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1. 发明申请

US20070287147A1 Method of Monitoring a Microorganism That Causes Infectious Disease of a Laboratory Animal 审中-公开
标题翻译：监测导致实验动物传染病的微生物的方法
公开(公告)号：US20070287147A1
公开(公告)日：2007-12-13
申请号：US10599367
申请日：2005-03-02
申请人： Teruyuki Nagamune , Akihiko Tajima , Yutaka Yamagata , Hiroyoshi Aoki
发明人： Teruyuki Nagamune , Akihiko Tajima , Yutaka Yamagata , Hiroyoshi Aoki
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/569 , C12Q1/04 , G01N33/54366
摘要： This invention provides a method to monitor a microorganism that causes infectious disease of a laboratory animal by using a micro flow channel chip immobilized with a molecular to be tested such as an antigen or an antibody of the microorganism that causes infectious disease, the method comprises flowing serum or body fluid taken from the laboratory animal through the minute flow channel of the micro flow channel chip and detecting the antigen antibody reaction on the chip. The method of this invention enabled medical inspection of an infectious disease of a laboratory animal and microorganism monitoring of a laboratory animal, by using minute amount of animal serum or body fluid in a closed system rapidly and sensitively.
摘要翻译：本发明提供了一种通过使用固定有被测分子的微流通道芯片来监测引起实验动物感染性疾病的微生物的方法，例如引起感染性疾病的微生物的抗原或抗体，该方法包括流动血清或体液通过微流通芯片的微流通道从实验室动物取出，并检测芯片上的抗原抗体反应。本发明的方法通过在密闭系统中使用微量的动物血清或体液快速且敏感地实现实验室动物的感染性疾病和实验室动物的微生物监测。

2. 发明授权

US06482596B1 Method for measuring antigen concentration 有权
标题翻译：抗原浓度测定方法
公开(公告)号：US06482596B1
公开(公告)日：2002-11-19
申请号：US09313350
申请日：1999-05-18
申请人： Hiroshi Ueda , Teruyuki Nagamune , Hajime Nishimura , Izumi Kumagai , Kouhei Tsumoto , Walter C. Mahoney , Greg Winter , Paula A. Schueler
发明人： Hiroshi Ueda , Teruyuki Nagamune , Hajime Nishimura , Izumi Kumagai , Kouhei Tsumoto , Walter C. Mahoney , Greg Winter , Paula A. Schueler
IPC分类号： G01N3353
CPC分类号： G01N33/6845 , C07K16/18 , G01N33/68 , G01N33/6857
摘要： This invention provides a method for measuring an antigen concentration in a sample, which comprises: preparing VH-domain polypeptide and VL-domain polypeptide of an antibody specific to the antigen; labeling one of the polypeptides with a reporter molecule to form labeled polypeptides, and immobilizing the other polypeptide onto solid-phase to form immobilized polypeptides; contacting the antigen-containing sample and the labeled polypeptides with the solid-phase; and measuring the reporter molecule of the labeled polypeptides bound to the immobilized polypeptides. The present invention permits simpler and quicker sandwich ELISA for measurements of an antigen concentration in high sensitivity.
摘要翻译：本发明提供了一种测定样品中抗原浓度的方法，包括：制备抗原特异性抗体的VH结构域多肽和VL结构域多肽; 用报告分子标记多肽之一以形成标记的多肽，并将另一多肽固定在固相上以形成固定的多肽; 使含抗原的样品和标记的多肽与固相接触; 并测量与固定化多肽结合的标记多肽的报道分子。本发明允许更快和更快速的夹心ELISA来测量高灵敏度的抗原浓度。

3. 发明授权

US5334497A Method of feeding a substrate into tubular bioreactor 失效
标题翻译：将基质喂入管状生物反应器的方法
公开(公告)号：US5334497A
公开(公告)日：1994-08-02
申请号：US786819
申请日：1991-11-04
申请人： Hideki Inaba , Isao Endo , Teruyuki Nagamune , Susumu Tachikawa
发明人： Hideki Inaba , Isao Endo , Teruyuki Nagamune , Susumu Tachikawa
IPC分类号： C12M1/12 , C12M1/36 , C12Q3/00
CPC分类号： C12M23/06 , C12M29/16 , C12M29/18 , C12M41/00 , C12M41/40 , Y10S435/813
摘要： A method of feeding substrates into a tubular bioreactor incorporating a reacting vessel and a separating membrane in which the reaction and separation or collection can be continuously and surely effected in the same vessel with high efficiency.
摘要翻译：将基材输送到包含反应容器和分离膜的管状生物反应器中的方法，其中反应和分离或收集可以在高效率的同一容器中连续且可靠地进行。

4. 发明授权

US07595202B2 Analysis method using reporter (label) intermolecular interaction 有权
标题翻译：分析方法采用报告（标记）分子间相互作用
公开(公告)号：US07595202B2
公开(公告)日：2009-09-29
申请号：US10475540
申请日：2002-04-23
申请人： Teruyuki Nagamune , Hiroshi Ueda , Yoshiyuki Ohiro , Norio Shibata
发明人： Teruyuki Nagamune , Hiroshi Ueda , Yoshiyuki Ohiro , Norio Shibata
IPC分类号： G01N33/541 , G01N21/76 , G01N33/533 , G01N33/566 , G01N33/53 , G01N33/542
CPC分类号： G01N33/54306 , G01N33/533 , G01N33/542 , G01N33/582
摘要： The present invention provides a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good precision and high sensitivity, and a measurement system using the method. Two types of material having affinity for the subject material to be measured are respectively labeled with a combination of reporters that give rise to energy transfer; those that have been thus obtained by labeling these materials are each further labeled with materials that have weak affinity for each other to give reagents, which are then mixed with a sample to give the reaction complex. Each of the materials is brought into spatial proximity by binding based on the affinity among the materials having weak affinity for each other in the reaction complex, and since that condition is stably maintained, a more efficient energy transfer occurs.
摘要翻译：本发明提供了一种用于控制反应复合物中能量供体和能量受体的空间排列的方法，以便以高精度和高灵敏度进行测量，以及使用该方法的测量系统。分别用引起能量转移的记者的组合来标示对被测量物质具有亲和性的两种类型的材料; 通过标记这些材料得到的那些物质每个进一步用彼此具有弱亲和力的材料进行标记，得到试剂，然后将其与样品混合以得到反应络合物。通过基于在反应络合物中彼此之间具有弱亲和力的材料之间的亲和力，通过结合使每种材料变得空间接近，并且由于稳定地保持该条件，因此发生更有效的能量转移。

5. 发明申请

US20050106721A1 Immobilized cells and liposomes and method of immobilizing the same 失效
标题翻译：固定化细胞和脂质体及其固定方法
公开(公告)号：US20050106721A1
公开(公告)日：2005-05-19
申请号：US10506210
申请日：2003-02-28
申请人： Teruyuki Nagamune , Jun Miyake , Masato Miyake , Koichi Kato
发明人： Teruyuki Nagamune , Jun Miyake , Masato Miyake , Koichi Kato
IPC分类号： C12N5/00 , C12N11/02 , C12N11/06 , C12N11/08 , C12N5/02 , C12N5/06
CPC分类号： C12N11/06 , C12N5/0068 , C12N11/02 , C12N11/08 , C12N2533/20 , C12N2533/30
摘要： In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized by causing the cell to contact a support having a hydrophobic chain and a hydrophilic chain.
摘要翻译：在固定悬浮细胞，磷脂囊泡等的便宜且方便的方法中，无论细胞类型如何，在固相表面上，通过使细胞与具有疏水性链的载体和亲水链。

6. 发明授权

US5888805A Detecting apparatus for monitoring culture broth in bio-reactor 失效
标题翻译：用于监测生物反应器中培养液的检测装置
公开(公告)号：US5888805A
公开(公告)日：1999-03-30
申请号：US864398
申请日：1997-05-28
申请人： Isao Endo , Teruyuki Nagamune , Kozo Inoue , Kinichi Kawamura
发明人： Isao Endo , Teruyuki Nagamune , Kozo Inoue , Kinichi Kawamura
IPC分类号： C12M1/00 , C12M1/34 , C12M1/36 , C12M3/00
CPC分类号： C12M23/00 , C12M41/00 , Y10S435/817
摘要： A detecting apparatus is disclosed, that comprises plural measurement devices with respective sensors and a support for holding the measurement devices in such a manner that the individual sensors contact a culture broth, the turbidity, dissolved oxygen, dissolved carbon dioxide the temperature, pH, and so forth of the culture broth being obtained by the measurement devices.
摘要翻译：公开了一种检测装置，其包括具有相应传感器的多个测量装置和用于保持测量装置的支撑件，使得各个传感器接触培养液，浊度，溶解氧，溶解二氧化碳的温度，pH和所以通过测量装置获得的培养肉汤。

7. 发明授权

US07198945B2 Cell having modified cell membrane 有权
标题翻译：细胞具有改变的细胞膜
公开(公告)号：US07198945B2
公开(公告)日：2007-04-03
申请号：US10211587
申请日：2002-08-05
申请人： Teruyuki Nagamune , Chika Itoh , Tohru Yasukohchi , Syunsuke Ohhashi , Kazuhiro Kubo
发明人： Teruyuki Nagamune , Chika Itoh , Tohru Yasukohchi , Syunsuke Ohhashi , Kazuhiro Kubo
IPC分类号： C12N5/00
CPC分类号： C12N5/0006
摘要： A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).
摘要翻译：其中待修饰物质和两亲性化合物的反应产物与细胞膜非共价结合的细胞，其中所述化合物具有以下特征

8. 发明申请

US20050208644A1 Method of immobilizing cells on solid-phase surface 审中-公开
标题翻译：将细胞固定在固相表面上的方法
公开(公告)号：US20050208644A1
公开(公告)日：2005-09-22
申请号：US11085184
申请日：2005-03-22
申请人： Hiroshi Takiguchi , Hitoshi Fukushima , Takashi Masuda , Teruyuki Nagamune , Masashige Shinkai , Kengo Yamawaki
发明人： Hiroshi Takiguchi , Hitoshi Fukushima , Takashi Masuda , Teruyuki Nagamune , Masashige Shinkai , Kengo Yamawaki
IPC分类号： C12M1/40 , C10G32/00 , C12M3/00 , C12N11/00 , C12N11/02
CPC分类号： B82Y30/00 , B01J2219/00659 , B01J2219/00743 , C12N11/00
摘要： Aspects of the invention can provide a method of immobilizing a chemical compound having the affinity for the cell membrane on the solid-phase surface in a desired pattern. The method of immobilizing a cell in a desired pattern on a solid-phase surface by use of a first chemical compound having an affinity for the cell and can include a step of immobilizing a second chemical compound, which is more easily immobilized on the solid-phase surface than the first chemical compound dose and has a molecular binding site that can bind to the first chemical compound, on the solid-phase surface according to the pattern.
摘要翻译：本发明的方面可以提供一种将所述细胞膜具有亲和性的化合物以期望的图案固定在固相表面上的方法。通过使用对细胞具有亲和力的第一化合物，将固定相的表面上的细胞以期望的图案固定的方法，其可以包括将更容易固定在固相上的第二化合物固定化的步骤，相表面比第一化合物剂量，并且具有可以根据图案在固相表面上结合第一化合物的分子结合位点。

9. 发明授权

US5185255A Cell culture method 失效
标题翻译：细胞培养法
公开(公告)号：US5185255A
公开(公告)日：1993-02-09
申请号：US504694
申请日：1990-04-04
申请人： Isao Endo , Teruyuki Nagamune , Minoru Nishimura , Tetsuo Kobayashi
发明人： Isao Endo , Teruyuki Nagamune , Minoru Nishimura , Tetsuo Kobayashi
IPC分类号： C12M1/16 , C12M3/00
CPC分类号： C12M33/16 , C12M25/16 , C12M29/26 , C12M41/40 , C12M47/02 , Y10S435/822 , Y10S435/911 , Y10S435/918
摘要： A cell culture method proliferates microorganisms, particularly fungi such as molds, actinomycetes, animal cells, plant cells and so on to produce useful substances such as antibiotics, enzymes, proteins, polysaccharides, physiological active substances, and animal and plant hormones. Porous material including medium and cells to be proliferated is moved, whereby air is supplied to the surface of the porous material.
摘要翻译：细胞培养方法增殖微生物，特别是真菌如霉菌，放线菌，动物细胞，植物细胞等，以产生有用的物质，如抗生素，酶，蛋白质，多糖，生理活性物质和动植物激素。包括培养基在内的多孔材料和要增殖的细胞移动，由此向多孔材料的表面供应空气。

10. 发明授权

US4725148A Turbidimeter employing a semiconductor laser diode and a photodiode 失效
标题翻译：浊度计采用半导体激光二极管和光电二极管
公开(公告)号：US4725148A
公开(公告)日：1988-02-16
申请号：US739319
申请日：1985-05-30
申请人： Isao Endo , Teruyuki Nagamune , Ichiro Inoue , Kozo Inoue , Tadashi Nohira , Ikuzo Kagami , Tatsuya Iwakura
发明人： Isao Endo , Teruyuki Nagamune , Ichiro Inoue , Kozo Inoue , Tadashi Nohira , Ikuzo Kagami , Tatsuya Iwakura
IPC分类号： G01N21/59 , G01N21/53 , G01N21/85 , G01N21/84
CPC分类号： G01N21/8507 , G01N21/534 , G01N2201/0621 , G01N2201/0631 , G01N2201/064
摘要： In a turbidimeter for measuring a turbidity of a test solution to be measured i.e. culture solution in a fermentation apparatus, a semiconductor laser diode and a semiconductor photodiode are integrally arranged in a detection portion of the turbidimeter in such a manner that a laser beam emitted from the semiconductor laser diode is made incident upon the semiconductor photodiode through the test solution. Moreover, a protection circuit for the semiconductor laser diode and the semiconductor photodiode is also arranged in the turbidimeter to cut off a current flowed therethrough when an environmental temperature becomes above a predetermined temperature. Therefore, the turbidimeter can be made small in size and light in weight, and the turbidity can be measured accurately over wide range.
摘要翻译：在浊度计中，用于测量待测试的测试溶液的浊度，即发酵设备中的培养溶液，半导体激光二极管和半导体光电二极管一体地布置在浊度计的检测部分中，使得从半导体激光二极管通过测试溶液入射到半导体光电二极管上。此外，当环境温度高于预定温度时，用于半导体激光二极管和半导体光电二极管的保护电路也布置在浊度计中以截断流过其中的电流。因此，可以使浊度计尺寸小，重量轻，并且可以在宽范围内精确地测量浊度。

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