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1. 发明授权

US5080670A Bioprosthetic valve 失效
标题翻译：生物阀
公开(公告)号：US5080670A
公开(公告)日：1992-01-14
申请号：US238233
申请日：1988-08-30
申请人： Eisaburo Imamura , Yasuharu Noishiki , Hitoshi Koyanagi , Teruo Miyata , Masayasu Furuse
发明人： Eisaburo Imamura , Yasuharu Noishiki , Hitoshi Koyanagi , Teruo Miyata , Masayasu Furuse
IPC分类号： A61L27/00 , A61F2/24 , A61L2/00 , A61L27/36
CPC分类号： A61L27/3687 , A61F2/2412 , A61L2/0088 , A61L27/3625 , A61L27/507 , A61L2400/02 , Y10S623/915
摘要： A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.

2. 发明授权

US4749689A Hemostatic agent composed of collagen/gelatin and protamine 失效
标题翻译：止血剂由胶原/明胶和鱼精蛋白组成
公开(公告)号：US4749689A
公开(公告)日：1988-06-07
申请号：US87966
申请日：1987-08-17
申请人： Teruo Miyata , Kazuhiko Kodaira , Masayasu Furuse , Yasuharu Noishiki
发明人： Teruo Miyata , Kazuhiko Kodaira , Masayasu Furuse , Yasuharu Noishiki
IPC分类号： A61K38/16 , A61K38/17 , A61K38/39 , A61L15/12 , A61L26/00 , A61K37/08 , A61L15/01 , A61L17/00 , C08L89/06
CPC分类号： A61L15/125 , A61K38/39 , A61L26/0052 , A61L2400/04 , Y10S128/08
摘要： This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.
摘要翻译：本发明涉及用于外科手术的止血剂，其可以以两种方式制备：一种将胶原蛋白/明胶与鱼精蛋白混合，另一种将胶原/明胶与鱼精蛋白混合和双功能交联剂混合制成所述胶原/明胶与所述鱼精蛋白具有共价键。所生产的止血剂可以在比由纯胶原制成的常规止血剂的时间更短的时间内止血。

3. 发明授权

US4690973A Production process of an antithrombogenic and antiadhesive material for medical use 失效
标题翻译：用于医疗用途的抗血栓形成和抗粘附材料的生产工艺
公开(公告)号：US4690973A
公开(公告)日：1987-09-01
申请号：US885782
申请日：1986-07-15
申请人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata , Takeaki Miyamoto , Hiraku Ito
发明人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata , Takeaki Miyamoto , Hiraku Ito
IPC分类号： A61L33/10 , A61L33/00 , A61M25/00 , C08H1/06 , C08L89/04 , C08L89/06
CPC分类号： A61L33/0023 , Y10S128/08
摘要： This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.
摘要翻译：本发明涉及可有利地用作人造血管，人造瓣膜，心血管器官接枝片，人造心导管等的抗血栓形成和抗粘附材料的生产方法。本发明的要点基本上是将缩水甘油三烷基铵卤化物如缩水甘油基三甲基氯化铵与含有纯胶原或胶原和其他组分如粘多糖的材料进行反应，以便在材料的胶原分子中引入阳离子季铵官能团，肝素与阳离子官能团的离子组合引入。同时，在上述化学处理之前，通过从牛的跟腱中除去胶原蛋白之外的蛋白质从狗的血管中制备，通过粉碎，从人羊膜中通过在蒸馏水中冲洗或从聚酯针织管中涂覆其内部制备材料以胶原蛋白粉为例。

4. 发明授权

US4833200A Antithrombogenic medical material and method of preparing same 失效
标题翻译：抗凝血药物及其制备方法
公开(公告)号：US4833200A
公开(公告)日：1989-05-23
申请号：US889654
申请日：1986-07-25
申请人： Yasuharu Noishiki , Teruo Miyata
发明人： Yasuharu Noishiki , Teruo Miyata
IPC分类号： A61K38/16 , A61K38/17 , A61L33/00 , C08L5/10
CPC分类号： A61L33/0029 , C08L5/10 , Y10S514/801 , Y10S514/822
摘要： An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is provided, wherein a synthetic polymer material is subjected to a coating or impregnating treatment with a collagen-containing solution, followed by heparinization of the collagen, and the heparinized collagen is fixed to the synthetic polymer material. This method allows manufacturing of antithrombogenic medical material with ease.
摘要翻译：本发明提供具有抗凝血性能和组织相容性以及通过将肝素化胶原固定在合成高分子材料上形成的充分体力的抗血栓形成的医用材料。提供一种制备抗血栓形成的医药材料的方法，其中合成聚合物材料用含胶原的溶液进行包衣或浸渍处理，然后将胶原蛋白肝素化，并将肝素化胶原蛋白固定在合成聚合物材料。该方法容易制造抗血栓形成的医用材料。

5. 发明授权

US4806595A Method of preparing antithrombogenic medical materials 失效
标题翻译：制备抗凝血药物的方法
公开(公告)号：US4806595A
公开(公告)日：1989-02-21
申请号：US891915
申请日：1986-08-01
申请人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata
发明人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata
IPC分类号： A61L33/10 , A61L33/00 , C08L5/10 , A61F2/04
CPC分类号： C08L5/10 , A61L33/0029 , Y10S514/822 , Y10S623/917
摘要： In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.
摘要翻译：在制备具有肝素化胶原蛋白作为抗血栓形成成分的抗血栓形成医学材料的方法中，提供了一种方法，其包括以下步骤：通过聚环氧化合物将鱼精蛋白固定在胶原蛋白上，并通过将肝素固定在鱼精蛋白上来使胶原蛋白肝素化。

6. 发明授权

US4695281A Medical material 失效
标题翻译：医疗材料
公开(公告)号：US4695281A
公开(公告)日：1987-09-22
申请号：US478773
申请日：1983-03-25
申请人： Teruo Miyata , Yasuharu Noishiki
发明人： Teruo Miyata , Yasuharu Noishiki
IPC分类号： A61F2/00 , A61L27/24 , A61L27/36 , A61L33/00 , C08H1/06 , A61F2/02 , A61F2/06
CPC分类号： C08H1/06 , A61L27/24 , A61L27/36 , A61L33/0082 , A61F2310/00365 , Y10S623/917
摘要： The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH.sub.2 groups of said chains attached to poly peptide chains of the collagen so that the --NH.sub.2 groups are converted into groups having --COOH groups. This succinylation can be carried out by reacting succinic anhydride with the --NH.sub.2 groups of the collagen. Since the above medical material has excellent compatibility with living bodies, especially, with blood, it is suitable to use it as a replacement material for tissues and/or organs which are kept in contact with blood at their surfaces, namely, is suitable for use in artificial blood vessels, artificial valves, some parts of artificial hearts which are kept in contact with blood at said parts, etc. and as a patching material for hearts.
摘要翻译：根据本发明的医疗材料包含胶原蛋白，其通过连接到胶原的多肽链的所述链的热-NH 2基团的凝血化而被化学修饰，使得-NH 2基团转化为具有-COOH基团的基团。该琥珀酰化可以通过使琥珀酸酐与胶原的-NH 2基团反应来进行。由于上述医用材料与生物体，特别是血液具有良好的相容性，因此适合用作与其表面保持与血液接触的组织和/或器官的替代材料，即适合使用在人造血管，人造瓣膜，与所述部分血液保持接触的人造心脏的一些部分等，以及作为心脏的修补材料。

7. 发明授权

US5116824A Biomaterial comprising a composite material of a chitosan derivative and collagen derivative 失效
标题翻译：包含壳聚糖衍生物和胶原衍生物的复合材料的生物材料
公开(公告)号：US5116824A
公开(公告)日：1992-05-26
申请号：US603370
申请日：1990-10-29
申请人： Teruo Miyata , Kazuhiko Kodaira , Hitoshi Higashijima , Takashi Kimura , Yasuharu Noishiki
发明人： Teruo Miyata , Kazuhiko Kodaira , Hitoshi Higashijima , Takashi Kimura , Yasuharu Noishiki
IPC分类号： A61L15/16 , A61L15/22 , A61L27/00 , A61L27/26 , A61L31/00
CPC分类号： A61L15/225 , A61L15/425 , A61L27/26 , A61L27/507 , A61L27/60 , A61L2400/04
摘要： A biomaterial excellent in biocompatibility comprising a composite material of an N-acylchitosan and collagen is described. This biomaterial is suitable for used as a wound dressing material, vascular prosthesis, artificial skin or hemostatic agent.
摘要翻译：描述了包含N-酰基壳聚糖和胶原的复合材料的生物相容性优异的生物材料。该生物材料适用于伤口敷料，血管假体，人造皮肤或止血剂。

8. 发明授权

US4704131A Medical materials 失效
标题翻译：医疗材料
公开(公告)号：US4704131A
公开(公告)日：1987-11-03
申请号：US661258
申请日：1984-10-15
申请人： Yasuharu Noishiki , Teruo Miyata
发明人： Yasuharu Noishiki , Teruo Miyata
IPC分类号： A61L33/10 , A61L33/00 , A61F2/04 , A01N1/02 , A61F2/06
CPC分类号： A61L33/0029 , Y10S128/08 , Y10S623/916
摘要： The medical material contains heparinized collagen in which heparin has been bonded to protamine covalently fixed on collagen, and, owing to its excellent compatibility with living bodies, especially, its superb antithrombotic property, can be suitably used as a substituent material for tissues or organs which are brought into direct contact with blood, namely, as aritificial vessels, artificial valves and patching materials for cardiovascular organs, and the above medical material is also suitable as a membrane having anti-adhesion effects. The medical material is obtained by immersing and treating a natural or artificial material successively in an aqueous protamine solution, an aqueous glutaraldehyde solution and an aqueous heparin solution.
摘要翻译：医用材料含有肝素化胶原蛋白，其中肝素已被共价固定在胶原上的鱼精蛋白结合，并且由于其与活体的相容性优异，特别是其极好的抗血栓性质，可以适合用作组织或器官的取代基材料与血液直接接触，即作为人造血管，人造瓣膜和心血管器官的修补材料，上述医用材料也适合作为具有抗粘连作用的膜。通过将天然或人造材料依次浸入鱼精蛋白水溶液，戊二醛水溶液和肝素水溶液中而获得医疗材料。

9. 发明申请

US20090215009A1 MEDICAL MATERIAL, ARTIFICIAL TOOTH ROOT, AND METHOD OF PRODUCING MEDICAL MATERIAL 审中-公开
标题翻译：医用材料，人造牙根和生产医用材料的方法
公开(公告)号：US20090215009A1
公开(公告)日：2009-08-27
申请号：US11816811
申请日：2006-02-23
申请人： Yasuharu Noishiki , Yoshinori Kuboki , Yasuo Seki , Hiroyuki Shiota
发明人： Yasuharu Noishiki , Yoshinori Kuboki , Yasuo Seki , Hiroyuki Shiota
IPC分类号： A61C19/00 , A61K9/00 , A61K35/12 , A61K35/28 , A61K38/16 , A61K31/715 , A61K38/43 , A61K38/14 , A61P43/00 , B05D1/18
CPC分类号： A61L27/12 , A61L27/56
摘要： [Problems] To provide a medical material having such a structure that enables even diffusion and distribution in the material of a sufficient amount a substance necessary for a medical treatment.[Means for Solving Problems] A medical material 10 composed of a porous three-dimensional construct 11, which is a rectangular parallelepiped having a porosity of from 20 to 97% and pores 12, 13, 14 and 15 provided in the main body. From this pore 12, a substance such as calcium phosphate or ceramics apatite and/or a physiologically active cell, tissue or protein and a substance suitable for exerting the functions thereof are introduced.
摘要翻译： [问题]提供具有这样的结构的医疗材料，其能够在材料中均匀地扩散和分布足量的药物所需的物质。解决问题的手段由主体中设置有孔隙率为20〜97％的长方体的多孔性三维构造体11和孔12,13,14,15组成的医疗用材料10。从该孔12中，引入磷酸钙或陶瓷磷灰石等物质和/或生理活性细胞，组织或蛋白质以及适用于其功能的物质。

10. 发明授权

US5986168A Prosthesis containing bioabsorbable materials insolubilized without chemical reagents and method of making the same 失效
标题翻译：含有不含化学试剂的生物可吸收材料的假体及其制造方法
公开(公告)号：US5986168A
公开(公告)日：1999-11-16
申请号：US928752
申请日：1997-09-12
申请人： Yasuharu Noishiki
发明人： Yasuharu Noishiki
IPC分类号： A61L27/00 , A61F2/06 , A61L27/20 , A61L27/22 , A61L27/34 , A61L27/36 , A61L27/38 , A61L27/56 , A61L27/58 , A61F2/02
CPC分类号： A61L27/3691 , A61L27/20 , A61L27/22 , A61L27/34 , A61L27/38 , A61L27/56 , A61L27/58 , Y02P20/582
摘要： The present invention relates to a prosthesis comprising one or more bioabsorbable substances insolubilized and/or immobilized in place by a physical method which excludes chemical reagents. A growth factor can be bound to the bioabsorbable substance for simulating growth of, for example, fibroblast and endothelial cells, around and into the prosthesis. The invention can include a porous fabric substrate having the bioabsorbable substance(s) insolubilized and immobilized therewithin by one or more of the physical methods. The physical method can include entanglement, dry-up, thermal crosslinkng, gamma irradiation, ultraviolet irradiation, or swelling up by hyper hydration with electric charge. The invention excludes the use of conventional chemical reagents, such as glutaraldehyde or formaldehyde, which are toxic. Since the invention does not use the chemical reagents of the prior art, it can avoid the toxicity and foreign body reaction problems associated therewith. The prosthesis of the invention does not have blood leakage and provides an excellent antithrombogenicity by rapid completion of neointima formation with endothelial cell lining at an early stage after implantation.
摘要翻译：本发明涉及一种假体，其包含一种或多种通过不包括化学试剂的物理方法不溶化和/或固定在适当位置的生物可吸收物质。生长因子可以结合生物可吸收物质，用于模拟假体周围的成纤维细胞和内皮细胞的生长。本发明可以包括具有生物可吸收物质的多孔织物基质，所述生物可吸收物质通过一种或多种物理方法不溶解并固定在其中。物理方法可以包括缠结，干燥，热交联，γ照射，紫外线照射或通过电荷高水合膨胀。本发明不包括使用有毒的常规化学试剂如戊二醛或甲醛。由于本发明不使用现有技术的化学试剂，因此可以避免与之相关的毒性和异物反应问题。本发明的假体不具有血液渗漏，并且通过在植入后的早期快速完成与内皮细胞衬里的新内膜形成而提供优异的抗血栓形成。

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