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1. 发明授权

US08815597B2 Baglike container for centrifugation and method of gene transfer using the same 有权
标题翻译：用于离心的袋状容器和使用其的基因转移方法
公开(公告)号：US08815597B2
公开(公告)日：2014-08-26
申请号：US12377234
申请日：2007-08-23
申请人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
发明人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
IPC分类号： C12N1/00 , C12M1/42 , C12N15/87 , A61J1/10 , C12M1/00 , C12M3/00 , C12N15/00 , C12P21/04 , C12P21/06 , B01L3/00
CPC分类号： A61J1/10 , B01L3/5021 , B01L3/505 , C12M23/14 , C12M35/04 , C12N15/87
摘要： The present invention provides a baglike container for centrifugation that is mounted in a centrifuge to thereby allow centrifugation of a dispersion liquid accommodated therein. The baglike container for centrifugation is less likely to tear or break as a result of centrifugation by disposing a container wall surface of the baglike container so as to apply centrifugal force perpendicular to the container wall surface.
摘要翻译：本发明提供一种用于离心的袋状容器，其安装在离心机中，从而允许其中容纳的分散液的离心。用于离心的袋状容器由于通过设置袋状容器的容器壁表面而离心而不易撕裂或破裂，从而施加垂直于容器壁表面的离心力。

2. 发明申请

US20100136680A1 BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME 失效
标题翻译：用于离心的巴格莱集装箱和使用该方法的基因转移方法
公开(公告)号：US20100136680A1
公开(公告)日：2010-06-03
申请号：US12377234
申请日：2006-08-23
申请人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
发明人： Hideto Chono , Junichi Mineno , Kazutoh Takesako , Takao Yoshida , Takashi Morimura , Kenji Sakai , Shin-ichi Yamada , Noritsugu Yabe , Yuko Taguchi
IPC分类号： C12N5/10 , B04B7/12
CPC分类号： A61J1/10 , B01L3/5021 , B01L3/505 , C12M23/14 , C12M35/04 , C12N15/87
摘要： Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and with flange portion (7) provided on an open face border of the recess portion (6) and constituted of flexible second container wall (4) having its peripheral portion sealed mutually with the flange portion (7) of the first container wall (3) so as to define storing space (6′) for dispersion liquid in cooperation with the recess portion (6) and further comprising port (5) fitted to the main frame in a fashion allowing communication with the storing space (6′), wherein the recess portion (6) defining the storing space (6′) can be set in the centrifuge so that centrifugal force perpendicular to the bottom plane of the recess portion (6) applies. Moreover, there is disclosed a method of gene introduction using this baglike container.
摘要翻译：袋状容器（1），其装配在离心机中，从而允许离心分离任何分散液体。用于离心的袋状容器是包括由具有凹部（6）的第一容器壁（3）构成的主框架，所述第一容器壁（3）形成为能够安装在离心机中，并且具有设置在凹部的开放面边界上的凸缘部（7）部分（6），并且由具有与第一容器壁（3）的凸缘部分（7）相互密封的周边部分的柔性第二容器壁（4）构成，以便在合作中限定用于分散液体的储存空间（6'）与所述凹部（6）相连并且还包括以允许与所述存放空间（6'）连通的方式装配到所述主框架的端口（5），其中限定所述存储空间（6'）的所述凹部（6）可以设置在离心机中，使得垂直于凹部（6）的底面的离心力适用。此外，公开了使用该袋状容器的基因导入方法。

3. 发明授权

US06518317B1 Antiviral agents 失效
标题翻译：抗病毒剂
公开(公告)号：US06518317B1
公开(公告)日：2003-02-11
申请号：US09367185
申请日：1999-08-09
申请人： Hiroaki Sagawa , Nobuto Koyama , Hideto Chono , Kazutoh Takesako , Ikunoshin Kato
发明人： Hiroaki Sagawa , Nobuto Koyama , Hideto Chono , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： A61K31122
CPC分类号： C07C323/58 , A23K20/105 , A23L2/52 , A23L33/10 , A61K31/122 , C07C323/59 , Y10S514/894
摘要： An antiviral agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译：一种抗病毒剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为有效成分。

4. 发明申请

US20100113566A1 NUCLEIC ACID FOR TREATMENT OR PREVENTION OF IMMUNODEFICIENCY VIRUS INFECTION 有权
标题翻译：用于治疗或预防免疫缺陷病毒感染的核酸
公开(公告)号：US20100113566A1
公开(公告)日：2010-05-06
申请号：US12064185
申请日：2006-08-10
申请人： Hideto Chono , Kazuya Matsumoto , Junichi Mineno , Ikunoshin Kato
发明人： Hideto Chono , Kazuya Matsumoto , Junichi Mineno , Ikunoshin Kato
IPC分类号： A61K31/7088 , C07H21/00 , C12N15/74 , C12N5/0783 , A61P31/18
CPC分类号： C12N15/86 , A61K31/7088 , A61K35/17 , A61K38/00 , A61K38/465 , A61K48/00 , C07K14/4702 , C12N5/0636 , C12N9/22 , C12N15/85 , C12N2510/00 , C12N2830/002 , Y02A50/473
摘要： A nucleic acid comprising a transcription regulation sequence whose transcription is induced by a trans-acting factor of a human immunodeficiency virus and a gene encoding a polypeptide having an endoribonuclease activity specific to single-stranded RNA, wherein the gene is located in such a position that the expression of the gene can be regulated by the transcription regulation sequence; a method for production of a cell showing an inhibited replication of a human immunodeficiency virus therein, the method comprising the step of introducing the nucleic acid into a cell; and a method for treatment or prevention of a human immunodeficiency virus infection.
摘要翻译：一种核酸，其包含其转录由人免疫缺陷病毒的反式作用因子诱导的转录调控序列和编码具有对单链RNA特异性的内切核糖核酸酶活性的多肽的基因，其中所述基因位于该基因的表达可以通过转录调控序列来调节; 一种在其中显示抑制人体免疫缺陷病毒复制的细胞的制备方法，所述方法包括将核酸引入细胞的步骤; 以及用于治疗或预防人类免疫缺陷病毒感染的方法。

5. 发明授权

US09057056B2 Method for producing retrovirus using human producer cells with increased N-acetylglucosaminyltransferase III activity 有权
标题翻译：使用具有增加的N-乙酰葡糖胺基转移酶III活性的人生产细胞产生逆转录病毒的方法
公开(公告)号：US09057056B2
公开(公告)日：2015-06-16
申请号：US11663990
申请日：2005-09-28
申请人： Hideto Chono , Hiromi Okuyama , Tomoe Egashira , Nobuto Koyama , Junichi Mineno , Ikunoshin Kato
发明人： Hideto Chono , Hiromi Okuyama , Tomoe Egashira , Nobuto Koyama , Junichi Mineno , Ikunoshin Kato
IPC分类号： C12N15/87 , C12N15/63 , C12N9/10 , C12N15/86
CPC分类号： C12N9/1051 , C12N15/86 , C12N2740/13043 , C12N2740/13052 , C12N2799/02 , C12N2810/10
摘要： The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high infection efficiency particularly in the presence of a functional substance.
摘要翻译：在携带逆转录病毒起始gag-pol基因和env基因的细胞中N-乙酰葡糖胺基转移酶III活性增强。通过使用上述细胞构建逆转录病毒载体，可以获得具有修饰的糖链结构的逆转录病毒载体。通过该方法构建的逆转录病毒载体特别是在功能性物质存在下显示高感染效率。

6. 发明申请

US20130109096A1 METHOD FOR GENE TRANSFER 有权
标题翻译：基因转移方法
公开(公告)号：US20130109096A1
公开(公告)日：2013-05-02
申请号：US13805373
申请日：2011-06-29
申请人： Katsuyuki Dodo , Naoki Saito , Hideto Chono , Junichi Mineno
发明人： Katsuyuki Dodo , Naoki Saito , Hideto Chono , Junichi Mineno
IPC分类号： C12N15/867
CPC分类号： C12N15/8676 , C12N15/86 , C12N15/87 , C12N2740/13043 , C12N2740/16043
摘要： Disclosed is a method for introducing a gene into a target cell using a retrovirus vector, which is simple and highly efficient. Specifically disclosed is a method for introducing a gene into a target cell using a retrovirus vector, which comprises the steps of (a) placing a liquor containing a retrovirus vector having a foreign gene carried thereon into a culture vessel on which a retrovirus-binding substance has been immobilized, and incubating the liquor at a temperature lower than 25° C. for 4 hours or longer, thereby producing a culture vessel having the retrovirus vector bound thereto, and (b) adding a target cell to the culture vessel that has been produced in step (a) and incubating the culture vessel. The gene introduction method is simple and highly efficient, and is useful particularly in the fields of medicine, cell technology, gene technology, embryologic technology and the like.
摘要翻译：公开了使用简单且高效的逆转录病毒载体将基因导入靶细胞的方法。具体公开的是使用逆转录病毒载体将基因引入靶细胞的方法，其包括以下步骤：（a）将含有携带有外来基因的逆转录病毒载体的液体放入其中具有逆转录病毒结合物质的培养容器中已经固定化，并在低于25℃的温度下将液体温育4小时或更长时间，从而产生结合有逆转录病毒载体的培养容器，和（b）将靶细胞添加到已经培养的培养容器中在步骤（a）中生产并培养培养容器。基因导入方法简单高效，特别适用于医药，细胞技术，基因技术，胚胎技术等领域。

7. 发明申请

US20120142109A1 METHOD FOR PRODUCING T CELL POPULATION UNDER PRESENCE OF RETINOIC ACID 审中-公开
标题翻译：在真菌酸存在下生产细胞群体的方法
公开(公告)号：US20120142109A1
公开(公告)日：2012-06-07
申请号：US13390378
申请日：2010-08-24
申请人： Yoshinori Katayama , Kensuke Sakai , Hirofumi Yoshioka , Hikaru Takakura , Hideto Chono , Naoki Saito , Junichi Mineno
发明人： Yoshinori Katayama , Kensuke Sakai , Hirofumi Yoshioka , Hikaru Takakura , Hideto Chono , Naoki Saito , Junichi Mineno
IPC分类号： C12N15/85 , C12N5/10 , C12N15/867 , C12N5/0783
CPC分类号： C12N5/0636 , C12N2501/385 , C12N2501/515 , C12N2501/58 , C12N2510/00
摘要： Disclosed is a method for producing a cell population containing memory-like T cells, said method being characterized by including a step for in vitro culturing of a cell population containing T cells or T cell precursor cells using a retinoic acid and a CD3 ligand. Further disclosed is a method for producing a cell population wherein the proportion of memory-like T cells is increased and wherein a desired gene is introduced with a high efficiency and is highly expressed.
摘要翻译：公开了一种用于产生含有记忆样T细胞的细胞群的方法，所述方法的特征在于包括使用视黄酸和CD3配体体外培养含有T细胞或T细胞前体细胞的细胞群的步骤。进一步公开了一种生产细胞群的方法，其中记忆样T细胞的比例增加，并且其中以高效率引入所需基因并高度表达。

8. 发明授权

US08889844B2 Nucleic acid for treatment or prevention of immunodeficiency virus infection 有权
标题翻译：用于治疗或预防免疫缺陷病毒感染的核酸
公开(公告)号：US08889844B2
公开(公告)日：2014-11-18
申请号：US12064185
申请日：2006-08-10
申请人： Hideto Chono , Kazuya Matsumoto , Junichi Mineno , Ikunoshin Kato
发明人： Hideto Chono , Kazuya Matsumoto , Junichi Mineno , Ikunoshin Kato
IPC分类号： C07H21/00 , C12N15/00 , C12N15/86 , C12N15/867 , A61K31/7088 , C12N9/22 , C12N15/85 , C12N5/0783 , C07K14/47 , A61K48/00 , A61K38/00
CPC分类号： C12N15/86 , A61K31/7088 , A61K35/17 , A61K38/00 , A61K38/465 , A61K48/00 , C07K14/4702 , C12N5/0636 , C12N9/22 , C12N15/85 , C12N2510/00 , C12N2830/002 , Y02A50/473
摘要： A nucleic acid comprising a transcription regulation sequence whose transcription is induced by a trans-acting factor of a human immunodeficiency virus and a gene encoding a polypeptide having an endoribonuclease activity specific to single-stranded RNA, wherein the gene is located in such a position that the expression of the gene can be regulated by the transcription regulation sequence; a method for production of a cell showing an inhibited replication of a human immunodeficiency virus therein, the method comprising the step of introducing the nucleic acid into a cell; and a method for treatment or prevention of a human immunodeficiency virus infection.
摘要翻译：一种核酸，其包含其转录由人免疫缺陷病毒的反式作用因子诱导的转录调控序列和编码具有对单链RNA特异性的内切核糖核酸酶活性的多肽的基因，其中所述基因位于该基因的表达可以通过转录调控序列来调节; 一种在其中显示抑制人体免疫缺陷病毒复制的细胞的制备方法，所述方法包括将核酸引入细胞的步骤; 以及用于治疗或预防人类免疫缺陷病毒感染的方法。

9. 发明申请

US20100137415A1 VECTOR FOR GENE THERAPY 审中-公开
标题翻译：基因治疗方案
公开(公告)号：US20100137415A1
公开(公告)日：2010-06-03
申请号：US12596744
申请日：2008-04-16
申请人： Hideto Chono , Kazuya Matsumoto , Hajima Matsumura , Junichi Mineno , Ikunoshin Kato
发明人： Hideto Chono , Kazuya Matsumoto , Hajima Matsumura , Junichi Mineno , Ikunoshin Kato
IPC分类号： A61K31/7088 , C12N15/74 , A61P35/00 , A61P31/12
CPC分类号： C12N9/22 , A61K38/00 , A61K48/00 , A61K48/005 , C12N15/86 , C12N2740/16043
摘要： The present invention provides a retroviral vector containing a transcription unit comprising a transcription regulatory sequence and a gene encoding a polypeptide having single-stranded RNA-specific endoribonuclease activity which is placed so that its expression can be controlled by the regulatory sequence, wherein the unit is placed so that the direction of the transcription of mRNA from the unit is opposite to the direction of transcription of the RNA genome of the retroviral vector. By using the vector constructed as described above, viral supernatant showing high gene transfer efficiency can be prepared. The retroviral vector of the present invention is useful for the treatment and/or prevention of cancers and virus infections.
摘要翻译：本发明提供了含有转录单位的逆转录病毒载体，该转录单位包含转录调节序列和编码具有单链RNA特异性核糖核酸内切酶活性的多肽的基因，所述多肽具有单链RNA特异性核糖核酸内切酶活性，以使得其表达可由调节序列控制，其中单位为使得来自该单位的mRNA的转录方向与逆转录病毒载体的RNA基因组的转录方向相反。通过使用如上所述构建的载体，可以制备显示高基因转移效率的病毒上清液。本发明的逆转录病毒载体可用于治疗和/或预防癌症和病毒感染。

10. 发明申请

US20090011485A1 METHOD OF RETROVIRUS STORAGE 审中-公开
标题翻译：逆转录病毒储存方法
公开(公告)号：US20090011485A1
公开(公告)日：2009-01-08
申请号：US11815681
申请日：2006-02-06
申请人： Hideto Chono , Yasushi Katayama , Hiromi Okuyama , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
发明人： Hideto Chono , Yasushi Katayama , Hiromi Okuyama , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N7/00
CPC分类号： C12N11/02 , C12N7/00 , C12N2740/10051
摘要： A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding activity is sealed in a container holding a solid phase having the substance with retrovirus binding activity immobilized thereon.
摘要翻译：一种逆转录病毒储存方法，其特征在于，在固相在固相上的具有逆转录病毒结合活性的物质存在下维持逆转录病毒。此外，提供了一种逆转录病毒组合物，其特征在于将具有逆转录病毒结合活性的物质结合形式的逆转录病毒密封在保持具有固定有反向病毒结合活性的物质的固相的容器中。

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