to adjust(a) the activity coefficient factor and/or(b) the junction potential factorto reduce the error involved in use of the compensated reference liquid to less than fifty percent of the error involved in use of a corresponding uncompensated reference liquid.
摘要翻译：一种与具有多个离子选择性电极的化学分析仪一起使用的参考液体系统包括多个参考液体，每个参比液体具有第一盐成分，使得待测量的第一元素的离子以预定浓度存在，第二盐成分，使得待测量的第二元素的离子以预定浓度存在，以及有效调整（a）活性系数因子和/或（b）结电位的浓度存在的误差补偿盐成分因素，以减少使用补偿参考液体所涉及的误差小于使用相应的未补偿参考液体所涉及的误差的百分之五十。

5. 发明授权

US4369127A Blood gas control 失效
标题翻译：血气控制
公开(公告)号：US4369127A
公开(公告)日：1983-01-18
申请号：US241600
申请日：1981-03-09
申请人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
发明人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
IPC分类号： G01N33/96 , G01N33/48 , B01J13/00 , C09K3/00 , G01N33/00
CPC分类号： G01N33/96 , G01N2496/70 , Y10T436/102499
摘要： A blood gas control liquid comprises a stable oil-in-water emulsion that has an oxygen solubility coefficient of at least 10 ml O.sub.2 per 100 ml emulsion and a viscosity of less than 10 centipoises. The emulsion includes water, 5-40 percent by volume of a water-insoluble non-protein compound material, 0.25-10 percent by volume of a nonionic surfactant, a pH buffering agent and a preservative agent which is substantially non-reactive with the pH buffering agent. A preferred blood gas control liquid has a density of about 1.08. The blood gas control liquid has a pH in the range of 7-8, a partial pressure of carbon dioxide in the range of 15-80 millimeters Hg, and a partial pressure of oxygen in the range of 20-600 mm Hg.
摘要翻译：血液气体控制液体包含稳定的水包油乳液，其氧溶解度系数为每100ml乳液至少10ml O2，粘度小于10厘泊。该乳液包括水，5-40体积％的不溶于水的非蛋白质复合材料，0.25-10体积％的非离子表面活性剂，pH缓冲剂和防腐剂，其基本上不与pH反应缓冲剂。优选的血液控制液体具有约1.08的密度。血液气体控制液体的pH值在7-8范围内，二氧化碳分压在15-80毫米汞柱之间，氧气分压在20-600毫米汞柱之间。

6. 发明授权

US4299728A Blood gas control 失效
标题翻译：血气控制
公开(公告)号：US4299728A
公开(公告)日：1981-11-10
申请号：US170600
申请日：1980-07-21
申请人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
发明人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
IPC分类号： A61B5/145 , A61B5/1495 , A61K9/66 , G01N33/49 , G01N33/96 , C09K3/00 , B01J13/00 , G01N33/00 , G01N33/48
CPC分类号： G01N33/96 , G01N2496/70 , Y10T436/102499
摘要： A blood gas control liquid comprises water, 5-40 percent by volume of a water-insoluble perfluorinated compound material that has an oxygen solubility coefficient, at one atmosphere pressure, 25.degree. C., and a volumetric proportion of 15 percent of at least 10 ml O.sub.2 per 100 mL emulsion, 0.25-10 percent by volume of a nonionic, fluorocarbon-based surfactant, a preservative agent and a buffering agent which is substantially non-reactive with said preservative agent. The blood gas control liquid has a pH in the range of 7-8, a partial pressure of carbon dioxide in the range of 15-80 millimeters Hg, and a partial pressure of oxygen in the range of 20-600 mm Hg.
摘要翻译：血液对照液含有5-40体积％的水溶性全氟化合物，其具有氧溶解度系数，一个大气压，25℃，体积比例为15％至少10 ml O 2 / 0.25ml体积的非离子型氟碳类表面活性剂，防腐剂和与所述防腐剂基本上不反应的缓冲剂。血液气体控制液体的pH值在7-8范围内，二氧化碳分压在15-80毫米汞柱之间，氧气分压在20-600毫米汞柱之间。

7. 发明授权

US5019238A Means for quantitative determination of analyte in liquids 失效
标题翻译：用于定量测定液体中分析物的方法
公开(公告)号：US5019238A
公开(公告)日：1991-05-28
申请号：US477172
申请日：1990-01-25
申请人： Alan D. Cormier , Melvin S. Weinberg
发明人： Alan D. Cormier , Melvin S. Weinberg
IPC分类号： G01N27/403
CPC分类号： G01N27/403
摘要： A testing module is provided having units which can be arranged seriatim to provide narrow through passageways linked to each other for quantitative determination of analytes passing through the units as by electrical testing with electrodes. Auxiliary passageways are preferably used in one unit to allow flushing of a first sample chamber without contamination from a second sample chamber. An electrode holder carries a membrane backed by a gel to aid in electrically linking the membrane to an electrode and to support the membrane in a substantially planar condition in use.
摘要翻译：提供了一种测试模块，其具有可以串联地布置以提供彼此连接的窄通道的单元，用于通过电极的电气测试来定量测定通过单元的分析物。辅助通道优选地用于一个单元中以允许冲洗第一样品室而不会污染第二样品室。电极保持器承载由凝胶支撑的膜，以有助于将膜电连接到电极并且在使用中以基本平坦的状态支撑膜。

8. 发明授权

US4627893A Means and methods for quantitative determination of analyte in liquids 失效
标题翻译：用于定量测定液体中分析物的方法和方法
公开(公告)号：US4627893A
公开(公告)日：1986-12-09
申请号：US594246
申请日：1984-03-28
申请人： Alan D. Cormier , Melvin S. Weinberg
发明人： Alan D. Cormier , Melvin S. Weinberg
IPC分类号： G01N27/26 , G01N27/27 , G01N27/28 , G01N27/333 , G01N27/38 , G01N27/403 , G01N27/30
CPC分类号： G01N27/403
摘要： A testing module is provided having units which can be arranged seriatim to provide narrow through passageways linked to each other for quantitative determination of analytes passing through the units as by electrical testing with electrodes. Auxiliary passageways are preferably used in one unit to allow flushing of a first sample chamber without contamination from a second sample chamber. An electrode holder carries a membrane backed by a gel to aid in electrically linking the membrane to an electrode and to support the membrane in a substantially planar condition in use.
摘要翻译：提供了一种测试模块，其具有可以串联地布置以提供彼此连接的窄通道的单元，用于通过电极的电气测试来定量测定通过单元的分析物。辅助通道优选地用于一个单元中以允许冲洗第一样品室而不会污染第二样品室。电极保持器承载由凝胶支撑的膜，以有助于将膜电连接到电极并且在使用中以基本平坦的状态支撑膜。

9. 发明授权

US4786372A Electrochemical measuring 失效
标题翻译：电化学测量
公开(公告)号：US4786372A
公开(公告)日：1988-11-22
申请号：US757648
申请日：1985-07-22
申请人： Ronald L. Jones , Alan D. Cormier , Melvin S. Weinberg
发明人： Ronald L. Jones , Alan D. Cormier , Melvin S. Weinberg
IPC分类号： G01N27/28 , G01N27/46
CPC分类号： G01N33/4915
摘要： A fluid arrangement for analyzing a fluid sample using an electrochemical measuring apparatus having an analyzing device with an inlet port and an outlet port, the outlet port connecting to an outlet tube, the inlet port connecting to an inlet tube having a sample fluid receiving end, and the inlet tube connecting at a junction along its length to one end of a fluid supply tube, which fluid supply tube is connected at its opposite end to at least one fluid source containing a fluid. In a first mode, the fluid from the supply source flows through the fluid supply tube to the junction and the fluid then flows simultaneously in a proximal direction and a distal direction within the inlet tube from the junction, and in a second mode, a fluid sample is drawn through the inlet tube past the junction and into the analyzing module.
摘要翻译：一种用于使用具有分析装置的电化学测量装置分析流体样品的流体装置，所述分析装置具有入口和出口，所述出口连接到出口管，所述入口连接到具有样品流体接收端的入口管，并且所述入口管沿其长度的连接处连接到流体供应管的一端，所述流体供应管在其相对端处连接到包含流体的至少一个流体源。在第一模式中，来自供应源的流体流经流体供应管流到连接处，然后流体沿着从连接处的入口管内的近端方向和远端方向同时流动，而在第二模式中，流体样品通过入口管穿过接头并进入分析模块。

10. 发明授权

US4361540A Analysis system 失效
标题翻译：分析系统
公开(公告)号：US4361540A
公开(公告)日：1982-11-30
申请号：US319314
申请日：1981-11-09
申请人： Melvin S. Weinberg , Alan D. Cormier
发明人： Melvin S. Weinberg , Alan D. Cormier
IPC分类号： G01N27/403 , G01N33/487 , G01N33/49 , G01N27/30
CPC分类号： G01N33/4915
摘要： An analysis system for measuring a plurality of parameters of a fluid sample comprises a housing, and a flow-through cell in the housing that has opposed surfaces with at least two ports in each surface. One of the ports is an inlet port, a second of the ports is an outlet port, and at least two of the ports are sensing ports. A sample flow path including a serpentine portion in the cell serially connects the ports and extends from a port in one surface to a port in the other surface and back to a port in the one surface, and a sensor is disposed in sealing engagement with each sensing port and forms a portion of the serpentine flow path so that sample fluid to be analyzed contacts a surface of each sensor.
摘要翻译：用于测量流体样品的多个参数的分析系统包括壳体和壳体中的流通池，其具有在每个表面中具有至少两个端口的相对表面。其中一个端口是入口端口，第二个端口是出口端口，并且至少两个端口是感测端口。包括单元中的蛇形部分的样品流动路径串联地连接并且从一个表面中的端口延伸到另一表面中的端口并且返回到一个表面中的端口，并且传感器设置成与每个端口密封接合感测端口并形成蛇形流动路径的一部分，使得待分析的样品流体接触每个传感器的表面。

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