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1. 发明申请

US20100099676A1 SULFONYLUREA DERIVATIVE CAPABLE OF SELECTIVELY INHIBITING MMP-13 审中-公开
标题翻译：选择性抑制MMP-13的SULFONYLUREA衍生物
公开(公告)号：US20100099676A1
公开(公告)日：2010-04-22
申请号：US12447743
申请日：2007-10-31
申请人： Takeshi Endoh , Yasuhiko Fujii , Eiichi Kojima , Genta Tadano , Naoko Yamaguchi , Yo Adachi , Sachie Tagashira , Yuki Tachibana , Naohiro Onodera
发明人： Takeshi Endoh , Yasuhiko Fujii , Eiichi Kojima , Genta Tadano , Naoko Yamaguchi , Yo Adachi , Sachie Tagashira , Yuki Tachibana , Naohiro Onodera
IPC分类号： A61K31/5377 , C07D417/10 , A61K31/497 , C07D413/14 , C07D401/02 , C07D413/02 , A61K31/4965 , C07D241/04
CPC分类号： C07D209/86 , C07D211/96 , C07D213/81 , C07D215/20 , C07D241/04 , C07D243/08 , C07D263/32 , C07D277/28 , C07D295/22 , C07D295/26 , C07D307/81 , C07D307/91
摘要： A compound represented by the general formula (I): wherein R1 is wherein R26 and R28 are each independently lower alkyloxy and the like; n1 is an integer of 0 to 3; Z is a optionally substituted C1-C5 alkynylene which may be interrupted with a substituent selected from Substituent group a and the like; A is a group represented by the formula: wherein R6 and R7 are each independently lower alkyl and the like; m and n are each independently 0, 1, or 2; R2 is a hydrogen atom and the like; R3 is optionally substituted lower alkyl and the like; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxyl and the like, or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：由通式（I）表示的化合物：其中R 1是其中R 26和R 28各自独立地为低级烷氧基等; n1为0〜3的整数， Z是可以被选自取代基组a等的取代基中断的任选取代的C 1 -C 5亚炔基; A是由下式表示的基团：其中R6和R7各自独立地为低级烷基等; m和n各自独立地为0,1或2; R2是氢原子等; R3是任选取代的低级烷基等; R4是氢原子; 或者R 3和R 4可以与相邻的碳原子一起与环一起取代; R5是羟基等，或光学活性异构体，其药学上可接受的盐或溶剂化物。

2. 发明授权

US08993763B2 Sulfonamide derivative having PGD2 receptor antagonistic activity 有权
标题翻译：具有PGD2受体拮抗活性的磺酰胺衍生物
公开(公告)号：US08993763B2
公开(公告)日：2015-03-31
申请号：US11992602
申请日：2006-09-25
申请人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi , Naohiro Onodera
发明人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi , Naohiro Onodera
IPC分类号： C07D295/26 , C07D417/12 , C07D413/10 , C07D407/10 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
摘要翻译：本发明提供具有DP受体拮抗活性的磺酰胺衍生物和含有上述化合物作为活性成分的药物组合物，还含有治疗过敏性疾病的治疗剂。通式（II）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; 环C为芳香族碳环等; R1是羧基等; R2独立地为卤素原子等; R3是任选取代的烷氧基等; R4独立地为卤素原子等; R5独立地是任意取代的烷基等; M是磺酰基等。 Y是单键等; L1是单键等; L2是单键等; k为0，1，2，3或4; n为0,1或2; q为0,1,2或3; 条件是当环B是含有一个或两个氮原子并且环C是苯环的6元含氮杂环时，a）k不为0; 其药学上可接受的盐或其水合物。

3. 发明授权

US08171910B2 Cylinder liner, cylinder block and process for the preparation of cylinder liner 有权
标题翻译：气缸套，缸体和气缸套的制备过程
公开(公告)号：US08171910B2
公开(公告)日：2012-05-08
申请号：US12552813
申请日：2009-09-02
申请人： Yuki Tachibana , Yoshiro Shina , Makoto Miyasaka , Hiroki Shimizu , Daisuke Shinkai
发明人： Yuki Tachibana , Yoshiro Shina , Makoto Miyasaka , Hiroki Shimizu , Daisuke Shinkai
IPC分类号： F02F1/00
CPC分类号： F02F1/004
摘要： The present invention a cylinder liner which controls gap formation at the interface between the cylinder liner and a cylinder block main body for accepting the cylinder liner therein, and serves to acquire closely contacting state and enhanced bonding strength between the cylinder liner and the cylinder block main body, and to provide a cylinder block, and further to provide a process for the preparation of the cylinder liner.A plurality of circumferential grooves 15 extending in the circumferential direction is formed from a first circumferential groove 16 having a shape of “J” of the alphabet in sectional view and extending in a circumferential direction formed on an outer surface 12 of an cast iron cylinder liner 10, and a second circumferential groove 18 having a shape of “J” of the alphabet in sectional view and linking to the first circumferential groove 16. In enclosing the cylinder liner 10 in a cylinder block main body 30 by casting, the movement of a molten aluminum alloy is depressed by the circumferential grooves 15 and therefore a residual stress generated on the solidification and shrinkage is equally dispersed whereby cracking of the cylinder block body 3 can be prevented and close contact and bonding strength at interface between the cylinder liner 10 and the cylinder block main body 30 are ensured.
摘要翻译：本发明是一种气缸套，其控制气缸套与缸体主体之间的界面处的间隙形成，用于接纳气缸套，并且用于获得气缸套和气缸体主体之间的紧密接触状态和增强的接合强度并且提供气缸体，并且还提供用于制备气缸套的过程。沿圆周方向延伸的多个周向槽15由具有字母“J”的剖面图形的第一周向槽16形成，并且沿圆周方向延伸，形成在铸铁气缸套的外表面12上以及第一圆周凹槽18，其剖面图中具有字母表“J”的形状，并与第一周向凹槽16相连。通过铸造将汽缸套10封装在汽缸体主体30中，熔融铝合金被周向槽15压下，因此在凝固和收缩时产生的残余应力相等地分散，从而可以防止缸体主体3的裂纹，并且气缸套10与缸套10之间的界面处的紧密接触和接合强度确保气缸体主体30。

4. 发明申请

US20090105274A1 Indolecarboxylic Acid Derivative Having PGD2 Receptor Antagonistic Activity 有权
标题翻译：具有PGD2受体拮抗活性的吲哚羧酸衍生物
公开(公告)号：US20090105274A1
公开(公告)日：2009-04-23
申请号：US11991551
申请日：2006-09-04
申请人： Akira Kugimiya , Yuki Tachibana
发明人： Akira Kugimiya , Yuki Tachibana
IPC分类号： A61K31/454 , C07D401/04 , A61K31/496 , A61P11/06 , C07D401/06
CPC分类号： C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/14 , C07D419/14 , C07D471/04
摘要： The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X1=X2-X3=X4- is a formula of —C(R1)═C(R2)—C(R3)═C(R4)— etc.; X5 is C(R5) or N; R1, R2, R3, R4 and R5 is independently a hydrogen atom, a halogen atom etc; R6 is a formula of -Z-R10 etc. wherein Z is alkylene etc., and R10 is carboxy etc.; R7 is optionally substituted alkyloxy etc.; R8 is independently a halogen atom etc.; R9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.;a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有DP受体拮抗作用的吲哚羧酸衍生物和包含所述化合物作为活性成分的药物组合物，还有用于治疗过敏性疾病的治疗剂。通式（I）的化合物：其中环A是芳族碳环等; 环B为含氮非芳族杂环等; -X1 = X2-X3 = X4-的式为-C（R1）-C（R2）-C（R3）-C（R4） - 等的式; X5为C（R5）或N; R1，R2，R3，R4和R5独立地为氢原子，卤素原子等; R6是-Z-R10等的化合物，其中Z是亚烷基等，R 10是羧基等; R7是任选取代的烷氧基等; R8独立地是卤素原子等; R9独立地是任选取代的烷基等; Y是单键等; n为0等 q为0等; 其药学上可接受的盐或其溶剂合物。

5. 发明授权

US08153793B2 Sulfonamide derivative having PGD2 receptor antagonistic activity 有权
标题翻译：具有PGD2受体拮抗活性的磺酰胺衍生物
公开(公告)号：US08153793B2
公开(公告)日：2012-04-10
申请号：US12622860
申请日：2009-11-20
申请人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
发明人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
IPC分类号： C07D403/10
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
摘要翻译：本发明提供具有DP受体拮抗活性的磺酰胺衍生物和含有上述化合物作为活性成分的药物组合物，还含有治疗过敏性疾病的治疗剂。通式（II）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; 环C为芳香族碳环等; R1是羧基等; R2独立地为卤素原子等; R3是任选取代的烷氧基等; R4独立地为卤素原子等; R5独立地是任意取代的烷基等; M是磺酰基等。 Y是单键等; L1是单键等; L2是单键等; k为0，1，2，3或4; n为0,1或2; q为0,1,2或3; 条件是当环B是含有一个或两个氮原子并且环C是苯环的6元含氮杂环时，a）k不为0; 其药学上可接受的盐或其水合物。

6. 发明授权

US08623903B2 Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity 失效
标题翻译：具有PGD2受体拮抗活性的吲哚羧酸衍生物
公开(公告)号：US08623903B2
公开(公告)日：2014-01-07
申请号：US13368687
申请日：2012-02-08
申请人： Akira Kugimiya , Yuki Tachibana
发明人： Akira Kugimiya , Yuki Tachibana
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/14 , C07D419/14 , C07D471/04
摘要： The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X1═X2—X3═X4— is a formula of —C(R1)═C(R2)—C(R3)═C(R4)— etc.; X5 is C(R5) or N; R1, R2, R3, R4 and R5 is independently a hydrogen atom, a halogen atom etc; R6 is a formula of —Z—R10 etc. wherein Z is alkylene etc., and R10 is carboxy etc.; R7 is optionally substituted alkyloxy etc.; R8 is independently a halogen atom etc.; R9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有DP受体拮抗作用的吲哚羧酸衍生物和包含所述化合物作为活性成分的药物组合物，还有用于治疗过敏性疾病的治疗剂。通式（I）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; -X1 = X2-X3 = X4-的式为-C（R1）= C（R2）-C（R3）= C（R4） - 等的式; X5为C（R5）或N; R1，R2，R3，R4和R5独立地为氢原子，卤素原子等; R6是-Z-R10等的化合物，其中Z是亚烷基等，R 10是羧基等; R7是任选取代的烷氧基等; R8独立地是卤素原子等; R9独立地是任选取代的烷基等; Y是单键等; n为0等 q为0等; 其药学上可接受的盐或其溶剂合物。

7. 发明授权

US08143285B2 Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity 有权
标题翻译：具有PGD2受体拮抗活性的吲哚羧酸衍生物
公开(公告)号：US08143285B2
公开(公告)日：2012-03-27
申请号：US11991551
申请日：2006-09-04
申请人： Akira Kugimiya , Yuki Tachibana
发明人： Akira Kugimiya , Yuki Tachibana
IPC分类号： A61K31/404 , C07D401/04 , C07D401/06 , C07D401/12
CPC分类号： C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/14 , C07D419/14 , C07D471/04
摘要： The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X1=X2-X3=X4- is a formula of —C(R1)═C(R2)—C(R3)═C(R4)— etc.; X5 is C(R5) or N; R1, R2, R3, R4 and R5 is independently a hydrogen atom, a halogen atom etc; R6 is a formula of -Z-R10 etc. wherein Z is alkylene etc., and R10 is carboxy etc.; R7 is optionally substituted alkyloxy etc.; R8 is independently a halogen atom etc.; R9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.;a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有DP受体拮抗作用的吲哚羧酸衍生物和包含所述化合物作为活性成分的药物组合物，还有用于治疗过敏性疾病的治疗剂。通式（I）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; -X1 = X2-X3 = X4-的公式为-C（R1）= C（R2）-C（R3）= C（R4） - 等的式; X5为C（R5）或N; R1，R2，R3，R4和R5独立地为氢原子，卤素原子等; R6是-Z-R10等的化合物，其中Z是亚烷基等，R 10是羧基等; R7是任选取代的烷氧基等; R8独立地是卤素原子等; R9独立地是任选取代的烷基等; Y是单键等; n为0等 q为0等; 其药学上可接受的盐或其溶剂合物。

8. 发明授权

US06805088B2 Air intake system of engine 失效
标题翻译：发动机进气系统
公开(公告)号：US06805088B2
公开(公告)日：2004-10-19
申请号：US10212088
申请日：2002-08-06
申请人： Yuki Tachibana , Kensuke Kobayashi , Yuji Chiba
发明人： Yuki Tachibana , Kensuke Kobayashi , Yuji Chiba
IPC分类号： F02M3510
CPC分类号： F02M35/10288 , F02B75/243 , F02B2075/1816 , F02M35/04 , F02M35/10032 , F02M35/10039 , F02M35/10111 , F02M35/10216 , F02M35/10222 , F02M35/10255 , F02M35/10321 , F02M35/10347 , F02M35/1165 , F05C2225/08
摘要： In the air intake system of an engine which introduces air passed through a cleaner case having filter element therein into a throttle box through a throttle, and distributes the air from the throttle box to each cylinder of the engine by an intake manifold, the throttle is provided in the throttle box such that a center axis of the throttle is provided substantially horizontally and in a center in the vertical direction between the ends on the upstream side of the intake pipes. The intake pipes are provided on both sides of the throttle box and the throttle is connected to the throttle box such that a center axis of the throttle is arranged substantially horizontal and, simultaneously, an intake route for linking the throttle (including the main port) to the filter element is substantially arranged linearly on the center axis of the throttle. Also, the inside of the cleaner case is in the form of a hollow and is divided by a partition into the air cleaner case and a blowby room. The throttle box and the intake manifold are separately formed in advance and then are monolithically connected to each other.
摘要翻译：在将通过其中具有过滤元件的清洁器壳体的空气通过节气门引入节流阀的发动机的进气系统中，并且通过进气歧管将空气从节气门分配到发动机的每个气缸，设置在节气门箱中，使得节气门的中心轴大致水平地设置，并且在进气管的上游侧的端部之间沿垂直方向设置中心。进气管设置在节气门的两侧，并且节流阀连接到节气门箱，使得节气门的中心轴基本上水平布置，并且同时具有用于连接节气门（包括主口）的进气路径，过滤元件基本上在节气门的中心轴上线性地布置。此外，清洁器壳体的内部是中空的形式，并且被隔板分成空气滤清器壳体和排气室。节气门箱和进气歧管预先分开形成，然后彼此单片连接。

9. 发明申请

US20120142687A1 INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY 失效
标题翻译：具有PGD2受体拮抗活性的吲哚酚酸衍生物
公开(公告)号：US20120142687A1
公开(公告)日：2012-06-07
申请号：US13368687
申请日：2012-02-08
申请人： Akira KUGIMIYA , Yuki Tachibana
发明人： Akira KUGIMIYA , Yuki Tachibana
IPC分类号： A61K31/454 , C07D403/04 , A61K31/405 , C07D401/14 , A61K31/4545 , A61P11/06 , A61K31/4375 , C07D403/06 , A61K31/496 , C07D413/14 , A61K31/5377 , A61P37/00 , C07D401/04 , C07D471/04
CPC分类号： C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/14 , C07D419/14 , C07D471/04
摘要： The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X1═X2—X3═X4— is a formula of —C(R1)═C(R2)—C(R3)═C(R4)— etc.; X5 is C(R5) or N; R1, R2, R3, R4 and R5 is independently a hydrogen atom, a halogen atom etc; R6 is a formula of —Z—R10 etc. wherein Z is alkylene etc., and R10 is carboxy etc.; R7 is optionally substituted alkyloxy etc.; R8 is independently a halogen atom etc.; R9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有DP受体拮抗作用的吲哚羧酸衍生物和包含所述化合物作为活性成分的药物组合物，还有用于治疗过敏性疾病的治疗剂。通式（I）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; -X 1 = X 2 -X 3 = X 4 - 的化学式为-C（R 1）= C（R 2）-C（R 3）= C（R 4） X5为C（R5）或N; R1，R2，R3，R4和R5独立地为氢原子，卤素原子等; R6是-Z-R10等的化合物，其中Z是亚烷基等，R 10是羧基等; R7是任选取代的烷氧基等; R8独立地是卤素原子等; R9独立地是任选取代的烷基等; Y是单键等; n为0等 q为0等; 其药学上可接受的盐或其溶剂合物。

10. 发明申请

US20100069638A1 SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY 有权
标题翻译：具有PGD2受体拮抗活性的磺酰胺衍生物
公开(公告)号：US20100069638A1
公开(公告)日：2010-03-18
申请号：US12622860
申请日：2009-11-20
申请人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
发明人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
IPC分类号： C07D401/04 , C07D211/44 , C07D241/04 , C07D211/34 , C07D405/12 , C07D413/12
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
摘要翻译：本发明提供具有DP受体拮抗活性的磺酰胺衍生物和含有上述化合物作为活性成分的药物组合物，还含有治疗过敏性疾病的治疗剂。通式（II）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; 环C为芳香族碳环等; R1是羧基等; R2独立地为卤素原子等; R3是任选取代的烷氧基等; R4独立地为卤素原子等; R5独立地是任意取代的烷基等; M是磺酰基等。 Y是单键等。 L1是单键等; L2是单键等; k为0，1，2，3或4; n为0,1或2; q为0,1,2或3; 条件是当环B是含有一个或两个氮原子并且环C是苯环的6元含氮杂环时，a）k不为0; 其药学上可接受的盐或其水合物。

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