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1. 发明申请

US20120298511A1 CHANNEL DEVICE AND SAMPLE TREATMENT APPARATUS INCLUDING THE SAME 有权
标题翻译：通道装置和样品处理装置，包括它们
公开(公告)号：US20120298511A1
公开(公告)日：2012-11-29
申请号：US13513331
申请日：2010-07-26
申请人： Takatoki Yamamoto
发明人： Takatoki Yamamoto
IPC分类号： G01N27/447 , B82Y30/00
CPC分类号： B03C5/026 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0864 , B01L2300/0896 , B01L2400/0415 , B03C2201/26 , G01N15/1031 , G01N15/1056
摘要： A channel device including a nanosize channel through which single molecule flows, at least one electrode pair arranged near the nanosize channel, and an AC power source that applies an AC voltage to the electrodes. This channel device is useful for identifying molecules one by one. Furthermore, a channel device including a nanosize channel through which single molecule flows, a branching portion, and a plurality of branching channels, wherein (i) an electrode pair is arranged near the nanosize channel so as to sandwich the nanosize channel between the electrodes, or (ii) one electrode of the electrode pair is located near the nanosize channel, whereas the other is arranged near the branching channels. This channel device is useful for separating single molecule. The present channel device achieves identification or separation at an accuracy of 100% in principle. A sample treatment apparatus according to present invention includes a channel device, a measurement section, and an arithmetic processing section. The measurement section applies a voltage (DC or AC) to between electrodes of an electrode pair installed in the nanosize channel, and measures an electric signal when single molecule passes between the electrodes to identify the molecule
摘要翻译：包括单分子流过的纳米尺寸通道，配置在纳米尺寸通道附近的至少一个电极对的通道器件以及向电极施加AC电压的AC电源。该通道装置可用于逐个识别分子。此外，包括单分子流过的纳米尺寸通道，分支部分和多个分支通道的通道器件，其中（i）电极对布置在纳米尺寸通道附近，以将纳米尺寸通道夹在电极之间，或（ii）电极对的一个电极位于纳米尺寸通道附近，而另一个设置在分支通道附近。该通道装置可用于分离单分子。本通道装置原则上以100％的精度实现识别或分离。根据本发明的样品处理装置包括通道装置，测量部和运算处理部。测量部分在安装在纳米尺寸通道中的电极对的电极之间施加电压（DC或AC），并且当单分子通过电极之间测量电信号以识别分子

2. 发明授权

US09114402B2 Channel device and sample treatment apparatus including the same 有权
标题翻译：通道装置和包括其的样品处理装置
公开(公告)号：US09114402B2
公开(公告)日：2015-08-25
申请号：US13513331
申请日：2010-07-26
申请人： Takatoki Yamamoto
发明人： Takatoki Yamamoto
IPC分类号： B03C5/02 , B01L3/00 , G01N15/10
CPC分类号： B03C5/026 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0864 , B01L2300/0896 , B01L2400/0415 , B03C2201/26 , G01N15/1031 , G01N15/1056
摘要： A channel device including a nanosize channel through which single molecule flows, at least one electrode pair arranged near the nanosize channel, and an AC power source that applies an AC voltage to the electrodes. This channel device is useful for identifying molecules one by one. Furthermore, a channel device including a nanosize channel through which single molecule flows, a branching portion, and a plurality of branching channels, wherein (i) an electrode pair is arranged near the nanosize channel so as to sandwich the nanosize channel between the electrodes, or (ii) one electrode of the electrode pair is located near the nanosize channel, whereas the other is arranged near the branching channels. This channel device is useful for separating single molecule. The present channel device achieves identification or separation at an accuracy of 100% in principle. A sample treatment apparatus according to present invention includes a channel device, a measurement section, and an arithmetic processing section. The measurement section applies a voltage (DC or AC) to between electrodes of an electrode pair installed in the nanosize channel, and measures an electric signal when single molecule passes between the electrodes to identify the molecule (see FIG. 1B).
摘要翻译：包括单分子流过的纳米尺寸通道，配置在纳米尺寸通道附近的至少一个电极对的通道器件以及向电极施加AC电压的AC电源。该通道装置可用于逐个识别分子。此外，包括单分子流过的纳米尺寸通道，分支部分和多个分支通道的通道器件，其中（i）电极对布置在纳米尺寸通道附近，以将纳米尺寸通道夹在电极之间，或（ii）电极对的一个电极位于纳米尺寸通道附近，而另一个设置在分支通道附近。该通道装置可用于分离单分子。本通道装置原则上以100％的精度实现识别或分离。根据本发明的样品处理装置包括通道装置，测量部和运算处理部。测量部分在安装在纳米尺寸通道中的电极对的电极之间施加电压（DC或AC），并且当单分子通过电极之间测量电信号以识别分子（参见图1B）。

3. 发明申请

US20110136234A1 CELL CULTURE SUBSTRATE AND ITS PRODUCTION METHOD 有权
标题翻译：细胞培养基质及其生产方法
公开(公告)号：US20110136234A1
公开(公告)日：2011-06-09
申请号：US13020193
申请日：2011-02-03
申请人： Shin OHYA , Takashi Inoue , Takatoki Yamamoto , Teruo Fujii , Yasuyuki Sakai , Masaki Nishikawa , Hitomi Sakai , Hirosuke Naruto
发明人： Shin OHYA , Takashi Inoue , Takatoki Yamamoto , Teruo Fujii , Yasuyuki Sakai , Masaki Nishikawa , Hitomi Sakai , Hirosuke Naruto
IPC分类号： C12N5/07 , C12N5/0735
CPC分类号： C12N5/0068 , C08G2261/3424 , C08L65/04 , C12N2533/30
摘要： A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): (wherein n is 0 or a positive integer, and m is a positive integer, the n and m representing degree of polymerization) formed by chemical vapor deposition of formyl[2.2]paracyclophane represented by the following formula (I): (wherein k is 0 or 1) with a polymer having at least one amino group (—NH2) capable of forming Schiff base in its monomer. The production method of the cell culture substrate comprises the step of synthesizing such polymer on the substrate.
摘要翻译：提供耐久性且能够以低成本容易地以商业规模生产的细胞培养基材及其制造方法。细胞培养基材包括基材和通过表面改性形成的层，其包含通过使由下式（II）表示的聚合物反应而生成的含氨基的聚合物：（其中n为0或正整数，m为正整数，代表聚合度的n和m）通过化学气相沉积由下式（I）表示的甲酰基[2.2]对环烷烃形成：（其中k为0或1）与具有至少一个氨基的聚合物 -NH2）能够在其单体中形成席夫碱。细胞培养基质的制造方法包括在基材上合成这样的聚合物的工序。

4. 发明授权

US08383409B2 Cell culture substrate and its production method 有权
标题翻译：细胞培养基质及其制备方法
公开(公告)号：US08383409B2
公开(公告)日：2013-02-26
申请号：US13020193
申请日：2011-02-03
申请人： Shin Ohya , Takashi Inoue , Takatoki Yamamoto , Teruo Fujii , Yasuyuki Sakai , Masaki Nishikawa , Hitomi Sakai , Hirosuke Naruto
发明人： Shin Ohya , Takashi Inoue , Takatoki Yamamoto , Teruo Fujii , Yasuyuki Sakai , Masaki Nishikawa , Hitomi Sakai , Hirosuke Naruto
IPC分类号： C12N5/02
CPC分类号： C12N5/0068 , C08G2261/3424 , C08L65/04 , C12N2533/30
摘要： The invention is directed to methods for the propagation or cultivation of cells including preparing a cell culture substrate, wherein the cell culture substrate includes a substrate and a layer formed by surface modification. The layer includes a polymer containing an amino group. The polymer is produced by reacting a polymer represented by formula (II): with a polymer having at least one amino group, —NH2, capable of forming a Schiff base in a monomer of formula (II), thereby forming a polymer layer constituting the layer formed by surface modification. “n” in Formula (II) is 0 or a positive integer, and m is a positive integer. n and m represent the degree of polymerization. Formula (II) is formed by chemical vapor deposition of formyl[2.2]paracyclophane. The methods further include providing cells in a medium; inoculating the cells onto the cell culture substrate; and culturing the cells, wherein the cells adhere to the cell culture substrate.
摘要翻译：本发明涉及细胞繁殖或培养方法，包括制备细胞培养基质，其中细胞培养基质包括基质和通过表面改性形成的层。该层包括含有氨基的聚合物。该聚合物通过使由式（II）表示的聚合物与具有至少一个氨基的聚合物-NH 2反应生成，该聚合物能够在式（II）的单体中形成席夫碱，从而形成构成通过表面改性形成的层。式（II）中的n为0或正整数，m为正整数。 n和m表示聚合度。式（II）由甲酰基[2.2]对环磷酰胺的化学气相沉积形成。所述方法还包括在培养基中提供细胞; 将细胞接种到细胞培养基底上; 并培养细胞，其中细胞粘附于细胞培养基质。

5. 发明授权

US07189367B2 Reactor and process for production thereof 失效
标题翻译：反应器及其生产方法
公开(公告)号：US07189367B2
公开(公告)日：2007-03-13
申请号：US09950718
申请日：2001-09-13
申请人： Takatoki Yamamoto , Teruo Fujii , Jong Wook Hong , Isao Endo
发明人： Takatoki Yamamoto , Teruo Fujii , Jong Wook Hong , Isao Endo
IPC分类号： B01L3/02 , B01J19/00
CPC分类号： B01L7/52 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00873 , B01J2219/00961 , B01L3/5027 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/1827 , B01L2400/0487
摘要： In order to be capable of a chemical reaction, analysis or the like wherein a small amount of samples is used, a reactor comprises a flat plate-like first substrate the inside of which is provided with a heating means; and a flat plate-like second substrate, which is placed on the top of the above-described first substrate, and on a surface thereof to be placed on the top of the above-described first substrate a flow channel having a predetermined contour has been defined.
摘要翻译：为了能够进行使用少量样品的化学反应，分析等，反应器包括平板状的第一基板，其内部设有加热装置; 以及设置在上述第一基板的顶部上的平板状的第二基板，并且在其表面上放置在上述第一基板的顶部上，具有预定轮廓的流路定义

6. 发明授权

US08956494B2 Method of adhering hard silicone resin, method of adhering substrate having fine structure, and preparation method of micro fluidic device utilizing adhesion method 有权
标题翻译：粘附硬质硅树脂的方法，具有精细结构的基材的粘合方法以及利用粘合方法的微流体装置的制备方法
公开(公告)号：US08956494B2
公开(公告)日：2015-02-17
申请号：US13522507
申请日：2011-01-19
申请人： Takatoki Yamamoto
发明人： Takatoki Yamamoto
IPC分类号： B29C65/14 , B01L3/00 , B29C59/14 , B29C59/16 , B29C65/48 , B29C65/52 , B29C65/82 , B29C65/00 , B81C3/00 , B29C35/08 , B29L31/00
CPC分类号： B29C65/1432 , B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0896 , B01L2300/123 , B01L2300/16 , B29C59/14 , B29C59/16 , B29C65/1406 , B29C65/1435 , B29C65/1483 , B29C65/4845 , B29C65/521 , B29C65/8215 , B29C66/028 , B29C66/1122 , B29C66/474 , B29C66/53461 , B29C66/71 , B29C66/73151 , B29C66/73755 , B29C66/7465 , B29C66/8322 , B29C2035/0827 , B29C2059/145 , B29K2995/0027 , B29K2995/007 , B29L2031/756 , B81B2201/058 , B81C3/001 , B81C2203/032 , B81C2203/038 , B29K2083/00
摘要： A method for adhering a major substrate to which nano sized concave and convex structures are formed without damaging the concave and convex structures can be used in a production method of a microfluidic device including nano sized fluidic channels. The substrates may be adhered under heat free and adhesive agent free environment by exciting the substrate surface including hard silicone resin with atmospheric plasma or vacuum ultraviolet light, then juxtaposing and pressurizing the surface of the hard silicone resin substrate and glass substrate. The silicone rubber composition is applied on the contact face of the cover substrate and then the silicone rubber composition is cured to form the silicone rubber layer and then the ultraviolet light is exposed under the condition that the surface of the major substrate being formed with concave and convex structures is contacted closely to the silicone rubber layer of the cover substrate.
摘要翻译：可以在包括纳米尺寸的流体通道的微流体装置的制造方法中使用粘附形成纳米尺寸的凹凸结构而不损坏凹凸结构的主基板的方法。可以通过在大气等离子体或真空紫外线下激发包括硬质硅树脂的基板表面，然后将硬硅树脂基板和玻璃基板的表面并列加压，从而可以在无热和无粘合剂的环境下粘合基板。将硅橡胶组合物涂布在覆盖基板的接触面上，然后使硅橡胶组合物固化形成硅橡胶层，然后在主基板的表面形成有凹部和凸形结构紧密地与覆盖基板的硅橡胶层接触。

7. 发明申请

US20130037207A1 METHOD OF ADHERING HARD SILICONE RESIN, METHOD OF ADHERING SUBSTRATE HAVING FINE STRUCTURE, AND PREPARATION METHOD OF MICRO FLUIDIC DEVICE UTILIZING ADHESION METHOD 有权
标题翻译：加入硬质硅树脂的方法，具有微细结构的基材的加入方法以及利用粘合方法的微流体装置的制备方法
公开(公告)号：US20130037207A1
公开(公告)日：2013-02-14
申请号：US13522507
申请日：2011-01-19
申请人： Takatoki Yamamoto
发明人： Takatoki Yamamoto
IPC分类号： B32B37/06 , B05D3/06
CPC分类号： B29C65/1432 , B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0896 , B01L2300/123 , B01L2300/16 , B29C59/14 , B29C59/16 , B29C65/1406 , B29C65/1435 , B29C65/1483 , B29C65/4845 , B29C65/521 , B29C65/8215 , B29C66/028 , B29C66/1122 , B29C66/474 , B29C66/53461 , B29C66/71 , B29C66/73151 , B29C66/73755 , B29C66/7465 , B29C66/8322 , B29C2035/0827 , B29C2059/145 , B29K2995/0027 , B29K2995/007 , B29L2031/756 , B81B2201/058 , B81C3/001 , B81C2203/032 , B81C2203/038 , B29K2083/00
摘要： A method for adhering a major substrate to which nano sized concave and convex structures are formed without damaging the concave and convex structures can be used in a production method of a microfluidic device including nano sized fluidic channels. The substrates may be adhered under heat free and adhesive agent free environment by exciting the substrate surface including hard silicone resin with atmospheric plasma or vacuum ultraviolet light, then juxtaposing and pressurizing the surface of the hard silicone resin substrate and glass substrate. The silicone rubber composition is applied on the contact face of the cover substrate and then the silicone rubber composition is cured to form the silicone rubber layer and then the ultraviolet light is exposed under the condition that the surface of the major substrate being formed with concave and convex structures is contacted closely to the silicone rubber layer of the cover substrate.
摘要翻译：可以在包括纳米尺寸的流体通道的微流体装置的制造方法中使用粘附形成纳米尺寸的凹凸结构而不损坏凹凸结构的主基板的方法。可以通过在大气等离子体或真空紫外线下激发包括硬质硅树脂的基板表面，然后将硬硅树脂基板和玻璃基板的表面并列加压，从而可以在无热和无粘合剂的环境下粘合基板。将硅橡胶组合物涂布在覆盖基板的接触面上，然后使硅橡胶组合物固化形成硅橡胶层，然后在主基板的表面形成有凹部和凸形结构紧密地与覆盖基板的硅橡胶层接触。

8. 发明申请

US20090042295A1 Cell culture substrate and its production method 审中-公开
标题翻译：细胞培养基质及其制备方法
公开(公告)号：US20090042295A1
公开(公告)日：2009-02-12
申请号：US11889067
申请日：2007-08-08
申请人： Shin Ohya , Takashi Inoue , Takatoki Yamamoto , Teruo Fujii , Yasuyuki Sakai , Masaki Nishikawa , Hitomi Sakai , Hirosuke Naruto
发明人： Shin Ohya , Takashi Inoue , Takatoki Yamamoto , Teruo Fujii , Yasuyuki Sakai , Masaki Nishikawa , Hitomi Sakai , Hirosuke Naruto
IPC分类号： C12N5/06
CPC分类号： C12N5/0068 , C08G2261/3424 , C08L65/04 , C12N2533/30
摘要： A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): (wherein n is 0 or a positive integer, and m is a positive integer, the n and m representing degree of polymerization) formed by chemical vapor deposition of formyl[2.2]paracyclophane represented by the following formula (I): (wherein k is 0 or 1) with a polymer having at least one amino group (—NH2) capable of forming Schiff base in its monomer. The production method of the cell culture substrate comprises the step of synthesizing such polymer on the substrate.
摘要翻译：提供耐久性且能够以低成本容易地以商业规模生产的细胞培养基材及其制造方法。细胞培养基材包括基材和通过表面改性形成的层，其包含通过使由下式（II）表示的聚合物反应而生成的含氨基的聚合物：（其中n为0或正整数，m为正整数，代表聚合度的n和m）通过化学气相沉积由下式（I）表示的甲酰基[2.2]对环烷烃形成：（其中k为0或1）与具有至少一个氨基的聚合物 -NH2）能够在其单体中形成席夫碱。细胞培养基质的制造方法包括在基材上合成这样的聚合物的工序。

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