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1. 发明授权

US4399362A Liquid handling apparatus 失效
标题翻译：液体处理设备
公开(公告)号：US4399362A
公开(公告)日：1983-08-16
申请号：US239025
申请日：1981-02-27
申请人： Alan D. Cormier , John D. Czaban , Thomas J. Schillinger , Kenneth D. Legg , Thomas F. Kelley
发明人： Alan D. Cormier , John D. Czaban , Thomas J. Schillinger , Kenneth D. Legg , Thomas F. Kelley
IPC分类号： G01N35/08 , G01N21/01
CPC分类号： G01N35/08
摘要： A clinical analyzer system flows a small volume (less than 200 microliters) of liquid sample to be analyzed from an inlet port past a sensor array to a series of analysis chambers. The sensor array includes two optical sensor units that are spaced a fixed distance apart, and each sensor unit transmits a beam of infrared radiation through the flow tube for sensing by a detector. Each detector output has a low value when blood is in the flow tube, an intermediate value when air is in the flow tube, and a high value when a clear liquid is in the flow tube. Control logic senses changes in the outputs of the detectors and accurately indicates gas-liquid interface transitions. The noninvasive system accurately locates leading and trailing edges of samples of biological fluids to be analyzed, monitors the integrity of those samples, and distinguishes between types of sample liquids processed by the analyzer.
摘要翻译：临床分析仪系统将小分子量（小于200微升）的液体样品从入口通过传感器阵列流向一系列分析室。传感器阵列包括间隔开固定距离的两个光学传感器单元，每个传感器单元透过一束红外线辐射通过流管，以便由检测器检测。当血液在流管中时，每个检测器输出值都较低，空气在流管中时的中间值，而当流管中有透明液体时，其值为高值。控制逻辑检测检测器输出的变化并准确地指示气 - 液界面转变。非侵入性系统准确地定位要分析的生物流体样品的前缘和后缘，监测这些样品的完整性，并区分由分析仪处理的样品液体的类型。

2. 发明授权

US4531088A Blood analysis 失效
标题翻译：血液分析
公开(公告)号：US4531088A
公开(公告)日：1985-07-23
申请号：US405870
申请日：1982-08-06
申请人： John D. Czaban , Alan D. Cormier , Kenneth D. Legg
发明人： John D. Czaban , Alan D. Cormier , Kenneth D. Legg
IPC分类号： G01N27/416 , G01N27/28 , G01N33/487 , G01N33/49 , G01N27/00
CPC分类号： G01N33/4915
摘要： Rapid and accurate whole blood analysis measurements are made with analysis systems of the potentiometric type that employ restricted diffusion type liquid junctions where the whole blood sample is flowed past sensing electrode and liquid junction at a velocity of at least one centimeter per second during a data acquisition interval that is at least twenty-five milliseconds in duration.
摘要翻译：使用限制性扩散型液体接头的电位分析系统进行快速准确的全血分析测量，在数据采集期间，全血样以每秒至少一厘米的速度流过检测电极和液体接头间隔至少为25毫秒。

3. 发明授权

US4369127A Blood gas control 失效
标题翻译：血气控制
公开(公告)号：US4369127A
公开(公告)日：1983-01-18
申请号：US241600
申请日：1981-03-09
申请人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
发明人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
IPC分类号： G01N33/96 , G01N33/48 , B01J13/00 , C09K3/00 , G01N33/00
CPC分类号： G01N33/96 , G01N2496/70 , Y10T436/102499
摘要： A blood gas control liquid comprises a stable oil-in-water emulsion that has an oxygen solubility coefficient of at least 10 ml O.sub.2 per 100 ml emulsion and a viscosity of less than 10 centipoises. The emulsion includes water, 5-40 percent by volume of a water-insoluble non-protein compound material, 0.25-10 percent by volume of a nonionic surfactant, a pH buffering agent and a preservative agent which is substantially non-reactive with the pH buffering agent. A preferred blood gas control liquid has a density of about 1.08. The blood gas control liquid has a pH in the range of 7-8, a partial pressure of carbon dioxide in the range of 15-80 millimeters Hg, and a partial pressure of oxygen in the range of 20-600 mm Hg.
摘要翻译：血液气体控制液体包含稳定的水包油乳液，其氧溶解度系数为每100ml乳液至少10ml O2，粘度小于10厘泊。该乳液包括水，5-40体积％的不溶于水的非蛋白质复合材料，0.25-10体积％的非离子表面活性剂，pH缓冲剂和防腐剂，其基本上不与pH反应缓冲剂。优选的血液控制液体具有约1.08的密度。血液气体控制液体的pH值在7-8范围内，二氧化碳分压在15-80毫米汞柱之间，氧气分压在20-600毫米汞柱之间。

4. 发明授权

US4299728A Blood gas control 失效
标题翻译：血气控制
公开(公告)号：US4299728A
公开(公告)日：1981-11-10
申请号：US170600
申请日：1980-07-21
申请人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
发明人： Alan D. Cormier , Marvin Feil , Kenneth D. Legg
IPC分类号： A61B5/145 , A61B5/1495 , A61K9/66 , G01N33/49 , G01N33/96 , C09K3/00 , B01J13/00 , G01N33/00 , G01N33/48
CPC分类号： G01N33/96 , G01N2496/70 , Y10T436/102499
摘要： A blood gas control liquid comprises water, 5-40 percent by volume of a water-insoluble perfluorinated compound material that has an oxygen solubility coefficient, at one atmosphere pressure, 25.degree. C., and a volumetric proportion of 15 percent of at least 10 ml O.sub.2 per 100 mL emulsion, 0.25-10 percent by volume of a nonionic, fluorocarbon-based surfactant, a preservative agent and a buffering agent which is substantially non-reactive with said preservative agent. The blood gas control liquid has a pH in the range of 7-8, a partial pressure of carbon dioxide in the range of 15-80 millimeters Hg, and a partial pressure of oxygen in the range of 20-600 mm Hg.
摘要翻译：血液对照液含有5-40体积％的水溶性全氟化合物，其具有氧溶解度系数，一个大气压，25℃，体积比例为15％至少10 ml O 2 / 0.25ml体积的非离子型氟碳类表面活性剂，防腐剂和与所述防腐剂基本上不反应的缓冲剂。血液气体控制液体的pH值在7-8范围内，二氧化碳分压在15-80毫米汞柱之间，氧气分压在20-600毫米汞柱之间。

5. 发明授权

US4343705A Biological liquid fractionation using alternate opposite flow directions across a membrane 失效
$Biological liquid fractionation using alternate opposite flow directions across a membrane$
标题翻译：使用跨膜的交替相反流动方向的生物液体分馏
公开(公告)号：US4343705A
公开(公告)日：1982-08-10
申请号：US202478
申请日：1980-10-31
申请人： Kenneth D. Legg
发明人： Kenneth D. Legg
IPC分类号： A61K35/14 , B01D61/14 , B01D63/08 , B01D65/08 , G01N33/49 , B01D13/00 , B01D31/00
CPC分类号： B01D65/08 , G01N33/491 , B01D2321/2083
摘要： A fractionation system for providing a clarified fraction or a fraction for analysis of biological fluids and the like includes a disposable filtration vessel with a first reservoir chamber adapted to receive the fluid to be fractionated, a second reservoir chamber and a flow channel that extends between the reservoir chambers. The lower surface of the flow channel is defined by a microporous sheet membrane, and collection structure is disposed on the side of the membrane opposite the flow channel. Low gas pressure (less than ten psi) applied alternately to liquid surfaces in the reservoir chambers produced reciprocating flow of the fluid between the reservoir chambers in a wide thin stream through the flow channel with resulting collection of a fraction of the liquid material that passes through the membrane. A one-half milliliter volume of plasma from a two milliliter volume sample of blood is obtained with the system in less than one minute without any discernible hemolysis.
摘要翻译：用于提供用于分析生物流体等的澄清馏分或馏分的分馏系统包括一次性过滤容器，其具有适于接收要分馏的流体的第一储存室，第二储存室和在第二储存室之间延伸的流动通道储存室。流动通道的下表面由微孔片膜限定，并且收集结构设置在与流动通道相对的膜侧。交替地施加到储存室中的液体表面的低气压（小于10psi）产生了在宽的薄流中的储存室之间的流体的往复流动通过流动通道，从而导致通过一部分液体材料的通过膜。使用系统在不到一分钟内获得来自两毫升体积血液样品的半毫升体积的血浆，而没有任何可辨别的溶血。

6. 发明授权

US06319665B1 Home test kit and method with telephone verification of results 失效
标题翻译：家庭测试套件和方法与电话验证结果
公开(公告)号：US06319665B1
公开(公告)日：2001-11-20
申请号：US08255008
申请日：1994-06-07
申请人： Ron Zwanziger , Kenneth D. Legg
发明人： Ron Zwanziger , Kenneth D. Legg
IPC分类号： C12Q170
CPC分类号： A61B5/411 , A61B5/0002 , B01L3/5055 , G01N30/90 , G01N33/558 , G01N33/56988 , Y10S435/974
摘要： Self-testing for a disease or physiological condition is achieved by having the individual being tested obtain a sample of physiological fluid, e.g., blood, urine, sputum or saliva, from him or herself. The sample is introduced into an assay system which produces a coded pattern indicative of the presence or a different coded pattern indicative of the absence of the disease or physiological condition. The individual then transmits the coded pattern to a remote location, for example by making a telephone call to an interpretation center, and receives from the remote location an interpretation of the coded pattern together with any counseling which may be appropriate in view of the interpretation of the coded pattern. The coded patterns are selected such that the individual may not interpret the test results without consulting the interpretation center. Further, the assay system employed is advantageously made so that the coded patterns indicative of a positive or negative result are dependent on an identifier, such as a lot number or serial number, assigned to the assay system or kit containing the assay system.
摘要翻译：通过测试个体从他或她自己获得生理液体样品例如血液，尿液，痰液或唾液来实现疾病或生理状态的自我检测。将样品引入测定系统，其产生指示存在的编码模式或指示不存在疾病或生理状况的不同编码模式。个体然后将编码模式发送到远程位置，例如通过向解释中心进行电话呼叫，并从远程位置接收编码模式的解释以及鉴于对编码模式。选择编码模式，使得个人在不咨询解释中心的情况下可能不解释测试结果。此外，所采用的测定系统有利地进行，使得指示正或负结果的编码模式取决于分配给包含测定系统的测定系统或试剂盒的标识符，例如批号或序列号。

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