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1. 发明授权

US5219211A Braking system for motorcycle having apportioning control 失效
标题翻译：具有分配控制的摩托车制动系统
公开(公告)号：US5219211A
公开(公告)日：1993-06-15
申请号：US673209
申请日：1991-03-20
申请人： Tetsuo Tsuchida , Yukimasa Nishimoto , Takao Yoshida , Kanau Iwashita , Yoshiaki Sawano , Masaru Sasaguchi
发明人： Tetsuo Tsuchida , Yukimasa Nishimoto , Takao Yoshida , Kanau Iwashita , Yoshiaki Sawano , Masaru Sasaguchi
IPC分类号： B60T8/18 , B60T8/26 , B60T8/54 , B60T11/20 , B62L1/00 , B62L3/08 , F16D65/14 , F16D65/18
CPC分类号： B62L1/00 , B60T11/20 , B60T8/1862 , B60T8/26 , B60T8/261 , B60T8/54 , B62L3/08 , F16D65/18 , F16D2121/02 , F16D2127/08
摘要： A primary brake system operated by either one of a hand operated means and a foot operated system is mounted on one of the front and rear wheels, and a secondary brake system operated in response to the operation of the primary brake system is mounted on the other wheel. Consequently, it is possible to provide a braking-force distribution for the front and rear wheels with a predetermined common characteristic, leading to an improved brake feel. A braking-force control is provided for controlling the braking-force distribution to the front and rear wheels in accordance with the operating forces of a first input operated by the hand operated element and a second input operated by the foot operated element, so that an ideal distribution characteristic falls within a region between a first braking-force distribution characteristic for the front and rear wheels by the hand operated element and a second braking-force distribution characteristic for the wheels by the foot operated element, such region being a braking-force distribution characteristic region at a time when the hand and foot operated elements are operated simultaneously.
摘要翻译：由手动装置和脚踏操作系统中的任一个操作的主制动系统安装在前轮和后轮中的一个上，并且响应于主制动系统的操作而操作的二次制动系统安装在另一个上轮。因此，可以以预定的共同特征为前轮和后轮提供制动力分配，从而提高制动感。根据由手动操作元件操作的第一输入的操作力和由脚踏元件操作的第二输入，提供制动力控制来控制对前轮和后轮的制动力分配，使得理想的分配特性落在通过手动元件的前后轮的第一制动力分布特性和脚踏操作元件的车轮的第二制动力分布特性之间的区域内，这样的区域是制动力当手和脚操作元件同时操作时的分布特征区域。

2. 发明授权

US08815597B2 Baglike container for centrifugation and method of gene transfer using the same 有权
标题翻译：用于离心的袋状容器和使用其的基因转移方法
公开(公告)号：US08815597B2
公开(公告)日：2014-08-26
申请号：US12377234
申请日：2007-08-23
申请人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
发明人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
IPC分类号： C12N1/00 , C12M1/42 , C12N15/87 , A61J1/10 , C12M1/00 , C12M3/00 , C12N15/00 , C12P21/04 , C12P21/06 , B01L3/00
CPC分类号： A61J1/10 , B01L3/5021 , B01L3/505 , C12M23/14 , C12M35/04 , C12N15/87
摘要： The present invention provides a baglike container for centrifugation that is mounted in a centrifuge to thereby allow centrifugation of a dispersion liquid accommodated therein. The baglike container for centrifugation is less likely to tear or break as a result of centrifugation by disposing a container wall surface of the baglike container so as to apply centrifugal force perpendicular to the container wall surface.
摘要翻译：本发明提供一种用于离心的袋状容器，其安装在离心机中，从而允许其中容纳的分散液的离心。用于离心的袋状容器由于通过设置袋状容器的容器壁表面而离心而不易撕裂或破裂，从而施加垂直于容器壁表面的离心力。

3. 发明申请

US20130164294A1 SUBSTANCE SPECIFIC TO HUMAN PD-1 有权
公开(公告)号：US20130164294A1
公开(公告)日：2013-06-27
申请号：US13548807
申请日：2012-07-13
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.

4. 发明申请

US20110123550A1 USE OF AN EFFICACY MARKER FOR OPTIMIZING THERAPEUTIC EFFICACY OF AN ANTI-HUMAN PD-1 ANTIBODY ON CANCERS 有权
标题翻译：使用有效标记来优化抗人PD-1抗体对癌症的治疗效果
公开(公告)号：US20110123550A1
公开(公告)日：2011-05-26
申请号：US13001875
申请日：2009-07-03
申请人： Shiro Shibayama , Takao Yoshida , Tamon Hayashi , Akio Hayashi , Jun Murai
发明人： Shiro Shibayama , Takao Yoshida , Tamon Hayashi , Akio Hayashi , Jun Murai
IPC分类号： A61K39/395 , G01N33/53 , G01N33/50 , A61P35/00
CPC分类号： C07K16/2818 , A61K2039/505 , G01N2800/52
摘要： A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.
摘要翻译：本发明的目的是提供一种能够更有效地制备用于抗癌治疗的抗人PD-1抗体的方法，用于估计或优化其治疗功效的方法，以及可用于方法。本发明能够通过测量在施用后多于血液中的几种功效标记物的一定水平的变化来选择将来能够预期抗人PD-1抗体的治疗功效的癌症患者的选择与施用初始剂量之前的抗人PD-1抗体的初始剂量或剂量相比较，并且提供了用于抗癌治疗的抗人PD-1抗体的新处方。

5. 发明授权

US07858746B2 Substance that specifically recognizes PD-1 有权
标题翻译：具体识别PD-1的物质
公开(公告)号：US07858746B2
公开(公告)日：2010-12-28
申请号：US12057637
申请日：2008-03-28
申请人： Tasuku Honjo , Shiro Shibayama , Masayoshi Matsuo , Takao Yoshida
发明人： Tasuku Honjo , Shiro Shibayama , Masayoshi Matsuo , Takao Yoshida
IPC分类号： C07K14/00
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/55 , C07K2317/626 , C07K2319/00
摘要： Compounds that can recognize selectively both PD-1 protein and a membrane protein co-existing with PD-1 on a cell membrane, and can transmit a suppressive signal of PD-1. The compounds are useful for medical treatment and/or prevention of diseases caused by immune abnormality.
摘要翻译：可以选择性识别PD-1蛋白和细胞膜上与PD-1共存的膜蛋白的化合物，并且可以传递PD-1的抑制信号。该化合物可用于治疗和/或预防由免疫异常引起的疾病。

6. 发明申请

US20100136680A1 BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME 失效
标题翻译：用于离心的巴格莱集装箱和使用该方法的基因转移方法
公开(公告)号：US20100136680A1
公开(公告)日：2010-06-03
申请号：US12377234
申请日：2006-08-23
申请人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
发明人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
IPC分类号： C12N5/10 , B04B7/12
CPC分类号： A61J1/10 , B01L3/5021 , B01L3/505 , C12M23/14 , C12M35/04 , C12N15/87
摘要： Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and with flange portion (7) provided on an open face border of the recess portion (6) and constituted of flexible second container wall (4) having its peripheral portion sealed mutually with the flange portion (7) of the first container wall (3) so as to define storing space (6′) for dispersion liquid in cooperation with the recess portion (6) and further comprising port (5) fitted to the main frame in a fashion allowing communication with the storing space (6′), wherein the recess portion (6) defining the storing space (6′) can be set in the centrifuge so that centrifugal force perpendicular to the bottom plane of the recess portion (6) applies. Moreover, there is disclosed a method of gene introduction using this baglike container.
摘要翻译：袋状容器（1），其装配在离心机中，从而允许离心分离任何分散液体。用于离心的袋状容器是包括由具有凹部（6）的第一容器壁（3）构成的主框架，所述第一容器壁（3）形成为能够安装在离心机中，并且具有设置在凹部的开放面边界上的凸缘部（7）部分（6），并且由具有与第一容器壁（3）的凸缘部分（7）相互密封的周边部分的柔性第二容器壁（4）构成，以便在合作中限定用于分散液体的储存空间（6'）与所述凹部（6）相连并且还包括以允许与所述存放空间（6'）连通的方式装配到所述主框架的端口（5），其中限定所述存储空间（6'）的所述凹部（6）可以设置在离心机中，使得垂直于凹部（6）的底面的离心力适用。此外，公开了使用该袋状容器的基因导入方法。

7. 发明申请

US20080247084A1 Disk Device, Shutter Control Device, and Computer Program for Shutter Opening/Closing Control 失效
标题翻译：磁盘设备，快门控制设备和快门打开/关闭控制的计算机程序
公开(公告)号：US20080247084A1
公开(公告)日：2008-10-09
申请号：US11886881
申请日：2006-03-27
申请人： Hiroyuki Matsumoto , Takeshi Matsumoto , Katsunori Tamamura , Takao Yoshida , Fumito Inaba , Makoto Ikehata
发明人： Hiroyuki Matsumoto , Takeshi Matsumoto , Katsunori Tamamura , Takao Yoshida , Fumito Inaba , Makoto Ikehata
IPC分类号： G11B17/051 , G11B33/02
CPC分类号： G11B17/0405 , G11B17/0407
摘要： To assuredly determine whether a shutter pinches a disk in a disk device including a shutter at a disk insertion slot. A shutter control device 10 includes a pinch determining unit 14 that determines whether the disk is pinched by the shutter based on a position of the shutter during a process of closing the shutter, and a sensitivity changing unit that sets sensitivity of determination to be high as ambient temperature of a shutter driving mechanism increases.
摘要翻译：为了确定地确定快门是否在包括盘插入槽的快门的盘装置中夹住盘。快门控制装置10包括捏合确定单元14，其确定在关闭快门的过程期间基于快门的快门的盘被盘夹住;以及灵敏度改变单元，其将确定的灵敏度设置为高，如快门驱动机构的环境温度升高。

8. 发明授权

US06980493B2 Information recording medium conveyer 失效
标题翻译：信息记录介质输送机
公开(公告)号：US06980493B2
公开(公告)日：2005-12-27
申请号：US10427988
申请日：2003-05-02
申请人： Yuichi Kimikawa , Nobutaka Kawakita , Katsunori Tamamura , Hiroyuki Matsumoto , Takao Yoshida , Masashi Takano
发明人： Yuichi Kimikawa , Nobutaka Kawakita , Katsunori Tamamura , Hiroyuki Matsumoto , Takao Yoshida , Masashi Takano
IPC分类号： G11B17/26 , G11B17/04 , G11B17/22 , G11B7/085
CPC分类号： G11B17/051 , G11B17/021 , G11B17/0404
摘要： An information recording medium conveyer is provided, which provides countermeasures against power interruptions with high reliability. When a power interruption occurs during a loading operation with a conveying roller, the first unloading operation is initiated. When the outputs from detection sensors satisfy a predetermined condition during the first unloading operation, the process is initialized to cause the conveying roller to initiate a re-loading operation, thereby loading an information recording medium into a tray. On the other hand, when the outputs from the detection sensors do not change in accordance with a predetermined sequence during the re-loading operation, the process initiates the second unloading operation. When the detection sensors have detected the information recording medium during the second unloading operation and then the outputs from the detection sensors satisfy the predetermined condition, the process is initialized to cause the conveying roller to initiate another loading operation, thereby loading the information recording medium into the tray. Even when a power interruption occurs during an unloading operation, the same processing is performed to eject the information recording medium.
摘要翻译：提供了一种信息记录介质输送机，提供了高可靠性的电力中断对策。当在与输送辊的装载操作期间发生电力中断时，开始第一卸载操作。当检测传感器的输出在第一卸载操作期间满足预定条件时，初始化处理以使输送辊开始重新加载操作，从而将信息记录介质装载到托盘中。另一方面，当检测传感器的输出在重新加载操作期间根据预定顺序不改变时，处理开始第二卸载操作。当检测传感器在第二卸载操作期间检测到信息记录介质，然后检测传感器的输出满足预定条件时，初始化处理以使输送辊开始另一加载操作，从而将信息记录介质装入托盘。即使在卸载操作期间发生电源中断时，也执行相同的处理以弹出信息记录介质。

9. 发明授权

US5114004A Filled and sealed, self-contained mixing container 失效
标题翻译：填充和密封，自包含混合容器
公开(公告)号：US5114004A
公开(公告)日：1992-05-19
申请号：US654037
申请日：1991-02-12
申请人： Keinosuke Isono , Takao Yoshida , Tatsuo Suzuki
发明人： Keinosuke Isono , Takao Yoshida , Tatsuo Suzuki
IPC分类号： A61J1/00 , A61J1/20 , B65D81/32
CPC分类号： A61J1/2093 , B65D81/3266 , A61J1/201 , A61J1/2027 , A61M2207/00
摘要： Disclosed herein is a filled and sealed, self-contained mixing container. The container has compartments which are isolated from each other. Plural substances which contain components susceptible to mutual reaction unless isolated from each other are contained in the respective compartments. In use, these compartments are communicated together so that the individual contents can be mixed within the container. A flow passage or passages, each of which has an isolator for the contents and is adapted to communicate the compartments with each other, and is formed by a side channel provided on an outer surface of a wall of the container. Mixing of the contents without exposure to the external atmosphere can be realized by irreversible destruction of the isolator upon use. The container is suited particularly for a closed therapy system.

10. 发明授权

US4909854A Process for augmenting or enhancing the aroma or taste of smoking tobacco or smoking tobacco articles using tricyclic alcohols, ethers and/or esters and smoking tobacco compositions and articles so modified 失效
标题翻译：使用三环醇，醚和/或酯增强或增强吸烟烟草或烟草制品的香气或味道的方法，以及吸烟烟草组合物和如此修改的制品
公开(公告)号：US4909854A
公开(公告)日：1990-03-20
申请号：US311142
申请日：1981-10-13
申请人： Kenneth K. Light , Joseph A. McGhie , Futoshi Fujioka , Takao Yoshida
发明人： Kenneth K. Light , Joseph A. McGhie , Futoshi Fujioka , Takao Yoshida
IPC分类号： A23L27/20 , A24B15/34 , C07C45/00 , C07C45/67 , C07C49/453
CPC分类号： C07C49/453 , A23L27/203 , C07C403/02 , C07C45/00 , C07C45/67 , C07C2101/16
摘要： Described for use in augmenting or enhancing the aroma or taste of smoking tobaccos and smoking tobacco articles, e.g., the body of smoking tobacco, the wrapper or the filter therefor in a cigarette or cigar, or the whole cigarette or cigar itself are compounds defined according to the generic structure: ##STR1## wherein R.sub.1 represents hydrogen, methyl or acetyl and wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent the same or different hydrogen, methyl or ethyl.
摘要翻译：描述用于增强或增强吸烟烟草和烟草制品的香气或味道，例如吸烟烟草，香烟或雪茄中的包装物或其过滤器，或整个香烟或雪茄本身是根据涉及通用结构：其中R 1表示氢，甲基或乙酰基，其中R 2，R 3，R 4和R 5表示相同或不同的氢，甲基或乙基。

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