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1. 发明申请

US20050032820A1 Novel spiro compounds 失效
公开(公告)号：US20050032820A1
公开(公告)日：2005-02-10
申请号：US10922869
申请日：2004-08-23
申请人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
发明人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
IPC分类号： C07D491/107 , A61K31/438 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P27/06 , A61P29/00 , A61P43/00 , C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10 , C07D519/00 , C07D487/14 , A61K31/4747 , A61K31/519
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： A Compound represented by the general formula (I): wherein AR1 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of hydroxy, halogen, nitro, lower alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, cyclo(lower)alkyl, lower alkenyl, lower alkoxy, halo(lower)alkoxy, lower alkylthio, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylene optionally substituted with oxo, and a group represented by the formula —Q—Ar2; Ar2represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, cyano, lower alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, hydroxy, lower alkoxy, halo(lower)alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl; n represents 0 or 1; Q represents a single bond or carbonyl; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen; and a salt, ester or N-oxide derivative thereof exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like, central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal and the like, metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia and the like, sexual and reproductive dysfunction, gastro-intestinal disorder, respiratory disorder, inflammation or glaucoma, and the like.

2. 发明授权

US07304072B2 Spiro compounds 失效
标题翻译：螺环化合物
公开(公告)号：US07304072B2
公开(公告)日：2007-12-04
申请号：US10922869
申请日：2004-08-23
申请人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
发明人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
IPC分类号： A61K31/4355 , C07D491/048
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： Compounds represented by the general formula (I) wherein Ar1 represents an aryl or heteroaryl which may be substituted; n represents 0 or 1; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen; and a salt, ester or N-oxide derivative thereof. The compounds exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders, central nervous system disorders, metabolic diseases, sexual and reproductive dysfunctions, gastro-intestinal disorders, respiratory disorders, inflammation or glaucoma, and the like.
摘要翻译：由通式（I）表示的化合物

3. 发明申请

US20090075319A1 Method of Detecting Reactive Metabolite 审中-公开
标题翻译：检测活性代谢物的方法
公开(公告)号：US20090075319A1
公开(公告)日：2009-03-19
申请号：US11991829
申请日：2006-09-13
申请人： Hiroyuki Takahashi , Kazuko Inoue , Yoshihiro Shibata , Masato Chiba , Yasuyuki Ishii
发明人： Hiroyuki Takahashi , Kazuko Inoue , Yoshihiro Shibata , Masato Chiba , Yasuyuki Ishii
IPC分类号： C12Q1/26
CPC分类号： G21H5/02 , G01N33/60
摘要： A method of detecting a reactive metabolite which comprises steps of conducting a metabolic reaction of a test compound in the presence of two labeled nucleophiles, and detecting the label of the nucleophiles bound to the reactive metabolite, and a method of detecting a reactive metabolite which further comprises separating liquid layer using ammonium acetate to obtain an organic layer after the aforementioned reaction step are disclosed. In these detection methods, a reactive metabolite can be quantitatively detected by easy preparation. Furthermore, generation of a false positive signal can be prevented, and generation of a false negative signal can be decreased. Accordingly, screening of a test compound can be efficiently performed with higher accuracy.
摘要翻译：一种检测反应性代谢物的方法，其包括在两个标记的亲核试剂存在下进行测试化合物的代谢反应并检测与活性代谢物结合的亲核试剂的标记的步骤，以及进一步检测反应性代谢物的方法包括在公开上述反应步骤之后使用乙酸铵分离液体层以获得有机层。在这些检测方法中，可以通过容易的制备定量检测反应性代谢物。此外，可以防止产生假阳性信号，并且可以减少假阴性信号的产生。因此，可以更高精度有效地进行试验化合物的筛选。

4. 发明授权

US09254758B2 Control apparatus, vehicle, and control method 有权
标题翻译：控制装置，车辆和控制方法
公开(公告)号：US09254758B2
公开(公告)日：2016-02-09
申请号：US14043102
申请日：2013-10-01
申请人： Hiroshi Sato , Hiroaki Tabuchi , Ken Koibuchi , Masato Chiba , Kazuhiko Sakakibara , Nobuyuki Okabe
发明人： Hiroshi Sato , Hiroaki Tabuchi , Ken Koibuchi , Masato Chiba , Kazuhiko Sakakibara , Nobuyuki Okabe
IPC分类号： H02J7/00 , H02P1/00 , B60L11/18 , B60R16/033
CPC分类号： B60L11/1879 , B60R16/033
摘要： A control apparatus for a vehicle having an idle stop function includes a measurement unit that measures the characteristic of a battery provided in the vehicle, an identification unit that identifies the type of the battery based on the measured characteristic, and a control unit that stops the idle stop function in a case where the identified type of the battery indicates that the battery is not for an idle-stop vehicle, and permits execution of the idle stop function in a case where the execution of the idle stop function is permitted by an input of a predetermined signal from an external terminal even when the identified type of the battery indicates that the battery is not for the idle-stop vehicle.
摘要翻译：一种具有怠速停止功能的车辆的控制装置，包括测量车辆中设置的电池的特性的测量单元，基于测量特性识别电池类型的识别单元，以及停止在所识别的电池类型指示电池不是用于怠速停止车辆的情况下，并且在通过输入允许执行怠速停止功能的情况下允许执行怠速停止功能的怠速停止功能即使当所识别的电池类型指示电池不是用于怠速停止车辆时，来自外部终端的预定信号。

5. 发明授权

US08410803B2 Test apparatus of semiconductor device and method thereof 有权
标题翻译：半导体器件的测试装置及其方法
公开(公告)号：US08410803B2
公开(公告)日：2013-04-02
申请号：US12820623
申请日：2010-06-22
申请人： Nobuhiro Sawa , Kouichi Minami , Masato Chiba
发明人： Nobuhiro Sawa , Kouichi Minami , Masato Chiba
IPC分类号： G01R31/00 , G01R31/20
CPC分类号： G01R31/2891
摘要： A test apparatus according to the present invention includes a probe card recognition unit that recognizes positions of at least two probe card marks formed to a probe card and assumes a probe card mark connection line connecting the positions of the probe card marks, a backing material recognition unit that recognizes positions of at least two backing material marks formed to a backing material where a semiconductor chip is fixed thereto and assumes a backing material mark connection line connecting the positions of the backing material mark, a positional relationship recognition unit that recognizes a positional relationship between the probe card and the backing material according to the probe card mark connection line and the backing material mark connection line, and a correction unit that corrects the position of at least one of the probe card and the backing material according to the positional relationship.
摘要翻译：根据本发明的测试装置包括探针卡识别单元，其识别形成在探针卡上的至少两个探针卡标记的位置，并且采用连接探针卡标记的位置的探针卡标记连接线，背衬材料识别单元，其识别形成在其上固定有半导体芯片的背衬材料上的至少两个背衬材料标记的位置，并且呈现连接背衬材料标记的位置的背衬材料标记连接线;识别位置关系的位置关系识别单元根据探针卡标记连接线和背衬材料标记连接线在探针卡和背衬材料之间，以及根据位置关系校正探针卡和背衬材料中的至少一个的位置的校正单元。

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