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1. 发明授权

US08779523B2 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US08779523B2
公开(公告)日：2014-07-15
申请号：US13491909
申请日：2012-06-08
申请人： Koji Shirai , Ken Inadumi , Tsuyoshi Hirayu , Toshihiro Sakamoto
发明人： Koji Shirai , Ken Inadumi , Tsuyoshi Hirayu , Toshihiro Sakamoto
IPC分类号： H01L29/76
CPC分类号： H01L27/092 , H01L21/823814 , H01L21/823892 , H01L29/0653 , H01L29/0847 , H01L29/1083 , H01L29/42368 , H01L29/7835
摘要： According to one embodiment, a semiconductor device includes a semiconductor substrate with a p-type conductivity, a buried layer with an n-type conductivity provided on the semiconductor substrate, a back gate layer with a p-type conductivity provided on the buried layer, a drain layer with an n-type conductivity provided on the back gate layer, a source layer with an n-type conductivity provided spaced from the drain layer, a gate electrode provided in a region immediately above a portion of the back gate layer between the drain layer and the source layer, and a drain electrode in contact with a part of an upper surface of the drain layer. A thickness of the drain layer in a region immediately below a contact surface between the drain layer and the drain electrode is half a total thickness of the back gate and drain layers in the region.
摘要翻译：根据一个实施例，半导体器件包括具有p型导电性的半导体衬底，设置在半导体衬底上的具有n型导电体的掩埋层，设置在掩埋层上的具有p型导电性的背栅层，设置在背栅层上的具有n型导电性的漏极层，与漏极层隔开设置的具有n型导电性的源极层，设置在背栅层之间的紧邻上部的区域之间的栅电极漏极层和源极层，以及与漏极层的上表面的一部分接触的漏电极。在漏极层和漏极之间的接触表面正下方的区域中的漏极层的厚度是该区域中的背栅极和漏极层的总厚度的一半。

2. 发明授权

US08507505B2 Dihydropyrazolopyrimidinone derivative 有权
标题翻译：二氢吡唑并嘧啶酮衍生物
公开(公告)号：US08507505B2
公开(公告)日：2013-08-13
申请号：US13133673
申请日：2009-12-09
申请人： Makoto Bamba , Hidetomo Furuyama , Toshihiro Sakamoto , Satoshi Sunami , Keiji Takahashi , Fuyuki Yamamoto , Takashi Yoshizumi
发明人： Makoto Bamba , Hidetomo Furuyama , Toshihiro Sakamoto , Satoshi Sunami , Keiji Takahashi , Fuyuki Yamamoto , Takashi Yoshizumi
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61K31/5377 , A61P35/00 , A61P35/02
CPC分类号： A61K31/519 , A61K31/5377 , C07D487/04 , C07D519/00
摘要： The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Ar1 is an optionally substituted aryl or heteroaryl group; R1 is a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; R2 is an optionally substituted aryl, aralkyl, or heteroaryl group; and R3 is a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy.
摘要翻译：本发明涉及以下通式（I）的化合物等。在式中，Ar 1是任选取代的芳基或杂芳基; R 1是氢原子，任选取代的C 1 -C 6烷基，或任选取代的芳基，芳烷基或杂芳基; R2是任选取代的芳基，芳烷基或杂芳基; 并且R 3是氢原子或C 1 -C 6烷基。本发明的化合物具有优异的Wee1激酶抑制作用，因此可用于医药领域，特别是在各种类型的癌症治疗中。

3. 发明授权

US08329711B2 Pyridone-substituted-dihydropyrazolopyrimidinone derivative 失效
标题翻译：吡啶酮取代的二氢吡唑并嘧啶酮衍生物
公开(公告)号：US08329711B2
公开(公告)日：2012-12-11
申请号：US12738885
申请日：2008-10-20
申请人： Hidetomo Furuyama , Mikako Kawamura , Toshihiro Sakamoto , Fuyuki Yamamoto , Takashi Yoshizumi
发明人： Hidetomo Furuyama , Mikako Kawamura , Toshihiro Sakamoto , Fuyuki Yamamoto , Takashi Yoshizumi
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D519/00 , A61K2300/00
摘要： The invention relates to compounds of general formula (I-0): wherein R1, R2, R3, R4, R5, R6, R7a, R8a, X, and Y are as defined herein. Compounds of the invention have, based on excellent Wee1 kinase-inhibitory effect, a cell growth-inhibitory effect and an additive/synergistic effect with any other anticancer agent, and are therefore useful in the field of medicine.
摘要翻译：本发明涉及通式（I-0）的化合物：其中R1，R2，R3，R4，R5，R6，R7a，R8a，X和Y如本文所定义。本发明的化合物基于优异的Wee1激酶抑制作用，具有细胞生长抑制作用和与任何其它抗癌剂的添加/协同作用，因此可用于医学领域。

4. 发明授权

US08198281B2 Crystalline forms of dihydropyrazolopyrimidinone 有权
标题翻译：二氢吡唑并嘧啶酮的结晶形式
公开(公告)号：US08198281B2
公开(公告)日：2012-06-12
申请号：US12597012
申请日：2008-04-22
申请人： Masashi Kawasaki , Hiroo Mizuno , Toshihiro Sakamoto , Kimimasa Suzuki , Arlene E. McKeown
发明人： Masashi Kawasaki , Hiroo Mizuno , Toshihiro Sakamoto , Kimimasa Suzuki , Arlene E. McKeown
IPC分类号： A61K31/497 , A61K31/519 , A01N43/90 , C07D487/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D487/04
摘要： The present invention relates to the crystalline forms of 2-allyl-1-[6-(I-hydroxy-1 methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one or a salt thereof, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
摘要翻译：本发明涉及2-烯丙基-1- [6-（1-羟基-1-甲基乙基）吡啶-2-基] -6 - {[4-（4-甲基哌嗪-1-基）苯基] 氨基} -1,2-二氢-3H-吡唑并[3,4-d]嘧啶-3-酮或其盐，其可用于治疗作为激酶抑制剂的各种癌症的领域，特别是作为Weel激酶抑制剂。

5. 发明申请

US20120004240A1 INHIBITORS OF AKT ACTIVITY 有权
标题翻译： AKT活动的抑制剂
公开(公告)号：US20120004240A1
公开(公告)日：2012-01-05
申请号：US13255785
申请日：2010-03-03
申请人： Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
发明人： Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
IPC分类号： A61K31/4985 , A61P35/00 , A61K31/4375 , C07D401/14 , A61K31/519
CPC分类号： C07D471/14 , C07D487/14 , C07D519/00
摘要： The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供抑制Akt活性的取代的稠合萘啶衍生物。特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

6. 发明申请

US20110189130A1 DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVES 有权
标题翻译：二氢吡唑并嘧啶酮衍生物
公开(公告)号：US20110189130A1
公开(公告)日：2011-08-04
申请号：US13053798
申请日：2011-03-22
申请人： Takeshi Sagara , Sachie Otsuki , Satoshi Sunami , Toshihiro Sakamoto , Kenji Niiyama , Fuyuki Yamamoto , Takashi Yoshizumi , Hidetomo Furuyama , Yasuhiro Goto , Makoto Bamba , Keiji Takahashi , Hiroshi Hirai , Toshihide Nishibata
发明人： Takeshi Sagara , Sachie Otsuki , Satoshi Sunami , Toshihiro Sakamoto , Kenji Niiyama , Fuyuki Yamamoto , Takashi Yoshizumi , Hidetomo Furuyama , Yasuhiro Goto , Makoto Bamba , Keiji Takahashi , Hiroshi Hirai , Toshihide Nishibata
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/664 , A61K31/675 , A61K31/7008 , A61K31/7076 , A61K31/52 , A61K31/708 , A61K31/704 , A61K33/24 , A61K39/395 , A61K38/21 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/519
摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
摘要翻译：本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

7. 发明授权

US07935708B2 Dihydropyrazolopyrimidinone derivatives 有权
标题翻译：二氢吡唑并嘧啶酮衍生物
公开(公告)号：US07935708B2
公开(公告)日：2011-05-03
申请号：US12226707
申请日：2007-04-25
申请人： Takeshi Sagara , Sachie Otsuki , Satoshi Sunami , Toshihiro Sakamoto , Kenji Niiyama , Fuyuki Yamamoto , Takashi Yoshizumi , Hidetomo Furuyama , Yasuhiro Goto , Makoto Bamba , Keiji Takahashi , Hiroshi Hirai , Toshihide Nishibata
发明人： Takeshi Sagara , Sachie Otsuki , Satoshi Sunami , Toshihiro Sakamoto , Kenji Niiyama , Fuyuki Yamamoto , Takashi Yoshizumi , Hidetomo Furuyama , Yasuhiro Goto , Makoto Bamba , Keiji Takahashi , Hiroshi Hirai , Toshihide Nishibata
IPC分类号： A01N43/90 , A01N43/56 , A61K31/519 , A61K31/415 , C07D487/00 , C07D403/02
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/519
摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
摘要翻译：本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

8. 发明授权

US07875633B2 Phenylpyridone derivative 失效
标题翻译：苯基吡啶酮衍生物
公开(公告)号：US07875633B2
公开(公告)日：2011-01-25
申请号：US11990889
申请日：2006-08-23
申请人： Akira Naya , Toshihiro Sakamoto , Yuji Haga , Norikazu Otake
发明人： Akira Naya , Toshihiro Sakamoto , Yuji Haga , Norikazu Otake
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/5377 , A61K31/4545 , A61P9/00 , A61P25/00 , A61P3/00 , C07D213/64 , C07D401/02 , C07D413/02 , C07D401/14
CPC分类号： C07D213/69 , C07D213/64 , C07D401/10 , C07D413/10
摘要： A compound represented by the formula (I) is contained as an active ingredient: wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like, or R1 together with a nitrogen atom to which L, Z2 and R1 are attached may form an aliphatic nitrogenated heterocyclic group and R1 and R2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents —CH2—O—, —CH═CH— or the like; Z1 represents a single bond, a C1-4 alkylene group or the like; Z2 represents a single bond or a C1-4 alkylene group; L represents a methylene group, a C3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.
摘要翻译：作为活性成分，含有式（I）所示的化合物：其中，R 1和R 2分别独立地表示氢原子，低级烷基等，或者与连接有L，Z 2和R 1的氮原子一起形成可以形成脂族氮杂环基，并且R 1和R 2与它们所连接的氮原子一起形成脂族氮杂环基; X表示次甲基或氮原子; Y表示-CH 2 -O-，-CH = CH-等; Z1表示单键，C1-4亚烷基等; Z2表示单键或C1-4亚烷基; L表示亚甲基，C3-8亚环烷基等; Ar表示芳族碳环基等。该化合物可用作中枢神经系统疾病，心血管疾病或代谢疾病的药物。

9. 发明授权

US07292739B2 Optical modulator 有权
标题翻译：光调制器
公开(公告)号：US07292739B2
公开(公告)日：2007-11-06
申请号：US10527214
申请日：2003-09-10
申请人： Takashi Shinriki , Toshihiro Sakamoto , Masanao Kurihara , Toru Sugamata , Norikazu Miyazaki
发明人： Takashi Shinriki , Toshihiro Sakamoto , Masanao Kurihara , Toru Sugamata , Norikazu Miyazaki
IPC分类号： G02F1/035
CPC分类号： G02F1/0305 , G02F1/0316 , G02F1/225
摘要： An optical modulator in which stabilized driving is realized over a long time by relaxing stress generated in a recess formed in the surface of a substrate in the optical modulator and controlling deterioration of optical modulation control caused by stress-strain in the substrate including an optical waveguide. The optical modulator comprises a substrate of a material exhibiting electrooptic effect, an optical waveguide (4) provided on the substrate, and control electrodes (20-25) for controlling the phase of light being guided through the optical waveguide characterized in that a recess (12) is provided in the surface of the substrate for forming the control electrodes, and the control electrode (24) being formed on the recess is provided with a stress relaxing means.
摘要翻译：一种光调制器，其特征在于，通过在形成于所述光调制器的基板的表面上形成的凹部中产生的应力，在长时间内实现稳定的驱动，并控制由包括光波导的基板中的应力应变引起的光调制控制的劣化。光学调制器包括具有电光效应的材料的衬底，设置在衬底上的光波导（4）和用于控制通过光波导引导的光的相位的控制电极（20-25），其特征在于，凹部 12）设置在用于形成控制电极的基板的表面中，并且形成在凹部上的控制电极（24）设置有应力缓和装置。

10. 发明授权

US06806113B2 Optical waveguide device and method for forming optical waveguide device 失效
标题翻译：光波导器件及其形成方法
公开(公告)号：US06806113B2
公开(公告)日：2004-10-19
申请号：US09959156
申请日：2002-05-06
申请人： Yasuyuki Miyama , Hirotoshi Nagata , Toshihiro Sakamoto , Tetsuya Fujino
发明人： Yasuyuki Miyama , Hirotoshi Nagata , Toshihiro Sakamoto , Tetsuya Fujino
IPC分类号： G02B627
CPC分类号： G02F1/035 , G02F1/225 , G02F2001/212 , G02F2201/07 , G02F2203/07
摘要： An optical waveguide is formed on a substrate made of a material with an electro-optic effect. Then, an intermediate layer is fabricated, on the main surface of the substrate, by a dielectric material selected from the group consisting of AOx, B2Oy, COz (A: divalent element, B: trivalent element, C: quadrivalent element, 0
摘要翻译：在由具有电光效应的材料制成的基板上形成光波导。然后，通过选自AOx，B2Oy，COz（A：二价元素，B：三价元素，C：四价元素，0

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