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1. 发明申请

US20110202105A1 BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
标题翻译：用于可植入器件应用的BIOELECTRIC BATTERY
公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , H01M8/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

2. 发明授权

US08709631B1 Bioelectric battery for implantable device applications 有权
标题翻译：用于植入式设备应用的生物电池
公开(公告)号：US08709631B1
公开(公告)日：2014-04-29
申请号：US11737307
申请日：2007-04-19
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： H01M4/00 , H01M8/16
CPC分类号： A61N1/362 , A61N1/378 , H01M4/466 , H01M4/92 , H01M12/06 , H01M2220/30 , Y02E60/50
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

3. 发明授权

US08574737B2 Bioelectric battery for implantable device applications 有权
标题翻译：用于植入式设备应用的生物电池
公开(公告)号：US08574737B2
公开(公告)日：2013-11-05
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： H01M4/00 , H01M8/16 , H01M4/02 , H01M2/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

4. 发明授权

US07418868B1 Pressure sensor and method of fabricating such a module 有权
标题翻译：压力传感器及其制造方法
公开(公告)号：US07418868B1
公开(公告)日：2008-09-02
申请号：US11359952
申请日：2006-02-21
申请人： Annapurna Karicherla , Sheldon Williams , Gene A. Bornzin , John W. Poore , Dion F. Davis
发明人： Annapurna Karicherla , Sheldon Williams , Gene A. Bornzin , John W. Poore , Dion F. Davis
IPC分类号： G01L7/00
CPC分类号： G01L19/142 , G01L19/0046 , G01L19/0061 , G01L19/0645
摘要： A body fluid pressure sensor module according to the invention comprises a housing having a first end and a second end and enclosing a pressure sensor. The pressure sensor is electrically coupled to a plurality of electrical conductors extending into the housing through a feedthrough disposed within, and hermetically sealing, the first end of the housing. The housing defines a chamber disposed between the feedthrough and the second end of the housing. The chamber contains a material in communication with the pressure sensor, the material being capable of transmitting pressure variations to the pressure sensor. The plurality of electrical conductors have ends within the housing, and the pressure sensor is mounted on the end of at least one of the conductors. Also disclosed are medical leads incorporating the pressure sensor module, and methods for fabricating the modules. The pressure sensor module is compact, and particularly so where cable conductors are utilized and the sensor is directly mounted on at least one of the cable conductors. The compactness of a pressure sensor module pursuant to the invention facilitates its incorporation into a small diameter, flexible medical lead enhancing its placement within a patient's body, for example, within the left atrium of the heart.
摘要翻译：根据本发明的体液压力传感器模块包括具有第一端和第二端并且包围压力传感器的壳体。压力传感器电耦合到通过设置在壳体的第一端内并且密封地密封壳体中的馈通部延伸到壳体中的多个电导体。壳体限定设置在馈通和壳体的第二端之间的室。该室包含与压力传感器连通的材料，该材料能够将压力变化传递到压力传感器。多个电导体具有在壳体内的端部，并且压力传感器安装在至少一个导体的端部上。还公开了结合压力传感器模块的医疗引线以及用于制造模块的方法。压力传感器模块是紧凑的，特别是在使用电缆导体并且传感器直接安装在至少一个电缆导体上的情况下。根据本发明的压力传感器模块的紧凑性便于其结合到小直径的柔性医疗引线中，从而增强其在患者身体内的放置，例如在心脏的左心房内。

5. 发明授权

US07448999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07448999B1
公开(公告)日：2008-11-11
申请号：US11053468
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/0422 , A61B5/6852 , A61B5/6853 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B5/6859 , A61N1/057 , A61N1/0587
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

6. 发明授权

US08538555B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US08538555B1
公开(公告)日：2013-09-17
申请号：US12973810
申请日：2010-12-20
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/00
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

7. 发明授权

US08311648B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US08311648B1
公开(公告)日：2012-11-13
申请号：US12973800
申请日：2010-12-20
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.
摘要翻译：一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

8. 发明授权

US07389134B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07389134B1
公开(公告)日：2008-06-17
申请号：US11053374
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

9. 发明授权

US07450999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07450999B1
公开(公告)日：2008-11-11
申请号：US11053566
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/378
CPC分类号： A61N1/057 , A61B5/02152 , A61B5/02158 , A61B5/6853 , A61B5/6857 , A61B5/6882
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

10. 发明授权

US07340288B1 Trans-septal intra-cardiac lead system 失效
公开(公告)号：US07340288B1
公开(公告)日：2008-03-04
申请号：US11053493
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61N1/3627 , A61N1/36514 , A61N2001/0585
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

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