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1. 发明授权

US08299296B2 Spiro compounds and pharmaceutical use thereof 有权
标题翻译：螺环化合物及其药物用途
公开(公告)号：US08299296B2
公开(公告)日：2012-10-30
申请号：US12258033
申请日：2008-10-24
申请人： Takashi Shimada , Hiroshi Ueno , Kazuhiro Tsutsumi , Kouichi Aoyagi , Tomoyuki Manabe , Shin-Ya Sasaki , Susumu Katoh
发明人： Takashi Shimada , Hiroshi Ueno , Kazuhiro Tsutsumi , Kouichi Aoyagi , Tomoyuki Manabe , Shin-Ya Sasaki , Susumu Katoh
IPC分类号： C07C62/00 , C07C65/00 , A01N43/40
CPC分类号： C07C59/72 , C07B2200/07 , C07C59/86 , C07C69/734 , C07C235/34 , C07C235/78 , C07C2602/50 , C07D213/64 , C07D213/643 , C07D257/04 , C07D263/32 , C07D277/20 , C07D277/34
摘要： The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof
摘要翻译：由以下通式[Ia]表示的螺环化合物，其药学上可接受的盐或其溶剂合物

2. 发明申请

US20130109710A1 SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： SPIRO化合物及其药物用途
公开(公告)号：US20130109710A1
公开(公告)日：2013-05-02
申请号：US13616389
申请日：2012-09-14
申请人： Takashi Shimada , Hiroshi Ueno , Kazuhiro Tsutsumi , Kouichi Aoyagi , Tomoyuki Manabe , Shin-Ya Sasaki , Susumu Katoh
发明人： Takashi Shimada , Hiroshi Ueno , Kazuhiro Tsutsumi , Kouichi Aoyagi , Tomoyuki Manabe , Shin-Ya Sasaki , Susumu Katoh
IPC分类号： C07C59/72 , C07D213/64 , C07D263/32 , C07D277/34 , C07D257/04 , C07C235/78
CPC分类号： C07C59/72 , C07B2200/07 , C07C59/86 , C07C69/734 , C07C235/34 , C07C235/78 , C07C2602/50 , C07D213/64 , C07D213/643 , C07D257/04 , C07D263/32 , C07D277/20 , C07D277/34
摘要： The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof
摘要翻译：由以下通式[Ia]表示的螺环化合物，其药学上可接受的盐或其溶剂合物

3. 发明申请

US20090170908A1 SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF 有权
标题翻译： SPIRO化合物及其药物用途
公开(公告)号：US20090170908A1
公开(公告)日：2009-07-02
申请号：US12258033
申请日：2008-10-24
申请人： Takashi Shimada , Hiroshi Ueno , Kazuhiro Tsutsumi , Kouichi Aoyagi , Tomoyuki Manabe , Shin-Ya Sasaki , Susumu Katoh
发明人： Takashi Shimada , Hiroshi Ueno , Kazuhiro Tsutsumi , Kouichi Aoyagi , Tomoyuki Manabe , Shin-Ya Sasaki , Susumu Katoh
IPC分类号： A61K31/4412 , C07C59/00 , A61K31/192 , C07D257/04 , A61K31/41 , C07C229/02 , A61K31/195 , C07D263/30 , A61K31/421 , C07D277/20 , A61K31/426 , C07D213/62 , A61P3/00
CPC分类号： C07C59/72 , C07B2200/07 , C07C59/86 , C07C69/734 , C07C235/34 , C07C235/78 , C07C2602/50 , C07D213/64 , C07D213/643 , C07D257/04 , C07D263/32 , C07D277/20 , C07D277/34
摘要： The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof
摘要翻译：由以下通式[Ia]表示的螺环化合物，其药学上可接受的盐或其溶剂合物

4. 发明申请

US20060160359A1 Vacuum processing apparatus 审中-公开
标题翻译：真空加工设备
公开(公告)号：US20060160359A1
公开(公告)日：2006-07-20
申请号：US10546803
申请日：2004-02-12
申请人： Shigeru Kasai , Susumu Katoh , Tomohito Komatsu , Tetsuya Saito , Sumi Tanaka
发明人： Shigeru Kasai , Susumu Katoh , Tomohito Komatsu , Tetsuya Saito , Sumi Tanaka
IPC分类号： H01L21/44 , C23C16/00
CPC分类号： C23C16/45521 , C23C16/455
摘要： A vacuum processing apparatus is constituted of the following portions: a processing container with the bottom, capable of drawing vacuum; a placement platform installed in the container; a heating portion for heating a substrate on the platform; a processing gas-feeding portion for feeding a processing gas into the container; a partitioning portion surrounding a space between the platform and the bottom of the container and partitioning off the space from a processing space in the container; a purge gas-feeding portion for feeding a purge gas into the space surrounded by the partitioning portion; a purge gas-discharging portion for discharging the purge gas from the space surrounded by the partitioning portion; a control portion for controlling the purge gas-feeding portion and/or the purge gas-discharging portion so as to regulate the pressure in the space surrounded by the partitioning portion; and a temperature-detecting portion penetrating the bottom of the container, inserted in the space surrounded by the partitioning portion, and having the top end in contact with the platform. The partitioning portion has the lower end in surface-contact with the bottom of the container. The control portion regulates the pressure in the space surrounded by the partitioning portion to a pressure higher than that in the processing space in the container.
摘要翻译：真空处理装置由以下部分构成：具有底部的能够抽真空的处理容器; 安装在容器中的放置平台; 用于加热所述平台上的基板的加热部分; 处理气体供给部，用于将处理气体供给到所述容器中; 围绕所述平台和所述容器的底部之间的空间并将所述空间与所述容器中的处理空间分隔开的分隔部分; 净化气体供给部分，用于将净化气体供给到由分隔部分包围的空间中; 净化气体排出部，用于从由分隔部包围的空间排出净化气体; 用于控制净化气体供给部分和/或净化气体排出部分以便调节由分隔部分包围的空间中的压力的控制部分; 以及穿过容器底部的温度检测部分，插入由分隔部分包围的空间中，并且顶端与平台接触。分隔部分的下端与容器的底部表面接触。控制部将由分隔部包围的空间内的压力调整为高于容器内的处理空间的压力。

5. 发明申请

US20080161311A1 Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor 审中-公开
标题翻译：含氮稠环化合物及其作为HIV整合酶抑制剂的用途
公开(公告)号：US20080161311A1
公开(公告)日：2008-07-03
申请号：US11783270
申请日：2007-04-06
申请人： Susumu Miyazaki , Susumu Katoh , Kaoru Adachi , Hirotaka Isoshima , Satoru Kobayashi , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki
发明人： Susumu Miyazaki , Susumu Katoh , Kaoru Adachi , Hirotaka Isoshima , Satoru Kobayashi , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki
IPC分类号： A61K31/519 , A61K31/503
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.
摘要翻译：本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。因为它显示出整合酶特异性的高抑制活性，所以化合物可以是对人体安全的药剂，其副作用较小。

6. 发明授权

US06207006B1 Vacuum processing apparatus 有权
标题翻译：真空加工设备
公开(公告)号：US06207006B1
公开(公告)日：2001-03-27
申请号：US09156752
申请日：1998-09-16
申请人： Susumu Katoh
发明人： Susumu Katoh
IPC分类号： C23F102
CPC分类号： C23C16/45565 , C23C16/4412 , C23C16/45589 , H01J37/3244 , H01J37/32834 , H01L21/67017 , H01L21/68785 , Y02C20/30 , Y02P70/605
摘要： The vacuum processing apparatus of the present invention comprises a process chamber in which predetermined processing is performed on a target object in a predetermined vacuum condition, a mount stage provided in the process chamber, for mounting thereon the target object, a shower head provided so as to oppose to the mount stage, for supplying a process gas in the process chamber, an exhaust path provided in a housing forming the process chamber, and extending so as to surround the mount stage outside the mount stage, an exhaust port formed around the mount stage, for connecting the exhaust path with the process chamber, a porous member provided at the exhaust port so as to partition the exhaust path and the process chamber from each other, and having a plurality of ventilation holes for making the exhaust path communicating with the process chamber, branching means for branching a gas flowing from the process chamber through the ventilation holes of the porous member, into a plurality of directions, such that the gas flows to the exhaust path, a plurality of upper exhaust pipes extending in an upper side of the process chamber and communicating with the exhaust path, and a lower exhaust pipe extending toward a lower side of the process chamber and communicating with all the upper exhaust pipes.
摘要翻译：本发明的真空处理装置包括在预定的真空条件下对目标物体进行预定处理的处理室，设置在处理室中的安装台，用于安装目标物体;淋浴头，其设置为与安装台相反，用于在处理室中提供处理气体，设置在形成处理室的壳体中并且围绕安装台围绕安装台延伸的排气路径，形成在安装台周围的排气口用于将排气路径与处理室连接的多孔构件，设置在排气口处以将排气路径和处理室彼此分隔开的多孔构件，并且具有多个通气孔，用于使排气路径与排气路径连通处理室，分支装置，用于将从处理室流出的气体通过多孔构件的通风孔分支成多个方向的方向，使得气体流到排气路径，在处理室的上侧延伸并与排气路径连通的多个上排气管，以及朝向处理室的下侧延伸的下排气管并与所有上排气管连通。

7. 发明授权

US5132545A Ion implantation apparatus 失效
标题翻译：离子植入装置
公开(公告)号：US5132545A
公开(公告)日：1992-07-21
申请号：US568191
申请日：1990-08-16
申请人： Kazuhiro Shono , Shigeo Sasaki , Susumu Katoh , Masao Naitou , Tetsuya Nakanishi , Naomitsu Fujishita , Kazuhiko Noguchi , Masayasu Tanjo
发明人： Kazuhiro Shono , Shigeo Sasaki , Susumu Katoh , Masao Naitou , Tetsuya Nakanishi , Naomitsu Fujishita , Kazuhiko Noguchi , Masayasu Tanjo
IPC分类号： H01J37/302 , H01J37/317
CPC分类号： H01J37/302 , H01J37/3171 , H01J2237/24542
摘要： An ion implantation apparatus includes an ion source having an arc chamber generating ions and a drawing electrode drawing ions from the arc chamber, a mass separator transporting only ions desired for implantation, an ion implantation chamber in which the material to be implanted by ions is placed, and a controller means for automatically controlling the distance between the arc chamber and the drawing electrode incrementally in accordance with a theoretical calculation using normalized perveance considering the kind of ions to be implanted, the accelerating voltage, and the ion current and current density distribution.

8. 发明申请

US20050054645A1 Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor 审中-公开
标题翻译：含氮稠环化合物及其作为HIV整合酶抑制剂的用途
公开(公告)号：US20050054645A1
公开(公告)日：2005-03-10
申请号：US10958225
申请日：2004-10-05
申请人： Susumu Miyazaki , Susumu Katoh , Kaoru Adachi , Hirotaka Isoshima , Satoru Kobayashi , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki
发明人： Susumu Miyazaki , Susumu Katoh , Kaoru Adachi , Hirotaka Isoshima , Satoru Kobayashi , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki
IPC分类号： A61K31/4985 , A61K31/519 , A61K31/53 , A61K31/551 , A61P31/12 , A61P31/18 , A61P43/00 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Becuae it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.
摘要翻译：本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。它表现出整合酶特异性的高抑制活性，该化合物可以作为人体安全的药物，这只会减少副作用。

9. 发明授权

US06630472B1 Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation 失效
标题翻译：化合物，药物组合物和刺激神经元生长和伸长的方法
公开(公告)号：US06630472B1
公开(公告)日：2003-10-07
申请号：US09356240
申请日：1999-07-16
申请人： Susumu Katoh , Hiroshi Kawakami , Hiroki Tada , Maria Angelica Linton , Vincent Kalish , John Howard Tatlock , Jesus Ernesto Villafranca
发明人： Susumu Katoh , Hiroshi Kawakami , Hiroki Tada , Maria Angelica Linton , Vincent Kalish , John Howard Tatlock , Jesus Ernesto Villafranca
IPC分类号： C07D47118
CPC分类号： C07D471/08
摘要： Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic azaamide nucleus. Pharmaceutical compositions containing such compounds help stimulate the outgrowth of neurites in nerve cells and augmenting nerve regeneration. Methods of treating nerve cells with such compositions are useful to promote repair of neuronal damage caused by disease and physical trauma.
摘要翻译：描述了抑制FK-506结合蛋白（FKBP）的肽基 - 脯氨酰异构酶（旋转异构酶）酶活性的化合物和包含这些化合物的组合物。 FKBP抑制化合物具有双环[3.3.1]，[4.3.1]或多环氮杂酰胺核。含有这些化合物的药物组合物有助于刺激神经细胞中神经突的生长并增加神经再生。用这种组合物治疗神经细胞的方法可用于促进由疾病和身体创伤引起的神经元损伤的修复。

10. 发明授权

US07211572B2 Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor 有权
标题翻译：含氮稠环化合物及其作为HIV整合酶抑制剂的用途
公开(公告)号：US07211572B2
公开(公告)日：2007-05-01
申请号：US11255605
申请日：2005-10-13
申请人： Susumu Miyazaki , Susumu Katoh , Kaoru Adachi , Hirotaka Isoshima , Satoru Kobayashi , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki
发明人： Susumu Miyazaki , Susumu Katoh , Kaoru Adachi , Hirotaka Isoshima , Satoru Kobayashi , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki
IPC分类号： A01N43/00 , A01N43/58 , A61K31/55 , A61K31/553 , A61K31/554
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.
摘要翻译：本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。因为它显示出整合酶特异性的高抑制活性，所以化合物可以是对人体安全的药剂，其副作用较小。

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