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1. 发明申请

US20090010807A1 DRUG CREATING SCREENING APPARATUS 审中-公开
标题翻译：药物制作筛选装置
公开(公告)号：US20090010807A1
公开(公告)日：2009-01-08
申请号：US12113998
申请日：2008-05-02
申请人： Yasunori YOKOYAMA , Takayuki KEI , Kenta MIKURIYA
发明人： Yasunori YOKOYAMA , Takayuki KEI , Kenta MIKURIYA
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6458 , G01N2021/6482
摘要： A drug creating screening apparatus characterized in a drug creating screening apparatus including a well plate provided with a plurality of wells and glass brought into contact with a bottom face of the well plate for carrying out drug creating screening based on information of fluorescence emitted by irradiating exciting light to samples mounted between a plurality of the wells and the glass, wherein at least one opening portion for measuring a thickness of the glass is provided at the well plate.
摘要翻译：一种药物制备筛选装置，其特征在于药物制备筛选装置，其包括设置有多个孔的孔板和与所述孔板的底面接触的玻璃，用于基于通过辐射刺激而发射的荧光的信息进行药物制备筛选对安装在多个孔和玻璃之间的样品进行光照，其中在孔板处设置用于测量玻璃厚度的至少一个开口部分。

2. 发明授权

US07400446B2 Confocal microscope 失效
标题翻译：共焦显微镜
公开(公告)号：US07400446B2
公开(公告)日：2008-07-15
申请号：US11362228
申请日：2006-02-27
申请人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
发明人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
IPC分类号： G02B21/06
CPC分类号： G02B21/004 , G02B21/0044 , G02B21/0076
摘要： A confocal microscope uses fluorescent or reflected light obtained by irradiating a plurality of beam spots to a sample so as to observe the sample. The confocal microscope has a phase modulator element which modulates phase of laser light to form the beam spots, a liquid crystal element which forms a plurality of pinholes through which only the fluorescent or the reflected light is transmitted, and a control section which controls the phase modulator element and the liquid crystal element.
摘要翻译：共焦显微镜使用通过对样品照射多个束斑而获得的荧光或反射光，以观察样品。共聚焦显微镜具有调制激光相位以形成光束斑的相位调制元件，形成仅透过荧光或反射光的多个针孔的液晶元件和控制相位的控制部调制元件和液晶元件。

3. 发明授权

US5428475A Confocal optical scanner 失效
标题翻译：共焦光学扫描仪
公开(公告)号：US5428475A
公开(公告)日：1995-06-27
申请号：US942156
申请日：1992-09-08
申请人： Takeo Tanaami , Kenta Mikuriya
发明人： Takeo Tanaami , Kenta Mikuriya
IPC分类号： G02B3/00 , G02B3/08 , G02B21/00 , G02B26/02
CPC分类号： G02B3/0056 , G02B21/0044 , G02B21/0064 , G02B3/08 , G02B3/0006
摘要： A confocal optical scanner which realizes optical scanning without nonuniformity of brightness at the inside and outside periperies of the pinhole disk by arraying the pinholes along spiral tracks at the same pitch; which allows adjustment of decentering to be readily performed by disposing pinholes so that stripes do not occur even when decentering is large; which allows more incident light to be collected at the pinholes through a plurality of collector elements by disposing the pinholes at focal points of the collector elements; which improves luminous utilization efficacy by reducing the illumination area of light by adopting the collector elements to focus outside of the aperture pupil; which prevents decrease of confocal resolution due to pinhole diameter by causing the light reflected from the sample to not enter a collector disk; and which reduces stray light from the pinhole disk by covering non-collector portions of the collector disk with a shading film.
摘要翻译：一种共焦光学扫描仪，通过以相同的间距沿着螺旋轨道排列针孔，实现光学扫描，而不会在针孔盘的内侧和外侧的亮度不均匀; 这允许通过布置针孔来容易地进行偏心调节，使得即使在偏心较大时也不会发生条纹; 这允许通过将针孔设置在集电器元件的焦点处，通过多个收集器元件在针孔处收集更多的入射光; 通过采集收集器元件聚焦在孔径光瞳外部，通过减小光的照明面积来提高发光效率; 通过使得从样品反射的光不进入集电盘，防止由于针孔直径引起的共聚焦分辨率降低; 并且通过用遮光膜覆盖收集盘的非集电器部分来减少来自针孔盘的杂散光。

4. 发明申请

US20070096014A1 CONFOCAL SCANNER 失效
标题翻译：协同扫描仪
公开(公告)号：US20070096014A1
公开(公告)日：2007-05-03
申请号：US11382724
申请日：2006-05-11
申请人： Kenta Mikuriya , Takashi Yoshida , Yasuhito Kosugi
发明人： Kenta Mikuriya , Takashi Yoshida , Yasuhito Kosugi
IPC分类号： H01J3/14
CPC分类号： G02B21/0044 , G02B21/0032 , G02B27/30
摘要： There is achieved a confocal scanner capable of being adjusted can be achieved with ease so as to be in a well-balanced state where a utilization ratio of an excited light is high and light quantity distribution on the cross-section of beams is excellent in evenness even in the case of being coupled with an optical fiber varying in a beam spread-angle. The confocal scanner is provided with a collimator lens for causing beams outgoing from an emission end of an optical fiber for guiding an excited light, with a predetermined spread-angle, to be converted into collimated beams before falling on a microlens disk, wherein a beam spread-angle adjusting means for adjusting the spread-angle is provided between the emission end, and the collimator lens.
摘要翻译：实现能够被调整的共焦扫描器能够容易地实现，以便处于激发光的利用率高的良好平衡状态，并且横梁的横截面上的光量分布具有优异的均匀性即使在与光束扩展角度变化的光纤耦合的情况下也是如此。共焦扫描器设置有准直透镜，用于使得从光纤的发射端射出的光束以预定的扩展角度引导激发的光，在被落入微透镜盘之前被转换为准直的光束，其中光束在发射端和准直透镜之间设置用于调整扩展角的扩展角度调节装置。

5. 发明授权

US07190514B2 Confocal scanning microscope 有权
标题翻译：共焦扫描显微镜
公开(公告)号：US07190514B2
公开(公告)日：2007-03-13
申请号：US10916425
申请日：2004-08-12
申请人： Kenta Mikuriya , Yasuhiro Tanibata , Hideomi Negishi , Naoki Seki , Yasuhito Kosugi
发明人： Kenta Mikuriya , Yasuhiro Tanibata , Hideomi Negishi , Naoki Seki , Yasuhito Kosugi
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/0024
摘要： The present invention provides a confocal scanning microscope whereby fluorescence observations can be made using a plurality of types of excitation light without the need for attaching and detaching a light source to and from the optical fiber. The confocal scanning microscope comprises: a light source unit for emitting excitation light that excites a sample; a scanner unit for scanning the sample with the excitation light; and an imaging camera for capturing an image of the sample by receiving fluorescent light emitted from the sample; the light source unit having a plurality of light sources for emitting laser light with different wavelengths and a multicore optical fiber cable for transmitting light from the plurality of light sources, one end of the multicore optical fiber cable being separated into a plurality of optical fibers, and light from each of the plurality of light sources being input to one end of each of the separate optical fibers.
摘要翻译：本发明提供一种共焦扫描显微镜，其中可以使用多种类型的激发光进行荧光观察，而不需要将光源连接到光纤和从光纤分离。共焦扫描显微镜包括：用于发射激发样品的激发光的光源单元; 用于用激发光扫描样品的扫描器单元; 以及成像摄像机，用于通过接收从样本发射的荧光来捕获样本的图像; 所述光源单元具有用于发射具有不同波长的激光的多个光源和用于透射来自所述多个光源的光的多芯光缆，所述多芯光缆的一端被分离成多根光纤，并且来自多个光源中的每一个的光被输入到每个分离的光纤的一端。

6. 发明申请

US20060068488A1 Screening apparatus 审中-公开
标题翻译：筛选仪器
公开(公告)号：US20060068488A1
公开(公告)日：2006-03-30
申请号：US11238045
申请日：2005-09-29
申请人： Akihiko Anyoji , Katsuyoshi Hori , Kenta Mikuriya
发明人： Akihiko Anyoji , Katsuyoshi Hori , Kenta Mikuriya
IPC分类号： G06K9/00 , C12M1/34
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2035/00158
摘要： A screening apparatus detects images of a plurality of wells provided at a plate to perform screening in a new drug process. The screening apparatus has a plurality of detecting portions which are fixedly arranged and individually detect images of wells different from each other, a movable stage on which the plate is mounted, a carrying portion which moves the stage so that positions of the wells of the plate correspond with measuring positions of the detecting portions, and a detection controlling portion which controls the detecting portions to simultaneously detect the images of the wells different from each other.
摘要翻译：筛选装置检测设置在板上的多个孔的图像，以在新的药物过程中进行筛选。筛选装置具有多个检测部分，其固定地布置并且分别检测彼此不同的孔的图像，安装有板的可移动台，移动台的承载部分，使得板的孔的位置对应于检测部分的测量位置，以及检测控制部分，其控制检测部分以同时检测彼此不同的孔的图像。

7. 发明申请

US20060044648A1 THREE-DIMENSIONAL CONFOCAL MICROSCOPE 失效
标题翻译：三维共焦显微镜
公开(公告)号：US20060044648A1
公开(公告)日：2006-03-02
申请号：US10929554
申请日：2004-08-31
申请人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
发明人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B3/14 , G02B21/006 , G02B21/0084 , G02B26/005
摘要： This invention realizes a three-dimensional confocal microscope in which mechanical vibrations do not occur in the scanning unit for scanning in the direction of optical axis, and in which scanning in the direction of optical axis can be carried out at a high speed. This invention has the following features. In the confocal microscope having a confocal scanner attached to an optical microscope and constructed to enable acquisition of an image of a sample as a confocal image by the confocal scanner, a variable-focus lens of surface tension control type having no moving part is uses as the field lens.
摘要翻译：本发明实现了三维共聚焦显微镜，其中在扫描单元中不会在光轴方向上进行机械振动，并且可以高速地进行光轴方向的扫描。本发明具有以下特征。在具有附着到光学显微镜并被构造为能够通过共聚焦扫描仪获取样品的图像作为共焦图像的共聚焦扫描器的共聚焦显微镜中，具有无移动部分的表面张力控制型变焦聚焦透镜用作现场镜头。

8. 发明授权

US07002737B1 Three-dimensional confocal microscope 失效
标题翻译：三维共聚焦显微镜
公开(公告)号：US07002737B1
公开(公告)日：2006-02-21
申请号：US10929554
申请日：2004-08-31
申请人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
发明人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B3/14 , G02B21/006 , G02B21/0084 , G02B26/005
摘要： This invention realizes a three-dimensional confocal microscope in which mechanical vibrations do not occur in the scanning unit for scanning in the direction of optical axis, and in which scanning in the direction of optical axis can be carried out at a high speed. This invention has the following features. In the confocal microscope having a confocal scanner attached to an optical microscope and constructed to enable acquisition of an image of a sample as a confocal image by the confocal scanner, a variable-focus lens of surface tension control type having no moving part is uses as the field lens.
摘要翻译：本发明实现了三维共聚焦显微镜，其中在扫描单元中不会在光轴方向上进行机械振动，并且可以高速地进行光轴方向的扫描。本发明具有以下特征。在具有附着到光学显微镜并被构造为能够通过共聚焦扫描仪获取样品的图像作为共焦图像的共聚焦扫描器的共聚焦显微镜中，具有无移动部分的表面张力控制型变焦聚焦透镜用作现场镜头。

9. 发明申请

US20050012989A1 Three-dimensional confocal microscope system 失效
标题翻译：三维共焦显微镜系统
公开(公告)号：US20050012989A1
公开(公告)日：2005-01-20
申请号：US10800754
申请日：2004-03-16
申请人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
发明人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B21/0024
摘要： The present invention is characterized in that it is possible to provide a three-dimensional confocal microscope system configured so that an objective lens can be scanned in the optical-axis direction using an actuator to obtain sliced confocal images of a sample, wherein the actuator is driven using a scanning waveform signal, which is triangular or step-like and has been corrected so that acceleration is kept virtually constant at discontinuous points of change in the scanning waveform signal, thereby consistently providing sliced confocal images of the sample.
摘要翻译：本发明的特征在于，可以提供一种三维共聚焦显微镜系统，其被配置为使得可以使用致动器在光轴方向上扫描物镜，以获得样品的切片共聚焦图像，其中致动器是使用三角形或阶梯状的扫描波形信号进行驱动，并且已被校正，使得加速度在扫描波形信号的不连续点处几乎保持不变，从而一致地提供样品的切片共聚焦图像。

10. 发明授权

US5592292A Interference spectrometer with a moving mirror 失效
标题翻译：干涉光谱仪带有移动镜
公开(公告)号：US5592292A
公开(公告)日：1997-01-07
申请号：US353679
申请日：1994-12-12
申请人： Tomoaki Nanko , Takeo Tanaami , Kenta Mikuriya
发明人： Tomoaki Nanko , Takeo Tanaami , Kenta Mikuriya
IPC分类号： G01J3/45 , G01J3/453 , G01B9/02
CPC分类号： G01J3/4535
摘要： An interference spectrometer which causes an interference by dividing an output light from a light source into two optical paths and by changing the length of each optical path, and which comprises a moving mirror for changing the optical path lengths, position detecting means for detecting the position of the moving mirror and driving control means for controlling the position of the moving mirror, based on the output from the position detecting means. The spectrometer utilizes leaf springs to support the moving mirror, and the driving control means is driven at the natural frequency of the combined moving mirror and leaf springs and based on the output of the position detecting means. Advantageously, the invention has improved vibration resistance and improved power consumption.
摘要翻译：一种干涉光谱仪，其通过将来自光源的输出光分成两个光路而引起干扰，并且通过改变每个光路的长度，并且包括用于改变光路长度的移动镜，用于检测位置的位置检测装置以及用于根据位置检测装置的输出来控制移动反射镜的位置的驱动控制装置。光谱仪利用板簧支撑移动反射镜，驱动控制装置以组合的移动反射镜和板簧的固有频率，并基于位置检测装置的输出而被驱动。有利地，本发明具有改善的抗振性和改善的功率消耗。

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