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1. 发明申请

US20060072191A1 Confocal microscope 审中-公开
标题翻译：共焦显微镜
公开(公告)号：US20060072191A1
公开(公告)日：2006-04-06
申请号：US11242871
申请日：2005-10-05
申请人： Takashi Akiyama , Kenta Mikuriya , Yasuhito Kosugi
发明人： Takashi Akiyama , Kenta Mikuriya , Yasuhito Kosugi
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G02B21/0044 , G02B21/0048 , G02B21/0084
摘要： In A confocal microscope, a mirror reflects illumination light to focus on a focal point face of a sample through an object lens. The mirror is rotated to scan a focal point of the illumination light. A confocal image provided based on returned light from the sample. The confocal microscope has a first multipinhole array which has a plurality of pinholes, and to which light emitted from a light source is illuminated, and a second multipinhole array which has a plurality of pinholes, and intercepts light from other than the focal point face out of the returned light from the sample. The first multipinhole array functions as a plurality of point light sources, and the illumination light is light which passes through the pinholes of the first multipinhole array.
摘要翻译：在共聚焦显微镜中，镜子反射照明光以通过物镜聚焦在样品的焦点面上。旋转镜子以扫描照明光的焦点。基于来自样品的返回光提供的共焦图像。共焦显微镜具有第一多孔阵列，其具有多个针孔，并且从光源发射的光被照射到该第一多孔阵列，以及第二多孔阵列，其具有多个针孔，并且将来自焦点以外的光截取为面向外来自样品的返回光。第一多孔阵列用作多个点光源，并且照明光是穿过第一多孔阵列的针孔的光。

2. 发明申请

US20070096014A1 CONFOCAL SCANNER 失效
标题翻译：协同扫描仪
公开(公告)号：US20070096014A1
公开(公告)日：2007-05-03
申请号：US11382724
申请日：2006-05-11
申请人： Kenta Mikuriya , Takashi Yoshida , Yasuhito Kosugi
发明人： Kenta Mikuriya , Takashi Yoshida , Yasuhito Kosugi
IPC分类号： H01J3/14
CPC分类号： G02B21/0044 , G02B21/0032 , G02B27/30
摘要： There is achieved a confocal scanner capable of being adjusted can be achieved with ease so as to be in a well-balanced state where a utilization ratio of an excited light is high and light quantity distribution on the cross-section of beams is excellent in evenness even in the case of being coupled with an optical fiber varying in a beam spread-angle. The confocal scanner is provided with a collimator lens for causing beams outgoing from an emission end of an optical fiber for guiding an excited light, with a predetermined spread-angle, to be converted into collimated beams before falling on a microlens disk, wherein a beam spread-angle adjusting means for adjusting the spread-angle is provided between the emission end, and the collimator lens.
摘要翻译：实现能够被调整的共焦扫描器能够容易地实现，以便处于激发光的利用率高的良好平衡状态，并且横梁的横截面上的光量分布具有优异的均匀性即使在与光束扩展角度变化的光纤耦合的情况下也是如此。共焦扫描器设置有准直透镜，用于使得从光纤的发射端射出的光束以预定的扩展角度引导激发的光，在被落入微透镜盘之前被转换为准直的光束，其中光束在发射端和准直透镜之间设置用于调整扩展角的扩展角度调节装置。

3. 发明授权

US07190514B2 Confocal scanning microscope 有权
标题翻译：共焦扫描显微镜
公开(公告)号：US07190514B2
公开(公告)日：2007-03-13
申请号：US10916425
申请日：2004-08-12
申请人： Kenta Mikuriya , Yasuhiro Tanibata , Hideomi Negishi , Naoki Seki , Yasuhito Kosugi
发明人： Kenta Mikuriya , Yasuhiro Tanibata , Hideomi Negishi , Naoki Seki , Yasuhito Kosugi
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/0024
摘要： The present invention provides a confocal scanning microscope whereby fluorescence observations can be made using a plurality of types of excitation light without the need for attaching and detaching a light source to and from the optical fiber. The confocal scanning microscope comprises: a light source unit for emitting excitation light that excites a sample; a scanner unit for scanning the sample with the excitation light; and an imaging camera for capturing an image of the sample by receiving fluorescent light emitted from the sample; the light source unit having a plurality of light sources for emitting laser light with different wavelengths and a multicore optical fiber cable for transmitting light from the plurality of light sources, one end of the multicore optical fiber cable being separated into a plurality of optical fibers, and light from each of the plurality of light sources being input to one end of each of the separate optical fibers.
摘要翻译：本发明提供一种共焦扫描显微镜，其中可以使用多种类型的激发光进行荧光观察，而不需要将光源连接到光纤和从光纤分离。共焦扫描显微镜包括：用于发射激发样品的激发光的光源单元; 用于用激发光扫描样品的扫描器单元; 以及成像摄像机，用于通过接收从样本发射的荧光来捕获样本的图像; 所述光源单元具有用于发射具有不同波长的激光的多个光源和用于透射来自所述多个光源的光的多芯光缆，所述多芯光缆的一端被分离成多根光纤，并且来自多个光源中的每一个的光被输入到每个分离的光纤的一端。

4. 发明授权

US07592582B2 Confocal scanner having beam spread angle adjustment device 失效
标题翻译：共焦扫描器具有光束扩展角度调节装置
公开(公告)号：US07592582B2
公开(公告)日：2009-09-22
申请号：US11382724
申请日：2006-05-11
申请人： Kenta Mikuriya , Takashi Yoshida , Yasuhito Kosugi
发明人： Kenta Mikuriya , Takashi Yoshida , Yasuhito Kosugi
IPC分类号： H01J3/14 , G02B21/06
CPC分类号： G02B21/0044 , G02B21/0032 , G02B27/30
摘要： There is achieved a confocal scanner capable of being adjusted can be achieved with ease so as to be in a well-balanced state where a utilization ratio of an excited light is high and light quantity distribution on the cross-section of beams is excellent in evenness even in the case of being coupled with an optical fiber varying in a beam spread-angle. The confocal scanner is provided with a collimator lens for causing beams outgoing from an emission end of an optical fiber for guiding an excited light, with a predetermined spread-angle, to be converted into collimated beams before falling on a microlens disk, wherein a beam spread-angle adjusting means for adjusting the spread-angle is provided between the emission end, and the collimator lens.
摘要翻译：实现能够被调整的共焦扫描器能够容易地实现，以便处于激发光的利用率高的良好平衡状态，并且横梁的横截面上的光量分布具有优异的均匀性即使在与光束扩展角度变化的光纤耦合的情况下也是如此。共焦扫描器设置有准直透镜，用于使得从光纤的发射端射出的光束以预定的扩展角度引导激发的光，在被落入微透镜盘之前被转换为准直的光束，其中光束在发射端和准直透镜之间设置用于调整扩展角的扩展角度调节装置。

5. 发明申请

US20060033988A1 Confocal scanning microscope 有权
标题翻译：共焦扫描显微镜
公开(公告)号：US20060033988A1
公开(公告)日：2006-02-16
申请号：US10916425
申请日：2004-08-12
申请人： Kenta Mikuriya , Yasuhiro Tanibata , Hideomi Negishi , Naoki Seki , Yasuhito Kosugi
发明人： Kenta Mikuriya , Yasuhiro Tanibata , Hideomi Negishi , Naoki Seki , Yasuhito Kosugi
IPC分类号： G02B21/06
CPC分类号： G02B21/0024
摘要： The present invention provides a confocal scanning microscope whereby fluorescence observations can be made using a plurality of types of excitation light without the need for attaching and detaching a light source to and from the optical fiber. The confocal scanning microscope comprises: a light source unit for emitting excitation light that excites a sample; a scanner unit for scanning the sample with the excitation light; and an imaging camera for capturing an image of the sample by receiving fluorescent light emitted from the sample; the light source unit having a plurality of light sources for emitting laser light with different wavelengths and a multicore optical fiber cable for transmitting light from the plurality of light sources, one end of the multicore optical fiber cable being separated into a plurality of optical fibers, and light from each of the plurality of light sources being input to one end of each of the separate optical fibers.
摘要翻译：本发明提供一种共焦扫描显微镜，其中可以使用多种类型的激发光进行荧光观察，而不需要将光源连接到光纤和从光纤分离。共焦扫描显微镜包括：用于发射激发样品的激发光的光源单元; 用于用激发光扫描样品的扫描器单元; 以及成像摄像机，用于通过接收从样本发射的荧光来捕获样本的图像; 所述光源单元具有用于发射具有不同波长的激光的多个光源和用于透射来自所述多个光源的光的多芯光缆，所述多芯光缆的一端被分离成多根光纤，并且来自多个光源中的每一个的光被输入到每个分离的光纤的一端。

6. 发明申请

US20060044648A1 THREE-DIMENSIONAL CONFOCAL MICROSCOPE 失效
标题翻译：三维共焦显微镜
公开(公告)号：US20060044648A1
公开(公告)日：2006-03-02
申请号：US10929554
申请日：2004-08-31
申请人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
发明人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B3/14 , G02B21/006 , G02B21/0084 , G02B26/005
摘要： This invention realizes a three-dimensional confocal microscope in which mechanical vibrations do not occur in the scanning unit for scanning in the direction of optical axis, and in which scanning in the direction of optical axis can be carried out at a high speed. This invention has the following features. In the confocal microscope having a confocal scanner attached to an optical microscope and constructed to enable acquisition of an image of a sample as a confocal image by the confocal scanner, a variable-focus lens of surface tension control type having no moving part is uses as the field lens.
摘要翻译：本发明实现了三维共聚焦显微镜，其中在扫描单元中不会在光轴方向上进行机械振动，并且可以高速地进行光轴方向的扫描。本发明具有以下特征。在具有附着到光学显微镜并被构造为能够通过共聚焦扫描仪获取样品的图像作为共焦图像的共聚焦扫描器的共聚焦显微镜中，具有无移动部分的表面张力控制型变焦聚焦透镜用作现场镜头。

7. 发明授权

US07002737B1 Three-dimensional confocal microscope 失效
标题翻译：三维共聚焦显微镜
公开(公告)号：US07002737B1
公开(公告)日：2006-02-21
申请号：US10929554
申请日：2004-08-31
申请人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
发明人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B3/14 , G02B21/006 , G02B21/0084 , G02B26/005
摘要： This invention realizes a three-dimensional confocal microscope in which mechanical vibrations do not occur in the scanning unit for scanning in the direction of optical axis, and in which scanning in the direction of optical axis can be carried out at a high speed. This invention has the following features. In the confocal microscope having a confocal scanner attached to an optical microscope and constructed to enable acquisition of an image of a sample as a confocal image by the confocal scanner, a variable-focus lens of surface tension control type having no moving part is uses as the field lens.
摘要翻译：本发明实现了三维共聚焦显微镜，其中在扫描单元中不会在光轴方向上进行机械振动，并且可以高速地进行光轴方向的扫描。本发明具有以下特征。在具有附着到光学显微镜并被构造为能够通过共聚焦扫描仪获取样品的图像作为共焦图像的共聚焦扫描器的共聚焦显微镜中，具有无移动部分的表面张力控制型变焦聚焦透镜用作现场镜头。

8. 发明申请

US20050142608A1 Screening method and device, and new drug screening method and device 审中-公开
标题翻译：筛选方法和装置，以及新的药物筛选方法和装置
公开(公告)号：US20050142608A1
公开(公告)日：2005-06-30
申请号：US10928173
申请日：2004-08-30
申请人： Isao Uchida , Kenta Mikuriya , Toshiyuki Suzuki , Toshio Iino , Takashi Akiyama
发明人： Isao Uchida , Kenta Mikuriya , Toshiyuki Suzuki , Toshio Iino , Takashi Akiyama
IPC分类号： G01N21/64 , G01N33/50 , C12Q1/68 , C12M1/34 , G01N33/48 , G01N33/53 , G01N33/567 , G06F19/00
CPC分类号： G01N33/502 , G01N21/6408 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/5008 , G02B21/0044 , G02B21/0076
摘要： The present invention realizes a screening method and device able to obtain the entire image of a cell as a detailed and accurate (with a good SN ratio) image at high speed by observing the cell image while a Nipkow system confocal scanner is used and the focal position of an objective lens is changed in the optical axis direction. In the present invention, a reagent and a fluorescent marked cell are injected into a well. The focal position is changed in the optical axis direction by using the Nipkow system confocal scanner. Excitation light is irradiated to the well in each focal position, and fluorescent light generated from the cell is received and the degree of activity, and so on, of the cell is measured and displayed on the basis of a slice image of the cell.
摘要翻译：本发明实现了一种筛选方法和装置，其能够在使用Nipkow系统共聚焦扫描仪的同时观察细胞图像，以高速度获得细胞的整个图像（具有良好的SN比）图像，并且聚焦物镜的位置在光轴方向上变化。在本发明中，将试剂和荧光标记的细胞注入孔中。使用Nipkow系统共聚焦扫描仪在光轴方向上改变焦点位置。激发光被照射到每个焦点位置的阱，并且接收从单元产生的荧光，并且基于单元的切片图像来测量和显示单元的活动程度等。

9. 发明申请

US20050287520A1 Screening method and device, and new drug screening method and device 审中-公开
公开(公告)号：US20050287520A1
公开(公告)日：2005-12-29
申请号：US11200143
申请日：2005-08-10
申请人： Isao Uchida , Kenta Mikuriya , Toshiyuki Suzuki , Toshio Iino , Takashi Akiyama
发明人： Isao Uchida , Kenta Mikuriya , Toshiyuki Suzuki , Toshio Iino , Takashi Akiyama
IPC分类号： G01N21/64 , G01N33/50 , C12Q1/68 , C12M1/34 , C12Q1/00 , G06K9/00
CPC分类号： G01N33/502 , G01N21/6408 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/5008 , G02B21/0044 , G02B21/0076
摘要： The present invention realizes a screening method and device able to obtain the entire image of a cell as a detailed and accurate (with a good SN ratio) image at high speed by observing the cell image while a Nipkow system confocal scanner is used and the focal position of an objective lens is changed in the optical axis direction. In the present invention, a reagent and a fluorescent marked cell are injected into a well. The focal position is changed in the optical axis direction by using the Nipkow system confocal scanner. Excitation light is irradiated to the well in each focal position, and fluorescent light generated from the cell is received and the degree of activity, and so on, of the cell is measured and displayed on the basis of a slice image of the cell.

10. 发明授权

US07400446B2 Confocal microscope 失效
标题翻译：共焦显微镜
公开(公告)号：US07400446B2
公开(公告)日：2008-07-15
申请号：US11362228
申请日：2006-02-27
申请人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
发明人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
IPC分类号： G02B21/06
CPC分类号： G02B21/004 , G02B21/0044 , G02B21/0076
摘要： A confocal microscope uses fluorescent or reflected light obtained by irradiating a plurality of beam spots to a sample so as to observe the sample. The confocal microscope has a phase modulator element which modulates phase of laser light to form the beam spots, a liquid crystal element which forms a plurality of pinholes through which only the fluorescent or the reflected light is transmitted, and a control section which controls the phase modulator element and the liquid crystal element.
摘要翻译：共焦显微镜使用通过对样品照射多个束斑而获得的荧光或反射光，以观察样品。共聚焦显微镜具有调制激光相位以形成光束斑的相位调制元件，形成仅透过荧光或反射光的多个针孔的液晶元件和控制相位的控制部调制元件和液晶元件。

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