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1. 发明授权

US09303083B2 Therapeutic agent for malignant tumors expressing MHC class II 有权
标题翻译：表达MHC II类恶性肿瘤的治疗剂
公开(公告)号：US09303083B2
公开(公告)日：2016-04-05
申请号：US13877844
申请日：2011-10-04
申请人： Shuji Matsuoka , Yasuyuki Ishii
发明人： Shuji Matsuoka , Yasuyuki Ishii
IPC分类号： C07K16/28 , C07K16/18 , C07K16/30
CPC分类号： C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/34 , G01N2333/70539
摘要： Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56).
摘要翻译：提供一种特异于表达II类MHC的恶性肿瘤的新型治疗剂。本发明提供一种抗体，其识别构成在恶性肿瘤上表达的II类MHC的蛋白质，所述抗体包含选自重链CDR1（SEQ ID NO：54的49至54位的氨基酸序列）中的至少一种，重链 CDR2（SEQ ID NO：54的第69〜84位的氨基酸序列），重链CDR3（SEQ ID NO：54的117〜128位的氨基酸序列），轻链CDR1（由位置 SEQ ID NO：56的46〜55），轻链CDR2（由SEQ ID NO：56的71〜77位表示的氨基酸序列）和轻链CDR3（SEQ ID NO：：56）。

2. 发明授权

US08948638B2 Image forming apparatus 有权
标题翻译：图像形成装置
公开(公告)号：US08948638B2
公开(公告)日：2015-02-03
申请号：US13215700
申请日：2011-08-23
申请人： Yuji Ishikura , Yasuyuki Ishii , Hideki Kosugi , Tetsuro Hirota , Masaaki Yamada , Yoshiko Ogawa , Atsushi Kurokawa , Hideyasu Seki , Masanori Horike , Shin Kayahara
发明人： Yuji Ishikura , Yasuyuki Ishii , Hideki Kosugi , Tetsuro Hirota , Masaaki Yamada , Yoshiko Ogawa , Atsushi Kurokawa , Hideyasu Seki , Masanori Horike , Shin Kayahara
IPC分类号： G03G15/06 , G03G15/08 , G03G15/01 , G03G15/16
CPC分类号： G03G15/0131 , G03G15/0189 , G03G15/1605
摘要： An image forming apparatus includes a latent image carrier; a latent image writer to write a latent image on the latent image carrier; a developing unit including a toner carrier having first and second electrodes insulated via an insulator member and a voltage applying unit to apply voltages to the first and second electrodes having a potential difference to generate first electric fields to cause the toner to hop from the toner carrier to the latent image carrier to develop a toner image; and a transfer unit to transfer the developed toner image to a transferring member. When alternating voltages having a same phase and same amplitude are applied to the first and second electrodes to form second electric fields between the latent image carrier and the toner carrier, the toner is discharged from the toner carrier to the latent image carrier in a toner discharge mode.
摘要翻译：图像形成装置包括潜像载体; 潜像写入器，用于在潜像载体上写入潜像; 显影单元，包括具有通过绝缘体构件绝缘的第一和第二电极的调色剂载体和施加电压的电压施加到具有电位差的第一和第二电极，以产生第一电场，以使调色剂从调色剂载体到潜像载体以形成调色剂图像; 以及将显影的调色剂图像转印到转印部件的转印单元。当具有相同相位和相同振幅的交变电压施加到第一和第二电极以在潜像载体和调色剂载体之间形成第二电场时，调色剂在调色剂排出物中从调色剂载体排出到潜像载体模式。

3. 发明授权

US08716031B2 Method for quantification of antigen-specific canine IgE 有权
标题翻译：抗原特异性犬IgE定量方法
公开(公告)号：US08716031B2
公开(公告)日：2014-05-06
申请号：US12992476
申请日：2009-05-12
申请人： Kenichi Masuda , Yasuyuki Ishii , Nobutaka Yasuda
发明人： Kenichi Masuda , Yasuyuki Ishii , Nobutaka Yasuda
IPC分类号： C07K16/06 , C07K16/42 , G01N33/53 , G01N33/536 , G01N33/537 , G01N33/543 , G01N33/563 , G01N33/96 , G01N33/68 , C12N5/20 , C12N5/16
CPC分类号： G01N33/6854 , C07K16/06 , C07K16/42 , C07K16/4291 , C07K2317/33 , C12N5/163 , G01N33/536 , G01N33/537 , G01N33/543 , G01N33/96 , G01N2333/435 , G01N2469/20 , G01N2496/05 , G01N2800/24 , Y10S435/975 , Y10T436/10 , Y10T436/106664
摘要： Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which comprises the following steps (A) to (D): (A) contacting a biological sample collected from a subject with an antigen to conjugate IgE contained in the sample with the antigen; (B) measuring the quantity of IgE in a standard sample collected from an experimental animal which is different from the subject and has been sensitized with the same antigen as that used in step (A) by using a substance capable of recognizing both IgE from the subject and IgE from the experimental animal, thereby producing a standard curve; (C) detecting a conjugate formed in step (A) by using the same substance capable of recognizing both IgE from the subject and IgE from the experimental animal as that used in step (B); and (D) determining the quantity of IgE in the biological sample collected from the subject by utilizing the quantity of the conjugate detected in step (C) and the standard curve produced in step (B). Also specifically disclosed is a method for quantifying an antigen-specific human IgE.
摘要翻译：公开了用于定量抗原特异性犬或人IgE的方便和有效的方法。具体公开的是定量抗原特异性犬IgE的方法，其包括以下步骤（A）至（D）：（A）使从受试者收集的生物样品与抗原接触，将样品中含有的IgE与抗原; （B）测量从与受试者不同的实验动物收集的标准样品中的IgE的量，并且已经用与步骤（A）中使用的相同的抗原致敏，通过使用能够识别来自受试者和IgE，从而产生标准曲线; （C）通过使用能够从受试者中识别出两种IgE的相同物质和步骤（B）中使用的实验动物的IgE，检测步骤（A）中形成的缀合物; 和（D）通过利用在步骤（C）中检测到的共轭物的量和步骤（B）中产生的标准曲线来确定从受试者收集的生物样品中的IgE的量。还具体公开了一种定量抗原特异性人IgE的方法。

4. 发明申请

US20130216250A1 DEVELOPMENT DEVICE AND IMAGE FORMING APPARATUS INCORPORATING SAME 审中-公开
标题翻译：开发设备和形成装置的图像形成装置
公开(公告)号：US20130216250A1
公开(公告)日：2013-08-22
申请号：US13749028
申请日：2013-01-24
申请人： Hideyasu SEKI , Yasuyuki Ishii , Yoshiko Ogawa , Osamu Endou , Yuuji Ishikura , Masayuki Yamane , Keiichi Yoshida , Atsushi Kurokawa , Masahiro Watanabe , Akihiro Kawakami
发明人： Hideyasu SEKI , Yasuyuki Ishii , Yoshiko Ogawa , Osamu Endou , Yuuji Ishikura , Masayuki Yamane , Keiichi Yoshida , Atsushi Kurokawa , Masahiro Watanabe , Akihiro Kawakami
IPC分类号： G03G15/08
CPC分类号： G03G15/0812 , G03G15/0808 , G03G15/0818
摘要： A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer, and a developer regulator to adjust an amount of developer transported to the development range by the developer bearer. Multiple projections are formed in a surface of the developer bearer, and the developer bearer rotates in a reverse direction to a direction of rotation for image development while image development is not performed. The developer regulator includes a blade having a first end held by a regulator holder and a second end that contacts the multiple projections formed in the surface of the developer bearer and is disposed in a direction counter to the direction of rotation of the developer bearer for image development.
摘要翻译：开发设备包括由旋转开发者携带到面向潜像承载的开发范围的开发者承载件，以及开发者调节器，以通过开发者承载来调整运送到开发范围的开发者的数量。在显影剂载体的表面上形成多个突起，并且显影剂承载体在与图像显影的旋转方向相反的方向上旋转，而不进行图像显影。显影剂调节器包括具有由调节器保持器保持的第一端和接触形成在显影剂载体的表面中的多个突起的第二端的刀片，并且设置在与图像显影剂载体的旋转方向相反的方向发展。

5. 发明申请

US20110164892A1 DEVELOPMENT DEVICE, PROCESS CARTRIDGE INCORPORATING SAME, AND IMAGE FORMING APPARATUS INCORPORATING SAME 失效
标题翻译：开发设备，与其同时使用的工艺盒和与其成像的图像形成装置
公开(公告)号：US20110164892A1
公开(公告)日：2011-07-07
申请号：US12980951
申请日：2010-12-29
申请人： Yoshiko OGAWA , Yasuyuki ISHII , Hideki KOSUGI , Masaaki YAMADA , Atsushi KUROKAWA , Yuji ISHIKURA
发明人： Yoshiko OGAWA , Yasuyuki ISHII , Hideki KOSUGI , Masaaki YAMADA , Atsushi KUROKAWA , Yuji ISHIKURA
IPC分类号： G03G15/06
CPC分类号： G03G15/0818 , G03G2215/0634 , G03G2215/0651
摘要： A development device includes a developer container, a rotary developer carrier that is disposed facing the latent image carrier and including multiple outer electrodes arranged in a circumferential direction of the developer carrier, an inner electrode electrically insulated from the multiple outer electrodes, an insulation layer disposed between the inner and outer electrodes, and a surface layer overlaying the outer electrodes and electrically insulating the multiple outer electrodes from each other, a bias power source to generate electrical fields that change with time by applying a first and second bias voltages to the inner and outer electrodes, respectively, an electrical field adjuster to regulate the electrical fields in accordance with a thickness of the surface layer of the developer carrier, and a controller.
摘要翻译：显影装置包括显影剂容器，与潜像载体相对设置的旋转显影剂载体，包括沿着显影剂载体的圆周方向布置的多个外部电极，与多个外部电极电绝缘的内部电极，设置有绝缘层在内电极和外电极之间，以及覆盖外电极并使多个外电极彼此电绝缘的表面层，偏压电源，以产生电场，其随时间而变化，通过施加第一和第二偏置电压到内和外部电极分别是电场调节器，以根据显影剂载体的表面层的厚度来调节电场，以及控制器。

6. 发明申请

US20110111529A1 METHOD FOR QUANTIFICATION OF ANTIGEN-SPECIFIC CANINE OR HUMAN IGE 有权
标题翻译：抗原特异性犬或人脑的定量方法
公开(公告)号：US20110111529A1
公开(公告)日：2011-05-12
申请号：US12992476
申请日：2009-05-12
申请人： Kenichi Masuda , Yasuyuki Ishii , Nobutaka Yasuda
发明人： Kenichi Masuda , Yasuyuki Ishii , Nobutaka Yasuda
IPC分类号： G01N33/566
CPC分类号： G01N33/6854 , C07K16/06 , C07K16/42 , C07K16/4291 , C07K2317/33 , C12N5/163 , G01N33/536 , G01N33/537 , G01N33/543 , G01N33/96 , G01N2333/435 , G01N2469/20 , G01N2496/05 , G01N2800/24 , Y10S435/975 , Y10T436/10 , Y10T436/106664
摘要： Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which comprises the following steps (A) to (D): (A) contacting a biological sample collected from a subject with an antigen to conjugate IgE contained in the sample with the antigen; (B) measuring the quantity of IgE in a standard sample collected from an experimental animal which is different from the subject and has been sensitized with the same antigen as that used in step (A) by using a substance capable of recognizing both IgE from the subject and IgE from the experimental animal, thereby producing a standard curve; (C) detecting a conjugate formed in step (A) by using the same substance capable of recognizing both IgE from the subject and IgE from the experimental animal as that used in step (B); and (D) determining the quantity of IgE in the biological sample collected from the subject by utilizing the quantity of the conjugate detected in step (C) and the standard curve produced in step (B). Also specifically disclosed is a method for quantifying an antigen-specific human IgE.
摘要翻译：公开了用于定量抗原特异性犬或人IgE的方便和有效的方法。具体公开的是定量抗原特异性犬IgE的方法，其包括以下步骤（A）至（D）：（A）使从受试者收集的生物样品与抗原接触，将样品中含有的IgE与抗原; （B）测量从与受试者不同的实验动物收集的标准样品中的IgE的量，并且已经用与步骤（A）中使用的相同的抗原致敏，通过使用能够识别来自受试者和IgE，从而产生标准曲线; （C）通过使用能够从受试者中识别出两种IgE的相同物质和步骤（B）中使用的实验动物的IgE，检测步骤（A）中形成的缀合物; 和（D）通过利用在步骤（C）中检测到的共轭物的量和步骤（B）中产生的标准曲线来确定从受试者收集的生物样品中的IgE的量。还具体公开了一种定量抗原特异性人IgE的方法。

7. 发明授权

US07920812B2 Development device and image forming apparatus that uses this device 有权
标题翻译：使用该装置的显影装置和图像形成装置
公开(公告)号：US07920812B2
公开(公告)日：2011-04-05
申请号：US12261302
申请日：2008-10-30
申请人： Hideki Kosugi , Yasuyuki Ishii , Tomoko Takahashi , Masaaki Yamada , Ichiro Kadota , Yoshinori Nakagawa
发明人： Hideki Kosugi , Yasuyuki Ishii , Tomoko Takahashi , Masaaki Yamada , Ichiro Kadota , Yoshinori Nakagawa
IPC分类号： G03G15/08
CPC分类号： G03G15/0818 , G03G2215/0653
摘要： A development device provided with a first electrode layer and a second electrode layer, which are laminated so as to overlap one another in a normal direction with respect to the surface of the roller part of the toner bearing roller. A plurality of openings are provided in the second electrode layer, over the entire latent image bearable area of a photosensitive body in the orthogonal-to-movement direction. The toner on the surface of the roller part is caused to hop between a plurality of spots directly beneath the openings that respectively exist directly beneath the plurality of openings in the second electrode layer, and a plurality of spots between the openings that respectively exist between the plurality of openings in the second electrode layer, within the entire area of the first electrode layer which is uniformly formed in the roller circumferential direction.
摘要翻译：一种显影装置，其具有第一电极层和第二电极层，该第一电极层和第二电极层相对于调色剂承载辊的辊部的表面在法线方向上彼此重叠。在第二电极层中，在正交移动方向上的感光体的整个潜像可承受区域上设置多个开口。导致辊部分表面上的调色剂在直接位于开口下面的多个位于第二电极层的多个开口正下方的多个点之间跳跃，并且开口之间的多个点分别存在于第二电极层之间在第一电极层的沿辊周向均匀地形成的整个区域内的第二电极层中的多个开口。

8. 发明申请

US20100184215A1 MODIFIED THIOREDOXIN 审中-公开
标题翻译：改性三羟甲基纤维素
公开(公告)号：US20100184215A1
公开(公告)日：2010-07-22
申请号：US12692912
申请日：2010-01-25
申请人： YASUYUKI ISHII , JUNII YODOI , HAJIME NKAKMURA , NORIHIKO KONDO
发明人： YASUYUKI ISHII , JUNII YODOI , HAJIME NKAKMURA , NORIHIKO KONDO
IPC分类号： C12N5/02
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention relates to a human modified thioredoxin composed of any of the following polypeptides: (a) a polypeptide modified by alteration or chemical modification of a cysteine residue at position 35 with another amino acid in an amino acid sequence of SEQ ID NO:2; and (b) a polypeptide having an amino acid sequence having one or more substituted, deleted, inserted or added amino acids in positions except for positions 32 and 35, preferably positions 32 to 35 in the amino acid sequence of SEQ ID NO:2, and having an apoptosis-inducing activity.
摘要翻译：本发明涉及由以下任何多肽组成的人修饰硫氧还蛋白：（a）通过在SEQ ID NO：2的氨基酸序列中与另一个氨基酸在位置35改变或化学修饰半胱氨酸残基而修饰的多肽 ; 和（b）具有在SEQ ID NO：2的氨基酸序列中的位置32和35，优选位置32至35之外的位置具有一个或多个取代，缺失，插入或添加的氨基酸的氨基酸序列的多肽，并具有凋亡诱导活性。

9. 发明授权

US07734233B2 Development device, process cartridge, and image forming apparatus 失效
标题翻译：显影装置，处理盒和成像装置
公开(公告)号：US07734233B2
公开(公告)日：2010-06-08
申请号：US11734389
申请日：2007-04-12
申请人： Katsuhiro Aoki , Hideki Zemba , Tomoko Takahashi , Nobuaki Kondoh , Masanori Horike , Masaaki Yamada , Takeo Tsukamoto , Hideki Kosugi , Ichiro Kadota , Yoshinori Nakagawa , Yasuyuki Ishii
发明人： Katsuhiro Aoki , Hideki Zemba , Tomoko Takahashi , Nobuaki Kondoh , Masanori Horike , Masaaki Yamada , Takeo Tsukamoto , Hideki Kosugi , Ichiro Kadota , Yoshinori Nakagawa , Yasuyuki Ishii
IPC分类号： G03G15/08
CPC分类号： G03G15/0803 , G03G2215/0651
摘要： A disclosed development device includes: a latent image carrier; a conveying member disposed so as to face the latent image carrier, the conveying member having plural electrodes insulated from one another and arranged at predetermined intervals so as to generate an electric field for moving toner on the conveying member; a voltage application unit applying a voltage of n phases (n is a positive integer not less than one) to the electrodes so as to form a cloud of the toner and the toner is adhered to the latent image carrier so as to form a visualized toner image; a toner supply unit supplying the toner to the conveying member; and a height adjusting member adjusting a uniform height for a toner layer of the toner immediately before a development area on the conveying member in which development is performed.
摘要翻译：所公开的显影装置包括：潜像载体; 所述输送部件被设置为面对所述潜像载体，所述输送部件具有彼此绝缘并且以预定间隔布置的多个电极，以便产生用于在所述输送部件上移动调色剂的电场; 电压施加单元，对电极施加n相（n为1以上的正整数）的电压，以形成调色剂云，调色剂粘附在潜像载体上，形成可视化的调色剂图片; 将调色剂供给到输送构件的调色剂供应单元; 以及高度调节构件，其在紧接着进行显影的输送构件上的显影区域之前调节调色剂的调色剂层的均匀高度。

10. 发明授权

US07664442B2 Developing apparatus 有权
标题翻译：开发设备
公开(公告)号：US07664442B2
公开(公告)日：2010-02-16
申请号：US11751211
申请日：2007-05-21
申请人： Koichiro Takashima , Yasuyuki Ishii , Yuichiro Hirata , Tomonori Matsunaga
发明人： Koichiro Takashima , Yasuyuki Ishii , Yuichiro Hirata , Tomonori Matsunaga
IPC分类号： G03G15/08
CPC分类号： G03G15/0808
摘要： A developing apparatus including: a developer carrying member carrying a developer with which an electrostatic image on an image bearing member is developed; a developer supplying/removing member having a conductive member and an insulating member on the surface thereof, and provided apart from the developer carrying member to supply and remove the developer to and from the developer carrying member, and moving directions of the developer carrying member and the developer supplying/removing member being opposed in a developer supplying position; and an electric field producing device producing between the developer carrying member and the developer supplying/removing member an oscillating electric field, in which direct potentials of the conductive member and the developer carrying member are the same, or the direct potential of the conductive member, with respect to the direct potential of the developer carrying member, is on the opposite side to a normal charging polarity of the developer.
摘要翻译：一种显影装置，包括：承载显影剂的显影剂承载构件，其上显影图像承载构件上的静电图像; 在其表面上具有导电构件和绝缘构件的显影剂供应/去除构件，并且与显影剂承载构件分开设置，以将显影剂供应到显影剂承载构件和从显影剂承载构件移除，以及显影剂承载构件的移动方向和显影剂供应/去除构件在显影剂供应位置相对; 以及在显影剂承载构件和显影剂供给/去除构件之间产生其中导电构件和显影剂承载构件的直接电位相同的振荡电场或导电构件的直接电位的电场产生装置，相对于显影剂承载构件的直接电位，与显影剂的正常充电极性相反。

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