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1. 发明申请

US20180001320A1 FLUIDIC DEVICE, SYSTEM, AND METHOD 审中-公开
公开(公告)号：US20180001320A1
公开(公告)日：2018-01-04
申请号：US15685329
申请日：2017-08-24
申请人： The University of Tokyo , NIKON CORPORATION
发明人： Takanori ICHIKI , Taro UENO , Ryo KOBAYASHI , Hirofumi SHIONO
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0861 , B01L2300/0867 , B01L2400/049 , G01N33/54366 , G01N35/08 , G01N37/00
摘要： A fluidic device includes: a first flow path in which two or more solutions are mixed; and a second circulation flow path in which a solution mixed in the first flow path is circulated and which has a capture part configured to capture a sample substance included in the solution and/or a detection part configured to detect a sample substance included in the solution.

2. 发明申请

US20150225688A1 DEVICE FOR MEASURING ACTIVITY OF CULTURED CELLS, MICROCHAMBER AND METHOD OF MEASURING ACTIVITY OF CULTURED CELLS 审中-公开
标题翻译：用于测量培养细胞活性的装置，MICROCHAMBER和测量培养细胞活性的方法
公开(公告)号：US20150225688A1
公开(公告)日：2015-08-13
申请号：US14642265
申请日：2015-03-09
申请人： THE UNIVERSITY OF TOKYO , NIKON CORPORATION
发明人： Takanori ICHIKI , Hirofumi SHIONO
IPC分类号： C12M1/34 , G01N33/50 , C12Q1/02
CPC分类号： C12M41/46 , C12Q1/02 , G01N33/5008
摘要： A device for measuring activity of cultured cells includes a position detecting unit specifying a position of a cell to be measured, a microchamber controlling unit disposing in the culture container a microchamber which surrounds the cell and forms a measurement space, the measurement space being minute with respect to a volume of the culture container, and a measuring unit measuring environmental factors contained in the measurement space.
摘要翻译：用于测量培养细胞活性的装置包括：指定待测细胞位置的位置检测单元，设置在培养容器中的微室控制单元，其包围细胞并形成测量空间，测量空间微小于相对于培养容器的体积，以及测量单元，测量包含在测量空间中的环境因素。

3. 发明申请

US20170370922A1 FLUIDIC DEVICE, SYSTEM, AND METHOD 审中-公开
公开(公告)号：US20170370922A1
公开(公告)日：2017-12-28
申请号：US15679816
申请日：2017-08-17
申请人： The University of Tokyo , NIKON CORPORATION
发明人： Takanori ICHIKI , Taro UENO , Ryo KOBAYASHI , Hirofumi SHIONO
IPC分类号： G01N33/543 , C12Q1/68 , B01L3/00
摘要： A fluidic device includes: a circulation flow path; and a capture part arranged on the circulation flow path and configured to capture a sample substance in a solution and/or a detection part arranged on the circulation flow path and configured to detect a sample substance in a solution. A method of capturing a sample substance that is bound to a carrier particle, using a fluidic device which includes a circulation flow path and a capture part arranged on the circulation flow path and configured to capture the carrier particle and in which the circulation flow path has two or more circulation flow path valves, includes: an introduction step of, in a state where the circulation flow path valve is closed, introducing a solution that includes a sample substance to at least one of partitions partitioned by the circulation flow path valve and introducing a solution that includes a carrier particle which is bound to the sample substance to at least another of the partitions; a mix step of opening all of the circulation flow path valves and circulating and mixing a solution in the circulation flow path; and a capture step of capturing the carrier particle by the capture part.

4. 发明申请

US20150028235A1 VALVE, MICROFLUIDIC DEVICE, MICROSTRUCTURE, VALVE SHEET, METHOD OF MANUFACTURING VALVE SHEET, AND METHOD OF MANUFACTURING MICROFLUIDIC DEVICE 审中-公开
标题翻译：阀，微流体装置，微结构，阀片，制造阀门的方法以及制造微流体装置的方法
公开(公告)号：US20150028235A1
公开(公告)日：2015-01-29
申请号：US14511907
申请日：2014-10-10
申请人： The University of Tokyo , NIKON CORPORATION
发明人： Takanori ICHIKI , Hiroaki TAKEHARA , Hirofumi SHIONO
IPC分类号： F16K99/00
CPC分类号： F16K99/0038 , B01J19/00 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/1827 , B01L2300/1861 , B01L2400/0661 , F16K99/0026 , F16K99/0044 , F16K99/0049 , F16K2099/0078 , F16K2099/008 , F16K2099/0084
摘要： Provided is a valve formed of a shape-memory polymer disposed in a flow channel, in which a flow of fluid in the flow channel is adjusted by deformation of the valve.
摘要翻译：提供一种由形状记忆聚合物形成的阀，该形状记忆聚合物设置在流动通道中，其中流动通道中的流体流通过阀的变形来调节。

5. 发明申请

US20160298070A1 TRANSFER DEVICE FOR CULTURE VESSEL, CULTURE DEVICE AND HOLDER FOR CULTURE VESSEL 审中-公开
标题翻译：文化船舶文化装置转运装置及文化船舶货架
公开(公告)号：US20160298070A1
公开(公告)日：2016-10-13
申请号：US15096523
申请日：2016-04-12
申请人： NIKON CORPORATION
发明人： Takayuki UOZUMI , Yasujiro KIYOTA , Nobuhiko MAIYA , Hirofumi SHIONO
IPC分类号： C12M1/00 , C12M1/36
CPC分类号： C12M23/52 , C12M23/48 , C12M23/50 , C12M41/48
摘要： A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture vessel, and a holder for a culture vessel for holding a culture vessel, in which the transfer device for a culture vessel includes a transferring unit transferring a culture vessel for culturing a cell, an inputting unit inputting a kind of the culture vessel, a speed setting unit setting a transfer speed of the culture vessel based on a kind of the culture vessel inputted to the inputting unit, and a controlling unit controlling a transfer speed of the transferring unit to be the transfer speed set by the speed setting unit.
摘要翻译：用于转移培养细胞的培养容器的培养容器的转移装置，包括用于培养容器的转移装置的培养装置和用于保持培养容器的培养容器的保持器，其中用于培养的转移装置容器包括：转移单元，其传送用于培养细胞的培养容器;输入单元，输入培养容器的种类;速度设定单元，基于输入到输入单元的培养容器的种类，设定培养容器的传送速度; 以及控制单元，其将所述传送单元的传送速度控制为由所述速度设定单元设定的传送速度。

6. 发明申请

US20130138451A1 INFECTION SPREAD PREVENTION SUPPORT SYSTEM, INFECTION SPREAD PREVENTION SUPPORT SERVER, EXAMINATION TERMINAL, MOBILE TERMINAL AND PROGRAM 审中-公开
标题翻译：感染传播预防支持系统，感染传播预防支持服务器，检查终端，移动终端和程序
公开(公告)号：US20130138451A1
公开(公告)日：2013-05-30
申请号：US13724740
申请日：2012-12-21
申请人： Nikon Corporation
发明人： Hirofumi SHIONO , Masahiro NEI , Hideya INOUE , Ryoichi YAMASHITA , Miyuki SHIBAYAMA
IPC分类号： G06F19/00 , G06Q50/22
CPC分类号： G06F19/34 , G06Q50/22
摘要： An infection spread prevention support system includes an examination terminal and an infection spread prevention support server. The examination terminal includes an examination information acquisition unit that acquires examination information to examine the infection of an infectious disease in subjects and a transmission and reception unit that transmits the examination information to the infection spread prevention support server. The infection spread prevention support server includes a receiving unit that receives examination information, an infection determination unit that determines the presence or degree of infection of the infectious disease using the examination information, an activity regulation information generation unit that generates activity regulation information to regulate the an activity of the infected patient based on infection determination information, which is a determination result of the infection determination unit, and information regarding the subjects, and an output unit that outputs the activity regulation information.
摘要翻译：感染传播预防支持系统包括检查终端和感染传播预防支持服务器。检查终端包括检查信息获取单元，其获取检查对象中感染性感染的检查信息，以及将检查信息发送到感染传播预防支持服务器的发送和接收单元。感染传播预防支援服务器包括接收检查信息的接收单元，使用检查信息确定传染病感染的存在或程度的感染判定单元，生成调节信息的活动调节信息的活动调节信息生成单元基于感染确定信息的感染患者的活动，其是感染确定单元的确定结果，以及关于受试者的信息，以及输出单元，其输出活动调节信息。

7. 发明申请

US20210348992A1 FLUIDIC DEVICE, SYSTEM, AND MIXING METHOD 有权
公开(公告)号：US20210348992A1
公开(公告)日：2021-11-11
申请号：US17256151
申请日：2018-06-29
申请人： NIKON CORPORATION
发明人： Ryo KOBAYASHI , Hirofumi SHIONO
IPC分类号： G01N1/38 , G01N35/08 , B01F13/00
摘要： The present invention provides a fluidic device in which solutions of different concentrations can be easily obtained. The fluidic device includes: a first substrate and a second substrate which are stacked in a thickness direction; an undiluted solution introduction flow path which has an undiluted solution introduction port and which is constituted of a groove part provided on at least one of the first substrate and the second substrate; a first circulation flow path which is constituted of a groove part having an annular shape and having a shared part that shares part of a flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; a second circulation flow path which is provided independently of the first circulation flow path and which is constituted of a groove part having an annular shape and having a shared part that shares some flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; and/or a third circulation flow path which is constituted of a groove part having an annular shape and having a shared flow path that shares part of a flow path with the first circulation flow path and a non-shared flow path which is not shared with the first circulation flow path and which is connected to a diluting solution introduction port, wherein the undiluted solution introduction flow path includes a valve at both ends of the shared part.

8. 发明申请

US20160319236A1 CULTURE DEVICE 审中-公开
标题翻译：文化装置
公开(公告)号：US20160319236A1
公开(公告)日：2016-11-03
申请号：US15161796
申请日：2016-05-23
申请人： NIKON CORPORATION
发明人： Yasujiro KIYOTA , Takayuki UOZUMI , Hirofumi SHIONO , Nobuhiko MAIYA
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： C12M41/46 , C12M23/48 , C12M41/14
摘要： A culture device containing a culture vessel for culturing a cell, in which the culture device includes a thermostatic vessel having a stacker containing a plurality of culture vessels for culturing a cell, and an observation portion arranged to be isolated from an atmosphere at inside of the thermostatic vessel and having an object lens, an object lens drive portion, and a camera portion to observe a cell at inside of the culture vessel installed at an observation position at inside of the thermostatic vessel.
摘要翻译：一种培养装置，其含有用于培养细胞的培养容器，其中培养装置包括具有堆叠器的恒温容器，该堆积器含有多个用于培养细胞的培养容器，以及观察部分，被布置成与所述培养容器内的气氛隔离恒温容器，具有物镜，物镜驱动部和照相机部，以观察安装在恒温容器内部的观察位置的培养容器内部的细胞。

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