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1. 发明授权

US07711415B1 Implantable devices, and methods for use therewith, for monitoring sympathetic and parasympathetic influences on the heart 有权
标题翻译：可植入装置及其使用方法，用于监测对心脏的交感神经和副交感神经影响
公开(公告)号：US07711415B1
公开(公告)日：2010-05-04
申请号：US11557814
申请日：2006-11-08
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Mark W. Kroll , Michael E. Benser , Kevin S. Jurkowski
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Mark W. Kroll , Michael E. Benser , Kevin S. Jurkowski
IPC分类号： A61B5/04
CPC分类号： A61B5/0245 , A61B5/0452 , A61B5/4035 , G06K9/00523
摘要： Provided herein are implantable devices, and methods for use therewith, that independently monitor levels of parasympathetic and sympathetic tone of a patient. In accordance with an embodiment, a cardiac electrogram (EGM) signal is sensed using implanted electrodes, cardiac intervals are measured within a portion of the sensed EGM signal, and levels of parasympathetic tone and sympathetic tone are independently assessed based on the measured cardiac intervals. This abstract is not intended to describe all of the various embodiments of the present invention.
摘要翻译：本文提供了可植入装置及其使用的方法，其独立地监测患者的副交感神经和交感神经紧张的水平。根据实施例，使用植入电极感测心电图（EGM）信号，在所感测的EGM信号的一部分内测量心脏间隔，并且基于测量的心脏间隔独立地评估副交感神经紧张和交感神经张力的水平。该摘要不旨在描述本发明的所有各种实施例。

2. 发明授权

US07856266B1 Implantable cardiac stimulation device providing reduced defibrillation thresholds and method 有权
标题翻译：植入式心脏刺激装置提供降低的除颤阈值和方法
公开(公告)号：US07856266B1
公开(公告)日：2010-12-21
申请号：US11756283
申请日：2007-05-31
申请人： Gene A. Bornzin , Michael E. Benser , Euljoon Park , Taraneh Ghaffari Farazi
发明人： Gene A. Bornzin , Michael E. Benser , Euljoon Park , Taraneh Ghaffari Farazi
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/36521 , A61N1/3943
摘要： An implantable cardiac defibrillation device provides pre-shock stimuli to reduce the defibrillation threshold (DFT). The device includes an arrhythmia detector that detects fibrillation of a fibrillating chamber of a heart and a pulse generator that provides a fibrillation therapy output responsive to the arrhythmia detector detecting fibrillation of the fibrillating chamber of the heart. The therapy output includes a defibrillating shock having an output magnitude exceeding a temporary defibrillation threshold of the fibrillating chamber and at least one pre-defibrillating shock output pulse that reduces an initial defibrillation threshold of the fibrillating chamber to the temporary defibrillation threshold. An electrode system having at least two defibrillation electrodes delivers both the at least one pre-defibrillating shock output pulse to the heart and the defibrillating shock to the fibrillating chamber of the heart.
摘要翻译：植入式心脏除颤装置提供预冲击刺激以减少除颤阈值（DFT）。该装置包括心律失常检测器，其检测心脏的原纤化室的原纤维和脉冲发生器，其提供响应于心律失常检测器检测心脏原纤化室的纤颤的原纤维化治疗输出。治疗输出包括具有超过原纤化室的暂时除颤阈值的输出量值的至少一个除纤颤前冲击输出脉冲，其将原纤化室的初始除颤阈值降低到临时除颤阈值。具有至少两个除颤电极的电极系统将至少一个除颤前的冲击输出脉冲和心脏的去纤维化颤动传递给心脏的原纤维室。

3. 发明授权

US08706239B2 Systems and methods for controlling neurostimulation based on regional cardiac performance for use by implantable medical devices 有权
标题翻译：基于区域心脏性能的控制神经刺激的系统和方法，用于可植入医疗器械
公开(公告)号：US08706239B2
公开(公告)日：2014-04-22
申请号：US13485404
申请日：2012-05-31
申请人： Rupinder Bharmi , Taraneh Ghaffari Farazi , Ryan Rooke , Stuart Rosenberg , Kritika Gupta , Riddhi Shah , Gene A. Bornzin , Wenbo Hou , Laurence S. Sloman
发明人： Rupinder Bharmi , Taraneh Ghaffari Farazi , Ryan Rooke , Stuart Rosenberg , Kritika Gupta , Riddhi Shah , Gene A. Bornzin , Wenbo Hou , Laurence S. Sloman
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61B5/029 , A61B5/042 , A61B5/0538 , A61B5/1116 , A61B5/4836 , A61B5/686 , A61B5/7239 , A61N1/36139 , A61N1/36146 , A61N1/36185
摘要： Techniques are provided for controlling neurostimulation such as spinal cord stimulation (SCS) using a cardiac rhythm management device (CRMD). In various examples described herein, neurostimulation is delivered to a patient while regional cardiac performance of the heart of the patient is assessed by the CRMD. The delivery of further neurostimulation is adjusted or controlled based, at least in part, on the regional cardiac performance, preferably to enhance positive effects on the heart due to the neurostimulation or to mitigate any negative effects. Regional cardiac performance is assessed based on parameters derived from cardiogenic impedance signals detected along various vectors through the heart.
摘要翻译：提供了使用心律管理装置（CRMD）来控制神经刺激如脊髓刺激（SCS）的技术。在本文描述的各种示例中，神经刺激被递送给患者，同时通过CRMD来评估患者心脏的区域心脏性能。至少部分地基于区域心脏性能来调整或控制进一步神经刺激的递送，优选地由于神经刺激而增强对心脏的积极作用或减轻任何负面影响。基于通过心脏沿着各种载体检测到的心源性阻抗信号的参数来评估区域心脏性能。

4. 发明授权

US08170664B1 Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
标题翻译：使用由其确定的可植入传感器和斜坡来监测心脏病
公开(公告)号：US08170664B1
公开(公告)日：2012-05-01
申请号：US11931165
申请日：2007-10-31
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.
摘要翻译：本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。确定斜率，其中斜率表示在一段时间内生理特性的变化。基于斜率的大小来监测心脏病。在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。根据斜率的变化监测患者心脏病变化。

5. 发明授权

US08135464B1 Painless ventricular rate control during supraventricular tachycardia 有权
标题翻译：室上性心动过速期间无痛心室率控制
公开(公告)号：US08135464B1
公开(公告)日：2012-03-13
申请号：US11830499
申请日：2007-07-30
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/362
CPC分类号： A61N1/3624
摘要： In various embodiments of the present invention, lower amplitude high frequency burst stimulation of cardiac fat pad(s) innervating the AV node and/or ventricle tissue performed in conjunction with ventricular pacing during refractory period is used to reduce the ventricular rate in order to terminate arrhythmias such as supraventricular tachycardia. In an embodiment of the present invention, one or more pace pulse delivered during a ventricular refractory period can be used to further extend the duration of the refractory period followed by a short burst of cardiac fat pad stimulation to temporarily slow AV conduction. In an embodiment of the present invention, this therapy slows the ventricular rate by altering conduction speed in both the AV node and the ventricles.
摘要翻译：在本发明的各种实施例中，使用在不稳定期间结合心室起搏执行支配AV结节和/或心室组织的心脏脂肪垫的较低振幅高频爆发刺激来降低心室率以终止心律失常如室上性心动过速。在本发明的一个实施方案中，可以使用在心室不应期期间递送的一个或多个步速脉冲来进一步延长不应期的持续时间，随后是心脏脂肪垫刺激的短暂爆发以暂时缓慢AV传导。在本发明的一个实施方案中，该疗法通过改变AV节点和心室中的传导速度来减慢心室率。

6. 发明申请

US20100210960A1 PACING SCHEMES FOR REVEALING T-WAVE ALTERNANS (TWA) AT LOW TO MODERATE HEART RATES 审中-公开
标题翻译：用于将T波形变换器（TWA）发送到低至中等心率的计划
公开(公告)号：US20100210960A1
公开(公告)日：2010-08-19
申请号：US12770592
申请日：2010-04-29
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61B5/0402
CPC分类号： A61N1/3622 , A61B5/0452
摘要： Implantable systems that can monitor myocardial electrical stability, and methods for use therewith, are provided. Also provided are novel pacing sequences that are used in such monitoring. Such pacing sequences are designed to reveal alternans at low to moderate heart rates.
摘要翻译：提供了可监测心肌电稳定性的可植入系统及其使用方法。还提供了用于这种监测的新型起搏序列。这种起搏序列旨在以低至中等心率显示交替神经元。

7. 发明申请

US20090036788A1 SYSTEMS AND METHODS FOR DETECTION OF VT AND VF FROM REMOTE SENSING ELECTRODES 有权
标题翻译：用于从远程感测电极检测VT和VF的系统和方法
公开(公告)号：US20090036788A1
公开(公告)日：2009-02-05
申请号：US12244607
申请日：2008-10-02
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
IPC分类号： A61B5/0456
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.
摘要翻译：提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。然后使用所选择的监测模式进行室性心律失常监测。

8. 发明授权

US08449472B2 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for prevention of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏预防房性快速性心律失常
公开(公告)号：US08449472B2
公开(公告)日：2013-05-28
申请号：US12891429
申请日：2010-09-27
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61B5/02 , A61N1/00
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems and method for use therewith are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments are for use with an implantable device that includes one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering Atrial Anti-Tachycardia Pacing (AATP) and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用的方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。具体实施方案用于可植入装置，其包括一个或多个心房电极，用于感测心房颤动（AF）和/或递送心房抗心动过速起搏（AATP）和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

9. 发明授权

US08385999B1 Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
标题翻译：在植入式传感器中处理静脉血氧饱和度和血细胞比容信息
公开(公告)号：US08385999B1
公开(公告)日：2013-02-26
申请号：US12028261
申请日：2008-02-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/00
CPC分类号： A61N1/39 , A61B5/0031 , A61B5/14535 , A61B5/14551 , A61B5/4836 , A61N1/362
摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.
摘要翻译：提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。对光检测器的输出进行采样以测量透射光的强度。对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

10. 发明申请

US20110202105A1 BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
标题翻译：用于可植入器件应用的BIOELECTRIC BATTERY
公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , H01M8/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

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